Announcements

4 March 2024
MDPI Insights: The CEO's Letter #9 - Romania, Research Integrity, Viruses

Welcome to the MDPI Insights: The CEO's Letter.

In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.


Opening Thoughts


Reka Kovacs (Deputy Office Manager, MDPI), Stefan Tochev (CEO, MDPI), and Sandra Ana Spatariu (Office Manager, MDPI) at the MDPI office in Cluj, Romania.

MDPI’s Impact on Romania

In February, I visited our office in Cluj, Romania. I worked closely with our senior office managers and various teams, including the departments of training, marketing and conferences, as well as our journal relationship specialists, reviewing our service to the local scholarly community. During the visit, I also met with representatives from Babes-Bolyai University and the Technical University of Cluj-Napoca. Our multifunctional Romanian office plays an important role in supporting our collaborations with the local market as well as helping to meet MDPI’s overall business needs.


Feedback and strategy meeting with a group of MDPI’s Journal Relationship Specialists at the MDPI office in Cluj, Romania.

With 22,436 articles, Romania ranks as a top 20 contributing country to MDPI’s total number of papers published as at 28 February 2024. This highlights the importance of our collaboration with Romanian-affiliated authors and the growing opportunity to support their publishing needs. MDPI is one of the few academic publishers with a significant presence in Romania, boasting over 360 colleagues across our offices in Bucharest and Cluj. We are also proud to hire colleagues from local institutions to launch their careers within publishing.

Romania ranks as a top 20 contributing country.

The Numbers: 2019–2023

MDPI has seen a healthy increase in submissions from Romanian authors over the past three years, from 8,439 in 2021 to 11,866 by end of 2023, with most submissions going to journals such as Sustainability, Medicina, Diagnostics, IJMS, Applied Sciences, and JCM. From 2019 to 2023, MDPI published articles from 32,145 authors affiliated with Romanian institutions. Over those years, we have worked with Romanian Guest Editors on nearly 3,000 occasions to support their Special Issue and Topical collections.

With more than 300 Editorial Board Members from Romania, 34 appear on the board of Mathematics, 27 on Materials, 19 on Polymers, 18 on Coatings, and 16 on Molecules, while three serve as Section Editors-in-Chief (SEiC) on our journals Coatings (3.4 IF, 4.6 Citescore), Magnetochemistry (2.7 IF, 3.5 Citescore), and Chemosensors (4.2 IF, 3.9 Citescore).

Institutional Open Access Programs

Our commitment to working with institutions is evident in Romania, where we have established eight Institutional Open Access Programs (IOAP) with esteemed institutions such as the University of Bucharest, the University of Medicine and Pharmacy Cluj-Napoca, and most recently the National Institute for Laser, Plasma and Radiation Physics.

Our growth and presence in Romania are a true testament.

We also have IOAP agreements with Babes-Bolyai University and the Technical University of Cluj-Napoca, where I had the opportunity to meet senior stakeholders during my visit. Below are a few photos capturing our meeting with Prof. Radu Silaghi-Dumitrescu (Head of Faculty of Chemistry, Babes-Bolyai University) at the MDPI office in Cluj, Romania, along with a photo from our meeting with Vice Deans Nicoleta Cobarzan, Nicoleta Ilies, and Hoda Gavril, from the faculty of Civil Engineering at the Technical University of Cluj, Romania.


Our growth and presence in Romania are a true testament to the service we provide to the scholarly community and the relationships we foster in that region. We look forward to continuing to support Romanian scholars and institutions by providing a valuable and trusted experience with MDPI, the leader in open access publishing.

Impactful Research

MDPI Joins the STM Integrity Hub

MDPI has long been a supporter and partner of STM, with our involvement ranging from sponsoring and attending events to helping organize event programs. By joining the STM Integrity Hub, we aim to further our commitment to STM initiatives aimed at safeguarding the integrity of science.

“We are pleased to welcome MDPI as the 35th organisation participating in the Hub. This expansion is critical, as every new member enhances our capacity to prevent fraudulent submissions from entering the academic record.”

Joris van Rossum, Director of Research Integrity, STM

MDPI operates in full alignment with STM Integrity Hub's values of shared data and experiences. We strongly believe in collaboration and open exchange for the purposes of creating a holistic approach to support research integrity at MDPI itself and across the entire academic publishing industry. The Integrity Hub is an excellent example of how publishers can come together to jointly address industry-wide challenges related to research integrity, such as manuscripts that breach research integrity standards and paper-mills.

I look forward to our Research Integrity and Publication Ethics Team (RIPE) team immersing themselves in this initiative, exchanging information, best practices, and tools for the benefit of the entire scholarly ecosystem. We believe that ethical publishing standards should be implemented across the board, and we aim to be rigorous in our approach, addressing research integrity issues and improving the impact of published research.

Inside MDPI

MDPI Expands Research Integrity and Publication Ethics Team (RIPE)

In addition to external collaborations and joint initiatives aimed at further strengthening our commitment to research integrity, we are also enhancing our internal efforts. This includes improving our processes and guidelines and expanding our teams and departments to ensure quality assurance throughout our publishing process.

We are pleased to announce the expansion of our Research Integrity and Publication Ethics Team (RIPE) at MDPI. The RIPE team has recently welcomed new colleagues, each bringing unique skills and a personal commitment to prioritize ethical considerations in all our work.

The demand for research integrity and high ethical standards in academic publishing is steadily rising across our industry. Our expanded RIPE team will work to enhance and align our practices with industry best practices, ensuring excellence in research integrity and publication ethics.


