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All Articles (80)

Squamous Cell Carcinomas in Cats: A Retrospective Study of 4300 Histopathological Cases (2017–2023)

  • Anna-Chiara Riedl,
  • Katharina Charlotte Jensen and
  • Heike Aupperle-Lellbach
  • + 3 authors

This retrospective study provides an extensive evaluation of feline squamous cell carcinoma (SCC), comparing oral and cutaneous SCC, as well as different oral/cutaneous sites, with respect to sex, age, breed, and coat length. It was based on 4300 SCCs submitted to LABOKLIN GmbH & Co. KG from 2017 to 2023. No sex predisposition was identified. Affected cats were predominantly older (median age 13 years). SCC risk increased with age, although cats of very young age were also affected. Breed predispositions were not found. However, compared to non-pedigree cats, Persians, Norwegian Forest Cats, British Shorthairs (BSH), Chartreux, and Siamese cats showed a reduced risk, as did longhaired cats. The predominant sites were the oral cavity (41.0%, 1762/4300) and skin (35.8%, 1540/4300). Maine Coons, BSHs, Persians, and Norwegian Forest Cats, as well as longhaired cats, developed oral SCC more frequently. Intraoral, gingival (36.2%, 637/1762) and lingual (19.0%, 334/1762) SCC predominated. Common cutaneous sites included the pinnae (35.0%, 539/1540), unspecified head/neck regions (8.8%, 135/1540), and the nose (8.7%, 134/1540). Maine Coons and BSHs showed less auricular SCC; Sphynx had more on the trunk. These findings emphasise SCC as a crucial differential diagnosis for oral and cutaneous lesions, even in young cats.

11 January 2026

(a) Violin plots of the age distribution in the feline SCC population across coat types; cases with unknown coat type were excluded; effect size η2 = 0.003; (b) Violin plots of the age distribution in the SCC population across sexes. F = female; FN = female neutered; M = male; MN = male neutered. Age differences were assessed using the Kruskal–Wallis test, followed by pairwise Mann–Whitney U tests with Bonferroni adjustment; effect size η2 = 0.006. Significance: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.
  • Systematic Review
  • Open Access

Research suggests that older adults might obtain health benefits from pet ownership; however, results are mixed. Pet attachment is suggested as both a mechanism for the relationship and a reason for differences in the association of pet ownership with health outcomes. This systematic review examines evidence for the relationship between pet attachment and health outcomes among older adults. The Open Science Foundation-registered review began with 20,795 candidate articles. We limited our review to the 58 articles that consisted of original research, published in peer-reviewed journals between 1965 and June 2025, written in English, included older adults (age ≥ 50 years) or were limited to only older adults, and examined the relationship between pet attachment and health outcomes. The articles included analyses of psychological (n = 53), social (n = 27), or physical (n = 2) health outcomes. Pet attachment was assessed with 19 tools; most frequently the Lexington Attachment to Pets Scale (n = 21) and the Pet Attachment Questionnaire (n = 8). The studies were not consistently of high quality according to OCEBM criteria. Except for grief, which was consistently related to pet attachment, the findings do not support a clear relationship between pet attachment and health outcomes in older adults. Findings suggest that the relationship between pet attachment and health outcomes may be more pronounced in younger than in older adults.

7 January 2026

PRISMA chart for identification of articles to include in this systematic review (n = 58).

Probiotics, prebiotics, and postbiotics are of interest for their potential gastrointestinal and immunological benefits in pet health. This study aimed to assess whether a unique blend of Bacillus subtilis, Bacillus clausii, Bacillus coagulans (Weizmannia coagulans), FOS, GOS, and a postbiotic yeast extract could provide beneficial gut and immunological effects when fed to healthy, adult dogs. Twenty-four healthy adult beagle dogs (mean age 5.17 yrs) were fed the probiotic, prebiotic, and yeast chew (PPYC) or control chew (CC) supplement for 31 days, accompanied by fecal and blood sampling. Following 31 days, PPYC fed dogs had decreased (p < 0.05) fecal calprotectin concentration, a biomarker indicative of reduced intestinal inflammation, compared with dogs receiving the CC. In the PPYC group, blood C-reactive protein levels, an indicator of tissue inflammation, tended (p = 0.11) to be reduced. In addition, dogs receiving the PPYC supplement showed an increase in the IL-17a cytokine (p < 0.05). Despite dogs being in a clinically healthy state, changes in some dysbiosis-related bacterial strains were observed. There was an increase (p < 0.05) in the % of total bacteria of Blautia in the PPYC group by the end of the study, as well as an increase in the percent change from Day 0 of C. hiranosis (p < 0.05). Increased alpha diversity, a measure related to the resilience to environmental change, was observed in the PPYC group (p < 0.05). These results suggest that after consuming a supplement containing probiotics, prebiotics and a postbiotic yeast extract, markers of gut and systemic health were improved in otherwise healthy dogs.

4 January 2026

Mean food consumption as expressed per unit of body weight held constant for PPYC but increased for CC. Note: There was a significant difference between the slopes (p &lt; 0.01) but not at time 0 (p &gt; 0.20). Further, the slope of CC was significantly different (p &lt; 0.05) from Time 0 but not for PPYC.
  • Brief Report
  • Open Access

DEA 1 Prevalence and Theoretical Transfusion Mismatch Estimates in Dogs from Southeastern Mexico

  • Carlos Antonio Arcos-Roa,
  • Luis Arturo Ortíz-Carbajal and
  • Beatriz Agame-Lagunes
  • + 5 authors

Ensuring blood group compatibility is essential in canine transfusion medicine, and Dog Erythrocyte Antigen (DEA) 1 is the most clinically relevant erythrocyte antigen due to its immunogenicity. However, information on its prevalence in Mexico is scarce. This study assessed the distribution of DEA 1 in client-owned dogs from Veracruz–Boca del Río, southeastern Mexico, and applied antigen frequencies to generate theoretical incompatibility scenarios in untyped populations. A cross-sectional study was conducted using blood samples from 192 clinically healthy dogs. DEA 1 typing was performed using a commercial immunochromatographicassay. Frequencies were compared using chi-square or Fisher’s exact test, and 95% confidence intervals were calculated with the Wilson method. Of all dogs sampled, 60.9% (95% CI: 53.6–67.8) were DEA 1-positive. No statistically significant differences were observed by sex or municipality (p > 0.05). Although frequencies varied among breeds, no significant association between breed and DEA 1 status was detected (p > 0.05). Based on observed antigen proportions, mathematical estimations were calculated to illustrate how DEA 1 distribution alone may contribute to potential donor–recipient mismatching when typing is not performed. These estimations are theoretical values and do not represent clinically documented sensitization or transfusion reactions. This study provides the first report of DEA 1 distribution in southeastern Mexico and establishes baseline information that may support future research on canine transfusion practices and donor selection.

18 December 2025

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Pets - ISSN 2813-9372