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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Compounds in Obesity and Its Metabolic Complications

edited by

Patricia Rios Chavez

and Héctor Eduardo Martínez-Flores

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2014 | Submission Open

Keywords: antioxidant; obesity; inflammation; oxidative stress; metabolic syndrome

(This special issue belongs to the Section Plant Metabolism)

Lipidomic and Metabolomic Analysis of Neurodegenerative Diseases

edited by

Marios Krokidis

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1227 | Submission Open

Keywords: neurodegenerative diseases; metabolomics; lipidomics; biofluids and patient samples; cellular models; animal models; mass-spectrometry; nuclear magnetic resonance; biomarkers; artifical intelligence; multi-omics analysis; bioinformatics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 30 Jun 2026 | 2 articles | Viewed by 21873 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 30 Jun 2026 | 6 articles | Viewed by 11334 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 8896 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Proteomics and Metabolomics in Human Health and Disease

edited by

Michele Costanzo

and

Margherita Ruoppolo

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5941 | Submission Open

Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Plant Natural Products Research, 2nd Edition

edited by

Junsong Wang

submission deadline 30 Jun 2026 | 5 articles | Viewed by 5538 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome: 2nd Edition

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Jun 2026 | 5 articles | Viewed by 4645 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management, 2nd Edition

edited by

Davide Masi

and

Renata Risi

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4498 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4062 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3696 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

The Role of Lipid Metabolism in Health and Disease

edited by

Mónica Narváez-Rivas

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3575 | Submission Open

Keywords: lipid metabolism; lipidomics; dyslipidemia; mass spectrometry; lipid biomarkers; lipid signaling; therapeutic targets; bioinformatics; clinical lipidomics

(This special issue belongs to the Section Lipid Metabolism)

Adipose Thermogenesis and Crosstalk: Signaling Networks in Obesity, Metabolic Disease and Beyond

edited by Lei Huang

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3315 | Submission Open

Keywords: adipose thermogenesis; BAT; WAT browning; adipokines; batokines; UCP1; single-cell/spatial omics; metabolic disease; obesity; insulin resistance; cardiovascular risk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Adaptations to Exercise: Mechanisms, Modulators, and Health Impacts

edited by

Kiwon Lim

and

Jisu Kim

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2671 | Submission Open

Keywords: exercise metabolism; metabolic adaptations; mitochondrial function; metabolic flexibility; energy substrate utilization; exercise-induced remodeling; skeletal muscle metabolism; metabolomics and multi-omics approaches

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mitochondrial Metabolism, Redox State and Immunology in Cancer

edited by

Alfredo Cruz-Gregorio

and

Gladis Fragoso

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2598 | Submission Open

Keywords: immune system; mitochondria; redox state; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional Interventions and Lipid Metabolism

edited by

Cecilia Bender

and

Mariano Stornaiuolo

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2489 | Submission Open

Keywords: lipid metabolism; nutritional interventions; dietary fats; bioactive compounds; functional foods; chronic diseases; nutrigenomics; weight management; inflammation; personalized nutrition

(This special issue belongs to the Section Lipid Metabolism)

State-of-the-Art NMR-Based Metabolomics and Its Applications

edited by

Pau Nolis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1180 | Submission Open

Keywords: NMR spectroscopy; metabolomics; metabolic profiling; biomarker; multivariate analysis; high-throughput data analysis

Advancements in Mass Spectrometry Techniques for Metabolomic and Pharmaceutical Analysis

edited by

Xiaowei Song

and Fangling Wu

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1044 | Submission Open

Keywords: ambient ionization; mass spectrometry imaging; sample pretreatment; isomer analysis; marker discovery; ion annotation; structural identification; artificial intelligence; multi-omics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Microbial Metabolites and Host Health

edited by Weilan Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: microbial metabolites; host– microbe interactions; host health; inflammatory bowel disease; chronic metabolic disorders; cancer; autoimmune diseases; neurodegenerative conditions; metabolism and immune status

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

The Interaction Between Metabolic Dysfunction and Hypothalamic Inflammation

edited by

Joana M. Gaspar

submission deadline 30 Jun 2026 | 1 articles | Viewed by 578 | Submission Open

Keywords: metabolic disorders; neuroinflammation; hypothalamus; energy homeostasis; feeding behavior; high-fat diets; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Veterinary Metabolomics: Emerging Tools for Animal Health

edited by

Ionela Hotea

Adrian Maximilian Macri

and Emil Tirziu

submission deadline 30 Jun 2026 | Viewed by 398 | Submission Open

Keywords: veterinary metabolomics; animal nutrition; nutrient utilization; feed efficiency; precision nutrition; metabolic health; microbiome– metabolome interactions; sustainable livestock production; multi-omics integration; animal welfare; one health

