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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Puberty and the Metabolic Syndrome

edited by Banu Aydin and Stephen J. Winters

submission deadline 15 Dec 2024 | Viewed by 206 | Submission Open

Keywords: puberty; rapid growth; obesity; insulin resistance; metabolic syndrome; polycystic ovary syndrome; cardiovascular disease; diabetes; gonadotropins; sex hormones; sex hormone binding globulin

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Fertilizer and Industrial Microbial Technology Based on Microbial Metabolites, 2nd Edition

edited by

Nan Gao

submission deadline 15 Dec 2024 | Viewed by 157 | Submission Open

Keywords: new fertilizer; industrial microbial technology; microbial metabolites; metabolic networks; abiotic stress adaption; plant-growth-promoting rhizobacteria

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Molecular Mechanisms in Cancer, Cardiovascular and Metabolic Diseases: Potential Therapies and Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 18 Dec 2024 | 2 articles | Viewed by 3864 | Submission Open

Keywords: molecular mechanisms; cancer; cardiovascular diseases; metabolic diseases; treatments

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 20 Dec 2024 | 5 articles | Viewed by 6437 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Microbial Metabolism and Food Safety

edited by

Wen-Wen Zhou

and

Junhua Han

submission deadline 20 Dec 2024 | 1 articles | Viewed by 2730 | Submission Open

Keywords: biocontrol; food safety; metabolic pathways; metabolites; metabolomics; microbial metabolism; toxin

(This special issue belongs to the Section Food Metabolomics)

Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases

edited by

Marcelo Macedo Rogero

and

Marco Antonio Hernández-Lepe

submission deadline 20 Dec 2024 | 1 articles | Viewed by 1307 | Submission Open

Keywords: metabolism; diseases; bioactive compounds; food; metabolites

(This special issue belongs to the Section Nutrition and Metabolism)

Lipidomic Signatures in Pediatric Metabolic Disorders

edited by

Mónica Narváez-Rivas

submission deadline 20 Dec 2024 | Viewed by 303 | Submission Open

Keywords: lipidomics; lipids; mass spectrometry; pediatric population; therapeutic targets; biomarkers; metabolic disorder

(This special issue belongs to the Section Lipid Metabolism)

Drug Metabolism: Latest Advances and Prospects

edited by

Michel Kranendonk

and Bernardo Brito Palma

submission deadline 30 Dec 2024 | 1 articles | Viewed by 1489 | Submission Open

Keywords: xenobiotic metabolism; drug-metabolizing enzymes; pharmacokinetics/toxicokinetics; pharmacody-namics/toxicodinamics; biotransformation; metabolomics; drug clearance; polymophisms; metabolic profiling; personalized medicine; adverse drug reactions (ADRs); drug-induced liver injury (DILI)

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomics in Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity

edited by

Pengcheng Wang

submission deadline 30 Dec 2024 | Viewed by 412 | Submission Open

Keywords: metabolomics; drug/xenobiotic metabolism; drug– drug interactions; drug toxicity; ADME; new modalities peptides; antibody-drug conjugates; protein therapeutics; oligonucleotide therapeutics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Advanced Metabolomics and Lipidomics Approaches in Studying Human Diseases

edited by

Judith Nzoughet Kouassi

submission deadline 31 Dec 2024 | 9 articles | Viewed by 16405 | Submission Open

Keywords: biomarkers discovery; metabolomics; lipidomics; human diseases; bioinformatics and data analysis; metabolic and molecular networks

(This special issue belongs to the Section Advances in Metabolomics)

Bioactive Metabolites from Natural Sources (2nd Edition)

edited by

Miroslava Zhiponova

and Zhenya P. Yordanova

submission deadline 31 Dec 2024 | 3 articles | Viewed by 7427 | Submission Open

Keywords: primary metabolites; secondary metabolites; nature-based synthetic molecules; molecular mechanisms; models; evolution; food; agriculture; health; in vitro biological activities; in vivo biological activities

