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Healthcare

Healthcare is an international, scientific, peer-reviewed, open access journal on health care systems, industry, technology, policy, and regulation, and is published semimonthly online by MDPI.
The European Medical Association (EMA), Ocular Wellness & Nutrition Society (OWNS) and Italian Society of Nephrology Nurses (SIAN) are affiliated with Healthcare and their members receive discounts on the article processing charges.
Indexed in PubMed | Quartile Ranking JCR - Q2 (Health Policy and Services | Health Care Sciences and Services)

All Articles (14,726)

Cardiovascular–Kidney–Metabolic (CKM) syndrome arises from interrelated cardiovascular, renal, and metabolic pathways that require coordinated therapeutic strategies. This narrative review synthesizes recent systematic reviews, meta-analyses, and original studies to evaluate the translational application of lifestyle medicine (LM) for CKM management. Evidence indicates that LM interventions targeting the six pillars of practice (nutrition, physical activity, stress management, sleep, social support, and avoidance of risky substances) can improve blood pressure, lipid profiles, glycemic control, and weight, with benefits that complement or at times rival pharmacotherapy. We outline opportunities at the LM–drug interface, including sodium-glucose cotransporter-2 inhibitors and nutrient-stimulated hormone agents such as GLP-1 and GIP, and highlight the need to test synergy and sequencing with LM. Persistent implementation barriers include prioritization of drug-centric care and limited protocolized delivery; the AHA 5A model and digital health tools, including wearables that enable real-time feedback, provide practical routes for integration. Marginalized populations carry a disproportionate burden of CKM, underscoring the need for equitable, culturally tailored approaches. Sex-specific gaps, particularly in post-menopausal lipid metabolism and insulin sensitivity, point to the promise of genomic and nutraceutical personalization. Future work should use preregistered, adequately powered multimodal trials to establish durable, scalable pathways for CKM care.

24 December 2025

The Pleiotropic Molecular Network: How Lifestyle Medicine Manages CKM Syndrome. The diagram depicts a pleiotropic molecular network in which the six pillars of Lifestyle Medicine, nutrition, physical activity, stress management, sleep, social support, and avoidance of risky substances, act as inputs (left) that simultaneously modulate multiple upstream signaling pathways. These inputs influence key molecular targets, including AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear factor erythroid 2-related factor 2 (Nrf2), endothelial nitric oxide synthase (eNOS), and nuclear factor κB (NF-κB), thereby attenuating systemic inflammation, oxidative stress, insulin resistance, and endothelial dysfunction (center). Together, these mechanisms converge to improve core CKM clinical phenotypes, blood pressure, lipid profiles, glycemic control, and weight management (right).

Background/Aim: Communities all across the world celebrate the birth of babies through distinct customs and traditional practices. While some of these traditions may bring comfort and cultural continuity, others may not be in line with medical recommendations and could pose major health risks to the newborn. This study examined rural Jordanian women’s perceptions on practices, knowledge sources, benefits, and challenges around caring for newborns in the northern region. Materials and Methods: In this qualitative descriptive study design, twelve women (aged 22 to 60 years) from the Kufr Som village in Northern Jordan, took part in in-depth semi-structured interviews in August 2025. The interviews focused on identifying caregiving practices, knowledge sources, and perceived benefits or challenges related to newborn care. The responses were verbatim transcribed from audio recordings for thematic analysis. Results: Nine themes emerged. “Thermal protection,” “bathing care,” “umbilical cord care,” and “feeding rites” are four themes that encapsulate the common practices women follow when caring for a newborn. The two themes that capture the sources of knowledge and direction for learning newborn care practices are “transmission of knowledge across generations” and “social influence”. The themes “spiritual safeguarding” and “perceived health protection” highlight the benefits of traditional practices, whereas “conflicts between tradition and modern care” underscores their challenges. Conclusions: Newborn care practices are deeply rooted in Northern Jordanian culture. Evidence-based strategies are needed to augment existing practices in order to improve neonatal care outcomes.

24 December 2025

Background: Hospital-acquired influenza remains a persistent threat that amplifies morbidity, mortality, length of stay, and operational strain, particularly among older and immunocompromised inpatients. The COVID-19 era reshaped control norms—normalizing N95 use during surges, ventilation improvements, and routine multiplex PCR—creating an opportunity to strengthen hospital outbreak management. Methods: We conducted a targeted narrative review of WHO/CDC/Infectious Diseases Society of America (IDSA) guidance and peer-reviewed studies (January 2015–August 2025), emphasizing adult inpatient care. This narrative review synthesizes recent evidence and discusses theoretical implications for practice, rather than establishing formal guidelines. Evidence was synthesized into pragmatic practice statements on detection, diagnostics, isolation/cohorting, antivirals, chemoprophylaxis, vaccination, surveillance, and communication. Results: Early recognition and test-based confirmation are pivotal. For inpatients, nucleic-acid amplification tests are preferred; negative antigen tests warrant PCR confirmation, and lower-respiratory specimens improve yield in severe disease. A practical outbreak threshold is ≥2 epidemiologically linked, laboratory-confirmed cases within 72 h on the same ward. Effective control may require immediate isolation or cohorting with dedicated staff, strict droplet/respiratory protection, and daily active surveillance. Early oseltamivir (≤48 h from onset or on admission) reduces mortality and length of stay; short-course post-exposure prophylaxis for exposed patients or staff lowers secondary attack rates. Integrated vaccination efforts for healthcare personnel and high-risk patients reinforce workforce resilience and reduce transmission. Conclusions: A standardized, clinician-led bundle—early molecular testing, do-not-delay antivirals, decisive cohorting and Personal protective equipment (PPE), targeted chemoprophylaxis, vaccination, and disciplined communication— could help curb transmission, protect vulnerable patients and staff, and preserve capacity. Hospitals should codify COVID-era layered controls for seasonal influenza and rehearse unit-level outbreak playbooks to accelerate response and recovery. These recommendations target clinicians and infection-prevention leaders in acute-care hospitals.

24 December 2025

Background/Objectives: This study aimed to examine awareness and behaviors related to injury prevention in the home among community-dwelling older adults according to age and gender. Methods: In this cross-sectional descriptive study, 299 adults aged ≥65 years who visited 10 senior welfare centers in Korea were included. Data were collected through structured face-to-face interviews using a questionnaire assessing general characteristics, awareness, and behaviors related to home injury prevention. Descriptive statistics, the chi-squared test, independent t-test, and one-way analysis of variance were used for data analysis. Results: Levels of interest in home injuries and awareness of first aid differed significantly by age and gender. The possession of a home emergency kit and participation in regular health check-ups varied by age, while the intention to participate in injury-prevention education differed by gender. Overall, female participants demonstrated higher levels of injury-prevention behavior than male participants. Conclusions: Older adults showed lower awareness and practice of specific home injury–prevention strategies, while women exhibited greater awareness and preventive behaviors than men. These findings suggest that tailored home injury–prevention interventions that consider age and gender characteristics may yield more effective and positive outcomes.

24 December 2025

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Editors: Klaudiusz Nadolny, Filip Jaśkiewicz

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Healthcare - ISSN 2227-9032