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A Decade of Transformation in the Management of Childhood Acute Lymphoblastic Leukemia: From Conventional Chemotherapy to Precision Medicine -
Sociodemographic Factors, Intent-Uptake Disparities, and Nirsevimab Availability in Infant RSV Immunoprophylaxis -
Use of Technological Devices in Children Aged 3–11 Years: Possible Effects on Sleep and Behavioral Difficulties
Journal Description
Pediatric Reports
Pediatric Reports
is an international, peer-reviewed, open access journal on all aspects of pediatrics, and is published bimonthly online by MDPI (since Volume 12, Issue 3 - 2020). The Italian Society of Pediatric Psychology (SIPPed) is affiliated with Pediatric Reports and its members receive discounts on the article processing charges.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), PubMed, PMC, Embase, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 31.7 days after submission; acceptance to publication is undertaken in 4.9 days (median values for papers published in this journal in the second half of 2025).
- Recognition of Reviewers: APC discount vouchers, optional signed peer review, and reviewer names published annually in the journal.
Impact Factor:
1.4 (2024);
5-Year Impact Factor:
1.2 (2024)
Latest Articles
A Customized Mouthguard Design for a Child with Orofacial Myofunctional Disorder: A Case Report
Pediatr. Rep. 2026, 18(1), 16; https://doi.org/10.3390/pediatric18010016 - 21 Jan 2026
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When fabricating custom-made mouthguards for children, tooth replacement is an important factor for dentists to consider. In addition, orofacial myofunctional disorders and deleterious oral habits—such as incompetent lip seal and tongue thrusting—are relatively common among children and are associated with an increased risk
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When fabricating custom-made mouthguards for children, tooth replacement is an important factor for dentists to consider. In addition, orofacial myofunctional disorders and deleterious oral habits—such as incompetent lip seal and tongue thrusting—are relatively common among children and are associated with an increased risk of oral and dental trauma. Therefore, individual oral functional characteristics should be taken into account when designing custom-made mouthguards for pediatric patients. This report presents a case involving the design, fabrication, and appliance management of a custom-made mouthguard for a Japanese boy exhibiting incompetent lip seal and tongue thrusting. In this case, the anterior palate region of the mouthguard was left uncut, and multiple holes were created using a carbide bur to permit tongue–palate contact and provide sensory feedback related to tongue elevation. Over a 20-month follow-up period, no oral or dental trauma was observed. During appliance use, the patient demonstrated improved tongue elevation and an increased frequency of lip seal at rest. This case illustrates a custom mouthguard design that incorporates individual oral functional characteristics in a pediatric patient.
Full article
Open AccessCase Report
A Pediatric Supracondylar Fracture with Bilateral (Medial and Lateral) Pillar Comminution–A Recommendation for a New Stable Pin Configuration for a Highly Unstable Fracture
by
Lara Marie Bogensperger, Sandeep Patwardhan and Stephan Payr
Pediatr. Rep. 2026, 18(1), 15; https://doi.org/10.3390/pediatric18010015 - 21 Jan 2026
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The management of supracondylar fractures in children remains a challenging area of orthopedic practice. Medial comminution is a recognized complication that can result in unstable fracture patterns, which can pose challenges in diagnosis and management. However, when anticipated surgical treatment with an additional
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The management of supracondylar fractures in children remains a challenging area of orthopedic practice. Medial comminution is a recognized complication that can result in unstable fracture patterns, which can pose challenges in diagnosis and management. However, when anticipated surgical treatment with an additional medial K-wire is administered, stable fixation is typically ensured. However, an additional radial comminution poses several challenges for reduction, alignment assessment, and pin configuration for stable fixation, as presented in this case. This case report presents a fracture pattern of a Gartland type 3 fracture with medial and lateral comminution that has not been sufficiently described previously and illustrates an effective pin configuration that has yet to be theoretically described.
