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Healthcare

Healthcare is an international, scientific, peer-reviewed, open access journal on health care systems, industry, technology, policy, and regulation, and is published semimonthly online by MDPI.
The European Medical Association (EMA), Ocular Wellness & Nutrition Society (OWNS) and Italian Society of Nephrology Nurses (SIAN) are affiliated with Healthcare and their members receive discounts on the article processing charges.
Indexed in PubMed | Quartile Ranking JCR - Q2 (Health Policy and Services | Health Care Sciences and Services)

All Articles (14,777)

Background and Objectives: Oral nicotine pouches (ONPs) are rapidly expanding nicotine products with limited evidence from the Middle East, particularly among young adults. This study assessed the awareness, perceptions, and use of ONPs among university students in Jazan, Saudi Arabia. Materials and Methods: A cross-sectional survey (November 2024–April 2025) used multistage stratified random sampling across six colleges at Jazan University. A self-administered questionnaire captured sociodemographic characteristics, tobacco-use history, ONPs awareness (aided), ever use and current use (past 30 days), and self-reported perceptions items across nine domains. Multivariable logistic regression estimated adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Results: Among 624 students (mean age = 20.9 ± 1.7 years; 50.5% female), ONPs awareness was 69.7%, ever use 11.5%, and current use 7.5%. Awareness and use were higher among males and other tobacco users (p < 0.001). In multivariable models, male sex predicted awareness, ever use, and current use; rural residence was linked to lower awareness (aOR = 0.67; 95% CI 0.45–0.98), and being a medical student was linked to lower current use (aOR = 0.08; 95% CI 0.003–0.51) Most students perceived ONPs as addictive (80%) and harmful (68%), yet accessible (61%) and attractive (55%). Conclusions: ONPs awareness and use were high, particularly among males and tobacco users. Despite recognizing potential harm, students viewed ONPs as accessible and attractive. Ongoing surveillance, education, and balanced regulation are needed to guide harm-reduction policy and prevent unintended nicotine uptake.

31 December 2025

Overall perception of nicotine pouch characteristics among participants (n = 624). Stacked bars show the distribution of responses on a 5-point Likert scale for nine items: addictiveness–harm–accessibility–attractiveness/flavors–smoking initiation–cessation aid–ONP versus NRT effectiveness–social acceptability–and affordability. Right-hand percentages denote the proportion agreeing or strongly agreeing with each statement. Left-hand percentages denote the proportion disagreeing or strongly disagreeing. ONP = oral nicotine pouch; NRT = nicotine replacement therapy.

Background/Objectives: Older individuals are more vulnerable to stress and trauma. Although pressure injuries (PIs) are recognized as a significant complication, the specific impact of frailty on PI development in older Asian trauma patients remains insufficiently explored. This study aims to investigate the factors associated with the occurrence of hospital-acquired pressure injuries (HAPU) in older patients aged ≥65 years, including frailty. Methods: This study is a retrospective secondary data analysis of 3418 older trauma patients admitted to a regional trauma center (including ICU and trauma ward) from 1 January 2020 to 31 December 2023. Patients with PIs present on admission (POA) were excluded to strictly analyze new PI occurrence. Frailty was assessed using the mFI-5. Results: The mean age of participants was 77.33 years. During hospitalization, 2.5% (n = 84) of patients developed new PIs. Multivariate logistic regression identified that higher frailty score (Odds Ratio [OR] = 1.59, 95% Confidence Interval [CI]: 1.26–2.02), lower BMI (OR = 0.93, 95% CI: 0.86–0.99), hypoalbuminemia (OR = 0.55, 95% CI: 0.36–0.84), and prolonged hospital stay (OR = 1.05, 95% CI: 1.04–1.06) were independently associated with PI occurrence. Chronological age was not a significant predictor in the multivariate model. Conclusions: Frailty, nutritional status (BMI, albumin), and prolonged hospital stay are significant factors associated with HAPU in older trauma patients.

31 December 2025

Background: In the era of Health 4.0, Emergency Departments (EDs) face increasing crowding and complexity, necessitating smart management solutions to balance efficiency with equitable care. Effective scheduling is critical for optimizing patient throughput and mitigating congestion. Methods: This paper constructs a decision support framework using Discrete Event Simulation (DES) to evaluate three patient scheduling strategies, including the Initial-First policy, Alternating 1:1 policy and a Slack-Based dynamic policy. The simulation framework has been conducted using a standardized operational dataset representing typical ED dynamics. The threshold of SBP was optimized by a grid search method to guarantee an objective comparison. Results: The simulation results show that when adopting the optimized SBP policy, the mean waiting time was shortened by around 23.8%, thus meeting all triage service level targets. Also, it could be seen that Slack-Based dynamic policy was robust under different arrival rates and physician staffing levels. Conclusions: This proposed model can provide a real-time and dynamic solution for ED resource allocation, meeting the demand of modern smart hospitals management.

31 December 2025

Advancing a Hybrid Decision-Making Model in Anesthesiology: Applications of Artificial Intelligence in the Perioperative Setting

  • Gilberto Duarte-Medrano,
  • Natalia Nuño-Lámbarri and
  • Daniele Salvatore Paternò
  • + 4 authors

Artificial intelligence (AI) is rapidly transforming anesthesiology practice across perioperative settings. This review explores the evolution and implementation of hybrid decision-making models that integrate AI capabilities with human clinical expertise. From historical foundations to current applications, we examine how machine learning algorithms, deep learning networks, and big data analytics are enhancing anesthetic care. Key applications include perioperative risk prediction, AI-assisted patient education, automated analysis of clinical records, airway management support, predictive hemodynamic monitoring, closed-loop anesthetic delivery systems, and pain management optimization. In procedural contexts, AI demonstrates promising utility in regional anesthesia through anatomical structure identification and needle navigation, monitoring anesthetic depth via EEG analysis, and improving quality control in endoscopic sedation. Educational applications include intelligent simulators for procedural training and academic productivity tools. Despite significant advances, implementation challenges persist, including algorithmic bias, data security concerns, clinical validation requirements, and ethical considerations regarding AI-generated content. The optimal integration model emphasizes a complementary approach where AI augments rather than replaces clinical judgment—combining computational efficiency with the irreplaceable contextual understanding and ethical reasoning of the anesthesiologist. This hybrid paradigm reinforces the anesthesiologist’s leadership role in perioperative care while enhancing safety, precision, and efficiency through technological innovation. As AI integration advances, continued emphasis on algorithmic transparency, rigorous clinical validation, and human oversight remains essential to ensure that these technologies enhance rather than compromise patient-centered anesthetic care.

31 December 2025

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Healthcare - ISSN 2227-9032