Journal Description
Psychiatry International
Psychiatry International
is an international, peer-reviewed, open access journal on psychiatric research and practice, published bimonthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within ESCI (Web of Science), Scopus, EBSCO, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 27.6 days after submission; acceptance to publication is undertaken in 7.5 days (median values for papers published in this journal in the first half of 2026).
- Recognition of Reviewers: APC discount vouchers, optional signed peer review, and reviewer names published annually in the journal.
- Journal Cluster of Neurosciences: Brain Sciences, Neurology International, NeuroSci, Clinical and Translational Neuroscience, Neuroimaging, Neuroglia, Psychiatry International, Clocks & Sleep and Journal of Dementia and Alzheimer's Disease.
Impact Factor:
1.8 (2025);
5-Year Impact Factor:
1.6 (2025)
Latest Articles
Performance-Based Personality Functioning and Long-Term Outcome in Hospitalized Women with Depression: A Four-Year Follow-Up
Psychiatry Int. 2026, 7(4), 160; https://doi.org/10.3390/psychiatryint7040160 - 16 Jul 2026
Abstract
Background: Depression is among the most prevalent psychiatric conditions and markedly disrupts everyday functioning. Its origins are multifactorial, with biological, psychological, and contextual influences jointly shaping the course of recovery and the response to treatment. Personality has been proposed as a relatively stable
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Background: Depression is among the most prevalent psychiatric conditions and markedly disrupts everyday functioning. Its origins are multifactorial, with biological, psychological, and contextual influences jointly shaping the course of recovery and the response to treatment. Personality has been proposed as a relatively stable factor that may reflect developmental influences on emotional and cognitive functioning and may be associated with long-term clinical outcomes in depression. The present study aimed to examine the association between implicit personality characteristics in women hospitalized for depressive disorder and their long-term psychosocial functioning, using a performance-based measure of personality (the Rorschach Inkblot Method, RIM). Subjects and Methods: At baseline (T1), 58 women hospitalized for depressive disorder completed the Beck Depression Inventory (BDI-II) and the Rorschach Inkblot Method (RIM); Rorschach protocols were scored using the Ego Impairment Index—second revision (EII-2), a behaviorally derived index spanning perceptual accuracy, executive integrity, and social cognition. Demographic and clinical information was abstracted from medical records, and an independent rating of functioning was obtained with the Global Assessment of Functioning scale (GAF). Four years later (T2), patients were re-administered the BDI-II and the GAF, and major life events occurring during the follow-up interval were quantified with the Social Readjustment Rating Scale (SRRS). Results: Baseline implicit personality organization showed a significant association with psychosocial functioning four years after the index hospitalization. Among the variables examined, personality structure at admission outperformed both initial depressive symptom severity and the burden of intervening life events in predicting later functional status. In particular, EII-2 accounted for an additional 10.3% of the variance (ΔR2 = 0.103, p < 0.05) over and above age, chronicity, stress, and depressive symptom severity when predicting four-year GAF-rated functioning. Among the predictors examined, age was the most influential variable in the final model (β = 0.442), indicating that demographic factors carry substantial weight alongside personality functioning in shaping long-term outcomes. Conclusions: Our findings are consistent with the view that a patient’s personality may influence the course of recovery and suggest that personality-level factors deserve attention when planning care for this clinically complex disorder. The present results indicate that implicit cognitive–perceptual features—assessed through performance-based methods that bypass conscious self-report—may be associated with long-term psychosocial functioning in women hospitalized for depression. These findings suggest that performance-based personality assessment deserves further study as a potential prognostic aid, although replication in larger and more diverse samples is needed before clinical application.
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(This article belongs to the Special Issue Advances in Developmental Neuroscience and Psychiatry: Integrating Cognitive Science and Mental Health)
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Machine Learning-Assisted Identification of Biomarkers Associated with Schizotypal and Cyclothymic Traits
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Sabine Finlay, Gideon Vos, Imre Földesi, Diána Kata, Oyelola Adegboye, Donna Rudd, Brett McDermott, István Szendi, Mostafa Rahimi Azghadi and Zoltan Sarnyai
Psychiatry Int. 2026, 7(4), 159; https://doi.org/10.3390/psychiatryint7040159 - 15 Jul 2026
Abstract
Introduction: Schizotypal traits (unusual perceptual experiences and cognitive-perceptual differences) and cyclothymic traits (mood instability and affective fluctuations) represent subclinical personality dimensions observed in non-clinical populations. Allostatic load (AL), reflecting cumulative multisystem physiological stress, may provide insight into biological processes associated with these traits.