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Open AccessReview
Integrating the Genomic Revolution into Newborn Screening: Current Challenges and Future Perspectives
by
Albina Tummolo, Emanuela Ponzi, Simonetta Simonetti and Mattia Gentile
Pediatr. Rep. 2026, 18(1), 14; https://doi.org/10.3390/pediatric18010014 - 19 Jan 2026
Abstract
In recent years, the development of new diagnostic technologies, such as tandem mass spectrometry (MS/MS) and next-generation sequencing (NGS), has caused a veritable revolution in the diagnosis of genetic diseases, reducing time, cost, and invasiveness associated with prior diagnostic techniques. While MS/MS laid
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In recent years, the development of new diagnostic technologies, such as tandem mass spectrometry (MS/MS) and next-generation sequencing (NGS), has caused a veritable revolution in the diagnosis of genetic diseases, reducing time, cost, and invasiveness associated with prior diagnostic techniques. While MS/MS laid the foundation for the development of numerous, usually institutionally based, neonatal screening programs, NGS has gained traction in newborn screening (NBS), primarily through pilot projects and private funding across different countries. As a result, the traditional Wilson and Jungner criteria have been supplemented by additional criteria, including considerations of equity and access, in response to emerging technologies. This review aims to provide an up-to-date overview of the global landscape of metabolic screening panels, highlight the major ongoing genomic screening projects, and outline the current models for integrating these two screening systems. Substantial differences exist across countries in the numbers and types of diseases included in national NBS programmes. In this context, Italy represents a prominent case, as its neonatal screening framework has seen significant expansion and development in recent years, reaching a particularly comprehensive metabolic screening panel. Nonetheless, a number of initiatives to incorporate genomic technologies into the NBS pathway are currently underway, primarily involving high-income countries. Nonetheless, unlike metabolomic-based NBS programs, no country has a government-mandated NGS program as first-tier testing for newborns. New evidence is emerging from ongoing models of integration of multi-omics approaches into NBS, including the use of AI and machine learning. Identifying the most appropriate system for this integration to reduce the false-positive and false-negative rates associated with both screening types, ensure more equitable access to screening, and facilitate faster access to treatment may represent a useful and foresightful way to conceptualize NBS in the future. This transitional phase should promote rigorous improvements before full-scale adoption.
Full article
(This article belongs to the Special Issue Global Neonatal Screening: Expanding Horizons in Diagnostic Technologies)
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Open AccessArticle
Exploratory Study: The Impact of Online Coordinative Exercise in a Small Latinx Youth Sample
by
Nancy J. Hernandez and John S. Carlson
Pediatr. Rep. 2026, 18(1), 13; https://doi.org/10.3390/pediatric18010013 - 19 Jan 2026
Abstract
Background/Objectives: The effects of online physical activity (PA) interventions on executive function (EF) and Attention-Deficit Hyperactivity Disorder (ADHD) symptoms are promising; nonetheless, their benefits for Latinx youth remain unclear. Methods: This study explores levels of adherence, cognitive and behavioral outcomes and acceptability of
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Background/Objectives: The effects of online physical activity (PA) interventions on executive function (EF) and Attention-Deficit Hyperactivity Disorder (ADHD) symptoms are promising; nonetheless, their benefits for Latinx youth remain unclear. Methods: This study explores levels of adherence, cognitive and behavioral outcomes and acceptability of an online PA intervention, Zing Performance, among a Latinx youth sample; only a few of the participants completed their condition (n = 6). Results: There was wide variability in adherence levels at mid-treatment (n = 5) and high-level adherence at post-treatment (n = 2). A Mann–Whitney test yielded a statistically significant (p = 0.004) improvement in the treatment group’s inattention symptoms at mid-treatment (n = 5), compared to the Waitlist Control; (WLC; n = 6). EF and hyperactivity/impulsivity were not significantly different. Further, pre-, mid- and post-participant trajectory data revealed that one participant benefited significantly from treatment, one participant demonstrated little to no response to treatment, and most of the WLC participants remained in the severity ranges throughout the 12 weeks. The parents of the two children who completed treatment reported high levels of acceptability informally and on the quantitative measure. Conclusions: Exploratory findings support further investigation of Zing among Latinx families with cultural consideration to study procedures. The lessons learned from this study are valuable for future research procedures and interventions with this marginalized population.
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(This article belongs to the Special Issue Mental Health and Psychiatric Disorders of Children and Adolescents)
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Open AccessArticle
Forensic Perspectives on Child Sexual Abuse Disclosure in Greece: A Retrospective Study
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Konstantinos Dimitriou, Vasiliki Efthymiou, Kallirroi Fragkou, Pierre-Antoine Peyron, Laurent Martrille, Eric Baccino, Flora Bacopoulou and Stavroula Papadodima
Pediatr. Rep. 2026, 18(1), 12; https://doi.org/10.3390/pediatric18010012 - 16 Jan 2026
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Purpose: Child sexual abuse (CSA) is a major public health and forensic concern, often involving delayed disclosure that limits evidence collection and affects judicial outcomes. This study analyzed disclosure patterns, victim–perpetrator characteristics, and forensic findings in CSA cases evaluated in Greece, contributing to
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Purpose: Child sexual abuse (CSA) is a major public health and forensic concern, often involving delayed disclosure that limits evidence collection and affects judicial outcomes. This study analyzed disclosure patterns, victim–perpetrator characteristics, and forensic findings in CSA cases evaluated in Greece, contributing to the limited Southern European evidence base. Material and Methods: A retrospective review of 89 CSA cases (2014–2024) examined by a certified forensic physician at the Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, was conducted. Data from official medico-legal reports included demographics, abuse context, forensic findings, and disclosure interval. Statistical analyses explored factors associated with delayed disclosure (>7 days). Results: Victims were predominantly female (69.7%) with a mean age of 9.8 years. Most perpetrators were adult males, and over half of cases (53.9%) involved intrafamilial abuse. The mean delay in disclosure was 79 days; only 29.2% reported within one week. Recurrent abuse correlated with delayed disclosure (p = 0.006), while early disclosure was associated with biological evidence collection (p < 0.001). Physical injuries were observed in 23.6% of victims, genital findings in 17%, and anal findings in 3.4%. Conclusions: Delayed disclosure was common and significantly reduced the likelihood of identifying forensic evidence. The early application of trauma-informed examinations, which adopt a child-centered approach emphasizing safety, emotional regulation, and the prevention of re-traumatization, is essential for the medical and forensic evaluation of abused children. Adopting hospital-based multidisciplinary units could improve forensic documentation, interagency coordination, and psychosocial care in Greece.