Stefan Tochev (CEO, MDPI) introduces Dr. Tim Tait-Jamieson (Research Integrity Lead, MDPI) for his presentation on MDPI’s Retraction and Approval Process to a group of Journal Relationship Specialists at the MDPI office in Cluj, Romania: “The demand for research integrity and publication ethics is steadily rising across our industry.”

Introducing our Research Integrity and Publication Ethics Team

Led by Dr. Tim Tait-Jamieson (Research Integrity Lead), the RIPE team comprises Dr. Ivana Resanovic (Research Integrity Manager), Dr. Lavinia Rogojina (Research Integrity Manager), Ms. Diana Apodaritei (Research Integrity Specialist), Dr. Zoltan Mihaly (Research Integrity Specialist), Mr. Aleksandar Đukić (Research Integrity Specialist), Ms. Ana Stankovic (Research Integrity Specialist), and Ms. Anna Pena (Publication Ethics Assistant).

Please click here to access everything that you need to know about MDPI’s Research and Publication Ethics.

With this span of complementary roles, the RIPE team collaborates directly with journal editorial teams and works closely with various departments, including our Scientific Office Board and our Journal Relationship Specialists. The team’s primary objectives are to help prevent issues regarding research integrity and publication ethics during peer review, uphold MDPI’s ethics policies, adhere to industry standards, and resolve publication ethics and research integrity issues and complaints.

Quality Updates to Special Issues Oversight

At MDPI, we are committed to reviewing policies pertaining to the quality of research. In this blog post, Shaheena Patel (Communications Associate, MDPI), outlines two recent updates to MDPI journal processes. These updates pertain to Special Issue (SI) quality guidelines, in line with criteria provided by COPE and DOAJ. Alongside the SI updates, details regarding the new minor corrections policy introduced in 2024 are provided in the blog.

The two updates we implemented include greater oversight and the verification of Guest Editor credentials. These guidelines require that Editors-in-Chief (EiCs) and Editorial Board Members (EBMs) take responsibility for overseeing SIs.

PS. Thank you, James Butcher, for featuring this up in your 67th issue of the Journalogy newsletter.

Read more:

Coming Together for Science

Viruses 2024 – A World of Viruses

I am pleased to share the success of our MDPI conference Viruses 2024 – A World of Viruses, held 14-16 February, in Barcelona. With 240 registrations, this event brought together top scientists, researchers, and industry experts from 40 countries to share their findings on the latest developments in viral pathogenesis and immune responses.

Attendees gathered for the 5th edition of the Viruses’ conference, where we hosted influential keynote speeches from Nobel Prize laureate Dr. Charles M. Rice and ‘Distinguished Senior Virologist’ Prof. Luis Enjuanes, along with 14 invited speakers, 47 selected speakers, and nine flash poster presenters, to discuss the most significant issues in virology today.

Recap on the #Viruses2024 Conference

Take a look at the key moments from MDPI’s Viruses event and please join us in commemorating a gathering for global knowledge and cooperation. A heartfelt thank-you to all attendees; their passion and engagement played a crucial role in making this event an engaging success!

Below are calls to action from the keynote speakers encouraging collaboration and communication:

“There’s never been a better time than now to really take the power that we have both in terms of basic research and also in biotech and pharma to develop antiviral agents.” - Dr. Charles M. Rice, The Rockefeller University, New York, USA

“The collaboration between labs is absolutely essential. Improving initial detection and improving communication is a must for all of us working in science.” - Prof. Dr. Luis Enjuanes, National Center of Biotechnology (CNB-CSIC), Madrid, Spain

Our thanks go to our sponsors and partnering societies, our Viruses journal and editorial team, our Barcelona colleagues, and the social media, conference and other MDPI teams for making this event a memorable occasion. View the event gallery here.

Upcoming In-Person Event

24–26 April, 2024
4th MMCS – Harnessing the Power of New Drug Modalities
Location: Barcelona, Spain

Esteemed speakers at MMCS 2024 include Prof. Arun K. Ghosh, the mind behind the Darunavir molecule, and Prof. Paul Brennan, CSO of Alzheimer's Research UK Oxford Drug Discovery Institute.

Find more upcoming MDPI events here.


Organize Your Event with MDPI’s Sciforum

Sciforum is MDPI’s platform dedicated to the organization of scientific events. In line with our mission to promote science, Sciforum supports scholars, societies, research networks, and universities at all stages of organizing in-person events, virtual events and webinars. Our platforms are efficient, user-friendly, and cost-effective. We handle all steps related to event management. Contact us for details.

Closing Thoughts

Researcher to Reader (R2R) Conference

From 20–21 February 2024, I had the pleasure of attending the Researcher to Reader (R2R) conference in London, which MDPI has proudly sponsored over the years. The conference programme offered a variety of session formats, including workshops, panel discussions, debates, interviews, presentations, and lightning talks, with opportunities to discuss relevant topics.

We take pride in supporting the scientific community, bringing researchers across the world together to network, exchange ideas and share the latest in science and publishing. In 2023, MDPI invested close to 2 million CHF in sponsoring over 2,000 scientific and publishing-related conferences worldwide.

