Announcements
31 July 2025
MDPI INSIGHTS: The CEO's Letter #25 - 8,000 Staff Worldwide, Korea Visit, 100,000 Preprints, Malaysia Roundtable, Canada Consortium Deal
Welcome to the MDPI Insights: The CEO's Letter.
In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.
Opening Thoughts
Talent Drives Our Progress
For the first time in MDPI’s history, we now have over 8,000 colleagues across the company. I would like to take a moment to celebrate this milestone and acknowledge the driving force behind our growth and success: our people.
As the world’s leading fully open access publisher, MDPI has grown thanks to the dedication, talent, and teamwork of colleagues across the company. Already halfway through 2025, we’ve welcomed nearly 2,000 new colleagues.
“Our achievements are also about the people behind them”
We now manage over 475 journals, with 298 receiving an Impact Factor, and hundreds more indexed in major databases, including 343 in Scopus, and 92 by PubMed. As the reach and impact of our journals continues to grow, so does the need for dedicated and qualified teams to support that growth. Thus, attracting and retaining exceptional talent remains a cornerstone of our success.
Our achievements are not just about the results of journal expansion, however: they’re about the people behind them. From our hardworking editors to our meticulous English editing and production teams – from our journal relationship specialists, public relations, marketing and communications professionals to our conference teams and the project teams behind Preprints, Scilit, SciProfiles, JAMS and more. Our success reflects the work of thousands of people showing up each day, taking pride in their work, and committed to excellence and service.
What we’re doing to support talent:
- Investing in onboarding and training to help new colleagues feel welcomed and empowered to thrive.
- Creating clearer career paths across all functions, from editorial to communications and beyond.
- Launching mentorship programs and internal knowledge-sharing sessions to promote growth and collaboration.
- Evolving our recognition and rewards programs to better celebrate your contributions.
- Expanding our training systems and platforms.
MDPI’s in-house training department offers over 215 training courses, covering topics from editorial development to cross-cultural collaboration. In 2024 alone, we had 44 full-time trainers and 196 part-time training assistants supporting the learning and development needs of colleagues worldwide. These efforts ensure our teams are equipped with the skills and confidence to grow professionally and contribute meaningfully.
Over two-thirds of our workforce is editorial, and of our more than 5,400 editors, 87% hold a Master’s degree and 6% a PhD. Their collective contributions are central to delivering a high-quality publishing experience and supporting global academic communication.
As we celebrate this milestone, we also aim to continue on a path of steady and sustainable growth, one that balances journal expansion with investment in people, outreach, processes, and innovation. Together, we are shaping the future of open access and academic publishing. Thank you for your hard work, your ideas, and your commitment to serving the global research community.
Let’s continue working together to create a culture where great talent grows and every colleague feels valued.
Impactful Research
Visiting South Korea: Building Connections and Supporting the MDPI Seoul Office
In July, I had the opportunity to visit our team in Seoul and engage directly with academic communities in South Korea. The visit focused on deepening MDPI’s relationships with local universities, institutions, and partners, and supporting the great work of our colleagues at the MDPI Seoul office.
Korea Association of Private University Libraries (KAPUL) Conference
A highlight of the visit was our participation in the Korea Association of Private University Libraries (KAPUL) Conference, where we presented to over 100 academic librarians. I delivered a keynote speech titled “The Evolving Publishing Landscape: Open Access and Beyond,” while my colleague Dr. Jisuk Kang (Public Affairs Specialist) shared insights in her presentation, “Inside MDPI: Editorial Practices & Research Integrity.”
Our participation received media coverage, including:
NEWS1: “Publishing Open Access Papers' MDPI...Supporting the Expansion of Korean Research Influence”
UNN (University News Network): “MDPI Announces ‘Seoul Declaration’... “Presenting Standards for Authenticity and Transparency in Korea”
Beyond Post: MDPI CEO Visits Korea to 'Support for the Development of Domestic Knowledge Ecosystem'
Facts & Figures: South Korea
- South Korea is MDPI’s sixth-largest publishing country by article volume (over 90,000 MDPI papers published to date).
- In 2024, Korea ranked 16th globally by total publications, and 6th (among these top 20 countries) by citation impact.
- 52% of Korean publications in 2024 were OA – and 73% of those were Gold OA.
- MDPI published about 20% of all OA papers from Korea in 2024.
- Over 2,000 active Editorial Board Members from South Korea contribute to MDPI journals, with 11 Section Editors-in-Chief.
- We currently have 11 Institutional Open Access Program agreements and two society partnerships in Korea:
- Korean Society of Pharmaceutical Sciences and Technology (with MDPI journal Pharmaceutics)
- Korean Tribology Society (with MDPI journal Coatings)
MDPI Seoul Office and the First Korea Salon
Our Seoul office serves as a regional hub for marketing, communications, and community engagement. It continues to grow in size and influence, prioritizing supporting scholar visits, conference sponsorships, and outreach events such as the recent MDPI Korea Salon.
The inaugural Salon, themed “Exploring Research Trends in Medical Publishing, Ethics, and AI,” brought together over 20 scholars and Editorial Board members serving MDPI journals.
Thank you to our guest speakers including Professors Young-Joon Surh of Seoul National University, Kwang-Sig Lee of Korea University, and Jin-Won Noh of Yonsei University who presented on the landscape of medicine in South Korea and across the globe. The Salon also included presentations from MDPI colleagues on Open Access, ethics, and how the IOAP can support researchers in this field.
“Our Seoul office continues to grow in size and influence”
Looking Ahead
MDPI is already the leading OA publisher in South Korea, yet challenges and misconceptions around OA and APCs remain. Visits like this one, along with the ongoing efforts of our Seoul office, are important to building understanding, trust, and long-term relationships with the local academic community.
A big thank-you to our colleagues in Seoul for their warm hospitality, professionalism, and energy! Our new office is well situated, staffed, and ready to grow. This visit marked an important step forward in our continued mission to support global research communities and advance Open Science.
Inside MDPI
Preprints.org Reaches 100,000 Preprints: A Major Milestone for MDPI and Open Science
In case you missed it, Preprints.org recently surpassed 100,000 preprints posted. This is a major milestone for our platform and one worth celebrating.
Preprints are a key pillar of the Open Science movement, which promotes transparency, equity, and faster knowledge-sharing through initiatives such as Open Access, Open Data, Open Source, and Open Peer Review. The benefits of Open Science extend beyond researchers, as they support funders, educators, policymakers, and the public in advancing discovery and innovation.
What is behind the 100,000 preprints milestone?
Since its launch in 2016, Preprints.org has grown into one of the world’s leading preprint platforms, now ranked fifth globally by publication volume.
More than 350,000 researchers have contributed, helping shape this dynamic and collaborative space for sharing early-stage research across all disciplines.
Read the full announcement here:
https://www.mdpi.com/about/announcements/12202
“Preprints.org has grown into one of the world’s leading preprint platforms”
Some quick facts worth noting:
- About 56% of the preprints on Preprints.org are later published in peer-reviewed journals.
- The platform is now indexed in Web of Science (Preprint Citation Index), Europe PMC, and Crossref, helping improve visibility and trust in the preprints shared.
- Recent upgrades – including a revamped website, new features such as search subscriptions, curated reading lists, and community feedback tools (PREreview) – show our commitment to developing Preprints.org in line with researchers’ needs.
This growth and progress would not be possible without the dedication of the Preprints.org team, our Advisory Board members, screeners, and colleagues across MDPI who support the platform’s development. This milestone is a reminder of our shared mission: to accelerate scientific communication and build a more open, transparent, and inclusive research ecosystem.
I’m excited to see what’s ahead as we approach Preprints.org’s 10-year anniversary in 2026!
Coming Together for Science
Malaysia Media Roundtable: Educating on Open Access and MDPI’s Presence in Southeast Asia
At the end of June, I had the opportunity to participate in a strategic media roundtable in Kuala Lumpur, focused on raising awareness about the importance of Open Access (OA) and on MDPI’s growing presence in Southeast Asia.
We welcomed five Malaysian media outlets for an engaging private session that included presentations and open discussion.
I gave an overview of the benefits of Open Access, MDPI’s global developments, and our collaborations in Malaysia.
My colleague Yu Nwe Soe (Public Relations Specialist), presented on our editorial process, helping to clarify how MDPI supports authors and maintains research quality.