Full article
Open AccessArticle
Parental Knowledge and Attitudes Toward Emergency Management of Dental Trauma in Children: A Cross-Sectional Croatian Study
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Klaudia Aleric, Lidia Gavic, Mirna Draganja, Kristina Gorseta, Vesna Ambarkova and Antonija Tadin
Pediatr. Rep. 2026, 18(1), 11; https://doi.org/10.3390/pediatric18010011 - 15 Jan 2026
Abstract
Aim: Traumatic dental injuries (TDI) in children are a common but often underestimated emergency. Parental knowledge and timely response are crucial for successful treatment. This study aimed to evaluate parental knowledge, experiences, and awareness regarding dental trauma management and the use of
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Aim: Traumatic dental injuries (TDI) in children are a common but often underestimated emergency. Parental knowledge and timely response are crucial for successful treatment. This study aimed to evaluate parental knowledge, experiences, and awareness regarding dental trauma management and the use of protective mouthguards. Methods: A cross-sectional study was conducted using a self-administered questionnaire among 333 parents in dental clinics in Split and Zagreb, Croatia. The questionnaire assessed sociodemographic data, parental knowledge of TDIs, and prior experience with dental trauma. Statistical analysis included chi-square test (p < 0.05). Results: The overall level of parental knowledge regarding traumatic dental injuries was generally low (7.6 out of 15 points). Almost all parents correctly identified the age when children have primary or permanent teeth. However, less than half knew that an avulsed primary tooth should not be replanted, while about three-quarters recognized that professional help should be sought within 30 min after trauma. Overall, 43.5% of parents reported that their child had experienced dental trauma, most often affecting primary teeth (60.7%), particularly the maxillary central incisor (76.6%). Mothers demonstrated significantly higher knowledge than fathers (p = 0.025), and prior experience or information about dental trauma significantly improved awareness (p < 0.001). Although 54.3% of respondents were unaware of the purpose of dental shields, 82.3% considered them necessary during contact sports, yet only 12.9% reported that their child actually uses them. Conclusions: Within the limitations of this clinic-based study, the findings indicate gaps in parental knowledge regarding the appropriate management of dental trauma. Strengthening parents’ understanding of emergency response and preventive measures may support timelier and appropriate care and contribute to improved outcomes for children experiencing traumatic dental injuries.
Full article
Open AccessCase Report
Severe Abdominal Pain Mimicking Appendicitis Caused by Imperforate Hymen: Case Report and Narrative Review
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Julia Kleina, Marcin Wieczorek, Karolina Markowska, Katarzyna Nierzwicka, Julia Leszkowicz and Agnieszka Szlagatys-Sidorkiewicz
Pediatr. Rep. 2026, 18(1), 10; https://doi.org/10.3390/pediatric18010010 - 13 Jan 2026
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An imperforate hymen is a rare congenital genital anomaly causing menstrual blood retention during puberty. Treatment consists of a simple surgical incision of the hymenal membrane. We present a case of a 14-year-old girl who was admitted to the Emergency Department with severe
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An imperforate hymen is a rare congenital genital anomaly causing menstrual blood retention during puberty. Treatment consists of a simple surgical incision of the hymenal membrane. We present a case of a 14-year-old girl who was admitted to the Emergency Department with severe lower abdominal pain mimicking appendicitis. Medical history revealed a lack of menses and several months of cyclic abdominal pain. Imaging diagnostics confirmed an imperforate hymen with hematometrocolpos. Hymenotomy was performed with full recovery without complications. An imperforate hymen should be considered in the differential diagnosis of abdominal pain in adolescent girls, especially without expected menstruation. Early recognition allows for prompt treatment and prevents complications.