R2R Peer Review Innovations Workshop

I found the R2R conference to be engaging, with the workshops being particularly enjoyable. My colleague Giulia Stefenelli (Chair of Scientific Office Board) and I participated in the “Peer Review Innovations” workshop, which spanned four sessions over the two days. These sessions explored the future of peer review and how we can improve the peer review process for everyone involved. Notably, the large majority of attendees expressed their opinion that peer review, as currently practiced, requires significant improvement. Together, we collaborated on potential immediate and long-term improvements and innovative processes, aiming to create an ecosystem beneficial to all stakeholders by strengthening submission systems with the aim of reducing threats and making authors more responsible for their work. We also discussed the opportunity for academic institutions to better scrutinize the quality of the work produced and submitted to journals.

Our group comprised publishers, software providers, librarians, and more, bringing diverse perspectives to the discussions. These interactions were relevant to MDPI’s ongoing conversations, providing insights to our efforts. The session also made me appreciate that MDPI is doing well, as the group discussions included the subject of various quality checks that we have already embedded in our processes, ensuring that we keep abreast of industry standards.

The need for an optimized system to incentivize the activities of editors and reviewers was also a focus of discussion, as well as the support that reviewers need from publishers via the provision of strong reports through fixed forms, questionnaires and training.

At MDPI, we are currently auditing our reviewer program to improve reviewer recognition, guidelines, and methods for identifying suitable reviewers, while maintaining our commitment to quality and timeliness.

Congratulations to Mark Carden, Conference Director, and the R2R team for organizing a productive and successful event. PS: The break times were greatly appreciated as well!

Stefan Tochev
Chief Executive Officer
MDPI AG

4 February 2024
Metabolites | Highly Cited Papers in 2022 in the Section “Food Metabolomics”

1. “Mechanism of Soy Isoflavone Daidzein-Induced Female-Specific Anorectic Effect”
by Mina Fujitani, Takafumi Mizushige, Sudhashree Adhikari, Keshab Bhattarai and Taro Kishida
Metabolites 2022, 12(3), 252; https://doi.org/10.3390/metabo12030252
Available online: https://www.mdpi.com/2218-1989/12/3/252

2. “The Effects of Dietary Supplements, Nutraceutical Agents, and Physical Exercise on Myostatin Levels: Hope or Hype?”
by Heitor O. Santos, Henrique S. Cerqueira and Grant M. Tinsley
Metabolites 2022, 12(11), 1146; https://doi.org/10.3390/metabo12111146
Available online: https://www.mdpi.com/2218-1989/12/11/1146

3. “Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy”
by Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli and Alessia Cedola
Metabolites 2022, 12(11), 1149; https://doi.org/10.3390/metabo12111149
Available online: https://www.mdpi.com/2218-1989/12/11/1149

4. “Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration”
by Sarmistha Mitra, Raju Dash, Yeasmin Akter Munni, Nusrat Jahan Selsi, Nasrin Akter, Md Nazim Uddin, Kishor Mazumder and II Soo Moon
Metabolites 2022, 12(11), 1153; https://doi.org/10.3390/metabo12111153
Available online: https://www.mdpi.com/2218-1989/12/11/1153

5. “Measurement of the Effect of Accelerated Aging on the Aromatic Compounds of Gewürztraminer and Teroldego Wines, Using a SPE-GC-MS/MS Protocol”
by Silvia Carlin, Cesare Lotti, Ludovica Correggi, Fulvio Mattivi, Panagiotis Arapitsas and Urška Vrhovšek
Metabolites 2022, 12(2), 180; https://doi.org/10.3390/metabo12020180
Available online: https://www.mdpi.com/2218-1989/12/2/180

6. “Comprehensive Metabolomic Comparison of Five Cereal Vinegars Using Non-Targeted and Chemical Isotope Labeling LC-MS Analysis”
by Zhihua Li, Chi Zhao, Ling Dong, Yu Huan, Miwa Yoshimoto, Yongqing Zhu, Ipputa Tada, Xiaohang Wang, Shuang Zhao, Fengju Zhang et al.
Metabolites 2022, 12(5), 427; https://doi.org/10.3390/metabo12050427
Available online: https://www.mdpi.com/2218-1989/12/5/427

7. “Stimulation of GLUT4 Glucose Uptake by Anthocyanin-Rich Extract from Black Rice (Oryza sativa L.) via PI3K/Akt and AMPK/p38 MAPK Signaling in C2C12 Cells”
by Shui-Yuan Feng, Shu-Jing Wu, Yun-Ching Chang, Lean-Teik Ng and Sue-Joan Chang
Metabolites 2022, 12(9), 856; https://doi.org/10.3390/metabo12090856
Available online: https://www.mdpi.com/2218-1989/12/9/856

8. “Unlike Glycerophosphocholine or Choline Chloride, Dietary Phosphatidylcholine Does Not Increase Plasma Trimethylamine-N-Oxide Levels in Sprague-Dawley Rats”
by Bungo Shirouchi, Ayano Fukuda and Taiki Akasaka
Metabolites 2022, 12(1), 64; https://doi.org/10.3390/metabo12010064
Available online: https://www.mdpi.com/2218-1989/12/1/64

4 February 2024
Metabolites | Highly Cited Papers in 2023 in the Section “Microbiology and Ecological Metabolomics”

1. “Application of 1H HR-MAS NMR-Based Metabolite Fingerprinting of Marine Microalgae”
by Carolina da Silva Canielles Caprara, Tatiane Ksyvickas Mathias, Maria de Fátima C. Santos, Marcelo G. M. D’Oca, Caroline Da R. M. D’Oca, Fabio Roselet, Paulo Cesar Abreu and Daniela Fernandes Ramos
Metabolites 2023, 13(2), 202; https://doi.org/10.3390/metabo13020202
Available online: https://www.mdpi.com/2218-1989/13/2/202

