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Design and Flight Experiment of a Motor-Directly-Driven Flapping-Wing Micro Air Vehicle with Extension Springs -
Multifunctional Liposomes: Smart Nanomaterials for Enhanced Photodynamic Therapy -
Development of Variable Elastic Band with Adjustable Elasticities for Semi-Passive Exosuits -
Regenerative Strategies for Vocal Fold Repair Using Injectable Materials
Journal Description
Biomimetics
Biomimetics
is an international, peer-reviewed, open access journal on biomimicry and bionics, published monthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, Ei Compendex, CAPlus / SciFinder, and other databases.
- Journal Rank: JCR - Q1 (Engineering, Multidisciplinary) / CiteScore - Q2 (Biomedical Engineering)
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 17 days after submission; acceptance to publication is undertaken in 3.8 days (median values for papers published in this journal in the second half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
3.9 (2024);
5-Year Impact Factor:
4.0 (2024)
Latest Articles
A Bio-Inspired Approach to Sustainable Building Design Optimization: Multi-Objective Flow Direction Algorithm with One-Hot Encoding
Biomimetics 2026, 11(1), 31; https://doi.org/10.3390/biomimetics11010031 (registering DOI) - 2 Jan 2026
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The urgent need for sustainable building design calls for advanced optimization methods that simultaneously address economic and environmental objectives, particularly those involving mixed discrete-continuous variables such as insulation material, heating source, and insulation thickness. While nature-inspired metaheuristics have shown promise in engineering optimization,
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The urgent need for sustainable building design calls for advanced optimization methods that simultaneously address economic and environmental objectives, particularly those involving mixed discrete-continuous variables such as insulation material, heating source, and insulation thickness. While nature-inspired metaheuristics have shown promise in engineering optimization, their application to building envelope design remains limited, especially in handling discrete choices efficiently within a multi-objective framework. Inspired by the natural process of rainwater runoff and drainage basin dynamics, this study presents a novel hybrid approach integrating the Multi-Purpose Flow Direction Algorithm (MOFDA) with One-Hot Encoding to optimize external wall insulation. This bio-inspired algorithm mimics how water seeks optimal paths across terrain, enabling effective navigation of complex design spaces with both categorical and continuous variables. The model aims to minimize total lifecycle costs and CO2 emissions across Türkiye’s six updated climatic regions. Pareto-optimal solutions are created using MOFDA, after which the Complex Proportional Assessment (COPRAS) method, weighted by Shannon Entropy, selects the most balanced designs. The results reveal significant climate-dependent variations: in the warmest region, the cost-optimal thickness is 3.3 cm (Rock Wool), while the emission-optimal reaches 17.3 cm (Glass Wool). In colder regions, emission-driven scenarios consistently require up to 40 cm insulation, indicating a practical limit of current materials. Under balanced weighting, fuel preferences shift from LPG in milder climates to Fuel Oil in harsher climates. Notably, Shannon Entropy assigned a weight of 88–92% to emissions due to their wider variability across the Pareto front, underscoring the environmental priority in data-driven decisions. This study demonstrates that the bio-inspired MOFDA framework, enhanced with One-Hot Encoding, effectively handles mixed discrete-continuous optimization and provides a robust, climate-aware decision tool for sustainable building design, reinforcing the value of translating natural flow processes into engineering solutions.
Full article
Open AccessReview
Bioinspired Design for Space Robots: Enhancing Exploration Capability and Intelligence
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Guangming Chen, Xiang Lei, Shiwen Li, Gabriel Lodewijks, Rui Zhang and Meng Zou
Biomimetics 2026, 11(1), 30; https://doi.org/10.3390/biomimetics11010030 (registering DOI) - 2 Jan 2026
Abstract
Space exploration is a major global focus, advancing knowledge and exploiting new resources beyond Earth. Bioinspired design—drawing principles from nature—offers systematic pathways to increase the capability and intelligence of space robots. Prior reviews have emphasized on-orbit manipulators or lunar rovers, while a comprehensive
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Space exploration is a major global focus, advancing knowledge and exploiting new resources beyond Earth. Bioinspired design—drawing principles from nature—offers systematic pathways to increase the capability and intelligence of space robots. Prior reviews have emphasized on-orbit manipulators or lunar rovers, while a comprehensive treatment across application domains has been limited. This review synthesizes bioinspired capability and intelligence for space exploration under varied environmental constraints. We highlight four domains: adhesion and grasping for on-orbit servicing; terrain-adaptive mobility on granular and rocky surfaces; exploration intelligence that couples animal-like sensing with decision strategies; and design methodologies for translating biological functions into robotic implementations. Representative applications include gecko-like dry adhesives for debris capture, beetle-inspired climbers for truss operations, sand-moving quadrupeds and mole-inspired burrowers for granular regolith access, and insect flapping-wing robots for flight under Martian conditions. By linking biological analogues to quantitative performance metrics, this review highlights how bioinspired strategies can significantly improve on-orbit inspection, planetary mobility, subsurface access, and autonomous decision-making. Framed by capability and intelligence, bioinspired approaches reveal how biological analogues translate into tangible performance gains for on-orbit inspection, servicing, and long-range planetary exploration.