(This special issue belongs to the Section Plant Metabolism)

Brain Metabolic Alterations in Neurodegenerative Diseases

edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro

submission deadline 31 Dec 2024 | 1 articles | Viewed by 4586 | Submission Open

Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Nutrition and Metabolism)

Immunoregulatory Metabolites with Clinical Relevance

edited by

Johanna M. Gostner

Bohuslav Melichar

and

Dietmar Fuchs

submission deadline 31 Dec 2024 | 1 articles | Viewed by 3651 | Submission Open

Keywords: immunometabolism; (metabolite) biomarker; immunoregulation; crosstalk of immunity and metabolism; clinical relevance; immunobiochemistry

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

edited by

Boqun Liu

submission deadline 31 Dec 2024 | 2 articles | Viewed by 3469 | Submission Open

Keywords: peptide; absorption; metabolism; structure– function relationships; metabolic pathways

(This special issue belongs to the Section Nutrition and Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 31 Dec 2024 | 1 articles | Viewed by 3414 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Energy Metabolism in Neurodegenerative Diseases

edited by

Marta Tomczyk

and

Magdalena Podlacha

submission deadline 31 Dec 2024 | 1 articles | Viewed by 2292 | Submission Open

Keywords: energy metabolism; neurodegeneration; neurodegenerative disease; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; spinal muscular atrophy; Lewy body disease; multiple sclerosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Recent Developments and Emerging Trends in Metabolic Modelling and Metabolomics

edited by Johnjoe McFadden and

Khushboo Borah Slater

submission deadline 31 Dec 2024 | 1 articles | Viewed by 2262 | Submission Open

Keywords: constraint-based modelling; genome scale models; metabolic flux analysis; metabolomics; infectious disease

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomic Data Analysis in Plant Lipid Metabolism and Lipid Synthesis

edited by

Chengjiang Ruan

and

Jian Ding

submission deadline 31 Dec 2024 | 1 articles | Viewed by 1960 | Submission Open

Keywords: plant lipid; metabolomics; metabolic engineering; metabolic flux analysis; transcriptional regulation; metabolome Genome-Wide Association Study

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 31 Dec 2024 | 1 articles | Viewed by 1830 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management

edited by

Davide Masi

and

Renata Risi

submission deadline 31 Dec 2024 | 2 articles | Viewed by 1445 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Untargeted Profiling of Environmental Chemicals and Their Transformation Metabolites by Mass Spectrometry

edited by Jin Y. Chen

submission deadline 31 Dec 2024 | 2 articles | Viewed by 1334 | Submission Open

Keywords: LC-MS; GC-MS; metabolomics; exposomics; pollutants and xenobiotics; transformation metabolites; environmental samples; biological specimen; in vitro/in vivo experiments

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics of the Eye and Adnexa

edited by

Seher Yuksel

and

Igor A. Butovich

submission deadline 31 Dec 2024 | 1 articles | Viewed by 1125 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; Meibomian gland dysfunction; age-related macular de-generation; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatog-raphy-mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

Integration of Emerging Technologies in Metabolite Analysis

edited by Kumari Ubhayasekera

submission deadline 31 Dec 2024 | 1 articles | Viewed by 1094 | Submission Open

Keywords: liquid chromatography; mass spectrometry; NMR; metabolomics; smaller molecules; supercritical chromatography; gas chromatography

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolic Properties of Microbial Cells or Enzymes

edited by

Wei Zeng

and

Hao Wu

submission deadline 31 Dec 2024 | Viewed by 516 | Submission Open

Keywords: microbial cell; enzyme; metabolic property; metabolites; metabolic engineering; enzyme engineering; synthetic biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 31 Dec 2024 | Viewed by 449 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of the Glutamatergic System on Metabolic Alterations

edited by

Anna Serefko

Aleksandra Szopa

and

Katarzyna Świąder

submission deadline 31 Dec 2024 | Viewed by 419 | Submission Open

Keywords: glutamate; metabolic alternation; central nervous system disorders; preclinical studies; clinical studies; metabolism; glutamate pathways; amino acid; neurotransmitter