2. “Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice”
by Bei Gao, Lixia Chen, Weichen Xu, Jinjun Shan, Weishou Shen and Nan Gao
Metabolites 2023, 13(6), 707; https://doi.org/10.3390/metabo13060707
Available online: https://www.mdpi.com/2218-1989/13/6/707

3. “Oral Exposure to Epoxiconazole Disturbed the Gut Micro-Environment and Metabolic Profiling in Male Mice”
by You Weng, Ting Xu, Caihong Wang and Yuanxiang Jin
Metabolites 2023, 13(4), 522; https://doi.org/10.3390/metabo13040522
Available online: https://www.mdpi.com/2218-1989/13/4/522

4. “Mechanism for Utilization of the Populus-Derived Metabolite Salicin by a Pseudomonas—Rahnella Co-Culture”
by Sanjeev Dahal, Gregory B. Hurst, Karuna Chourey, Nancy L. Engle, Leah H. Burdick, Jennifer L. Morrell-Falvey, Timothy J. Tschaplinski, Mitchel J. Doktycz and Dale A. Pelletier
Metabolites 2023, 13(2), 140; https://doi.org/10.3390/metabo13020140
Available online https://www.mdpi.com/2218-1989/13/2/140

5. “GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants”
by Ding Yuan, Xiaolei Wu, Binbin Gong, Ruixiao Huo, Liran Zhao, Jingrui Li, Guiyun Lü and Hongbo Gao
Metabolites 2023, 13(3), 347; https://doi.org/10.3390/metabo13030347
Available online: https://www.mdpi.com/2218-1989/13/3/347

6. “High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery”
by Navid Jubaer Ayon
Metabolites 2023, 13(5), 625; https://doi.org/10.3390/metabo13050625
Available online: https://www.mdpi.com/2218-1989/13/5/625

7. “Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota”
by Huixia Niu, Shaojie Liu, Yujie Jiang, Yang Hu, Yahui Li, Luyang He, Mingluan Xing, Xueqing Li,
Lizhi Wu, Zhijian Chen et al.
Metabolites 2023, 13(6), 739; https://doi.org/10.3390/metabo13060739
Available online: https://www.mdpi.com/2218-1989/13/6/739

8. “Metabolic Role of GABA in the Secretory Function of Pancreatic β-Cells: Its Hypothetical Implication in β-Cell Degradation in Type 2 Diabetes”
by Jorge Tamarit-Rodriguez
Metabolites 2023, 13(6), 697; https://doi.org/10.3390/metabo13060697
Available online: https://www.mdpi.com/2218-1989/13/6/697

4 February 2024
Metabolites | Highly Cited Papers in 2022 in the Section “Microbiology and Ecological Metabolomics”

1. “NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health”
by Johannes Hertel, Daniel Fässler, Almut Heinken, Frank U. Weiß, Malte Rühlemann, Corinna Bang, Andre Franke, Kathrin Budde, Ann-Kristin Henning, Astrid Petersmann et al.
Metabolites 2022, 12(4), 308; https://doi.org/10.3390/metabo12040308
Available online: https://www.mdpi.com/2218-1989/12/4/308

2. “Solid-State Fermented Okara with Aspergillus spp. Improves Lipid Metabolism and High-Fat Diet-Induced Obesity”
by Natsumi Ichikawa, Li Shiuan Ng, Saneyuki Makino, Luo Lin Goh, Yun Jia Lim, Ferdinandus, Hiroyuki Sasaki, Shigenobu Shibata and Chi-Lik Ken Lee
Metabolites 2022, 12(3), 198; https://doi.org/10.3390/metabo12030198
Available online: https://www.mdpi.com/2218-1989/12/3/198

3. “Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose–Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model”
by Olha Kostiuchenko, Nadiia Kravchenko, Jan Markus, Stephen Burleigh, Olexandr Fedkiv, Ling Cao, Silvia Letasiova, Galyna Skibo, Frida Fåk Hållenius and Olena Prykhodko
Metabolites 2022, 12(11), 1027; https://doi.org/10.3390/metabo12111027
Available online: https://www.mdpi.com/2218-1989/12/11/1027

4. “ConCISE: Consensus Annotation Propagation of Ion Features in Untargeted Tandem Mass Spectrometry Combining Molecular Networking and In Silico Metabolite Structure Prediction”
by Zachary A. Quinlan, Irina Koester, Allegra T. Aron, Daniel Petras, Lihini I. Aluwihare, Pieter C. Dorrestein, Craig E. Nelson and Linda Wegley Kelly
Metabolites 2022, 12(12), 1275; https://doi.org/10.3390/metabo12121275
Available online: https://www.mdpi.com/2218-1989/12/12/1275

5. “Yeast Protein as an Easily Accessible Food Source”
by Monika Elżbieta Jach, Anna Serefko, Maria Ziaja and Marek Kieliszek
Metabolites 2022, 12(1), 63; https://doi.org/10.3390/metabo12010063
Available online: https://www.mdpi.com/2218-1989/12/1/63

6. “Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota”
by Hideki Mori, Gianluca Svegliati Baroni, Marco Marzioni, Francesca Di Nicola, Pierangelo Santori , Luca Maroni, Ludovico Abenavoli and Emidio Scarpellini
Metabolites 2022, 12(7), 647; https://doi.org/10.3390/metabo12070647
Available online: https://www.mdpi.com/2218-1989/12/7/647