Full article
(This article belongs to the Special Issue Bio-Inspired Robotics and Applications 2025)
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Open AccessArticle
Hybrid-Actuated Multimodal Cephalopod-Inspired Underwater Robot
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Zeyu Jian, Qinlin Han, Tongfu He, Chen Chang, Shihang Long, Gaoming Liang, Ziang Xu, Yuhan Xian and Xiaohan Guo
Biomimetics 2026, 11(1), 29; https://doi.org/10.3390/biomimetics11010029 (registering DOI) - 2 Jan 2026
Abstract
To overcome the limitations in maneuverability and adaptability of traditional underwater vehicles, a novel hybrid-actuated, multimodal cephalopod-inspired robot is proposed. This robot innovatively integrates a hybrid drive system wherein sinusoidal undulating fins provide primary propulsion and steering, water-flapping tentacles offer auxiliary burst propulsion,
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To overcome the limitations in maneuverability and adaptability of traditional underwater vehicles, a novel hybrid-actuated, multimodal cephalopod-inspired robot is proposed. This robot innovatively integrates a hybrid drive system wherein sinusoidal undulating fins provide primary propulsion and steering, water-flapping tentacles offer auxiliary burst propulsion, and a gear-and-rack center-of-gravity (CoG) adjustment module modulates the pitch angle to enable depth control through hydrodynamic lift during forward motion. The effectiveness of the design was validated through a series of experiments. Thrust tests demonstrated that the undulating fin thrust scales quadratically with oscillation frequency, aligning with hydrodynamic theory. Mobility experiments confirmed the multi-degree-of-freedom control of the robot, demonstrating effective diving and surfacing via the CoG module and high maneuverability, achieving a turning radius of approximately 15 cm through differential fin control. Furthermore, field trials in an outdoor artificial lake with a depth of less than 1 m validated its environmental robustness. These results confirm the versatile maneuvering capabilities of the robot and its robust adaptability to confined and shallow-water environments, presenting a novel platform for complex underwater observation tasks.
Full article
(This article belongs to the Special Issue Bionic Robotic Fish: 2nd Edition)
Open AccessArticle
Numerical Simulation Study on the Influence of MWCNT and Genipin Crosslinking on the Actuation Performance of Artificial Muscles
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Zhen Li, Yunqing Gu, Chendong He, Denghao Wu, Zhenxing Wu, Jiegang Mou, Caihua Zhou and Chengqi Mou
Biomimetics 2026, 11(1), 28; https://doi.org/10.3390/biomimetics11010028 - 2 Jan 2026
Abstract
To enhance the actuation performance of artificial muscles, a thermo-piezoelectric coupled model was developed based on the inverse piezoelectric effect of piezoelectric bimorphs. By altering the effective piezoelectric coefficient, elastic modulus, and effective thermal expansion coefficient of the thermo-piezoelectric bimorph model, the bending
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To enhance the actuation performance of artificial muscles, a thermo-piezoelectric coupled model was developed based on the inverse piezoelectric effect of piezoelectric bimorphs. By altering the effective piezoelectric coefficient, elastic modulus, and effective thermal expansion coefficient of the thermo-piezoelectric bimorph model, the bending motion of artificial muscles was simulated. The effects of multi-walled carbon nanotube (MWCNT) and Genipin crosslinking on the bending force and output displacement of the artificial muscles were analyzed, illustrating how crosslinking affects the equivalent actuation response. The results showed that MWCNT and Genipin crosslinking significantly improved the actuation performance of the artificial muscles. Through numerical simulation, the optimal crosslinking ratio was determined to be 43.34% MWCNT and 0.1% Genipin, at which the best actuation performance was achieved. Compared to non-crosslinked techniques, the artificial muscles with crosslinked structures exhibited markedly enhanced actuation behavior.
Full article
(This article belongs to the Special Issue Bioinspired Engineered Systems)
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Open AccessArticle
An Improved Red-Billed Blue Magpie Optimization for Function Optimization and Engineering Problems
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Chi Han, Tingwei Zhang, Huimin Han, Wenjuan Dai and Wangyu Wu
Biomimetics 2026, 11(1), 27; https://doi.org/10.3390/biomimetics11010027 - 2 Jan 2026
Abstract
The Red-Billed Blue Magpie Optimization (RBMO) algorithm is an emerging metaheuristic with strong potential applications in solving function optimization and various engineering problems, but it is often hampered by limitations such as premature convergence and an imbalanced exploration–exploitation mechanism. To overcome these deficiencies,
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The Red-Billed Blue Magpie Optimization (RBMO) algorithm is an emerging metaheuristic with strong potential applications in solving function optimization and various engineering problems, but it is often hampered by limitations such as premature convergence and an imbalanced exploration–exploitation mechanism. To overcome these deficiencies, an Improved Red-Billed Blue Magpie Optimization (IRBMO) algorithm is introduced in this paper. The IRBMO integrates three synergistic strategies within a multi-population cooperative framework: (1) an enhanced RBMO search with elite guidance to accelerate convergence; (2) an adaptive differential evolution operator to bolster local search and escape local optima; and (3) a mechanism for boosting global exploration and enhancing population diversity through quasi-opposition-based learning. The performance of IRBMO was rigorously evaluated on 26 classical benchmark functions and several real-world engineering design problems. As demonstrated by the experimental results, IRBMO significantly exceeds the performance of the original RBMO and other leading algorithms across the metrics of solution accuracy, convergence speed, and stability.