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Flexibility and Metabolic Engineering Associated with Health and Diseases

edited by

Maria D. Giron-Gonzalez

and

Rafael Salto-Gonzalez

submission deadline 31 Dec 2024 | Viewed by 415 | Submission Open

Keywords: metabolic flexibility; metabolic inflexibility; exercise; muscle; liver; adipose tissue; insulin resistance; obesity; cancer; metabolic syndrome; early programming

(This special issue belongs to the Section Cell Metabolism)

Metabolomics in Chronic Disease

edited by Xiaoyu Che

submission deadline 31 Dec 2024 | Viewed by 286 | Submission Open

Keywords: metabolomics; chronic diseases; multi-omics; bioinformatics; biomarker discovery; system biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Fat and Glucose Metabolism

edited by

Getachew D. Belew

and John Griffith Jones

submission deadline 31 Dec 2024 | Viewed by 200 | Submission Open

Keywords: nutrient metabolism; energy homeostasis; insulin resistance; diabetes; obesity; MAFLD; metabolic disorders; therapeutic agents

(This special issue belongs to the Section Cell Metabolism)

Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects

edited by

Woojin Kim

submission deadline 31 Dec 2024 | Viewed by 198 | Submission Open

Keywords: chemotherapy-induced side effects; pain; nausea and vomiting; neutropenia

(This special issue belongs to the Section Plant Metabolism)

Metabolic Programming of Hepatic Organ Function—2nd Edition

edited by

Philipp Kasper

submission deadline 31 Dec 2024 | Viewed by 133 | Submission Open

Keywords: metabolism; liver; early life environment; developmental programming; epigenetics; metabolic syndrome; obesity; metabolic-dysfunction-associated fatty liver disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Exercise on Cardiooncology and Cancer Metabolism

edited by Darpan I. Patel

submission deadline 4 Jan 2025 | Viewed by 267 | Submission Open

Keywords: exercise; physical activity; yoga; tai chi; metabolism; cardiooncology; cardiotoxicities; obesity; metabolism syndrome; metabolomics; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity and Metabolic Health

edited by

Natalia Ferreira Mendes

and Eliana Pereira De Araújo

submission deadline 5 Jan 2025 | Viewed by 414 | Submission Open

Keywords: glial cells; blood– brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy me-tabolism; food intake; brown adipose tissue; leptin; insulin resistance; bioactive compounds; epige-netics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Lipids in Neuroinflammatory Diseases

edited by

Alessandro Leuti

and

Giorgio Vivacqua

submission deadline 10 Jan 2025 | 1 articles | Viewed by 2352 | Submission Open

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics in Plant Natural Products Research

edited by

Junsong Wang

submission deadline 15 Jan 2025 | 3 articles | Viewed by 5331 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Advanced Metabolic Profiling via Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry

edited by

Ana Margarida Araújo

submission deadline 15 Jan 2025 | 1 articles | Viewed by 1306 | Submission Open

Keywords: chromatographic methods; mass spectrometry techniques; metabolic profiling; methodological advancements; biomarker discovery; environmental monitoring; food safety and quality; clinical diagnosis; drug development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics and Computational Research on Drugs and Diseases

edited by

Md. Altaf-Ul-Amin

Shigehiko Kanaya

, Naoaki Ono and

Ahmad Kamal Nasution

submission deadline 15 Jan 2025 | 1 articles | Viewed by 1157 | Submission Open

Keywords: metabolomics; natural products; computational research; drug discovery; disease diagnosis; disease mechanisms; machine learning algorithms