7. “Advances in Cell Engineering of the Komagataella phaffii Platform for Recombinant Protein Production”
by Cristina Bustos, Johan Quezada, Rhonda Veas, Claudia Altamirano, Stephanie Braun-Galleani,
Patrick Fickers and Julio Berrios
Metabolites 2022, 12(4), 346; https://doi.org/10.3390/metabo12040346
Available online: https://www.mdpi.com/2218-1989/12/4/346

8. “The Interaction between the Gut Microbiome and Bile Acids in Cardiometabolic Diseases”
by Cengiz Callender, Ilias Attaye and Max Nieuwdorp
Metabolites 2022, 12(1), 65; https://doi.org/10.3390/metabo12010065
Available online: https://www.mdpi.com/2218-1989/12/1/65

2 February 2024
Metabolites | Highly Cited Papers in 2023 in the Section “Food Metabolomics”

  1. “Hepatic Mitochondria-Gut Microbiota Interactions in Metabolism-Associated Fatty Liver Disease”
    by Francesco Bellanti, Aurelio Lo Buglio and Gianluigi Vendemiale
    Metabolites 2023, 13(3), 322; https://doi.org/10.3390/metabo13030322
    Available online: https://www.mdpi.com/2218-1989/13/3/322
  2. “Human Milk Lipids and Small Metabolites: Maternal and Microbial Origins”
    by Lisa F. Stinson and Alexandra D. George
    Metabolites 2023, 13(3), 422; https://doi.org/10.3390/metabo13030422
    Available online: https://www.mdpi.com/2218-1989/13/3/422
  3. “Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications”
    by Luigi Santacroce, Marica Colella, Ioannis Alexandros Charitos, Marina Di Domenico, Raffaele Palmirotta and Emilio Jirillo
    Metabolites 2023, 13(3), 461; https://doi.org/10.3390/metabo13030461
    Available online: https://www.mdpi.com/2218-1989/13/3/461
  4. “Unexpected Value of Honey Color for Prediction of a Non-Enzymatic H2O2 Production and Honey Antibacterial Activity: A Perspective”
    by Katrina Brudzynski
    Metabolites 2023, 13(4), 526; https://doi.org/10.3390/metabo13040526
    Available online: https://www.mdpi.com/2218-1989/13/4/526
  5. “Efficacy Confirmation Test of Black Cumin (Nigella sativa L.) Seeds Extract Using a High-Fat Diet Mouse Model”
    by Khawaja Muhammad Imran Bashir, Joo Wan Kim, Jong-Kyu Kim, Yoon-Seok Chun, Jae-Suk Choi and Sae-Kwang Ku
    Metabolites 2023, 13(4), 501; https://doi.org/10.3390/metabo13040501
    Available online: https://www.mdpi.com/2218-1989/13/4/501
  6. “Qualitative Analysis of Polyphenols in Glycerol Plant Extracts Using Untargeted Metabolomics”
    by Joseph Robert Nastasi, Venea Dara Daygon, Vassilis Kontogiorgos and Melissa A. Fitzgerald
    Metabolites 2023, 13(4), 566; https://doi.org/10.3390/metabo13040566
    Available online: https://www.mdpi.com/2218-1989/13/4/566
  7. “Quercetin Induces Apoptosis in HepG2 Cells via Directly Interacting with YY1 to Disrupt YY1-p53 Interaction”
    by Hui Guan, Wenyuan Zhang, Hui Liu, Yang Jiang, Feng Li, Maoyu Wu, Geoffrey I. N. Waterhouse,
    Dongxiao Sun-Waterhouse and Dapeng Li
    Metabolites 2023, 13(2), 229; https://doi.org/10.3390/metabo13020229
    Available online: https://www.mdpi.com/2218-1989/13/2/229
  8. “An Egg White-Derived Peptide Enhances Systemic Insulin Sensitivity and Modulates Markers of Non-Alcoholic Fatty Liver Disease in Obese, Insulin Resistant Mice”
    by Stepheny C. de Campos Zani, Ren Wang, Hellen Veida-Silva, Robin D. Clugston, Jessica T. Y. Yue, Marcelo A. Mori, Jianping Wu and Catherine B. Chan
    Metabolites 2023, 13(2), 174; https://doi.org/10.3390/metabo13020174
    Available online: https://www.mdpi.com/2218-1989/13/2/174

2 February 2024
Metabolites | Highly Cited Papers in 2023 in the Section “Environmental Metabolomics”

1. “The Relationship between Phthalates and Diabetes: A Review”
by Melissa Mariana and Elisa Cairrao
Metabolites 2023, 13(6), 746; https://doi.org/10.3390/metabo13060746
Available online: https://www.mdpi.com/2218-1989/13/6/746

2. “Cross-Platform Comparison of Amino Acid Metabolic Profiling in Three Model Organisms Used in Environmental Metabolomics”
by Jessica C. D’eon, Brian P. Lankadurai, André J. Simpson, Eric J. Reiner, David G. Poirier, Greg C. Vanlerberghe and Myrna J. Simpson
Metabolites 2023, 13(3), 402; https://doi.org/10.3390/metabo13030402
Available online: https://www.mdpi.com/2218-1989/13/3/402

3. “Impact of Heavy Metal Exposure on Mytilus galloprovincialis Spermatozoa: A Metabolomic Investigation”
by Gennaro Lettieri, Carmela Marinaro, Rosaria Notariale, Pasquale Perrone, Martina Lombardi, Alessio Trotta, Jacopo Troisi and Marina Piscopo
Metabolites 2023, 13(8), 943; https://doi.org/10.3390/metabo13080943
Available online: https://www.mdpi.com/2218-1989/13/8/943