We were also joined by two local Editorial Board Members (EBMs) who offered first-hand insights into their experiences working with MDPI and how OA has shaped their publishing choices.
The discussion covered a range of questions from the press, from OA publishing models to editorial standards, and highlighted MDPI’s unique contribution to accelerating scientific communication in the region.
As the leading fully OA publisher, we see it as our responsibility to continue educating research communities and the broader public on the impact of OA, especially in emerging and high-growth academic markets.
Spotlight on Malaysia
Malaysia continues to rise as a regional research hub, with five universities ranked in the global top 200 and 11 subjects in the global top 50. In 2024, Malaysia ranked 2nd in Southeast Asia in total publication output, 10th in Asia, and 25th globally.
MDPI’s presence in Malaysia:
- Over 21,000 research articles published to date from Malaysian institutions
- More than 1,100 articles published in 2024 alone
- In the period 2020–2024, 54% of Malaysia’s total publications were OA
- 36 EBMs from Malaysia, across 27 MDPI journals
- Around 100 conferences sponsored in Malaysia in the past five years
- MDPI is hosting the 2nd International Conference on AI Sensors and Transducers in Kuala Lumpur (29 July- 3 August 2025)
Media Coverage & Editorial Voices
Following the roundtable, we saw positive coverage across several local outlets, with articles highlighting MDPI’s role in empowering Malaysian researchers. Notable pieces included:
- Open-Access Empowers Malaysia’s Research Future
- Empowering Malaysian Researchers to Meet the Nation’s Innovation Ambitions
- MDPI and empowering Malaysian researchers
Our local EBMs also shared their perspectives:
Prof. Denny Ng Kok Sum (Sunway University, EBM of MDPI journal Processes) and Prof. Lee (EBM of MDPI journal Bacteria) share their experiences with MDPI and the role Open Access plays in their publication decisions.
“We see it as our responsibility to continue educating research communities on the impact of OA”
“I didn’t want my work stuck behind a paywall.”
— Prof. Denny Ng Kok Sum, Sunway University, Processes Editorial Board Member
“Open Access opens doors for collaboration and visibility, especially in fast-developing regions like ours.”
— Prof. Lee, Bacteria Editorial Board Member
This roundtable marked another step in building trust, understanding, and collaboration in Southeast Asia. A big thank-you to the MDPI Malaysia team and all those who contributed to the event’s success.
Closing Thoughts
MDPI Signs First North American Agreement with Canadian Consortium
We are proud to announce a major milestone for MDPI Canada and an important step forward for OA in North America.
In July, our Toronto office finalized MDPI’s first North American consortium agreement with the Federal Science Libraries Network (FSLN). This is a significant achievement that strengthens our expansion in Canada and reinforces our global commitment to supporting Open Science.
This two-year agreement gives Canadian federal agencies access to MDPI’s IOAP, including discounted article processing charges for affiliated researchers across our portfolio of over 475 OA journals. It lowers barriers for Canadian scientists to share their work more openly and reach a global audience.
Ryan Siu, Institutional Partnerships Manager at MDPI.
“The Open Science landscape in Canada is rapidly evolving, with the Tri-Agency Open Access Policy set for renewal by the end of 2025. This reflects ongoing efforts to foster greater scientific transparency and accessibility at a national policy level,” says Ryan Siu, Institutional Partnerships Manager at MDPI.
“Our new agreement with FSLN represents our shared commitment to further these efforts and foster wider readership. By aligning with these initiatives, we make progress towards research that’s both inclusive and impactful, benefiting local and global communities alike.”
Participating FSLN institutions include:
- Agriculture and Agri-Food Canada
- Environment and Climate Change Canada
- Health Canada
- National Research Council Canada
- Natural Resources Canada
By partnering with some of Canada’s largest science-based agencies, we reaffirm our goal of advancing OA across continents. We look forward to developing our support for Canadian researchers and continuing to drive progress in Open Science across North America and beyond.
Chief Executive Officer
MDPI AG
29 July 2025
Meet Us at the 61st Annual Meeting European Association for the Study of Diabetes (EASD 2025), 15–19 September 2025, Vienna, Austria
28 July 2025
World Hepatitis Day—“Hepatitis: Let’s Break It Down”, 28 July 2025
World Hepatitis Day is observed each year on 28 July to raise awareness of viral hepatitis, a type of inflammation of the liver that causes severe liver disease and liver cancer.
The theme for 2025—“Hepatitis: Let’s Break It Down”—calls for urgent action to dismantle the financial, social and systemic barriers, including stigma, that stand in the way of hepatitis elimination and liver cancer prevention.
Chronic hepatitis B and C silently cause liver damage and cancer—despite them being preventable, treatable, and, in the case of hepatitis C, curable. The theme emphasizes the need to simplify, scale up, and integrate hepatitis services—vaccination, safe injection practices, harm reduction and especially testing and treatment—into national health systems.
The campaign is a reminder that we must act now to expand access, integrate care, and end hepatitis as a public health problem by 2030.
In recognition of this important day, we recommend the following related articles, Special Issues, and journals spanning multidisciplinary fields, including clinical medicine. We believe that promoting such research contributes to enhanced public awareness and a greater understanding of viral hepatitis, an inflammation of the liver that causes severe liver disease and liver cancer.
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Biology & Life Sciences |
Medicine & Pharmacology |
“Curcumin Nanocarriers in the Protection Against Iron- and Alcohol-Induced Oxidative Stress in a Cellular Model of Liver Disease”
by Lucy Petagine, Mohammed G. Zariwala, Satyanarayana Somavarapu, Stefanie Ho Yi Chan and Vinood B. Patel
Biology 2025, 14(5), 455; https://doi.org/10.3390/biology14050455
“Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD”
by Ester S. Alves, Jessica D. M. Santos, Alessandra G. Cruz, Felipe N. Camargo, Carlos H. Z. Talarico, Anne R. M. Santos, Carlos A. A. Silva, Henrique J. N. Morgan, Sandro L. Matos, Layanne C. C. Araujo et al.
Pathophysiology 2025, 32(1), 1; https://doi.org/10.3390/pathophysiology32010001
“Change in Estimated Glomerular Filtration Rate After Direct-Acting Antiviral Treatment in Chronic Hepatitis C Patients”
by Gantogtokh Dashjamts, Amin-Erdene Ganzorig, Yumchinsuren Tsedendorj, Dolgion Daramjav, Enkhmend Khayankhyarvaa, Bolor Ulziitsogt, Otgongerel Nergui, Ganchimeg Dondov, Tegshjargal Badamjav, Tulgaa Lonjid et al.
Diseases 2025, 13(2), 26; https://doi.org/10.3390/diseases13020026
“Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver”
by Giovanni Colonna
Livers 2025, 5(1), 1; https://doi.org/10.3390/livers5010001
“Liver Cancer Neuroscience: Regulating Liver Tumors via Selective Hepatic Vagotomy”
by Kylynda C. Bauer, Shadin Ghabra, Chi Ma Lee Chedester and Tim F. Greten
Methods Protoc. 2024, 7(6), 99; https://doi.org/10.3390/mps7060099
“Role of Circulating microRNAs in Liver Disease and HCC: Focus on miR-122”
by Francesco Colaianni, Veronica Zelli, Chiara Compagnoni, Martina Sara Miscione, Mario Rossi, Davide Vecchiotti, Monica Di Padova, Edoardo Alesse, Francesca Zazzeroni and Alessandra Tessitore
Genes 2024, 15(10), 1313; https://doi.org/10.3390/genes15101313
“Impact of Hepatitis Delta Virus Infection on the Selection of Hepatitis B Surface Antigen Mutations”
by Kabo Baruti,Wonderful T. Choga, Bonolo B. Phinius, Basetsana Phakedi, Lynnette Bhebhe, Gorata G. A. Mpebe, Patience C. Motshosi, Tsholofelo Ratsoma, Sikhulile Moyo, Mosimanegape Jongman et al.
Genes 2024, 15(8), 982; https://doi.org/10.3390/genes15080982
“NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options”
by Natalia G. Vallianou, Dimitris Kounatidis, Sotiria Psallida, Nikolaos Vythoulkas-Biotis, Andreas Adamou, Tatiana Zachariadou, Sofia Kargioti, Irene Karampela and Maria Dalamaga
Metabolites 2024, 14(7), 366; https://doi.org/10.3390/metabo14070366
“miRNA Expression and HCC Occurrence in HCV Cirrhotic Patients Treated with Direct Acting Antivirals”
by Antonietta Romano, Alessandra Brocca, Zoe Mariño, Sofía Pérez-del-Pulgar, Sabela Lens, Loreto Boix, María Reig, Jordi Bruix, Giulio Ceolotto, Valeria Calvino et al.