(This special issue belongs to the Section Animal Metabolism)

Advances in Translational Oncology and Oncometabolism

edited by Graham Pidgeon and

Zivile Useckaite

submission deadline 30 Jun 2026 | Viewed by 393 | Submission Open

Keywords: oncometabolism; obesity; clinical research; clinical trials; oncogenes; translational oncology

(This special issue belongs to the Section Cell Metabolism)

Lipidomics and Metabolic Biomarkers in Heart Disease

edited by

Davide Radaelli

and Matteo Scopetti

submission deadline 30 Jun 2026 | Viewed by 378 | Submission Open

Keywords: lipidomic; metabolomic; biomarkers; cardiovascular disease; risk stratification

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Integrating Metabolism and Molecular Biology in Cancer Research and Therapeutics

edited by

Susmita Barman

submission deadline 30 Jun 2026 | Viewed by 266 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor microenvironment; oncometabolites; immunometabolism; therapeutic resistance; microbiome-derived metabolites; metabolomics; molecular signaling pathways

(This special issue belongs to the Section Integrative Metabolomics)

Endothelial Metabolism in Vascular Development and Diseases

edited by

Pengchun Yu

submission deadline 30 Jun 2026 | Viewed by 238 | Submission Open

Keywords: cellular metabolism; metabolites; metabolic network; blood endothelial cells; lymphatic endothelial cells; blood vessel development; lymphatic vascular development; vascular disease; cancer; ocular disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Studies in Urinary Diseases

edited by

Dechao Feng

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: metabolomics; lipidomics; biomarkers; chronic kidney disease (CKD); acute kidney injury (AKI); urolithiasis (kidney stones); bladder cancer; prostate cancer; diabetic nephropathy; polycystic kidney disease; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Jul 2026 | 6 articles | Viewed by 20157 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Novel Methods of Mass Spectrometry Imaging Towards Biomedical and Environmental Applications

edited by

Xiaoxiao Ma

Zhaoying Wang

and

Yanhua Chen

submission deadline 1 Jul 2026 | 1 articles | Viewed by 1415 | Submission Open

Keywords: mass spectrometry imaging; molecular mapping; new techniques; biomedicine; materials science; environmental research; pharmaceutics

(This special issue belongs to the Section Advances in Metabolomics)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 5 Jul 2026 | 5 articles | Viewed by 7973 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

Biomarkers for Fibrotic Diseases

edited by

Chao He

and Jennifer L. Larson-Casey

submission deadline 10 Jul 2026 | Viewed by 251 | Submission Open

Keywords: fibrosis; biomarkers; multi-omics; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutrition and Metabolism in Poultry

edited by

Catarina Stefanello

submission deadline 15 Jul 2026 | 2 articles | Viewed by 4898 | Submission Open

Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health

(This special issue belongs to the Section Animal Metabolism)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2133 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Nutrition and Metabolic Diseases: Mechanistic Insights and Personalized Dietary Strategies

edited by

Silvia Tagliamonte

and

Marcelo Macedo Rogero

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1395 | Submission Open

Keywords: personalized nutrition; metabolic diseases; metabolomics; food digestion; postprandial metabolism; biomarkers; gut microbiome; precision medicine; systems biology

(This special issue belongs to the Section Nutrition and Metabolism)

Multi-Omics Insights into Stress-Induced Metabolism of Bioactive Plant Compounds

edited by

Dan Gao

and

Junsong Wang

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: stress-induced metabolism; plant secondary metabolites; bioactive phytochemicals; medicinal plant compounds; multi-omics integration; comparative metabolomics; plant stress biology; metabolic and regulatory networks; network pharmacology

(This special issue belongs to the Section Plant Metabolism)

Environmental Exposures and Metabolic Health in Vulnerable Populations

edited by

Sandra India-Aldana

and Lauren Petrick

submission deadline 15 Jul 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: exposomics; metabolic health; metabolic diseases; metabolomics; metabolome; susceptible populations; susceptible windows; children; women’ s health; minorities

(This special issue belongs to the Section Environmental Metabolomics)

Vitamin D Metabolism: Implications in Metabolic Health and Disease

edited by

Gar Yee Koh

and

Elena Planells

submission deadline 15 Jul 2026 | 1 articles | Viewed by 694 | Submission Open

Keywords: vitamin D; metabolic disease; micronutrient; obesity; diabetes; cardiovascular health; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