Full article
(This article belongs to the Section Biological Optimisation and Management)
Open AccessArticle
FusionTCN-Attention: A Causality-Preserving Temporal Model for Unilateral IMU-Based Gait Prediction and Cooperative Exoskeleton Control
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Sichuang Yang, Kang Yu, Lei Zhang, Minling Pan, Haihong Pan, Lin Chen and Xuxia Guo
Biomimetics 2026, 11(1), 26; https://doi.org/10.3390/biomimetics11010026 - 2 Jan 2026
Abstract
Human gait exhibits stable contralateral coupling, making healthy-side motion a viable predictor for affected-limb kinematics. Leveraging this property, this study develops FusionTCN–Attention, a causality-preserving temporal model designed to forecast contralateral hip and knee trajectories from unilateral IMU measurements. The model integrates dilated temporal
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Human gait exhibits stable contralateral coupling, making healthy-side motion a viable predictor for affected-limb kinematics. Leveraging this property, this study develops FusionTCN–Attention, a causality-preserving temporal model designed to forecast contralateral hip and knee trajectories from unilateral IMU measurements. The model integrates dilated temporal convolutions with a lightweight attention mechanism to enhance feature representation while maintaining strict real-time causality. Evaluated on twenty-one subjects, the method achieves hip and knee RMSEs of 5.71 and 7.43 , correlation coefficients over 0.9, and a deterministic phase lag of 14.56 ms, consistently outperforming conventional sequence models including Seq2Seq and causal Transformers. These results demonstrate that unilateral IMU sensing supports low-latency, stable prediction, thereby establishing a control-oriented methodological basis for unilateral prediction as a necessary engineering prerequisite for future hemiparetic exoskeleton applications.
Full article
(This article belongs to the Section Bioinspired Sensorics, Information Processing and Control)
Open AccessArticle
Global Path Planning for Land–Air Amphibious Biomimetic Robot Based on Improved PPO
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Weilai Jiang, Jingwei Liu, Wei Wang and Yaonan Wang
Biomimetics 2026, 11(1), 25; https://doi.org/10.3390/biomimetics11010025 - 1 Jan 2026
Abstract
To address the path planning challenges for land–air amphibious biomimetic robots in unstructured environments, this study proposes a global path planning algorithm based on an Improved Proximal Policy Optimization (IPPO) framework. Unlike traditional single-domain navigation, amphibious robots face significant kinematic discontinuities when switching
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To address the path planning challenges for land–air amphibious biomimetic robots in unstructured environments, this study proposes a global path planning algorithm based on an Improved Proximal Policy Optimization (IPPO) framework. Unlike traditional single-domain navigation, amphibious robots face significant kinematic discontinuities when switching between terrestrial and aerial modes. To mitigate this, we integrate a Gated Recurrent Unit (GRU) module into the policy network, enabling the agent to capture temporal dependencies and make smoother decisions during mode transitions. Furthermore, to enhance exploration efficiency and stability, we replace the standard Gaussian noise with Ornstein–Uhlenbeck (OU) noise, which generates temporally correlated actions aligned with the robot’s physical inertia. Additionally, a Multi-Head Self-Attention mechanism is introduced to the value network, allowing the agent to dynamically prioritize critical environmental features—such as narrow obstacles—over irrelevant background noise. The simulation results demonstrate that the proposed IPPO algorithm significantly outperforms standard PPO baselines, achieving higher convergence speed, improved path smoothness, and greater success rates in complex amphibious scenarios.
Full article
Open AccessArticle
Gait Planning and Load-Bearing Capacity Analysis of Bionic Quadrupedal Robot Actuated by Water Hydraulic Artificial Muscles
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Jun Li, Zengmeng Zhang, Shoujie Feng, Yong Yang and Yongjun Gong
Biomimetics 2026, 11(1), 24; https://doi.org/10.3390/biomimetics11010024 - 1 Jan 2026
Abstract
The gecko-inspired crawling robot driven by water hydraulic artificial muscles (WHAMs) incorporates the stable structural characteristics of geckos, making it particularly suitable for operation in aquatic environments. Conventional crawling robots typically employ electric or oil hydraulic actuation systems, which require complex sealing and
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The gecko-inspired crawling robot driven by water hydraulic artificial muscles (WHAMs) incorporates the stable structural characteristics of geckos, making it particularly suitable for operation in aquatic environments. Conventional crawling robots typically employ electric or oil hydraulic actuation systems, which require complex sealing and waterproof designs when working in water. This study presented a bionic quadruped robot actuated by WHAMs that fundamentally circumvents waterproofing challenges. Although the joint module can dynamically adjust its output torque according to requirements, there has been a lack of theoretical basis for load adjustment. This research established the relationship between the leg joint load and the WHAM pressure difference, resulting in a pressure difference–load model for the leg joint. Through gait planning analysis, the maximum supporting force during robot motion was determined. Experimental tests on a single-leg prototype demonstrated a maximum static load capacity of 23 kg under stationary conditions, while during cycloidal motion the dynamic load capacity reached 10 kg. Both values satisfied the supporting force requirements of the planned gait. Furthermore, the pressure difference–load model showed good agreement with experimental results, providing theoretical guidance for load adjustment in leg joints.