Livers 2024, 4(2), 275-286; https://doi.org/10.3390/livers4020020
“The Full-Genome Analysis and Generation of an Infectious cDNA Clone of a Genotype 6 Hepatitis E Virus Variant Obtained from a Japanese Wild Boar: In Vitro Cultivation in Human Cell Lines”
by Putu Prathiwi Primadharsini, Masaharu Takahashi, Tsutomu Nishizawa, Yukihiro Sato, Shigeo Nagashima, Kazumoto Murata and Hiroaki Okamoto
Viruses 2024, 16(6), 842; https://doi.org/10.3390/v16060842
“Hepatitis C Prevalence and Birth Outcomes among Pregnant Women in the United States: A 2010–2020 Population Study”
by Paul Wasuwanich, Songyos Rajborirug, Robert S. Egerman, Tony S. Wen and Wikrom Karnsakul
Pathogens 2024, 13(4), 321; https://doi.org/10.3390/pathogens13040321
“Prospects for Controlling Hepatitis B Globally”
by Vicente Soriano, Víctor Moreno-Torres, Ana Treviño, Fernando de Jesús, Octavio Corral and Carmen de Mendoza
Pathogens 2024, 13(4), 291; https://doi.org/10.3390/pathogens13040291
“Longterm Outcome of Therapeutic Vaccination with a Third Generation Pre-S/S HBV Vaccine (PreHevbrioR) of Chronically HBV Infected Patients”
by Hedwig Roggendorf, Daniel Shouval, Michael Roggendorf and Guido Gerken
J. Pers. Med. 2024, 14(4), 364; https://doi.org/10.3390/jpm14040364
“NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic–Metabolic Interplay”
by Simona Cernea
Life 2024, 14(2), 272; https://doi.org/10.3390/life14020272
“Updated Clinical Guidelines on the Management of Hepatitis C Infection in Children”
by Chaowapong Jarasvaraparn, Christopher Hartley and Wikrom Karnsakul
Pathogens 2024, 13(2), 180; https://doi.org/10.3390/pathogens13020180
“Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients”
by Chinmay Bera, Nashla Hamdan-Perez and Keyur Patel
J. Clin. Med. 2024, 13(4), 1046; https://doi.org/10.3390/jcm13041046
“Real-World Utilization of Corticosteroids in Severe Alcoholic Hepatitis: Eligibility, Response, and Outcomes”
by Ana-Maria Singeap, Horia Minea, Oana Petrea, Madalina-Andreea Robea, Ioana-Miruna Balmuș, Raluca Duta, Ovidiu-Dumitru Ilie, Carmen Diana Cimpoesu, Carol Stanciu and Anca Trifan
Medicina 2024, 60(2), 311; https://doi.org/10.3390/medicina60020311
“Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview”
by Lydia A. Mercado, Fernando Gil-Lopez, Razvan M. Chirila and Denise M. Harnois
Diagnostics 2024, 14(4), 382; https://doi.org/10.3390/diagnostics14040382
“Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways”
by Min Kim, Seung-Cheol Jee and Jung-Suk Sung
Antioxidants 2024, 13(2), 180; https://doi.org/10.3390/antiox13020180
”Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation”
by Cong Meng, Yu Liu, Yuping Ming, Cao Lu, Yanggege Li, Yulu Zhang, Dongdong Su, Xueyun Gao and Qing Yuan
Pharmaceutics 2024, 16(1), 110; https://doi.org/10.3390/pharmaceutics16010110
“Hepatitis B Virus Reactivation with Immunosuppression: A Hidden Threat?”
by Sama Anvari and Keith Tsoi
J. Clin. Med. 2024, 13(2), 393; https://doi.org/10.3390/jcm13020393
“Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink”
by Cornelius J. Fernandez, Mohammed Alkhalifah, Hafsa Afsar and Joseph M. Pappachan
Pathogens 2024, 13(1), 68; https://doi.org/10.3390/pathogens13010068
“A Case Report: Idiopathic or Drug-Induced Autoimmune Hepatitis—Can We Draw a Line?”
by Dorotea Božić, Ante Tonkić, Jr,Katarina Vukojevic and Maja Radman
Clin. Pract. 2023, 13(6), 1393–1399; https://doi.org/10.3390/clinpract13060125
“Liver dECM–Gelatin Composite Bioink for Precise 3D Printing of Highly Functional Liver Tissues”
by Min Kyeong Kim, Wonwoo Jeong and Hyun-Wook Kang
J. Funct. Biomater. 2023, 14(8), 417; https://doi.org/10.3390/jfb14080417
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“Viral Hepatitis: Diagnosis, Treatment and Management” |
“New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases” |
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“The Surveillance, Prevention, and Treatment of Viral Hepatitis: Looking Forward to Global Elimination” |
“Viral Hepatitis and Therapeutic Strategies” |
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“Genetic Analysis of Hepatitis Virus Infection” |
“Oxidative Stress in Hepatic Diseases” |
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“Viral Hepatitis Among Specific Populations: Epidemiology, Transmission, Treatment, and Prevention” |
“Biology of Liver Diseases” |
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“Hepatitis E Virus (HEV) Infection Among Humans and Animals: Epidemiology, Clinical Characteristics, Treatment and Prevention—2nd Edition” |
“Human Hepatitis Viruses and Their Animal Homologues” |
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“Advances in Hepatitis: Prevention, Treatment, and Global Health Impact” |
“Pathogenesis of Viral Hepatitis” |
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“Liver Diseases: Diagnosis and Treatment in the Era of Personalized Medicine” |
“Gastrointestinal and Liver Diseases: New Advances in Diagnosis and Prognosis” |
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4 July 2025
MDPI’s Newly Launched Journals in June 2025
Six new journals covering a range of subjects launched their inaugural issues in June 2025. We are excited to be able to share with you the newest research rooted in the value of open access. We are pleased to present the latest research and to make it accessible to all.
We extend our sincere thanks to all the Editorial Board Members for their commitment and expertise. Each journal is dedicated to upholding strong editorial standards through a thorough peer review process, ensuring impactful open access scholarship.
Please feel free to browse and discover more about the new journals below.
| Journal | Founding Editor-in-Chief | Journal Topics (Selected) |
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Prof. Dr. Chang-Pu Sun, China Academy of Engineering Physics, Beijing, China; Computational Science Research Center, China Editorial | View inaugural issue |
quantum information and phenomena; condensed matter physics and statistical physics; atomic, molecular, and optical physics; computational physics and mathematical methods View journal scope | Submit an article |
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Prof. Dr. Hualiang Lin, Sun Yat-sen University, China; Prof. Dr. Jose L. Domingo, Universitat Rovira i Virgili, Spain Editorial | View inaugural issue |
green and organic food; green infrastructures; green exercise; environmental impact of the healthcare sector; effects of climate change on human health | View journal scope | Submit an article |
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Prof. Dr. Francesco Veglio, University of L’Aquila, Italy Editorial | View inaugural issue |
ultra-pure substances; water purification; air purification; gas purification; inorganic chemical purification; purification technologies View journal scope | Submit an article |
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Prof. Dr. Junxing Zheng, Huazhong University of Science and Technology, China Editorial | View inaugural issue |
computer-aided design and engineering; artificial intelligence and machine learning; building information modeling (BIM) and digital twins; robotics and automation in construction; smart sensors and Internet of Things (IoT); intelligent control systems and facilities management View journal scope | Submit an article |
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Prof. Dr. Assunta Di Vaio, University of Naples Parthenope, Italy Editorial | View inaugural issue |
sustainability, managerial, and biodiversity accounting; carbon management accounting; corporate social responsibility; artificial intelligence and disclosure View journal scope | Submit an article |
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Prof. Dr. Changjun Liu, Sichuan University, China Editorial | View inaugural issue |
bioeffects of electromagnetic waves; electromagnetic science and engineering; microwave, millimeter-wave, and terahertz technologies; metamaterials and metasurfaces; communication, sensing, and networks; energy, power, and sustainable applications; quantum and emerging technologies; artificial intelligence and advanced fabrication View journal scope | Submit an article |
2 July 2025
MDPI INSIGHTS: The CEO's Letter #24 - 2024 Impact Factor & CiteScore, MDPI Summits France & USA, Tu Youyou Award
Welcome to the MDPI Insights: The CEO's Letter.