4. “Suitability of Short- and Long-Term Storage of Volatile Organic Compounds Samples in Syringe-Based Containers: A Comparison Study”
by Paulo Henrique Costa Santos, Pedro Catalão Moura and Valentina Vassilenko
Metabolites 2023, 13(8), 903; https://doi.org/10.3390/metabo13080903
Available online: https://www.mdpi.com/2218-1989/13/8/903

5. “An Exploratory Study of the Metabolite Profiling from Pesticides Exposed Workers”
by Daniela Magalhães Nolasco, Michele P. R. Mendes, Luiz Paulo de Aguiar Marciano, Luiz Filipe Costa, Adriana Nori De Macedo, Isarita Martins Sakakibara, Alessandra Cristina Pupin Silvério, Maria José N. Paiva and Leiliane C. André
Metabolites 2023, 13(5), 596; https://doi.org/10.3390/metabo13050596
Available online: https://www.mdpi.com/2218-1989/13/5/596

6. “Effects of Ecologically Relevant Concentrations of Cadmium on the Microbiota, Short-Chain Fatty Acids, and FFAR2 Expression in Zebrafish”
by Jian Yang, Junyi Li, Xiaoshun Zhang, Qin Zhou, Junyi Wang, Qingsong Chen, Xiaojing Meng and Yuan Xia
Metabolites 2023, 13(5), 657; https://doi.org/10.3390/metabo13050657
Available online: https://www.mdpi.com/2218-1989/13/5/657

7. “Exposure to Particulate Matter in the Broiler House Causes Dyslipidemia and Exacerbates It by Damaging Lung Tissue in Broilers”
by Dan Shen, Qi Guo, Kai Huang, Weijia Mao, Kai Wang, Wenjie Zeng, Yansen Li, Zhendong Guo, Kentaro Nagaoka and Chunmei Li
Metabolites 2023, 13(3), 363; https://doi.org/10.3390/metabo13030363
Available online: https://www.mdpi.com/2218-1989/13/3/363

8. “Microbial Virulence Factors, Antimicrobial Resistance Genes, Metabolites, and Synthetic Chemicals in Cabins of Commercial Aircraft”
by Xi Fu, Mei Zhang, Yiwen Yuan, Yang Chen, Zheyuan Ou, Zailina Hashim, Jamal Hisham Hashim, Xin Zhang, Zhuohui Zhao, Dan Norbäck et al.
Metabolites 2023, 13(3), 343; https://doi.org/10.3390/metabo13030343
Available online: https://www.mdpi.com/2218-1989/13/3/343

2 February 2024
Metabolites | Highly Cited Papers in 2022 in the Section “Environmental Metabolomics”

1. “Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism: Achievements, Limitations, and Opportunities”
by David Lao-Martil, Koen J. A. Verhagen, Joep P. J. Schmitz, Bas Teusink, S. Aljoscha Wahl and Natal A. W. van Riel
Metabolites 2022, 12(1), 74; https://doi.org/10.3390/metabo12010074
Available online: https://www.mdpi.com/2218-1989/12/1/74

2. “Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens”
by Thibaut Dumas, Frédérique Courant, Hélène Fenet and Elena Gomez
Metabolites 2022, 12(2), 186; https://doi.org/10.3390/metabo12020186  
Available online: https://www.mdpi.com/2218-1989/12/2/186

3. “Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways”
by Hélène Lemieux and Pierre U. Blier
Metabolites 2022, 12(4), 360; https://doi.org/10.3390/metabo12040360
Available online: https://www.mdpi.com/2218-1989/12/4/360

4. “Host–Gut Microbiome Metabolic Interactions in PFAS-Impacted Freshwater Turtles (Emydura macquarii macquarii)”
by David J. Beale, Thao V. Nguyen, Rohan M. Shah, Andrew Bissett, Akhikun Nahar, Matthew Smith, Viviana Gonzalez-Astudillo, Christoph Braun, Brenda Baddiley and Suzanne Vardy
Metabolites 2022, 12(8), 747; https://doi.org/10.3390/metabo12080747
Available online: https://www.mdpi.com/2218-1989/12/8/747

5. “Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach”
by Gaëlle Ramirez, Elena Gomez, Thibaut Dumas, David Rosain, Olivier Mathieu, Hélène Fenet and Frédérique Courant
Metabolites 2022, 12(3), 197; https://doi.org/10.3390/metabo12030197
Available online: https://www.mdpi.com/2218-1989/12/3/197

6. “Mycorrhiza-Tree-Herbivore Interactions: Alterations in Poplar Metabolome and Volatilome”
by Prasath Balaji Sivaprakasam Padmanaban, Maaria Rosenkranz, Peiyuan Zhu, Moritz Kaling, Anna Schmidt, Philippe Schmitt-Kopplin, Andrea Polle and Jörg-Peter Schnitzler
Metabolites 2022, 12(2), 93; https://doi.org/10.3390/metabo12020093
Available online: https://www.mdpi.com/2218-1989/12/2/93

7. “Effects of Light and Temperature on the Metabolic Profiling of Two Habitat-Dependent Bloom-Forming Cyanobacteria”
by Bijayalaxmi Mohanty, Seyed Mohammad Majedi, Shruti Pavagadhi, Shu Harn Te, Chek Yin Boo, Karina Yew-Hoong Gin and Sanjay Swarup
Metabolites 2022, 12(5), 406; https://doi.org/10.3390/metabo12050406
Available online: https://www.mdpi.com/2218-1989/12/5/406