Full article
(This article belongs to the Section Locomotion and Bioinspired Robotics)
Open AccessArticle
The Advanced BioTRIZ Method Based on LTE and MPV
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Zhonghang Bai, Linyang Li, Yufan Hao and Xinxin Zhang
Biomimetics 2026, 11(1), 23; https://doi.org/10.3390/biomimetics11010023 - 1 Jan 2026
Abstract
While BioTRIZ is widely employed in biomimetic design to facilitate creative ideation and standardize workflows, accurately formulating domain conflicts and assessing design schemes during critical stages—such as initial concept development and scheme evaluation—remains a significant challenge. To address these issues, this study proposes
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While BioTRIZ is widely employed in biomimetic design to facilitate creative ideation and standardize workflows, accurately formulating domain conflicts and assessing design schemes during critical stages—such as initial concept development and scheme evaluation—remains a significant challenge. To address these issues, this study proposes an advanced BioTRIZ method. Firstly, the theory of technological evolution is integrated into the domain conflict identification stage, resulting in the development of a prompt framework based on patent analysis to guide large language models (LLMs) in verifying the laws of technological evolution (LTE). Building on these insights, domain conflicts encountered throughout the design process are formulated, and inventive principles with heuristic value, alongside standardized biological knowledge, are derived to generate conceptual solutions. Subsequently, a main parameter of value (MPV) model is constructed through mining user review data, and the evaluation of conceptual designs is systematically performed via the integration of orthogonal design and the fuzzy analytic hierarchy process to identify the optimal combination of component solutions. The optimization case study of a floor scrubber, along with the corresponding experimental results, demonstrates the efficacy and advancement of the proposed method. This study aims to reduce the operational difficulty associated with implementing BioTRIZ in product development processes, while simultaneously enhancing its accuracy.
Full article
(This article belongs to the Special Issue Biologically-Inspired Product Development)
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A Coral- and Goose Down-Inspired Coating with Integrated Anti-Scaling and Heat Retention for Energy Conservation
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Ran Zhao, Zhihao Shang, Xiaosong Deng, Jinze Lan and Jingxin Meng
Biomimetics 2026, 11(1), 22; https://doi.org/10.3390/biomimetics11010022 - 1 Jan 2026
Abstract
Scaling and thermal loss on the surfaces of industrial equipment and pipelines usually lead to increased energy consumption and reduced operational efficiency. To solve these severe problems, developing advanced coatings with the dual functions of scale resistance and thermal insulation is an effective
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Scaling and thermal loss on the surfaces of industrial equipment and pipelines usually lead to increased energy consumption and reduced operational efficiency. To solve these severe problems, developing advanced coatings with the dual functions of scale resistance and thermal insulation is an effective approach. Inspired by the antifouling agents released from corals and the thermal insulation of goose down, we herein have developed a bioinspired hollow silica microsphere-based (BHSM) coating, exhibiting the synergistic effect of anti-scaling and thermal insulation properties. The BHSM coating is composed of aluminum phosphate (AP) as an inorganic adhesive and scale inhibitor, and hollow silica microspheres (HSMs) as a thermal insulator. In brief, the effective anti-scaling capability comes from released phosphate ions of AP adhesive for chelating with mineral ions, while the high thermal insulation results from the internal air of the HSMs. Compared to the stainless steel (SS 304), the BHSM coating exhibited ~86% scale reduction. Furthermore, the extremely low thermal conductivity of the HSMs endows the BHSM coating with excellent thermal insulation, resulting in a 20% reduction in heat loss relative to the SS 304 surface. Thus, this work presents a promising strategy for anti-scaling and thermal insulation in industrial equipment and pipelines.