In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.
Opening Thoughts
MDPI’s 2024 Impact Factor Highlights
For those of our readers who are new to academic publishing, you may have heard some news in June around the Impact Factor release. Every year, typically in June, Clarivate releases its annual Journal Citation Reports (JCR), which include Journal Impact Factors (JIF). This metric is widely used in academic publishing to reflect the average number of citations received by recent articles in each journal.
While Impact Factor is just one of many indicators of journal influence, it remains a major milestone for authors, editors, and publishers. It’s used to assess journal visibility, researcher recognition, and scholarly reach. Throughout our international meetings and events, it’s clear that the Impact Factor is something many of our authors and editorial board members care about, as it can influence where they choose to submit an article and the funding they receive for their research.
“These results reflect the trust that the scholarly community places in MDPI”
MDPI’s 2024 Impact Factor Highlights
- 298 MDPI journals received a Journal Impact Factor.
- 60 journals earned their first-ever Impact Factor
- To put this in perspective: MDPI’s 60 new journal acceptances into the Web of Science was the second highest number of any publisher in 2024, behind Elsevier and ahead of Springer Nature. Our 87% acceptance rate for journals submitted to Web of Science shows the strength of our editorial process and our proven ability to develop journals aligned with Clarivate’s 24 evaluation criteria.
- Notably, Textiles, Mathematics, International Journal of Neonatal Screening, Smart Cities, Systems, and Pharmaceutics ranked in the top 10% in their respective categories, highlighting their growing influence and prestige within their academic fields. This shows that high-quality indexing goes beyond visibility; it upholds credibility and trust.
- 193 MDPI journals are now ranked in the top 50% (Q1/Q2) of their subject categories.
- What does this mean, and why is it important? Journals are ranked by quartiles within their field, based on their Impact Factor. Q1 represents the top 25% of journals in their category, Q2 the next 25%, and so on. Being in Q1 or Q2 shows that a journal is performing well relative to other journals in its category. Authors and institutions often look at quartile rankings when choosing where to publish – it’s an important indicator of visibility and recognition, within its respective category.
- 116 of our previously ranked journals increased their Impact Factor.
- 14 MDPI journals achieved an Impact Factor of 5.0 or higher, suggesting a high degree of influence and visibility.
These results reflect our staff's hard work: from our editorial and production teams to our indexing, communications, and data teams, and beyond. This also reflects the trust that the scholarly community places in MDPI, reinforcing the message that when researchers publish with MDPI, they publish with impact.
Open Access with Impact
As the leading fully open access publisher, our journals have received a total of 18.4 million citations in the Web of Science by the end of 2024, reflecting the growing reach and engagement of research published with MDPI. We are committed to making scientific research freely accessible to everyone, everywhere. With the support of more than 4.2 million contributing authors, we’re proud to support the global shift toward open access.
Further Reading
If you’d like to better understand how journals get indexed and why Impact Factors matter, please read this recent interview with Dr. Constanze Schelhorn (Head of Indexing). It gives you a behind-the-scenes look at the role our indexing team plays in supporting journal indexing and visibility.
You can also read our official news announcement shared last week: MDPI Journals in the 2024 Journal Citation Reports.
Thank you to everyone, from our authors and reviewers to our editors and internal teams, who contributed to the progress of our journal indexing in 2024. We’re continuing to build journals that are recognized and trusted across disciplines.
Impactful Research
MDPI Journals See Continued Growth in 2024 CiteScore Results
Continuing our indexing updates, I’m pleased to share that MDPI has achieved strong results in the latest CiteScore metrics, released on 5 June by Scopus. These results reflect the collective efforts of our editors, reviewers, authors, and internal teams, with their dedication to quality and visibility in scientific publishing. You can read the full announcement here.
2024 Highlights:
- 322 MDPI journals received a CiteScore (up from 274 last year).
- 283 journals (88%) are ranked in Q1 or Q2 of their subject categories.
- 237 journals (85%) saw an increase in their CiteScore compared to last year.
- 48 journals received a CiteScore for the first time.
- 39 journals are now placed in the top 10% of their subject areas.
“This growth highlights our commitment to supporting open, trusted science”
What is CiteScore and how is it measured?
CiteScore metrics are developed by Elsevier as an alternative to the Impact Factor. They measure the citation impact of journals and can be accessed freely on Scopus. The metric represents the yearly average number of citations to recent articles published in a journal. If you’re interested in learning more about citation metrics and how we use them, check out this blog post.
Why is this important?
These results show the growing recognition for, and impact of, MDPI journals across disciplines. CiteScore rankings help researchers, institutions, and funders assess where high-quality work is being published. This growth improves our journals’ positioning in the publishing landscape and highlights our commitment to supporting open, trusted science.
Inside MDPI
Highlights from the MDPI USA Summit in Boston (5–6 June)
With several Summits already behind us, I think this is a good time to reflect on the purpose of these Summits.
Why do we organize MDPI Summits?
These one-and-a-half-day, invite-only gatherings are designed to improve our relationships with Chief Editors who lead our journals and are respected voices in their fields. The Summits aim to:
- Share MDPI’s values, achievements, editorial practices, and local market collaborations.
- Collect feedback on MDPI operations and journal practices.
- Empower Chief Editors to confidently represent MDPI beyond the Summit.
While Chief Editors know their journals well, these events help them better understand MDPI. We want them to be ambassadors for our brand. The aim is for them to walk away informed, engaged, and equipped to share positively about MDPI.
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About the Boston Summit
Held on 5–6 June, our first USA Summit gathered over 25 Chief Editors to learn more about MDPI’s activities and collaborations in the USA. The program included presentations, Q&A, and a panel discussion.
Agenda Highlights:
Moderated by Summer Huggard (Operations Manager [Toronto], MDPI), the program featured:
- MDPI Overview and USA Collaboration – Stefan Tochev (CEO, MDPI)
- AI in Publishing and MDPI's Actions – Feichi Lu (Junior Data Scientist, MDPI)
- MDPI Editorial Process and Research Integrity – Dr. Giulia Stefenelli (Scientific Communications Lead, MDPI)
- Panel Discussion – Stefan, Feichi, Giulia, Claudia
- Society Partnerships – Dr. Clàudia Aunós (Society Partnerships Senior Manager, MDPI)
- Voice of the Customer and Closing Remarks – Stefan Tochev (CEO, MDPI)
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MDPI & the USA: Facts and Figures
- With over 216,000 publications, the USA is MDPI’s second-largest contributor after China.
- In 2024, the USA ranked 2nd in total submissions and 2nd in total MDPI publications, with more than 28,200 publications.
- As of 2020, the cumulative number of authors from the USA until April 2025 was 352,099.
- As at April 2025, there are more than 12,035 active Editorial Board Members (EBMs) from the USA, with 55% having an H-index over 26.
- Among them, 96 serve as Editors-in-Chief (EiC) and 218 as section-Editors-in-Chief (SEiC)
- MDPI has more than 920 Institutional Open Access Program agreements worldwide, with over 130 from the USA.
A special thanks to our Toronto team, and everyone who worked behind the scenes to make this event run smoothly.
Coming Together for Science
Highlights from the MDPI France Summit in Paris (12–13 June)
We completed our first MDPI France Summit in Paris last week, and it was a special event. Attendees were engaged from beginning to end, remaining after hours to network and collaborate.
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Why a France Summit?
We chose to host a France Summit in view of the recent challenges MDPI has faced with the National Centre for Scientific Research (CNRS). What we took away from the event is that our authors and editors very much appreciate and enjoy working with us, but we need to address the concerns raised by CNRS, around Article Processing Charges (APCs) and the funding of gold open access publications.
“Our authors and editors very much enjoy working with us”
Some of the claims made in the June 2023 interview with Alain Schuhl, the Deputy CEO for Science at the CNRS, are simply not factual. For example, they state that MDPI’s “average APC charges per article are now around the same as Springer Nature’s.” Here is the relevant passage, reproduced verbatim:
This is not accurate.