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Open AccessArticle
Testing the Reliability and Validity of the Turkish Adaptation of Sharenting Evaluation Scale
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Fatih Bayraktar and Hale Ögel-Balaban
Pediatr. Rep. 2026, 18(1), 9; https://doi.org/10.3390/pediatric18010009 - 12 Jan 2026
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Objectives: The aim of the present study was to adapt the Sharenting Evaluation Scale to Turkish and to test its reliability and validity. Methods: Through an online data collection platform, we recruited 391 parents (Mage = 42.2, SDage = 5.6, 76%
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Objectives: The aim of the present study was to adapt the Sharenting Evaluation Scale to Turkish and to test its reliability and validity. Methods: Through an online data collection platform, we recruited 391 parents (Mage = 42.2, SDage = 5.6, 76% female). They have at least one child under 18 years of age and actively engage with social media. Sharenting Evaluation Scale consists of 17 items rated on a 6-point Likert scale. Its Turkish adaptation underwent a two-phase process: exploratory and confirmatory factor analyses, along with testing for construct validity. Results: The exploratory factor analysis revealed that the 17 items in the questionnaire were loaded onto two factors (Social Behavior and Implications). The confirmatory factor analysis indicated that the two-factor model fitted the current sample well. To evaluate the construct validity of the Sharenting Evaluation Scale, we compared groups at the extreme ends of the scoring spectrum. A t-test was conducted to compare the scores of both groups across subscales, revealing a significant difference. We observed positive correlations between sharenting and parental self-regulation, authoritative parenting, permissive parenting, and digital media literacy which indicate the criterion validity. Conclusions: In conclusion, the current study demonstrates that the Turkish version of the Sharenting Evaluation Scale is a reliable and valid tool.
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Open AccessArticle
Nationwide Study of Pediatric Drug-Resistant Epilepsy in Estonia: Lower Incidence and Insights into Etiology
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Stella Lilles, Klari Heidmets, Kaisa Teele Oja, Karit Reinson, Laura Roht, Sander Pajusalu, Monica H Wojcik, Katrin Õunap and Inga Talvik
Pediatr. Rep. 2026, 18(1), 8; https://doi.org/10.3390/pediatric18010008 - 6 Jan 2026
Abstract
Background/Objectives: Drug-resistant epilepsy (DRE) is a significant health problem leading to cognitive impairment and reduced quality of life. This study aimed to investigate the incidence and etiology of DRE in children in Estonia. Methods: A retrospective, population-based study of childhood DRE was conducted
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Background/Objectives: Drug-resistant epilepsy (DRE) is a significant health problem leading to cognitive impairment and reduced quality of life. This study aimed to investigate the incidence and etiology of DRE in children in Estonia. Methods: A retrospective, population-based study of childhood DRE was conducted in Estonia from 1 January 2013, to 31 December 2017. All cases were identified through the only two pediatric neurology departments in the country, both located at tertiary care hospitals (Tartu University Hospital and Tallinn Children’s Hospital), ensuring complete nationwide coverage. Epidemiological, magnetic resonance imaging (MRI), and genetic data (chromosomal microarray, single-gene tests, gene panels, and exome/genome sequencing) were collected. Results: The incidence rate of childhood epilepsy was 84.1 per 100,000. DRE developed in 10% of children with new-onset epilepsy, corresponding to an incidence rate of 8.5 per 100,000. Etiologically relevant MRI abnormalities were identified in 43% of patients with DRE, most commonly congenital brain malformations (19%). Pathogenic single-gene sequence variants were detected in 25 of 110 patients (23%), copy number variants in four patients (4%), and chromosomal aberrations in one patient (1%). Novel candidate disease genes of uncertain pathogenicity were identified in four patients (4%). The most frequent etiology of DRE was structural (29%), followed by genetic (19%), with combined etiologies (13%) also contributing significantly. Conclusions: Our study is the first epidemiological study of DRE in children in Estonia and the Baltic region. The relatively low incidence observed may reflect the comprehensive national ascertainment and centralized management of pediatric epilepsy in tertiary care centers.
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Open AccessSystematic Review
Inflammatory Biomarkers and Neurotrophic Factors in Preterm Newborns as Predictors of Motor Development: A Systematic Review
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Letícia Silva Gabriel, Vicente Donisete Ferreira Júnior, Marina Ornelas Anastácia Pereira, Dayanne Gabriela de Melo Marques, Virgínia Mendes Russo Vallejos and Melina Barros-Pinheiro
Pediatr. Rep. 2026, 18(1), 7; https://doi.org/10.3390/pediatric18010007 - 5 Jan 2026
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Background/Objectives: Preterm newborns (NBs) are at increased risk of motor developmental impairments. Evidence on inflammatory and neurotrophic biomarkers measured in the neonatal period as predictors of motor outcomes is scarce and heterogeneous. This systematic review synthesised data on inflammatory biomarkers and neurotrophic factors
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Background/Objectives: Preterm newborns (NBs) are at increased risk of motor developmental impairments. Evidence on inflammatory and neurotrophic biomarkers measured in the neonatal period as predictors of motor outcomes is scarce and heterogeneous. This systematic review synthesised data on inflammatory biomarkers and neurotrophic factors in Preterm NB as predictors of motor development (MD) up to 24 months of corrected age. Methods: MEDLINE, SciELO, Web of Science and Embase were searched for longitudinal observational studies of Preterm NB (World Health Organization definition) that measured one or more inflammatory biomarkers and/or neurotrophic factors in blood, urine or saliva and applied validated neurodevelopmental scales up to 24 months. Non-original reports, populations outside scope and studies with incomplete data were excluded. Methodological quality of primary studies was assessed with the Newcastle–Ottawa Scale (NOS). The protocol was registered in PROSPERO (CRD42022365839). Results: Of 1475 records, eight studies met the eligibility criteria. Higher neonatal concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) were generally associated with poorer motor performance, although null findings occurred in some cohorts. One study assessing neurotrophic factors reported elevated urinary brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) among infants with below-expected MD. Conclusions: Inflammatory biomarkers show promise as early indicators of adverse MD in Preterm NB, but heterogeneity in populations, biospecimens, sampling windows, assays and outcome scales limits comparability and precludes definition of risk thresholds. Larger, standardised cohorts are needed to clarify the prognostic value of inflammatory and neurotrophic biomarkers and to inform early risk stratification.