Full article
(This article belongs to the Section Biomimetic Surfaces and Interfaces)
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Open AccessArticle
Numerical Investigation of the Water-Exit Performance of a Bionic Unmanned Aerial-Underwater Vehicle with Front-Mounted Propeller
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Yu Dong, Qigan Wang, Wei Wu and Zhijun Zhang
Biomimetics 2026, 11(1), 21; https://doi.org/10.3390/biomimetics11010021 - 31 Dec 2025
Abstract
This work presents a numerical study of the water-exit characteristics of a bioinspired unmanned aerial-underwater vehicle (UAUV) equipped with a front-mounted propeller. A robust solution framework was established on the basis of a modified Shear Stress Transport (SST) turbulence model, volume of fluid
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This work presents a numerical study of the water-exit characteristics of a bioinspired unmanned aerial-underwater vehicle (UAUV) equipped with a front-mounted propeller. A robust solution framework was established on the basis of a modified Shear Stress Transport (SST) turbulence model, volume of fluid (VOF) multiphase formulation, overset grid technique, and six degrees of freedom (6-DOF) motion model; the framework was verified against a canonical water-exit case of a sphere. Inspired by the morphology and water-exit behavior of flying fish, a bioinspired three-dimensional (3D) model was designed. Using this framework, the effects of the front-mounted propeller configuration, exit velocity, and exit angle were examined; the exit process under different conditions was analyzed; and the relationship between exit drag and exit state was quantified. The results demonstrate that the proposed approach can resolve the water-exit performance of the bioinspired UAUV in detail. Folding the front-mounted propeller effectively reduces exit drag and mitigates high-pressure concentrations on the blades. When the exit velocity is ≥8 m/s and the exit angle θ ≤ 30°, the peak exit drag does not surpass 90.004 N. The peak exit drag exhibits a pronounced quadratic relationship with both exit velocity and exit angle. To ensure safe water exit, the UAUV should avoid exiting with the front-mounted propeller deployed and avoid excessively low exit velocities and overly large exit angles. The numerical investigation of exit drag provides effective bioinspired design guidelines and a feasible analysis strategy for UAUV development. In conclusion, the findings provide crucial insights for designing more efficient bioinspired UAUVs, particularly in terms of minimizing water-exit drag and optimizing the configuration of the front-mounted propeller.
Full article
(This article belongs to the Special Issue Bio-Inspired Cross-Domain Dynamics: Advances in Aerial-Aquatic Multimodal Vehicles)
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Open AccessArticle
Compressive Strength Optimization of 3D-Printed Voronoi Trabecular Bone Using the Taguchi Method
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Suyeon Seo, Ju-Hee Lee, Minchae Kang, Eunsol Park and Min-Woo Han
Biomimetics 2026, 11(1), 20; https://doi.org/10.3390/biomimetics11010020 - 31 Dec 2025
Abstract
The surge in demand for patient-specific orthopedic implants necessitates the precise optimization of design and processing parameters for artificial trabecular bone. This research utilizes Voronoi-based porous structures to replicate the irregular geometry characteristic of natural trabecular bone. All specimens were fabricated through fused
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The surge in demand for patient-specific orthopedic implants necessitates the precise optimization of design and processing parameters for artificial trabecular bone. This research utilizes Voronoi-based porous structures to replicate the irregular geometry characteristic of natural trabecular bone. All specimens were fabricated through fused deposition modeling (FDM) with polylactic acid (PLA). The study systematically investigated the influence of four primary parameters, namely build orientation, extruder temperature, layer height, and pore count, on compressive strength. To ensure experimental efficiency, the research implemented a Taguchi L20 orthogonal array. Subsequent signal-to-noise (S/N) ratio analysis identified the optimal parameter set as a y-90° build orientation, an extruder temperature of 200 °C, a layer height of 0.2 mm, and a count of 150 pores. These findings underscore the necessity of integrated geometric and process parameter optimization to advance additive manufacturing for orthopedic applications.
Full article
(This article belongs to the Special Issue Advancements in 3D Printing and Additive Manufacturing for Orthopedic Applications)
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Open AccessArticle
Research on Aerodynamic Performance of Bionic Fan Blades with Microstructured Surface
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Meihong Gao, Xiaomin Liu, Meihui Zhu, Chun Shen, Zhenjiang Wei, Zhengyang Wu and Chengchun Zhang
Biomimetics 2026, 11(1), 19; https://doi.org/10.3390/biomimetics11010019 - 31 Dec 2025
Abstract
The frictional resistance of impeller machinery blades such as aircraft engines, gas turbines, and wind turbines has a decisive impact on their efficiency and energy consumption. Inspired by the micro-tooth structure on the surface of shark skin, microstructural drag reduction technology has become
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The frictional resistance of impeller machinery blades such as aircraft engines, gas turbines, and wind turbines has a decisive impact on their efficiency and energy consumption. Inspired by the micro-tooth structure on the surface of shark skin, microstructural drag reduction technology has become a cutting-edge research direction for improving aerodynamic performance and a continuous focus of researchers over the past 20 years. However, the significant difficulty in fabricating microstructures on three-dimensional curved surfaces has led to the limited widespread application of this technology in engineering. Addressing the issue of drag reduction and efficiency improvement for small axial flow fans (local Reynolds number range: (36,327–40,330), this paper employs Design of Experiments (DOE) combined with high-precision numerical simulation to clarify the drag reduction law of bionic microgroove surfaces and determine the dimensions of bionic microstructures on fan blade surfaces. The steady-state calculation uses the standard k-ω model and simpleFoam solver, while the unsteady Large Eddy Simulation (LES) employs the pimpleFoam solver and WALE subgrid-scale model. The dimensionless height (h+) and width (s+) of microgrooves are in the range of 8.50–29.75, and the micro-grooved structure achieves effective drag reduction. The microstructured surface is fabricated on the suction surface of the blade via a spray coating process, and the dimensions of the microstructures are determined according to the drag reduction law of grooved flat plates. Aerodynamic performance tests indicate that the shaft power consumed by the bionic fan blades during the tests is significantly reduced. The maximum static pressure efficiency of the bionic fan with micro-dimples is increased by 2.33%, while that of the bionic fan with micro-grooves is increased by 3.46%. The fabrication method of the bionic microstructured surface proposed in this paper is expected to promote the engineering application of bionic drag reduction technology.