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Insights into Pediatric Overweight and Obesity: Mechanisms, Impacts and Interventions

edited by Anca Balanescu and

Bogdan Pascu

submission deadline 15 Jan 2025 | Viewed by 749 | Submission Open

Keywords: childhood obesity; metabolic syndrome in children; insulin resistance; MAFLD; metabolic healthy obesity; metabolic unhealthy obesity; sarcopenic obesity in children; biomarkers; metabolic pathways; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Metabolism Disorders in Obesity

edited by

Klaudia Sztolsztener

and

Elzbieta Supruniuk

submission deadline 15 Jan 2025 | Viewed by 194 | Submission Open

Keywords: fatty liver diseases; overweight and obesity; cardiometabolic risks; lipid metabolism; metabolic syndrome; adipose tissue

(This special issue belongs to the Section Lipid Metabolism)

Application of Metabolomics to Study Osteoarticular Diseases

edited by

Nury Pérez-Hernández

submission deadline 15 Jan 2025 | Viewed by 186 | Submission Open

Keywords: metabolomics; nuclear magnetic resonance; mass spectrometry; osteoarticular diseases; dysregulated metabolism

(This special issue belongs to the Section Integrative Metabolomics)

Non-nutritive Sweeteners: Friend or Foe

edited by

Junrui Cheng

submission deadline 15 Jan 2025 | Viewed by 117 | Submission Open

Keywords: non-nutritive sweetener; foods; digestive health; metabolic health

(This special issue belongs to the Section Food Metabolomics)

Epidemiology, Nutrition and Metabolism, 2nd Edition

edited by

and

submission deadline 25 Jan 2025 | 1 articles | Viewed by 1729 | Submission Open

Keywords: nutrition; epidemiology; dietary intake; foods; micronutrients; biomarkers; metabolism

(This special issue belongs to the Section Nutrition and Metabolism)

Targeting Microbiota and Metabolites for Prevention and Treatment of Human Diseases

edited by

Zhipeng Tao

and

Danhui Wang

submission deadline 31 Jan 2025 | 4 articles | Viewed by 6098 | Submission Open

Keywords: microbiota; metabolites; metabolic diseases; cancer; cardiovascular diseases; liver diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Drug Metabolism and New Drug Development for Cancers

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 31 Jan 2025 | 3 articles | Viewed by 4023 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 31 Jan 2025 | 1 articles | Viewed by 782 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Responses to Abiotic Stress in Plants: Latest Advances and Prospects

edited by

Ghulam Hasnain

submission deadline 31 Jan 2025 | 1 articles | Viewed by 593 | Submission Open

Keywords: abiotic stress; plant metabolism; compatible solutes; antioxidant systems; energy metabolism; lipid metabolism; osmotic stress; drought stress; heat stress; salinity stress; heavy metal stress; crop productivity; stress tolerance; gene expression; proteomics; metabolomics; signaling pathways; transcription factors; reactive oxygen species

(This special issue belongs to the Section Plant Metabolism)

The Role of Hepatic Insulin Clearance in Obesity and Type 2 Diabetes

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 31 Jan 2025 | Viewed by 458 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Diet on Metabolic Health of Obese People

edited by

Magdalena Górnicka

Marta Jeruszka-Bielak

and Irena Keser

submission deadline 31 Jan 2025 | Viewed by 331 | Submission Open

Keywords: diet; dietary pattern; bioactive food compounds; body composition; nutrition-related biomarkers; metabolites; metabolic disorders; obesity

(This special issue belongs to the Section Nutrition and Metabolism)

Cell Death and Cancer Metabolism

edited by

Zhengrong Yuan

submission deadline 31 Jan 2025 | Viewed by 260 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor growth; metabolic biomarkers; therapeutic strategies; metabolic regulation; cancer treatment

(This special issue belongs to the Section Cell Metabolism)

The Roles of Diet, Gut Microbiome and Microbial Metabolome in Precision Nutrition

edited by Renny S. Lan and

Jiangjiang Zhu

submission deadline 31 Jan 2025 | Viewed by 252 | Submission Open

Keywords: metabolomics; gut microbiome; precision nutrition; diet; integration; integrative; lipidomic; person-alized nutrition; probiotics; prebiotics; microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

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