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Open AccessCase Report
Mandibular Distraction Osteogenesis Guided by 3D Model and Monitored with Ultrasonography: A Case Report
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Barbora Hocková, Julien Issa, Miroslav Malček, Krzysztof Dowgierd, Rastislav Slávik, Yu-Chi Cheng, Karol Králinský and Adam Stebel
Pediatr. Rep. 2026, 18(1), 6; https://doi.org/10.3390/pediatric18010006 - 3 Jan 2026
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This case report describes mandibular distraction osteogenesis (DO) in a six-year-old patient with first and second branchial arch syndrome and obstructive sleep apnea, in whom 3D surgical planning was combined with ultrasonography (US) for postoperative monitoring. The aim was to illustrate how patient-specific
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This case report describes mandibular distraction osteogenesis (DO) in a six-year-old patient with first and second branchial arch syndrome and obstructive sleep apnea, in whom 3D surgical planning was combined with ultrasonography (US) for postoperative monitoring. The aim was to illustrate how patient-specific 3D modeling and a structured ultrasonography protocol can support safe mandibular advancement while limiting radiation exposure in a pediatric patient with complex craniofacial deformity. Preoperatively, a 3D-printed model of the mandible, generated from a cone beam computed tomography (CBCT) scan, was used to guide precise osteotomy planning and vector orientation. The surgical procedure was conducted using a Risdon approach and piezoelectric tools to ensure minimal trauma. Postoperative monitoring incorporated serial panoramic radiography and US at predefined time points to assess gap size, callus formation, and vascularity during distraction and consolidation. US identified early callus formation, progressive cortical bridging, and preserved callus vascularity, and, together with radiographic findings, guided the timing of distraction termination and distractor removal at 16 weeks. This case adds to the limited literature on pediatric mandibular DO by demonstrating the feasibility of integrating patient-specific 3D virtual planning with US-based follow-up to improve the safety, precision, and radiation-conscious management of DO in pediatric patients with complex craniofacial deformities.
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Open AccessReview
Procedural Pain and Situational Anxiety in Pediatric Patients: A Narrative Review of Assessment Tools
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Anna Wojciechowska-Urbanek, Jowita Rosada-Kurasińska and Alicja Bartkowska-Śniatkowska
Pediatr. Rep. 2026, 18(1), 5; https://doi.org/10.3390/pediatric18010005 - 2 Jan 2026
Abstract
Background: Procedural pain and anxiety are common phenomena among children hospitalized in pediatric wards; however, they are often under-recognized. These experiences frequently accompany patients during various diagnostic and therapeutic procedures. Assessing pain is particularly challenging in pediatric care, as children may have
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Background: Procedural pain and anxiety are common phenomena among children hospitalized in pediatric wards; however, they are often under-recognized. These experiences frequently accompany patients during various diagnostic and therapeutic procedures. Assessing pain is particularly challenging in pediatric care, as children may have difficulty clearly expressing their pain experiences, which can result in the underestimation of their symptoms. Accurate assessment using an appropriately selected scale should be regarded as an essential component of high-quality healthcare. Methods: This narrative review summarizes standardized tools for assessing procedural pain and anxiety in pediatric patients, focusing on instruments adapted to different ages and cognitive abilities and on their applicability in everyday clinical practice. Results: Numerous standardized scales are available, ranging from behavioral to numerical instruments tailored to specific developmental stages. Despite this, the implementation of these tools in routine care remains inconsistent, largely due to organizational, educational, and communication barriers among healthcare professionals. Conclusions: Medical staff must not only receive adequate training but also exhibit the motivation and readiness to utilize available pain assessment methods. Education and increased awareness among staff regarding pain and procedural anxiety are crucial for improving patient comfort and safety.