Full article
(This article belongs to the Section Biomimetic Surfaces and Interfaces)
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Open AccessReview
Organ-on-a-Chip and Lab-on-a-Chip Technologies in Cardiac Tissue Engineering
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Daniele Marazzi, Federica Trovalusci, Paolo Di Nardo and Felicia Carotenuto
Biomimetics 2026, 11(1), 18; https://doi.org/10.3390/biomimetics11010018 - 30 Dec 2025
Abstract
Microfluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a specific focus on cardiovascular applications. OoCs, and particularly Heart-on-a-Chip
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Microfluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a specific focus on cardiovascular applications. OoCs, and particularly Heart-on-a-Chip systems, have advanced biomimicry to a higher level by recreating complex 3D cardiac microenvironments in vitro and dynamic fluid flow. These platforms employ induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), engineered extracellular matrices, and dynamic mechanical and electrical stimulation to reproduce the structural and functional features of myocardial tissue. LoCs have introduced miniaturization and integration of analytical functions into compact devices, enabling high-throughput screening, advanced diagnostics, and efficient pharmacological testing. They enable the investigation of pathophysiological mechanisms, the assessment of cardiotoxicity, and the development of precision medicine approaches. Furthermore, progress in multi-organ systems expands the potential of microfluidic technologies to simulate heart–liver, heart–kidney, and heart–tumor interactions, providing more comprehensive predictive models. However, challenges remain, including the immaturity of iPSC-derived cells, the lack of standardization, and scalability issues. In general, microfluidic platforms represent strategic tools for advancing cardiovascular research in translation and accelerating therapeutic innovation within precision medicine.
Full article
(This article belongs to the Special Issue Advancing Tissue Engineering and Regenerative Medicine Using Next-Gen Biomaterials)
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Open AccessReview
Bio-Inspired Reactive Approaches for Automated Guided Vehicle Path Planning: A Review
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Shiwei Lin, Jianguo Wang and Xiaoying Kong
Biomimetics 2026, 11(1), 17; https://doi.org/10.3390/biomimetics11010017 - 30 Dec 2025
Abstract
Automated guided vehicle (AGV) path planning aims to obtain an optimal path from the start point to the target point. Path planning methods are generally divided into classical algorithms and reactive algorithms, and this paper focuses on reactive algorithms. Reactive algorithms are classified
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Automated guided vehicle (AGV) path planning aims to obtain an optimal path from the start point to the target point. Path planning methods are generally divided into classical algorithms and reactive algorithms, and this paper focuses on reactive algorithms. Reactive algorithms are classified into swarm intelligence algorithms and artificial intelligence algorithms, and this paper reviews relevant studies from the past six years (2019–2025). This review involves 123 papers: 81 papers are about reactive algorithms, 44 are based on the swarm intelligence algorithm, and 37 are based on artificial intelligence algorithms. The main categories of swarm intelligence algorithms include particle swarm optimization, ant colony optimization, and genetic algorithms. Neural networks, reinforcement learning, and fuzzy logic represent the main trends in artificial intelligence–based algorithms. Among the cited papers, 45.68% achieve online implementations, and 33.33% address multi-AGV systems. Swarm intelligence algorithms are suitable for static or simplified dynamic environments with a low computational complexity and fast convergence, as 79.55% of papers are based on a static environment and 22.73% achieve online path planning. Artificial intelligence algorithms are effective for dealing with dynamic environments, which contribute 72.97% to online implementation and 54.05% to dynamic environments, while they face the challenge of robustness and the sim-to-real problem.