A recent preprint analysing APC data from Elsevier, Springer Nature, Wiley, PLOS, MDPI, and Frontiers (2019–2023) shows that MDPI’s average APCs remain significantly lower than those of Springer Nature and several other major publishers.
The MDPI Summits are part of our outreach and communication efforts to address misconceptions and clarify MDPI’s position as one of the most accessible and affordable major gold open access publishers in the world.
Summit Overview
Held on 12–13 June, the France Summit gathered over 20 Chief Editors to learn more about MDPI’s activities and collaborations in France. Many of these editors are influential in their institutions and professional societies. Several also have connections to CNRS, which makes this an important opportunity to clarify how we operate and build trust through open and transparent communication and hopefully turn our editors into informed advocates of MDPI.
Summit Feedback
The feedback has been very positive, with most attendees completing the post-event survey and all rating the experience as Excellent or Good. A few highlights:
- “The whole thing was highly professional and, above all, provided quantified details that will allow us to better answer questions surrounding MDPI.”
- “The summit was an opportunity to meet personally various people directly engaged in the organization and policies of MDPI, which made it possible to clarify some important points concerning publishing with MDPI.”
- “Very well organized! A great opportunity to see all French MDPI partners and editors.”
Program Highlights:
Moderated by Miruna Adelina Nicolcioiu (Senior Conference Producer), the program featured:
- MDPI Overview and France Collaboration – Stefan Tochev (CEO)
- MDPI Editorial Process and Peer-Review Quality – Dr. Marta Colomer (Public Affairs Specialist)
- Institutional Partnerships and Open Access Funding Models – Becky Castellon (Institutional Partnerships Manager)
- AI in Publishing and MDPI's Actions – Daniele Raimondi (Data Scientist)
- Publication Ethics: Global Trends – Diana Cristina Apodaritei (Research Integrity Specialist)
- Closing Remarks – Stefan Tochev
- Panel Discussion – Diana, Becky, Prof. Dr. Patrick Da Cost, and Stefan
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MDPI & France: Facts and Figures
- With over 51,000 publications, France is MDPI's tenth-largest contributor, and fifth largest among EU countries after Italy, Spain, Germany, and Poland.
- As of 2020, the cumulative number of authors from France until April 2025 was 87,592.
- As at April 2025, there are more than 2,800 active Editorial Board Members (EBMs) from France, with 59% having an H-index over 26.
- Among them, 22 serve as Editors-in-Chief (EiC) and 61 as section-Editors-in-Chief (SEiC)
- In 2024, IJMS, JCM, and Molecules were the top three MDPI journals in terms of submissions from French-affiliated authors.
Special thanks to our colleagues from Romanian offices for organizing this successful event.
Closing Thoughts
Richard DiMarchi and Rolf Müller Share the 2024 Tu Youyou Award
As we wrap up this month’s newsletter, I’d like to take a moment to recognize the winners of the 2024 Tu Youyou Award, presented by our journal Molecules. I am pleased to share that the 2024 Tu Youyou Award has been conferred upon Richard DiMarchi and Rolf Müller, in recognition of their significant contributions to natural products chemistry and medicinal chemistry.
I invite you to read the editorial co-authored by the Tu Youyou Award Committee, which highlights the significance of the award and the remarkable impact of the recipients’ research.
A sincere thank-you to the 2024 Award Committee for their dedication and selection process, and congratulations once again to this year’s honourees. Your work exemplifies the kind of research MDPI is proud to support and amplify.
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About the Tu Youyou Award For further information about the award and the winners, please visit the Tu Youyou Award website. |
Chief Executive Officer
MDPI AG
24 June 2025
Metabolites | Highly Cited Papers Published in 2023–2024 and Hot Topic Special Issues in the “Plant Metabolism” Section
We are delighted to share some of the highly cited papers from the Section “Plant Metabolism” that were published in Metabolites (ISSN: 2218-1989) in 2023 and 2024. In addition, some Special Issues related to this topic are currently open for submission.
The following is a list of articles and Special Issues that we believe will be interest of you:
1. “Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential”
by Lúcio Ricardo Leite Diniz, Leonardo Luiz Calado, Allana Brunna Sucupira Duarte and Damião Pergentino de Sousa
Metabolites 2023, 13(2), 276; https://doi.org/10.3390/metabo13020276
Available online: https://www.mdpi.com/2218-1989/13/2/276
2. “The Role of Quorum Sensing Molecules in Bacterial–Plant Interactions”
by Jan Majdura, Urszula Jankiewicz, Agnieszka Gałązka and Sławomir Orzechowski
Metabolites 2023, 13(1), 114; https://doi.org/10.3390/metabo13010114
Available online: https://www.mdpi.com/2218-1989/13/1/114
3. “Biosynthetic Pathways of Hormones in Plants”
by Andrzej Bajguz and Alicja Piotrowska-Niczyporuk
Metabolites 2023, 13(8), 884; https://doi.org/10.3390/metabo13080884
Available online: https://www.mdpi.com/2218-1989/13/8/884
4. “Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects”
by Lucas Fornari Laurindo, Ana Rita de Oliveira dos Santos, Antonelly Cassio Alves de Carvalho, Marcelo Dib Bechara, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Renata Vargas Sinatora, Adriano Cressoni Araújo and Sandra Maria Barbalho
Metabolites 2023, 13(1), 96; https://doi.org/10.3390/metabo13010096
Available online: https://www.mdpi.com/2218-1989/13/1/96
5. “Optimization of Phenolic Compounds Extraction and Antioxidant Activity from Inonotus hispidus Using Ultrasound-Assisted Extraction Technology”
by Liliana Machado-Carvalho, Tânia Martins, Alfredo Aires and Guilhermina Marques
Metabolites 2023, 13(4), 524; https://doi.org/10.3390/metabo13040524
Available online: https://www.mdpi.com/2218-1989/13/4/524
6. “Metabolomics Reveals Antioxidant Metabolites in Colored Rice Grains”
by Jinyan Zhu, Ruizhi Wang, Yu Zhang, Yanyao Lu, Shuo Cai and Qiangqiang Xiong
Metabolites 2024, 14(2), 120; https://doi.org/10.3390/metabo14020120
Available online: https://www.mdpi.com/2218-1989/14/2/120
7. “Widely Targeted Metabolomic Analysis Provides New Insights into the Effect of Rootstocks on Citrus Fruit Quality”
by Min Wang, Yang Chen, Shuang Li, Jianjun Yu, Lei Yang and Lin Hong
Metabolites 2024, 14(4), 242; https://doi.org/10.3390/metabo14040242
Available online: https://www.mdpi.com/2218-1989/14/4/242
8. “Phylogenetic and Expression Analysis of the Sucrose Synthase and Sucrose Phosphate Synthase Gene Family in Potatoes”
by Jun Hu, Yanfeng Duan, Jinxue Hu, Shuqing Zhang and Guangcun Li
Metabolites 2024, 14(1), 70; https://doi.org/10.3390/metabo14010070
Available online: https://www.mdpi.com/2218-1989/14/1/70
9. “5-ALA, DTA-6, and Nitrogen Mitigate NaCl Stress by Promoting Photosynthesis and Carbon Metabolism in Rice Seedlings”
by Yaxin Wang, Chaolu Tan, Yinghao Li, Fengyan Meng, Youwei Du, Shuyu Zhang, Wenxin Jiang, Naijie Feng, Liming Zhao and Dianfeng Zheng
Metabolites 2024, 14(3), 142; https://doi.org/10.3390/metabo14030142
Available online: https://www.mdpi.com/2218-1989/14/3/142
10. “Effect of Arbuscular Mycorrhizal Fungi and Rock Phosphate on Growth, Physiology, and Biochemistry of Carob under Water Stress and after Rehydration in Vermicompost-Amended Soil”
by Abderrahim Boutasknit, Mohamed Ait-El-Mokhtar, Boujemaa Fassih, Raja Ben-Laouane, Said Wahbi and Abdelilah Meddich
Metabolites 2024, 14(4), 202; https://doi.org/10.3390/metabo14040202
Available online: https://www.mdpi.com/2218-1989/14/4/202
Special Issues:
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“Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects” |
“Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine” |
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“Analysis of Specialized Metabolites in Natural Products” |
“Unlocking Nature's Toolbox: Advances in Plant Metabolites Identification” |
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“Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition” |
“Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights” |
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24 June 2025
Metabolites | Highly Cited Papers Published in 2023–2024 and Hot Topic Special Issues in the “Nutrition and Metabolism” Section
We are delighted to share some of the highly cited papers from the Section “Nutrition and Metabolism” that were published in Metabolites (ISSN: 2218-1989) in 2023 and 2024. In addition, some Special Issues related to this topic are currently open for submission.