Full article
Open AccessArticle
Effects of a Media Prevention Program on Media-Related Knowledge and Awareness in Children and Their Parents: A Non-Randomized Controlled Cluster Study
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Tanja Poulain, Wieland Kiess, Team Drahtseil and Christof Meigen
Pediatr. Rep. 2026, 18(1), 4; https://doi.org/10.3390/pediatric18010004 - 25 Dec 2025
Abstract
Background/Objectives: This study evaluates a media prevention program conducted in elementary schools. Methods: A one-week media program, carried out with fourth graders in Leipzig, Germany, was evaluated using a non-randomized controlled cluster design. Program participants (experimental group (EG), n = 84 children, 41
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Background/Objectives: This study evaluates a media prevention program conducted in elementary schools. Methods: A one-week media program, carried out with fourth graders in Leipzig, Germany, was evaluated using a non-randomized controlled cluster design. Program participants (experimental group (EG), n = 84 children, 41 parents) and non-participants (control group (CG), n = 19 children, 14 parents) completed questionnaires before the media program (t1), directly after the program (t2, EG only), and 3 months later (t3). The child questionnaire assessed media use frequency, rules at home, perceived and objective media-knowledge, and awareness of dangers on the Internet. The parent questionnaire assessed media-related topics discussed with their children and parents’ confidence regarding media education. Results: In the EG, children’s perceived and objective knowledge and their awareness of dangers on the Internet increased significantly between t1 and t2 and remained stable until t3, while no changes were observed in the CG. The number of children reporting that there exist rules on social media use also increased significantly in the EG but not in the CG. The amount of media-related topics discussed within the family and parents’ confidence regarding media education increased significantly from t1 to t3 in both EG and CG. Children’s media use frequency did not change across time, neither in the EG nor in the CG. Conclusions: Media prevention programs at school can have positive effects on children’s knowledge and awareness of dangers on the Internet and might improve parents’ confidence in and the realization of media education at home.
Full article
(This article belongs to the Section Pediatric Psychology)
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Open AccessCase Report
When Genes Reveal the Truth: Alport Syndrome Mimicking Steroid-Resistant Nephrotic Syndrome
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John Dotis, Antonia Kondou, George Liapis, Athina Ververi, Konstantinos Kollios and Nikoleta Printza
Pediatr. Rep. 2026, 18(1), 3; https://doi.org/10.3390/pediatric18010003 - 19 Dec 2025
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Τargeted genetic sequencing in a 6-year-old with steroid-resistant nephrotic syndrome and biopsy findings of focal segmental glomerulosclerosis (FSGS) revealed a novel COL4A3 pathogenic variant (p.Arg341His). Combined with electron microscopy findings of glomerular basement membrane abnormality, this led to a diagnosis of type IV
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Τargeted genetic sequencing in a 6-year-old with steroid-resistant nephrotic syndrome and biopsy findings of focal segmental glomerulosclerosis (FSGS) revealed a novel COL4A3 pathogenic variant (p.Arg341His). Combined with electron microscopy findings of glomerular basement membrane abnormality, this led to a diagnosis of type IV collagen-related nephropathy. This case underscores the benefit of early genetic testing in presumed FSGS for prognosis and avoiding unnecessary immunosuppression in pediatric nephrotic syndrome.
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Open AccessCase Report
Rapid Clinical Response to Omalizumab Treatment in Pediatric Acute Urticaria Associated with Mycoplasma Infection: A Two-Case Report
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Zhen-Li Wu, Yi-Siang Huang, Chien-Ting Chiang and Hong-Ren Yu
Pediatr. Rep. 2026, 18(1), 2; https://doi.org/10.3390/pediatric18010002 - 19 Dec 2025
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Background and Clinical Significance: Urticaria in children is generally self-limiting, and infections are a significant trigger. While anti-IgE therapy (Omalizumab) is approved for chronic spontaneous urticaria (CSU) in adolescents and adults, its role in treating acute urticaria, particularly in children, is not
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Background and Clinical Significance: Urticaria in children is generally self-limiting, and infections are a significant trigger. While anti-IgE therapy (Omalizumab) is approved for chronic spontaneous urticaria (CSU) in adolescents and adults, its role in treating acute urticaria, particularly in children, is not well defined. Case Presentation: We present two pediatric cases of acute urticaria associated with Mycoplasma pneumoniae infection. Both cases were refractory to antihistamines and corticosteroids but showed rapid response with anti-IgE treatment. Conclusions: This is the first case report in the literature of pediatric acute urticaria treated with Omalizumab. These cases suggest a potential role for IgE-mediated pathways in acute urticaria related to Mycoplasma infection and raise the question of broader applications for Omalizumab beyond CSU.
