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Data

Data is a peer-reviewed, open access journal on data in science, with the aim of enhancing data transparency and reusability.
The journal publishes in two sections: a section on the collection, treatment and analysis methods of data in science; a section publishing descriptions of scientific and scholarly datasets (one dataset per paper). The journal is published monthly online by MDPI.
Quartile Ranking JCR - Q2 (Multidisciplinary Sciences)

All Articles (1,273)

  • Data Descriptor
  • Open Access

The aryl hydrocarbon receptor (AhR) plays a crucial role in mediating xenobiotic responses, as well as regulating broader metabolic, differentiation, and stress response programs. In this study, we present a comprehensive long-read RNA sequencing dataset that examines transcriptional changes in the HepaRG human cell line during differentiation induced by dimethyl sulfoxide (DMSO) and acute activation of the AhR with 3-methylcholanthrene (3-MC). We identified 946 genes that were differentially expressed between the NonDiff and Diff conditions (303 genes upregulated and 643 genes downregulated), and 1786 genes that showed differential expression between Diff and Ind conditions (961 genes upregulated and 825 genes downregulated). The acute induction of 3-MC produced a robust AhR signature, characterized by the robust induction of CYP1A1 and CYP1B1, along with a coordinated downregulation of several constitutive hepatic genes involved in drug metabolism (e.g., CYP3A4 and CYP2C8). To facilitate further analysis and reuse of our data, we have provided processed gene-level count matrices, transcript per million (TPM) tables, and detailed differential expression results, as well as analysis scripts. This resource supports research into AhR biology, pharmacogene regulation, and the development of methods for long-read transcriptomics in liver models.

29 December 2025

Verification of HepaRG cell differentiation. (A,B) Morphology of HepaRG cells. (A) Proliferative phase. (B) Cells during induction of differentiation. Differentiated (hepatocyte-like) cells are marked with the letter “H”; cells that retain the epithelial phenotype are marked with “E”. Scale bar: 50 μm. (C) Relative mRNA expression of differentiation-related genes ALB, CYP3A4, and CYP2E1. NonDiff—undifferentiated proliferating cells, FC—full confluence (prior to DMSO treatment), and Diff—differentiated cells. Error bars indicate standard error of the mean. * p < 0.05, ** p < 0.01, and **** p < 0.0001 compared to NonDiff.
  • Data Descriptor
  • Open Access

Behavioral and educational researchers increasingly rely on rich datasets that capture how students respond to technology-enhanced instruction, yet few open resources document the full pipeline from experimental design to data curation in authentic classroom settings. This data descriptor presents a clustered quasi-experimental dataset on the impact of an instructional architecture that combines virtual reality (VR) simulations with artificial intelligence (AI)-driven formative feedback to enhance undergraduate students’ communication and problem-solving performance. The study was conducted at a large private university in Mexico during the 2024–2025 academic year and involved six intact classes (three intervention, three comparison; n = 180). Exposure to AI and VR was operationalized as a session-level “dose” (minutes of use, number of feedback events, number of scenarios, perceived presence), while performance was assessed with analytic rubrics (six criteria for communication and seven for problem solving) scored independently by two raters, with interrater reliability estimated via ICC (2, k). Additional Likert-type scales measured presence, perceived usefulness of feedback and self-efficacy. The curated dataset includes raw and cleaned tabular files, a detailed codebook, scoring guides and replication scripts for multilevel models and ancillary analyses. By releasing this dataset, we seek to enable reanalysis, methodological replication and cross-study comparisons in technology-enhanced education, and to provide an authentic resource for teaching statistics, econometrics and research methods in the behavioral sciences.

2 January 2026

  • Data Descriptor
  • Open Access

Forests provide a wide range of ecosystem services, and their importance in supporting human well-being is widely recognized. As goods and benefits from forests are exhaustible, it is therefore essential to gather sound data for their monitoring and management. Remote sensing has gained increasing importance in collecting data on forests, driven by the growing demand for regularly updated environmental data. However, remote sensing modeling of vegetation requires reference data to be collected in the field. This article presents a dataset on tree crown cover—both total and by species—of 528 georeferenced forest plots located in the Eastern Alps, Italy, an area affected by extensive wind and snow damage and subsequent widespread damage caused by bark beetles. The characteristic species of the forest types in the dataset are widely distributed over the Eurasian continent, making the dataset potentially useful to many users and researchers studying forest biodiversity or remote sensing applications to monitor forest cover changes. Data were collected within a still ongoing project aimed at detecting crown cover changes in small forest patches.

1 January 2026

  • Data Descriptor
  • Open Access

Seasonal Trap Captures Data of Stink and Leaf-Footed Bugs in a Northern Italian Ecosystem

  • Vito Antonio Giannuzzi,
  • Valeria Rossi and
  • Rihem Moujahed
  • + 7 authors

An essential first step to implement a control strategy against herbivorous insects is the monitoring of their populations. The efficacy of pheromone-based traps in capturing herbivorous insects can be enhanced by adding adjuvants and using slow-release dispensers to ensure long-lasting attractiveness. Here, we present datasets from a two-year field monitoring campaign of the invasive brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), using clear sticky traps baited with its aggregation pheromone and a synergist, tested towards different dispensers and adjuvants. Bycatch data for native stink bugs (all Hemiptera: Pentatomidae) and leaf-footed bugs (Hemiptera: Coreidae) are also presented. The R code provided was used to organize data and generate weekly captures or weekly density of both H. halys and non-target species. The information provided in this article may contribute to the optimization of pest control strategies in agriculture.

24 December 2025

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Data Mining and Computational Intelligence for E-learning and Education
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Data Mining and Computational Intelligence for E-learning and Education

Editors: Antonio Sarasa Cabezuelo, Ramón González del Campo Rodríguez Barbero
Recent Advances and Applications in Partial Least Squares Structural Equation Modeling (PLS-SEM)
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Recent Advances and Applications in Partial Least Squares Structural Equation Modeling (PLS-SEM)

Editors: María del Carmen Valls Martínez, José-María Montero, Pedro Antonio Martín Cervantes

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Data - ISSN 2306-5729