Reactive Oxygen Species and Metabolic Dysregulation: From Bench to Bedside

edited by

Paola Maycotte

Álvaro Marín-Hernández

and Annie Joubert

submission deadline 15 Jul 2026 | Viewed by 235 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Tumoral Microenvironment and Metabolic Reprogramming in Cancer

edited by

Beatrice Dufrusine

submission deadline 15 Jul 2026 | Viewed by 208 | Submission Open

Keywords: tumoral microenvironment; inflammation; cancer; immune system; stromal cells; metabolic reprogramming; warburg effect; reverse warburg effect

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring Metabolomic Signatures and the Metabolic Impact of Thyroid Dysfunction

edited by Janine Wirth

submission deadline 17 Jul 2026 | 3 articles | Viewed by 2729 | Submission Open

Keywords: thyroid function; hypothyroidism; hyperthyroidism; Hashimoto; metabolic health; metabolomics; inflammation; autoimmune

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry Imaging and Spatial Metabolomics—2nd Edition

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1257 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolic Signatures of Pediatric Endocrine and Metabolic Disorders

edited by

Tiago Jeronimo dos Santos

submission deadline 20 Jul 2026 | 1 articles | Viewed by 764 | Submission Open

Keywords: pediatric metabolomics; endocrine disorders; type 1 diabetes; type 2 diabetes; childhood obesity; insulin resistance; metabolic pathways; MASLD/MASH; biomarkers; environmental metabolic perturbations; multi-omics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Impact of Diet on the Metabolism and Body Composition of Patients with Skin Diseases

edited by

Giuseppe Annunziata

Luigi Barrea

and Matteo Megna

submission deadline 20 Jul 2026 | Viewed by 435 | Submission Open

Keywords: diet– skin axis; body composition; inflammatory skin diseases; nutritional interventions; metabolomics; adipose tissue dysfunction; nutraceutical

(This special issue belongs to the Section Nutrition and Metabolism)

Thyroid Dysfunction and Metabolic Disorders

edited by Dayami Lopez

submission deadline 20 Jul 2026 | Viewed by 324 | Submission Open

Keywords: thyroid hormones; metabolic disorders; metabolomics; lipidomics; metabolic reprogramming; obesity; diabetes mellitus; dyslipidemia; MASLD; metabolic biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Physical and Nutritional Lifestyle Contributions to Metabolic Health and Well-Being

edited by Arlette C. Perry

submission deadline 20 Jul 2026 | Viewed by 270 | Submission Open

Keywords: lifestyle behaviors; nutrition; body composition; physical activity and physical fitness

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Plant Metabolites for Managing Chemotherapy-Induced Side Effects

edited by

Woojin Kim

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: chemotherapy-induced side effects; pain; nausea and vomiting; neutropenia

(This special issue belongs to the Section Plant Metabolism)

Nutrition and Dietary Supplementation in the Context of Health, Disease, and Physical Performance

edited by

Magdalena Górnicka

and

Ewa Niedźwiedzka

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: diet; dietary pattern; bioactive food compounds; body composition; nutrition-related biomarkers; metabolites; physical activity

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Responses in Plants Under Abiotic Stress

edited by

Ghulam Hasnain

submission deadline 25 Jul 2026 | Viewed by 266 | Submission Open

Keywords: abiotic stress; plant metabolism; compatible solutes; antioxidant systems; energy metabolism; lipid metabolism; osmotic stress; drought stress; heat stress; salinity stress; heavy metal stress; crop productivity; stress tolerance; gene expression; proteomics; metabolomics; signaling pathways; transcription factors; reactive oxygen species

(This special issue belongs to the Section Plant Metabolism)

Nutritional Metabolism and Biomarkers in Patients with Inflammatory Bowel Disease

edited by

Małgorzata Godala

submission deadline 25 Jul 2026 | Viewed by 212 | Submission Open

Keywords: inflammatory bowel disease; diet; nutrition; malnutrition; nutritional status assessment; biomarkers; inflammation; metabolites; gut microbiome

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Immune Metabolism: Lipid Regulation and Disease Outcomes

edited by Hui Yang

submission deadline 30 Jul 2026 | 1 articles | Viewed by 419 | Submission Open

Keywords: immune cell; lipid metabolism; immune disease; inflammation; autoimmune; tumour

(This special issue belongs to the Section Lipid Metabolism)

Nutritional Intervention and Metabolic Health: Carbohydrates and Keto Diet

edited by

Louise Lu

submission deadline 30 Jul 2026 | Viewed by 262 | Submission Open

Keywords: metabolic health; carbohydrate metabolism; ketogenic diet; personalized nutrition; glycaemic control; insulin sensitivity; lipid profiles; gut microbiome; nutrient-sensing pathways; epigenetic modifications; personalized postprandial glucose response

(This special issue belongs to the Section Nutrition and Metabolism)

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