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Open AccessArticle
A Clinical Prediction Model for Genetic Risk in Children with GDD/ID: A Retrospective Study
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Yunshu Jiang, Ran Chen, Mengyin Chen, Luting Peng, Yuchen Zhao, Rong Li and Xiaonan Li
Pediatr. Rep. 2026, 18(1), 1; https://doi.org/10.3390/pediatric18010001 - 19 Dec 2025
Abstract
Objectives: Global Developmental Delay (GDD) and Intellectual Disability (ID) are prevalent neurodevelopmental disorders with significant disability burden, and genetic factors play a crucial role in their etiology. This study aimed to develop and validate a clinical prediction model for identifying children with GDD/ID
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Objectives: Global Developmental Delay (GDD) and Intellectual Disability (ID) are prevalent neurodevelopmental disorders with significant disability burden, and genetic factors play a crucial role in their etiology. This study aimed to develop and validate a clinical prediction model for identifying children with GDD/ID at high genetic risk, facilitating targeted genetic testing. Methods: We retrospectively analyzed clinical data of children with GDD/ID treated at Nanjing Children’s Hospital from January 2019 to December 2023. Children with comorbid Autism Spectrum Disorder (ASD) were excluded. The dataset was randomly split into training and validation sets (7:3 ratio). Lasso regression was used to identify potential predictive factors for positive genetic test results, followed by multivariable logistic regression to select independent predictors, which were incorporated into a nomogram. Model performance was evaluated by discrimination, calibration, and clinical utility using decision curve analysis in both sets. Results: Four independent predictors—craniofacial abnormalities, visceral abnormalities, physical growth abnormalities, and family history of ID—were identified. The resulting nomogram demonstrated an area under the curve (AUC) of 0.734., with good calibration and positive net benefit on decision curve analysis. Validation confirmed the reliability of the model. Conclusions: We developed a clinically applicable prediction model to identify high genetic risk among children with GDD/ID without ASD. This model may serve as a preliminary screening tool to assist clinicians in prioritizing genetic testing and improving diagnostic efficiency in clinical practice.
Full article
(This article belongs to the Special Issue Feature Papers on Child Developmental Disorders and Neurology Research)
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Open AccessBrief Report
Feasibility and Early Experience with Pediatric Open Access Endoscopy: A Pilot Study
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Monique T. Barakat, Dorsey M. Bass and Roberto Gugig
Pediatr. Rep. 2025, 17(6), 134; https://doi.org/10.3390/pediatric17060134 - 17 Dec 2025
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Background: Open access endoscopy (OAE) allows outpatient endoscopic procedures without prior consultation with the endoscopist, a practice common in adult gastroenterology but not part of pediatric gastroenterology practice. Here we evaluate the feasibility and safety of a newly implemented pediatric OAE program. Methods:
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Background: Open access endoscopy (OAE) allows outpatient endoscopic procedures without prior consultation with the endoscopist, a practice common in adult gastroenterology but not part of pediatric gastroenterology practice. Here we evaluate the feasibility and safety of a newly implemented pediatric OAE program. Methods: We identified patients aged 18 and under who underwent OAE in the first year of our program using a prospectively maintained endoscopy database. The program involved three experienced endoscopists and included demographics, indications, interventions, and adverse events. Patients/parents received follow-up calls on day 1 and day 7 to detect adverse events and assess perceptions of the OAE process. Results: A total of 54 outpatient OAE procedures were performed, with a median patient age of 10 years (range 18 months–18 years). This included 33 esophagogastroduodenoscopies (EGDs) and 16 colonoscopies, all with biopsies. ERCPs were performed for stone management (4) and stricture evaluation/stent exchange (1). All procedures were successful with no adverse events reported, and patient/parent feedback indicated that the OAE approach was beneficial in terms of lifestyle, socioeconomic, and psychological aspects. Some challenges were identified through follow-up discussions. Conclusions: Our early experience suggests that pediatric OAE is feasible and appeared safe within this small pilot cohort, with no adverse events observed. Advantages of pediatric OAE include minimizing missed school days and reducing medical anxiety. Feedback has led to refinements in practice at our institution, and further study on OAE is warranted at the endoscopy society level. Larger studies are needed to determine safety, effectiveness, and generalizability.