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(This article belongs to the Section Biological Optimisation and Management)
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Open AccessArticle
Flexural Strength of Different Restorative Materials Used for Direct Restoration in Pediatric Dentistry: An In Vitro Study
by
Ioana Elena Lile, Carolina Cojocariu, Ciprian Pasca, Andra-Alexandra Stăncioiu, Luminiţa Ligia Vaida and Diana Marian
Biomimetics 2026, 11(1), 16; https://doi.org/10.3390/biomimetics11010016 - 29 Dec 2025
Abstract
Background: Preservation of tooth structure is a key principle in pediatric dentistry, where restorative materials must balance mechanical strength with the preservation of pulp vitality and minimally invasive techniques. The aim of this in vitro study, as it relates to pediatric dentistry, was
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Background: Preservation of tooth structure is a key principle in pediatric dentistry, where restorative materials must balance mechanical strength with the preservation of pulp vitality and minimally invasive techniques. The aim of this in vitro study, as it relates to pediatric dentistry, was to investigate the flexural strength of common composite resins, glass ionomer cements, and resin-modified glass ionomer cement within standardized and homogeneous laboratory conditions. Methods: This study evaluated the flexural strength of seven restorative materials: four composites (Filtek™ Z250, Filtek™ Supreme XT, Gradia, Premise), two GICs (Ketac™ Molar Easymix, GC Fuji IX GP), and one RMGIC (Vitremer). Standardized specimens were prepared and tested using a three-point bending protocol with a universal testing machine (Zwick-Roell Z005). A total of 49 specimens were fabricated and analyzed. Statistical analysis was performed with a one-way ANOVA followed by Tukey’s post hoc test. Results: The flexural strength value of composite resins was significantly greater than that of the glass ionomer and resin-modified glass ionomer cements (p < 0.001). Filtek™ Z250 had the highest flexural strength, and Vitremer, a resin-modified glass ionomer cement, exhibited intermediate performance. Ketac™ Molar Easymix had the lowest values among conventional glass ionomer cements, whilst the flexural strength values obtained for GC Fuji IX GP were similar to some composite materials but with higher variability. Conclusions: Composite resins remain the most durable option for pediatric restorations in stress-bearing areas, whereas RMGICs provide a compromise between mechanical performance and biological advantages such as fluoride release and biocompatibility. Conventional GICs, despite their lower flexural strength, retain clinical relevance in low-load sites and for patients at a high risk of caries. Material selection in pediatric dentistry should therefore be tailored to the child’s age, tooth location, and functional demands to ensure long-lasting, minimally invasive restorations. This study involved only mechanical properties alone, and biological aspects, such as fluoride release and biocompatibility, were not considered. Material selection in pediatric dentistry should therefore take into account mechanical requirements, restorative location, and clinical environment.
Full article
(This article belongs to the Section Biomimetics of Materials and Structures)
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Open AccessArticle
Biomimetic Assessment of 3D-Printed T-Shape Joints Bio-Inspired by the Stem-Branch Junction in Common Ash (Fraxinus excelsior L.) Trees
by
Rastislav Lagaňa, Roman Nôta, Zuzana Tončíková, Tomáš Holeček, Nadežda Langová and Jaroslav Ďurkovič
Biomimetics 2026, 11(1), 15; https://doi.org/10.3390/biomimetics11010015 - 28 Dec 2025
Abstract
The stem–branch junction in trees demonstrates exceptional structural design. This study examined two key features of the branch junction in common ash (Fraxinus excelsior L.) wood: the interlocked area (ILA) formed above a knot and the spatial arrangement of fibers in the
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The stem–branch junction in trees demonstrates exceptional structural design. This study examined two key features of the branch junction in common ash (Fraxinus excelsior L.) wood: the interlocked area (ILA) formed above a knot and the spatial arrangement of fibers in the junction. Bio-inspired by the microstructural features revealed by micro-computed tomography imaging, we developed 3D-printed models and compared their mechanical performance to standard symmetrical T-joints. We evaluated the models using mechanical tests and finite element modeling (FEM). Asymmetrical 3D-printed joints mimicking vessel and fiber distribution in the stem–branch junction were 2% stiffer in the elastic region than symmetrical joints and showed, on average, 10% lower deflection at failure. While the ILA had minimal effect on elastic stiffness, measured surface strain analysis indicated that it positively influenced the redistribution of shear strain in the junctions. Thanks to the bio-inspired design, the joints were stiffer and can be utilized in multiple design configurations while maintaining the same underlying principle.
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(This article belongs to the Section Biomimetics of Materials and Structures)
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Open AccessArticle
Biomimetic Approach to Designing Trust-Based Robot-to-Human Object Handover in a Collaborative Assembly Task
by
S. M. Mizanoor Rahman
Biomimetics 2026, 11(1), 14; https://doi.org/10.3390/biomimetics11010014 - 27 Dec 2025
Abstract
We presented a biomimetic approach to designing robot-to-human handover of objects in a collaborative assembly task. We developed a human–robot hybrid cell where a human and a robot collaborated with each other to perform the assembly operations of a product in a flexible
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We presented a biomimetic approach to designing robot-to-human handover of objects in a collaborative assembly task. We developed a human–robot hybrid cell where a human and a robot collaborated with each other to perform the assembly operations of a product in a flexible manufacturing setup. Firstly, we investigated human psychology and biomechanics (kinetics and kinematics) for human-to-robot handover of an object in the human–robot collaborative set-up in three separate experimental conditions: (i) human possessed high trust in the robot, (ii) human possessed moderate trust in the robot, and (iii) human possessed low trust in the robot. The results showed that human psychology was significantly impacted by human trust in the robot, which also impacted the biomechanics of human-to-robot handover, i.e., human hand movement slowed down, the angle between human hand and robot arm increased (formed a braced handover configuration), and human grip forces increased if human trust in the robot decreased, and vice versa. Secondly, being inspired by those empirical results related to human psychology and biomechanics, we proposed a novel robot-to-human object handover mechanism (strategy). According to the novel handover mechanism, the robot varied its handover configurations and motions through kinematic redundancy with the aim of reducing potential impulse forces on the human body through the object during the handover when robot trust in the human was low. We implemented the proposed robot-to-human handover mechanism in the human–robot collaborative assembly task in the hybrid cell. The experimental evaluation results showed significant improvements in human–robot interaction (HRI) in terms of transparency, naturalness, engagement, cooperation, cognitive workload, and human trust in the robot, and in overall performance in terms of handover safety, handover success rate, and assembly efficiency. The results can help design and develop human–robot handover mechanisms for human–robot collaborative tasks in various applications such as industrial manufacturing and manipulation, medical surgery, warehouse, transport, logistics, construction, machine shops, goods delivery, etc.