8. “Multi-Omics, an Integrated Approach to Identify Novel Blood Biomarkers of Alzheimer’s Disease”
by Maxime François, Avinash V. Karpe, Jian-Wei Liu, David J. Beale, Maryam Hor, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, James D. Doecke et al.
Metabolites 2022, 12(10), 949; https://doi.org/10.3390/metabo12100949
Available online: https://www.mdpi.com/2218-1989/12/10/949

2 February 2024
Metabolites | Highly Cited Papers in 2023 in the Section “Cell Metabolism”

1. “Targeted Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution, Toxicity, and Tissue Classification Studies”
by Andreas Dannhorn, Maria Luisa Doria, James McKenzie, Paolo Inglese, John G. Swales, Gregory Hamm, Nicole Strittmatter, Gareth Maglennon, Sadaf Ghaem-Maghami, Richard J. A. Goodwin et al.
Metabolites 2023, 13(3), 377; https://doi.org/10.3390/metabo13030377
Available online: https://www.mdpi.com/2218-1989/13/3/377

2. “Revised Harris–Benedict Equation: New Human Resting Metabolic Rate Equation”
by Eleni Pavlidou, Sousana K. Papadopoulou, Kyriakos Seroglou and Constantinos Giaginis
Metabolites 2023, 13(2), 189; https://doi.org/10.3390/metabo13020189
Available online: https://www.mdpi.com/2218-1989/13/2/189

3. “Metabolically Active Zones Involving Fatty Acid Elongation Delineated by DESI-MSI Correlate with Pathological and Prognostic Features of Colorectal Cancer”
by Martin Kaufmann, Natasha Iaboni, Amoon Jamzad, David Hurlbut, Kevin Yi Mi Ren, John F. Rudan, Parvin Mousavi, Gabor Fichtinger, Sonal Varma, Antonio Caycedo-Marulanda et al.
Metabolites 2023, 13(4), 508; https://doi.org/10.3390/metabo13040508
Available online: https://www.mdpi.com/2218-1989/13/4/508

4. “Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT”
by Hugo J. R. Fernandes, Josh P. Kent, Michaela Bruntraeger, Andrew R. Bassett, Albert Koulman, Emmanouil Metzakopian and Stuart G. Snowden
Metabolites 2023, 13(1), 112; https://doi.org/10.3390/metabo13010112
Available online: https://www.mdpi.com/2218-1989/13/1/112

5. “Role of Oxidative Stress in Ocular Diseases: A Balancing Act”
*Feature Paper
by Daisy Y. Shu, Suman Chaudhary, Kin-Sang Cho, Anton Lennikov, William P. Miller, David C. Thorn, Menglu Yang and Tina B. McKay
Metabolites 2023, 13(2), 187; https://doi.org/10.3390/metabo13020187
Available online: https://www.mdpi.com/2218-1989/13/2/187

6. “Influence of Cholesterol on the Regulation of Osteoblast Function”
by Alena Akhmetshina, Dagmar Kratky and Elizabeth Rendina-Ruedy
Metabolites 2023, 13(4), 578; https://doi.org/10.3390/metabo13040578
Available online: https://www.mdpi.com/2218-1989/13/4/578

7. “Targeting Oncometabolites in Peritoneal Cancers: Preclinical Insights and Therapeutic Strategies”
by Revathy Nadhan, Srishti Kashyap, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro and Danny N. Dhanasekaran
Metabolites 2023, 13(5), 618; https://doi.org/10.3390/metabo13050618
Available online: https://www.mdpi.com/2218-1989/13/5/618

8. “Red Blood Cell Metabolism In Vivo and In Vitro”
by Angelo D’Alessandro, Alkmini T. Anastasiadi, Vassilis L. Tzounakas, Travis Nemkov, Julie A. Reisz, Anastsios G. Kriebardis, James C. Zimring, Steven L. Spitalnik and Michael P. Busch
Metabolites 2023, 13(7), 793; https://doi.org/10.3390/metabo13070793
Available online: https://www.mdpi.com/2218-1989/13/7/793

2 February 2024
Metabolites | Highly Cited Papers in 2022 in the Section “Cell Metabolism”

1. “Mass Spectrometry Imaging Disclosed Spatial Distribution of Defense-Related Metabolites in Triticum spp.”
by Laura Righetti, Sven Gottwald, Sara Tortorella, Bernhard Spengler and Dhaka Ram Bhandari
Metabolites 2022, 12(1), 48; https://doi.org/10.3390/metabo12010048
Available online: https://www.mdpi.com/2218-1989/12/1/48

2. “The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells”
by Lisa Zipper, Sai Batchu, Nida Hatice Kaya, Zeus Andrea Antonello and Tobias Reiff
Metabolites 2022, 12(4), 315; https://doi.org/10.3390/metabo12040315
Available online: https://www.mdpi.com/2218-1989/12/4/315

3. “The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study”
by Thomas Sonnweber, Philipp Grubwieser, Sabina Sahanic, Anna Katharina Böhm, Alex Pizzini, Anna Luger, Christoph Schwabl, Sabine Koppelstätter, Katharina Kurz, Bernhard Puchner et al.
Metabolites 2022, 12(6), 546; https://doi.org/10.3390/metabo12060546
Available online: https://www.mdpi.com/2218-1989/12/6/546