The following is a list of articles and Special Issues that we believe will be interest of you:
1. “Obesity-Induced Brain Neuroinflammatory and Mitochondrial Changes”
by Luisa O. Schmitt and Joana M. Gaspar
Metabolites 2023, 13(1), 86; https://doi.org/10.3390/metabo13010086
Available online: https://www.mdpi.com/2218-1989/13/1/86
2. “Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease”
by Sara Jarmakiewicz-Czaja, Katarzyna Ferenc and Rafał Filip
Metabolites 2023, 13(4), 573; https://doi.org/10.3390/metabo13040573
Available online: https://www.mdpi.com/2218-1989/13/4/573
3. “A Machine-Learning Approach to Target Clinical and Biological Features Associated with Sarcopenia: Findings from Northern and Southern Italian Aging Populations”
by Roberta Zupo, Alessia Moroni, Fabio Castellana, Clara Gasparri, Feliciana Catino, Luisa Lampignano, Simone Perna, Maria Lisa Clodoveo, Rodolfo Sardone and Mariangela Rondanelli
Metabolites 2023, 13(4), 565; https://doi.org/10.3390/metabo13040565
Available online: https://www.mdpi.com/2218-1989/13/4/565
4. “Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review”
by Muhammad Anas, Wellison J. S. Diniz, Ana Clara B. Menezes, Lawrence P. Reynolds, Joel S. Caton, Carl R. Dahlen and Alison K. Ward
Metabolites 2023, 13(5), 593; https://doi.org/10.3390/metabo13050593
Available online: https://www.mdpi.com/2218-1989/13/5/593
5. “Obesity, Dietary Fats, and Gastrointestinal Cancer Risk-Potential Mechanisms Relating to Lipid Metabolism and Inflammation”
by Kathleen A. J. Mitchelson, Fiona O’Connell, Jacintha O’Sullivan and Helen M. Roche
Metabolites 2024, 14(1), 42; https://doi.org/10.3390/metabo14010042
Available online: https://www.mdpi.com/2218-1989/14/1/42
6. “Iron Absorption: Molecular and Pathophysiological Aspects”
by Margherita Correnti, Elena Gammella, Gaetano Cairo and Stefania Recalcati
Metabolites 2024, 14(4), 228; https://doi.org/10.3390/metabo14040228
Available online: https://www.mdpi.com/2218-1989/14/4/228
7. “Physiological Perturbations in Combat Sports: Weight Cycling and Metabolic Function—A Narrative Review”
by Modesto A. Lebron, Jeffrey R. Stout and David H. Fukuda
Metabolites 2024, 14(2), 83; https://doi.org/10.3390/metabo14020083
Available online: https://www.mdpi.com/2218-1989/14/2/83
8. “Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project”
by Lanfranco D’Elia, Maria Masulli, Pietro Cirillo, Agostino Virdis, Edoardo Casiglia, Valerie Tikhonoff, Fabio Angeli, Carlo Maria Barbagallo, Michele Bombelli, Federica Cappelli et al.
Metabolites 2024, 14(3), 164; https://doi.org/10.3390/metabo14030164
Available online: https://www.mdpi.com/2218-1989/14/3/164
9. “The Effect of L-Carnitine on Critical Illnesses Such as Traumatic Brain Injury (TBI), Acute Kidney Injury (AKI), and Hyperammonemia (HA)”
by Bharti Sharma, Lee Schmidt, Cecilia Nguyen, Samantha Kiernan, Jacob Dexter-Meldrum, Zachary Kuschner, Scott Ellis, Navin D. Bhatia, George Agriantonis, Jennifer Whittington et al.
Metabolites 2024, 14(7), 363; https://doi.org/10.3390/metabo14070363
Available online: https://www.mdpi.com/2218-1989/14/7/363
10. “Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort”
by Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen J. Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R. Hilser, Jaana Hartiala, Hooman Allayee et al.
Metabolites 2024, 14(3), 174; https://doi.org/10.3390/metabo14030174
Available online: https://www.mdpi.com/2218-1989/14/3/174
11. “Grape/Blueberry Anthocyanins and Their Gut-Derived Metabolites Attenuate LPS/Nigericin-Induced Inflammasome Activation by Inhibiting ASC Speck Formation in THP-1 Monocytes”
by Inken Behrendt, Isabella Röder, Frank Will, Gabriela Michel, Elvira Friedrich, Daniela Grote, Zoe Martin, Hanna Pauline Dötzer, Mathias Fasshauer, Martin Speckmann et al.
Metabolites 2024, 14(4), 203; https://doi.org/10.3390/metabo14040203
Available online: https://www.mdpi.com/2218-1989/14/4/203
12. “Effects of the Menstrual Cycle and Hormonal Contraceptive Use on Metabolic Outcomes, Strength Performance, and Recovery: A Narrative Review”
by Hannah E. Cabre, Lacey M. Gould, Leanne M. Redman and Abbie E. Smith-Ryan
Metabolites 2024, 14(7), 347; https://doi.org/10.3390/metabo14070347
Available online: https://www.mdpi.com/2218-1989/14/7/347
13. “Fetal Hepatic Lipidome Is More Greatly Affected by Maternal Rate of Gain Compared with Vitamin and Mineral Supplementation at day 83 of Gestation”
by Ana Clara B. Menezes, Carl R. Dahlen, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz et al.
Metabolites 2023, 13(2), 175; https://doi.org/10.3390/metabo13020175
Available online: https://www.mdpi.com/2218-1989/13/2/175
14. “Effectiveness of Intermittent Hypoxia–Hyperoxia Therapy in Different Pathologies with Possible Metabolic Implications”
by Andreea-Bianca Uzun, Mădălina Gabriela Iliescu, Liliana-Elena Stanciu, Elena-Valentina Ionescu, Rodica Ana Ungur, Viorela Mihaela Ciortea, Laszlo Irsay, Irina Motoașcă, Marius Nicolae Popescu, Florina Ligia Popa et al.
Metabolites 2023, 13(2), 181; https://doi.org/10.3390/metabo13020181
Available online: https://www.mdpi.com/2218-1989/13/2/181
15. “The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation”
by Zhendong Sun, Yuzhuo Shao, Kunhao Yan, Tianzhao Yao, Lulu Liu, Feifei Sun, Jiarui Wu and Yunpeng Huang
Metabolites 2023, 13(10), 1048; https://doi.org/10.3390/metabo13101048
Available online: https://www.mdpi.com/2218-1989/13/10/1048
Special Issues:
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“Nutritional Intervention and Metabolic Health: Multi-Omics Insights” |
“Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions” |
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“Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases” |
“Metabolomics Techniques in Nutrition and Pharmacy Research” |
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“Nutrition, Metabolism and Physiology in Aquatic Animals” |
“Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases” |
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“Neuronutrition: Metabolomic Insights and Perspectives” |
“Brain Metabolic Alterations in Neurodegenerative Diseases” |
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24 June 2025
Metabolites | Highly Cited Papers Published in 2023–2024 and Hot Topic Special Issues in the “Bioinformatics and Data Analysis” Section
We are delighted to share some of the highly cited papers from the Section “Bioinformatics and Data Analysis” that were published in Metabolites (ISSN: 2218-1989) in 2023 and 2024. In addition, some Special Issues related to this topic are currently open for submission.