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Open AccessArticle
C-Reactive Protein Levels of Healthy Term Infants Born After Prolonged Rupture of Membranes
by
Anders Batman Mjelle, Vilde Solberg, Emma Rød, Eydís Oddsdóttir Stenersen, Håvard Tetlie Garberg, Per Arne Tølløfsrud, Arild Rønnestad and Anne Lee Solevåg
Pediatr. Rep. 2025, 17(6), 133; https://doi.org/10.3390/pediatric17060133 - 5 Dec 2025
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Background/Objective: Even in the absence of infection, prolonged rupture of membranes (PROM) has been associated with elevated neonatal C-reactive protein (CRP). As both the sensitivity and specificity of CRP in predicting early-onset neonatal sepsis (EOS) may be low, we aimed to describe CRP
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Background/Objective: Even in the absence of infection, prolonged rupture of membranes (PROM) has been associated with elevated neonatal C-reactive protein (CRP). As both the sensitivity and specificity of CRP in predicting early-onset neonatal sepsis (EOS) may be low, we aimed to describe CRP levels during the first 36 h of life in term infants born after PROM ≥ 24 h. Methods: CRP was measured at 1, 12, and 36 h. Descriptive statistics and correlation analyses were performed, taking gestational age, birth weight, sex, delivery mode, and antibiotic treatment into account. Reference CRP values in healthy neonates without sepsis born after PROM were established. Results: Median (range) CRP was 0 (0–62) mg/L, 0 (0–82) mg/L, and 4 (0–92) mg/L at 1, 12, and 36 h, respectively. CRP at 12 and 36 (p < 0.001) but not 1 h was positively correlated with gestational age and birth weight. There was no difference in CRP after C-section vs. vaginal delivery. Among infants without sepsis, CRP was higher at all time points in infants who did vs. those who did not receive antibiotics (p < 0.001). Conclusions: CRP was low in term infants without sepsis born after PROM but with outliers above 60, 80, and 90 mg/L after 1, 12, and 36 h, respectively. Research is needed on the long-term outcomes of infants with inflammation, as evidenced by an elevated CRP after PROM.
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Open AccessOpinion
Malignancy Ratio in Pediatric Patients with Hereditary Multiple Exostoses: True Association or Reporting Bias?
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Francesco Fabrizio Comisi, Andrea Maria Comisi, Elena Esposito and Salvatore Savasta
Pediatr. Rep. 2025, 17(6), 132; https://doi.org/10.3390/pediatric17060132 - 3 Dec 2025
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Background: Hereditary Multiple Exostoses (HME) is a rare autosomal dominant skeletal disorder resulting from loss-of-function variants in the EXT1, EXT2, or EXT3 genes. While malignant transformation into chondrosarcoma is well documented, the incidence and characterization of non-skeletal malignancies in HME remain
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Background: Hereditary Multiple Exostoses (HME) is a rare autosomal dominant skeletal disorder resulting from loss-of-function variants in the EXT1, EXT2, or EXT3 genes. While malignant transformation into chondrosarcoma is well documented, the incidence and characterization of non-skeletal malignancies in HME remain poorly defined. Objective: We aimed to comprehensively review the literature for reported cases of non-skeletal malignancies in individuals with HME and evaluate a potential association with hematologic cancers, particularly in the pediatric population. Methods: An extensive literature search was conducted in the PubMed database up to August 2025 using search terms related to HME and malignancy. Eligible reports included case descriptions of non-skeletal cancers occurring in patients with confirmed or suspected HME. Extracted data included patient age, sex, cancer type, and available genetic or molecular findings. Results: Thirteen cases of non-skeletal malignancies associated with HME were identified. Fewer than half underwent molecular genetic testing. Six cases occurred in pediatric patients, four of which involved hematologic malignancies, three leukemias and one Burkitt lymphoma. In adults, malignancies affected a range of organ systems, including respiratory, gastrointestinal, nervous, and endocrine. A marked male predominance was observed (11 males vs. 2 females). Conclusions: Although a definitive causal relationship cannot be established, hematologic malignancies in pediatric HME patients appear to be disproportionately represented among reported cases. This finding highlights the need for further investigation through large-scale, population-based studies incorporating both clinical and genetic data.
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Open AccessBrief Report
Early Upper Limb Function in Infants Under Three Months: Associations with Shoulder Biomechanics and General Movement Patterns
by
Lucía Fernanda Flores-Santy, Daniela Celi-Lalama and Juan Pablo Hervás-Pérez
Pediatr. Rep. 2025, 17(6), 131; https://doi.org/10.3390/pediatric17060131 - 3 Dec 2025
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Early identification of neurodevelopmental trajectories is essential for timely intervention in infancy. While joint mobility is often seen as an indicator of motor capacity, its link to early functional performance remains unclear. This study examined whether active shoulder range of motion and the
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Early identification of neurodevelopmental trajectories is essential for timely intervention in infancy. While joint mobility is often seen as an indicator of motor capacity, its link to early functional performance remains unclear. This study examined whether active shoulder range of motion and the quality of spontaneous movement quality relate to early upper limb function in infants under three months. Thirty-two healthy infants participated in a cross-sectional assessment. Video recordings analyzed with the General Movements Assessment classified movements as Fidgety or Writhing. Fine motor performance was evaluated using five items from the Denver II Screening Test. Active shoulder abduction was measured via two-dimensional frontal-plane analysis with Kinovea®. Data analysis involved t-tests and Pearson correlations. Results showed that infants with Fidgety movements scored higher on fine motor tests than those with Writhing movements. Shoulder range of motion was slightly higher in infants with Writhing movements, but not significantly. No sex differences were found. Weak, nonsignificant correlations existed between shoulder range of motion and fine motor performance. The findings suggest movement quality, rather than limb mobility, is more connected to early motor function. Combining movement quality assessments with simple tests may improve early detection of subtle neuromotor issues and guide early stimulation strategies.
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