4. “Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR”
by Sabine Bauer, Jana Eigenmann, Yuqi Zhao, Julia Fleig, Johann S. Hawe, Calvin Pan, Dario Bongiovanni, Simon Wengert, Angela Ma, Aldons J. Lusis et al.
Metabolites 2022, 12(9), 840; https://doi.org/10.3390/metabo12090840
Available online: https://www.mdpi.com/2218-1989/12/9/840

5. “The Role of Ferritin in Health and Disease: Recent Advances and Understandings”
by Nikhil Kumar Kotla, Priyata Dutta, Sanjana Parimi and Nupur K. Das
Metabolites 2022, 12(7), 609; https://doi.org/10.3390/metabo12070609
Available online: https://www.mdpi.com/2218-1989/12/7/609

6. “Impact of Micro- and Nanoplastics on Mitochondria”
by Seung Eun Lee, Yoojung Yi, Sangji Moon, Hyunkyung Yoon and Yong Seek Park
Metabolites 2022, 12(10), 897; https://doi.org/10.3390/metabo12100897
Available online: https://www.mdpi.com/2218-1989/12/10/897

7. “Metabolic Determinants in Cardiomyocyte Function and Heart Regenerative Strategies”
by Magda Correia, Francisco Santos, Rita da Silva Ferreira, Rita Ferreira, Bruno Bernardes de Jesus and Sandrina Nóbrega-Pereira
Metabolites 2022, 12(6), 500; https://doi.org/10.3390/metabo12060500
Available online: https://www.mdpi.com/2218-1989/12/6/500

8. “Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer”
by Yuji Nagayama and Koichiro Hamada
Metabolites 2022, 12(12), 1214; https://doi.org/10.3390/metabo12121214
Available online: https://www.mdpi.com/2218-1989/12/12/1214

2 February 2024
Metabolites | Highly Cited Papers in 2023 in the Section “Pharmacology and Drug Metabolism”

1. “Links between Metabolic Syndrome and Hypertension: The Relationship with the Current Antidiabetic Drugs”
by Silviu Stanciu, Emilia Rusu, Daniela Miricescu, Ana Cristina Radu, Bianca Axinia, Ana Maria Vrabie, Ruxandra Ionescu, Mariana Jinga and Carmen Adella Sirbu
Metabolites 2023, 13(1), 87; https://doi.org/10.3390/metabo13010087
Available online: https://www.mdpi.com/2218-1989/13/1/87

2. “Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications”
by Lei Sun, Kun Mi, Yixuan Hou, Tianyi Hui, Lan Zhang, Yanfei Tao, Zhenli Liu and Lingli Huang
Metabolites 2023, 13(8), 897; https://doi.org/10.3390/metabo13080897
Available online: https://www.mdpi.com/2218-1989/13/8/897

3. “Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease—Current Background, Hopes, and Perspectives”
by Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Gabriela Ștefănescu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu and Bogdan-Mircea Mihai
Metabolites 2023, 13(5), 581; https://doi.org/10.3390/metabo13050581
Available online: https://www.mdpi.com/2218-1989/13/5/581

4. “Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition”
by Kelsey Hu, Elizabeth Deya Edelen, Wenqing Zhuo, Aliya Khan, Josselyne Orbegoso, Lindsey Greenfield, Berna Rahi, Michael Griffin, Jasminka Z. Ilich and Owen J. Kelly
Metabolites 2023, 13(10), 1056; https://doi.org/10.3390/metabo13101056
Available online: https://www.mdpi.com/2218-1989/13/10/1056

5. “Integrating Metabolomics and Gene Expression Underlying Potential Biomarkers Compounds Associated with Antioxidant Activity in Southern Grape Seeds”
by Ahmed G. Darwish, Md Moniruzzaman, Violeta Tsolova and Islam El-Sharkawy
Metabolites 2023, 13(2), 210; https://doi.org/10.3390/metabo13020210
Available online: https://www.mdpi.com/2218-1989/13/2/210

6. “Prediction of a Large-Scale Database of Collision Cross-Section and Retention Time Using Machine Learning to Reduce False Positive Annotations in Untargeted Metabolomics”
by Marie Lenski, Saïd Maallem, Gianni Zarcone, Guillaume Garçon, Jean-Marc Lo-Guidice, Sébastien Anthérieu and Delphine Allorge
Metabolites 2023, 13(2), 282; https://doi.org/10.3390/metabo13020282
Available online: https://www.mdpi.com/2218-1989/13/2/282

7. “α-Methyltryptamine (α-MT) Metabolite Profiling in Human Hepatocyte Incubations and Postmortem Urine and Blood”
by Sara Malaca, Charline Bottinelli, Laurent Fanton, Nathalie Cartiser, Jeremy Carlier and Francesco Paolo Busardò
Metabolites 2023, 13(1), 92; https://doi.org/10.3390/metabo13010092
Available online: https://www.mdpi.com/2218-1989/13/1/92

8. “Regulation of Human Endogenous Metabolites by Drug Transporters and Drug Metabolizing Enzymes: An Analysis of Targeted SNP-Metabolite Associations”
by Jeffry C. Granados, Jeramie D. Watrous, Tao Long, Sara Brin Rosenthal, Susan Cheng, Mohit Jain and Sanjay K. Nigam
Metabolites 2023, 13(2), 171; https://doi.org/10.3390/metabo13020171
Available online: https://www.mdpi.com/2218-1989/13/2/171

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