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(This article belongs to the Special Issue Human-Inspired Grasp Control in Robotics 2025)
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Open AccessArticle
Mitigating Neural Habituation in Insect Bio-Bots: A Dual-Timescale Adaptive Control Approach
by
Le Minh Triet and Nguyen Truong Thinh
Biomimetics 2026, 11(1), 13; https://doi.org/10.3390/biomimetics11010013 - 27 Dec 2025
Abstract
Bio-cybernetic organisms combine biological locomotion with electronic control but face significant challenges regarding individual variability and stimulus habituation. This study introduces an Adaptive Neuro-Fuzzy Inference System (ANFIS) designed to dynamically calibrate to individual Gromphadorhina portentosa specimens. Using a miniaturized neural controller, we compared
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Bio-cybernetic organisms combine biological locomotion with electronic control but face significant challenges regarding individual variability and stimulus habituation. This study introduces an Adaptive Neuro-Fuzzy Inference System (ANFIS) designed to dynamically calibrate to individual Gromphadorhina portentosa specimens. Using a miniaturized neural controller, we compared ANFIS’s performance against natural behavior and non-adaptive control methods. Results demonstrate ANFIS’s superiority: obstacle navigation efficiency reached 81% (compared to 42% for non-adaptive methods), and effective behavioral modulation was sustained for 47 min (versus 26 min). Furthermore, the system achieved 73% target acquisition in complex terrain and maintained stimulus responsiveness 3.5-fold longer through sophisticated habituation compensation. Biocompatibility assessments confirmed interface functionality over 14-day periods. This research establishes foundational benchmarks for arthropod bio-cybernetics, demonstrating that adaptive neuro-fuzzy architectures significantly outperform conventional methods, enabling robust bio-hybrid platforms suitable for confined-space search-and-rescue operations.
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(This article belongs to the Special Issue Advancements in Nature-Inspired Engineering: Integrating Biomimicry into Modern Design Practices)
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Open AccessReview
Biomimetic Strategies for Bone Regeneration: Smart Scaffolds and Multiscale Cues
by
Sheikh Md Mosharof Hossen, Md Abdul Khaleque, Min-Su Lim, Jin-Kyu Kang, Do-Kyun Kim, Hwan-Hee Lee and Young-Yul Kim
Biomimetics 2026, 11(1), 12; https://doi.org/10.3390/biomimetics11010012 - 27 Dec 2025
Abstract
Bone regeneration remains difficult due to the complex bone microenvironment and the limited healing capacity of large defects. Biomimetic strategies offer promising solutions by using advanced 3D scaffolds guided by natural tissue cues. Recent advances in additive manufacturing, nanotechnology, and tissue engineering now
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Bone regeneration remains difficult due to the complex bone microenvironment and the limited healing capacity of large defects. Biomimetic strategies offer promising solutions by using advanced 3D scaffolds guided by natural tissue cues. Recent advances in additive manufacturing, nanotechnology, and tissue engineering now allow the fabrication of hierarchical scaffolds that closely mimic native bone. Smart scaffold systems combine materials with biochemical and mechanical signals. These features improve vascularization, enhance tissue integration, and support better regenerative outcomes. Bio-inspired materials also help connect inert implants with living tissues by promoting vascular network formation and improving cell communication. Multiscale design approaches recreate bone nano- to macro-level structure and support both osteogenic activity and immune regulation. Intelligent and adaptive scaffolds are being developed to respond to physiological changes and enable personalized bone repair. This review discusses the current landscape of biomimetic scaffold design, fabrication techniques, material strategies, biological mechanisms, and translational considerations shaping next-generation bone regeneration technologies. Future directions focus on sustainable, clinically translatable biomimetic systems that can integrate with digital health tools for improved treatment planning.
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(This article belongs to the Special Issue Advances in Bio-Inspired Design and Characterization of 3D-Printed Multimaterial Composites and Heterogeneous Structures)
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