The following is a list of articles and Special Issues that we believe will be interest of you:
1. “Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine”
by Partho Sen and Matej Orešič
Metabolites 2023, 13(7), 855; https://doi.org/10.3390/metabo13070855
Available online: https://www.mdpi.com/2218-1989/13/7/855
2. “Obstructive Sleep Apnea, Metabolic Dysfunction, and Periodontitis—Machine Learning and Statistical Analyses of the Dental, Oral, Medical Epidemiological (DOME) Big Data Study”
by Noya Ytzhaik, Dorit Zur, Chen Goldstein and Galit Almoznino
Metabolites 2023, 13(5), 595; https://doi.org/10.3390/metabo13050595
Available online: https://www.mdpi.com/2218-1989/13/5/595
3. “Context-Specific Genome-Scale Metabolic Modelling and Its Application to the Analysis of COVID-19 Metabolic Signatures”
by Miha Moškon and Tadeja Režen
Metabolites 2023, 13(1), 126; https://doi.org/10.3390/metabo13010126
Available online: https://www.mdpi.com/2218-1989/13/1/126
4. “The Omics Dashboard for Interactive Exploration of Metabolomics and Multi-Omics Data”
by Suzanne Paley and Peter D. Karp
Metabolites 2024, 14(1), 65; https://doi.org/10.3390/metabo14010065
Available online: https://www.mdpi.com/2218-1989/14/1/65
5. “Explainable AI to Facilitate Understanding of Neural Network-Based Metabolite Profiling Using NMR Spectroscopy”
by Hayden Johnson and Aaryani Tipirneni-Sajja
Metabolites 2024, 14(6), 332; https://doi.org/10.3390/metabo14060332
Available online: https://www.mdpi.com/2218-1989/14/6/332
6. “MAD HATTER Correctly Annotates 98% of Small Molecule Tandem Mass Spectra Searching in PubChem”
by Martin A. Hoffmann, Fleming Kretschmer, Marcus Ludwig and Sebastian Böcker
Metabolites 2023, 13(3), 314; https://doi.org/10.3390/metabo13030314
Available online: https://www.mdpi.com/2218-1989/13/3/314
7. “Comparison of Compound Identification Tools Using Data Dependent and Data Independent High-Resolution Mass Spectrometry Spectra”
by Rosalie Nijssen, Marco H. Blokland, Robin S. Wegh, Erik de Lange, Stefan P. J. van Leeuwen,
Bjorn J. A. Berendsen and Milou G. M. van de Schans
Metabolites 2023, 13(7), 777; https://doi.org/10.3390/metabo13070777
Available online: https://www.mdpi.com/2218-1989/13/7/777
8. “Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma”
by Michał Kaczmarek, Nanyun Zhang, Ludmila Buzhansky, Sharon Gilead and Ehud Gazit
Metabolites 2023, 13(8), 923; https://doi.org/10.3390/metabo13080923
Available online: https://www.mdpi.com/2218-1989/13/8/923
9. “md_harmonize: A Python Package for Atom-Level Harmonization of Public Metabolic Databases”
by Huan Jin and Hunter N. B. Moseley
Metabolites 2023, 13(12), 1199; https://doi.org/10.3390/metabo13121199
Available online: https://www.mdpi.com/2218-1989/13/12/1199
10. “metabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics”
by Hani Habra, Jennifer L. Meijer, Tong Shen, Oliver Fiehn, David A. Gaul, Facundo M. Fernández, Kaitlin R. Rempfert, Thomas O. Metz, Karen E. Peterson, Charles R. Evans et al.
Metabolites 2024, 14(2), 125; https://doi.org/10.3390/metabo14020125
Available online: https://www.mdpi.com/2218-1989/14/2/125
11. “Implementation of FAIR Practices in Computational Metabolomics Workflows—A Case Study”
by Mahnoor Zulfiqar, Michael R. Crusoe, Birgitta König-Ries, Christoph Steinbeck, Kristian Peters and Luiz Gadelha
Metabolites 2024, 14(2), 118; https://doi.org/10.3390/metabo14020118
Available online: https://www.mdpi.com/2218-1989/14/2/118
12. “Predicting the Pathway Involvement of Metabolites Based on Combined Metabolite and Pathway Features”
by Erik D. Huckvale and Hunter N. B. Moseley
Metabolites 2024, 14(5), 266; https://doi.org/10.3390/metabo14050266
Available online: https://www.mdpi.com/2218-1989/14/5/266
Special Issues:
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“Biostatistics and Bioinformatics in Metabolomics Research: From Study Design and Analytics to Clinical Insights and Public Health Implications” |
“Machine Learning Applications in Metabolomics Analysis: 2nd Edition” |
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“Machine Learning in Metabolomics: Unlocking the Future of Data Analysis” |
“Metabolomics and Computational Research on Drugs and Diseases” |
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24 June 2025
Metabolites | Highly Cited Papers Published in 2023–2024 and Hot Topic Special Issues in the “Metabolomic Profiling Technology” Section
We are delighted to share some of the highly cited papers from the Section “Metabolomic Profiling Technology” that were published in Metabolites (ISSN: 2218-1989) in 2023 and 2024. In addition, some Special Issues related to this topic are currently open for submission.
The following is a list of articles and Special Issues that we believe will be interest of you:
1. “Therapeutic and Toxic Effects of Valproic Acid Metabolites”
by Natalia A. Shnayder, Violetta V. Grechkina, Aiperi K. Khasanova, Elena N. Bochanova, Evgenia A. Dontceva, Marina M. Petrova, Azat R. Asadullin, German A. Shipulin, Kuanysh S. Altynbekov, Mustafa Al-Zamil et al.
Metabolites 2023, 13(1), 134; https://doi.org/10.3390/metabo13010134
Available online: https://www.mdpi.com/2218-1989/13/1/134
2. “Instrumental Drift in Untargeted Metabolomics: Optimizing Data Quality with Intrastudy QC Samples”
by Andre Märtens, Johannes Holle, Brit Mollenhauer, Andre Wegner, Jennifer Kirwan and Karsten Hiller
Metabolites 2023, 13(5), 665; https://doi.org/10.3390/metabo13050665
Available online: https://www.mdpi.com/2218-1989/13/5/665
3. “Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids”
by Eleonora Bossi, Elena Limo, Lisa Pagani, Nicole Monza, Simone Serrao, Vanna Denti, Giuseppe Astarita and Giuseppe Paglia
Metabolites 2024, 14(1), 46; https://doi.org/10.3390/metabo14010046
Available online: https://www.mdpi.com/2218-1989/14/1/46
4. “Challenges in the Metabolomics-Based Biomarker Validation Pipeline”
by Shenghan Li, Nikita Looby, Vinod Chandran and Vathany Kulasingam
Metabolites 2024, 14(4), 200; https://doi.org/10.3390/metabo14040200
Available online: https://www.mdpi.com/2218-1989/14/4/200
5. “Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid”
by Ryann M. Fame, Ilhan Ali, Maria K. Lehtinen, Naama Kanarek and Boryana Petrova
Metabolites 2024, 14(2), 79; https://doi.org/10.3390/metabo14020079
Available online: https://www.mdpi.com/2218-1989/14/2/79
6. “Accurate Prediction of 1H NMR Chemical Shifts of Small Molecules Using Machine Learning”
by Tanvir Sajed, Zinat Sayeeda, Brian L. Lee, Mark Berjanskii, Fei Wang, Vasuk Gautam and David S. Wishart
Metabolites 2024, 14(5), 290; https://doi.org/10.3390/metabo14050290
Available online: https://www.mdpi.com/2218-1989/14/5/290
7. “An Overview of Pre-Analytical Factors Impacting Metabolomics Analyses of Blood Samples”
by Amy Thachil, Li Wang, Rupasri Mandal, David Wishart and Tom Blydt-Hansen
Metabolites 2024, 14(9), 474; https://doi.org/10.3390/metabo14090474
Available online: https://www.mdpi.com/2218-1989/14/9/474
8. “Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites”
by Daniel Marques de Sá e Silva, Marlene Thaitumu, Georgios Theodoridis, Michael Witting and Helen Gika
Metabolites 2023, 13(10), 1038; https://doi.org/10.3390/metabo13101038
Available online: https://www.mdpi.com/2218-1989/13/10/1038
9. “Metabolic Bile Acid Profile Impairments in Dogs Affected by Chronic Inflammatory Enteropathy”
by Rossana Comito, Emanuele Porru, Nicolò Interino, Matteo Conti, Rossella Terragni, Roberto Gotti, Marco Candela, Patrizia Simoni, Aldo Roda and Jessica Fiori
Metabolites 2023, 13(9), 980; https://doi.org/10.3390/metabo13090980
Available online: https://www.mdpi.com/2218-1989/13/9/980
10. “Evaluation of Lipid Extraction Protocols for Untargeted Analysis of Mouse Tissue Lipidome”
by Ashraf M. Omar and Qibin Zhang
Metabolites 2023, 13(9), 1002; https://doi.org/10.3390/metabo13091002
Available online: https://www.mdpi.com/2218-1989/13/9/1002
11. “Opening the Random Forest Black Box of 1H NMR Metabolomics Data by the Exploitation of Surrogate Variables”
by Soeren Wenck, Thorsten Mix, Markus Fischer, Thomas Hackl and Stephan Seifert
Metabolites 2023, 13(10), 1075; https://doi.org/10.3390/metabo13101075
Available online: https://www.mdpi.com/2218-1989/13/10/1075
12. “Comparison of Various Extraction Approaches for Optimized Preparation of Intracellular Metabolites from Human Mesenchymal Stem Cells and Fibroblasts for NMR-Based Study”
by Slavomíra Nováková, Eva Baranovičová, Zuzana Hatoková, Gábor Beke, Janka Pálešová, Romana Záhumenská, Bibiána Baďurová, Mária Janíčková, Ján Strnádel, Erika Halašová et al.
Metabolites 2024, 14(5), 268; https://doi.org/10.3390/metabo14050268
Available online: https://www.mdpi.com/2218-1989/14/5/268
13. “NMR Precision Metabolomics: Dynamic Peak Sum Thresholding and Navigators for Highly Standardized and Reproducible Metabolite Profiling of Clinical Urine Samples”
by Alessia Trimigno, Nicole R. Holderman, Chen Dong, Kari D. Boardman, Jifang Zhao and Elizabeth M. O’Day
Metabolites 2024, 14(5), 275; https://doi.org/10.3390/metabo14050275
Available online: https://www.mdpi.com/2218-1989/14/5/275
14. “Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate”
by Isaiah Adelabu, Md Raduanul H. Chowdhury, Shiraz Nantogma, Clementinah Oladun, Firoz Ahmed, Lukas Stilgenbauer, Marianna Sadagurski, Thomas Theis, Boyd M. Goodson and Eduard Y. Chekmenev
Metabolites 2023, 13(2), 200; https://doi.org/10.3390/metabo13020200
Available online: https://www.mdpi.com/2218-1989/13/2/200
15. “Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table”
by Feiko J. M. de Jong, Thijs T. Wingelaar, Paul Brinkman, Pieter-Jan A. M. van Ooij, Anke H. Maitland-van der Zee, Markus W. Hollmann and Rob A. van Hulst
Metabolites 2023, 13(3), 316; https://doi.org/10.3390/metabo13030316
Available online: https://www.mdpi.com/2218-1989/13/3/316
Special Issues:
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“Integration of Emerging Technologies in Metabolite Analysis” |
“NMR-Based Metabolomics in Biomedicine and Food Science” |
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“New Technology and Workflows for Advancing Metabolomics” |
“Application of NMR in Food Metabolomics” |
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“Mass Spectrometry-Based Technology for Metabolic Profiling” |
“Mass Spectrometry Imaging and Spatial Metabolomics” |
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“Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation” |
“The Role of Isotope Tracers in Investigating Metabolic Disorders” |
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24 June 2025
Metabolites | Highly Cited Papers Published in 2023–2024 and Hot Topic Special Issues in the “Food Metabolomics” Section
We are delighted to share some of the highly cited papers from the Section “Food Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2023 and 2024. In addition, some Special Issues related to this topic are currently open for submission.
The following is a list of articles and Special Issues that we believe will be interest of you:
1. “Unexpected Value of Honey Color for Prediction of a Non-Enzymatic H2O2 Production and Honey Antibacterial Activity: A Perspective”
by Katrina Brudzynski
Metabolites 2023, 13(4), 526; https://doi.org/10.3390/metabo13040526
Available online: https://www.mdpi.com/2218-1989/13/4/526
2. “Mycotoxin Contamination Status of Cereals in China and Potential Microbial Decontamination Methods”
by Jing Zhang, Xi Tang, Yifan Cai and Wen-Wen Zhou
Metabolites 2023, 13(4), 551; https://doi.org/10.3390/metabo13040551
Available online: https://www.mdpi.com/2218-1989/13/4/551
3. “Qualitative Analysis of Polyphenols in Glycerol Plant Extracts Using Untargeted Metabolomics”
by Joseph Robert Nastasi 1, Venea Dara Daygon, Vassilis Kontogiorgos and Melissa A. Fitzgerald
Metabolites 2023, 13(4), 566; https://doi.org/10.3390/metabo13040566
Available online: https://www.mdpi.com/2218-1989/13/4/566
4. “Efficacy Confirmation Test of Black Cumin (Nigella sativa L.) Seeds Extract Using a High-Fat Diet Mouse Model”
by Khawaja Muhammad Imran Bashir, Joo Wan Kim, Jong-Kyu Kim, Yoon-Seok Chun, Jae-Suk Choi and Sae-Kwang Ku
Metabolites 2023, 13(4), 501; https://doi.org/10.3390/metabo13040501
Available online: https://www.mdpi.com/2218-1989/13/4/501
5. “Donkey Colostrum and Milk: How Dietary Probiotics Can Affect Metabolomic Profile, Alkaline Sphingomyelinase and Alkaline Phosphatase Activity”
by Fulvio Laus, Luca Laghi, Marilena Bazzano, Maria Grazia Cifone, Benedetta Cinque, Yaosen Yang and Andrea Marchegiani
Metabolites 2023, 13(5), 622; https://doi.org/10.3390/metabo13050622
Available online: https://www.mdpi.com/2218-1989/13/5/622
6. “Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome”
by Jan Šilhavý, Petr Mlejnek, Miroslava Šimáková, Hana Malínská, Irena Marková, Martina Hüttl, Denisa Miklánková, Ludmila Kazdová, Marek Vrbacký, Alena Pecinová et al.
Metabolites 2023, 13(2), 192; https://doi.org/10.3390/metabo13020192
Available online: https://www.mdpi.com/2218-1989/13/2/192
7. “Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions”
by Giovanni Martemucci, Mohamad Khalil, Alessio Di Luca, Hala Abdallah and Angela Gabriella D’Alessandro
Metabolites 2024, 14(6), 327; https://doi.org/10.3390/metabo14060327
Available online: https://www.mdpi.com/2218-1989/14/6/327
8. “Potential of Chlorogenic Acid in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Animal Studies and Clinical Trials—A Narrative Review”
by Agnieszka Ziółkiewicz, Przemysław Niziński, Jakub Soja, Tomasz Oniszczuk, Maciej Combrzyński, Adrianna Kondracka and Anna Oniszczuk
Metabolites 2024, 14(6), 346; https://doi.org/10.3390/metabo14060346
Available online: https://www.mdpi.com/2218-1989/14/6/346
9. “New Implications of Metabolites and Free Fatty Acids in Quality Control of Crossbred Wagyu Beef during Wet Aging Cold Storage”
by Shuji Ueda, Yuka Yoshida, Biniam Kebede, Chiaki Kitamura, Ryo Sasaki, Masakazu Shinohara, Itsuko Fukuda and Yasuhito Shirai
Metabolites 2024, 14(2), 95; https://doi.org/10.3390/metabo14020095
Available online: https://www.mdpi.com/2218-1989/14/2/95
10. “Metabolomics Reveals the Effects of Nitrogen/Phosphorus/Potassium (NPK) Fertilizer Levels on Cucumber Fruit Raised in Different Nutrient Soils”
by Na-Rae Lee, Yangmin X. Kim, Yerim Lee, Chanwook Lee, Yosung Song, Hyejin Park, Choong Hwan Lee and Yejin Lee
Metabolites 2024, 14(2), 102; https://doi.org/10.3390/metabo14020102
Available online: https://www.mdpi.com/2218-1989/14/2/102
11. “Time-Course Metabolomic Analysis: Production of Betaine Structural Analogs by Fungal Fermentation of Seaweed”
by Nao Inoue, Keisuke Tsuge, Teruyoshi Yanagita, Akira Oikawa and Koji Nagao
Metabolites 2024, 14(4), 201; https://doi.org/10.3390/metabo14040201
Available online: https://www.mdpi.com/2218-1989/14/4/201
Special Issues:
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“Emerging Applications of Metabolomics in Fermented Food” |
“New Insights into Microalgae Metabolism” |
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“Metabolomics in Food Science and Nutrition Using GC-MS” |
“Advances in Food Metabolomics for Functional Food Development and Analysis” |
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“Effects of Micronutrients on Human Metabolism” |
“Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites” |
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