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Introduction: Schizotypal traits (unusual perceptual experiences and cognitive-perceptual differences) and cyclothymic traits (mood instability and affective fluctuations) represent subclinical personality dimensions observed in non-clinical populations. Allostatic load (AL), reflecting cumulative multisystem physiological stress, may provide insight into biological processes associated with these traits. This study examined whether individuals with elevated schizotypy or cyclothymic traits show distinct AL-related biomarker patterns. Methods: Three groups were defined using validated psychometric measures: 30 individuals with schizotypy traits (PSF), 25 with cyclothymic traits (CF), and 30 control participants (CGs). Machine learning (ML) analyses included a Random Forest model with leave-one-subject-out cross-validation to examine differences in biomarker profiles between groups, and Shapley Additive exPlanations (SHAP) analysis was applied to determine the relative importance of biomarkers. The highest-ranking biomarkers were subsequently used to construct a reduced AL index. Results: Significant differences among groups were observed in oxidative stress system markers (p = 0.014). SHAP analysis identified creatinine, diastolic blood pressure, uric acid, and low-density lipids as key features for the CF group, and heart rate, TSH, uric acid, and glucose for the PSF group, with uric acid emerging as the strongest shared biomarker. A reduced biomarker panel selected using SHAP achieved subject-level classification accuracy of 63.6% (95% CI 50.9–76.4) and AUC of 0.625 (95% CI 0.469–0.768) and showed comparable performance to the full model. However, label-permutation testing yielded a borderline result (p = 0.055), indicating that these findings should be considered exploratory. The AL index derived from the top-ranked biomarkers was significantly lower in the CF than in the CG group (p = 0.007), whereas differences between the PSF and CG groups did not remain significant after correction. Findings are exploratory and require validation in an independent cohort. Conclusions: Distinct biomarker patterns associated with schizotypal and cyclothymic traits were identified in a non-clinical population, highlighting differences in stress-related physiological processes. ML-based feature-importance analysis identified a reduced set of biomarkers associated with trait-related biological profiles; however, these findings remain exploratory and require external validation.
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(This article belongs to the Special Issue Artificial Intelligence in Mental Health and Psychiatry: Methods, Applications and Implications)
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Short-Latency Changes in Closed-Eye EOG Following Medication Intake in ADHD
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Malthe Brændholt and Stefan Bjerrum
Psychiatry Int. 2026, 7(4), 158; https://doi.org/10.3390/psychiatryint7040158 - 15 Jul 2026
Abstract
Background: Optimising medication for Attention Deficit Hyperactivity Disorder (ADHD) is often hindered by the lack of practical physiological indicators that can inform treatment effects. Electrooculography (EOG) has been suggested as a low-burden marker of neurophysiological processes relevant to ADHD, but its responsiveness to
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Background: Optimising medication for Attention Deficit Hyperactivity Disorder (ADHD) is often hindered by the lack of practical physiological indicators that can inform treatment effects. Electrooculography (EOG) has been suggested as a low-burden marker of neurophysiological processes relevant to ADHD, but its responsiveness to medication within routine clinical settings is not well established. Methods: We analysed anonymised clinical records from adults with ADHD receiving stable, ongoing medication who underwent closed-eye EOG recordings immediately before and after taking their scheduled dose during standard consultations. Recordings were obtained using clinical EEG equipment. Heart rate and blood pressure, measured after each EOG session, were included as contextual indices of physiological state. Pre–post changes were assessed using paired t-tests and binomial tests, with effect sizes and confidence intervals reported for the main pre–post comparisons, with Pearson correlations used to evaluate associations between EOG and cardiovascular measures. Results: Both mean and peak EOG power showed consistent within-session reductions, with the majority of individuals exhibiting a decrease across measures. Cardiovascular parameters showed no systematic pre–post change, and differences in cardiovascular measures did not correlate with changes in EOG activity. Conclusions: Closed-eye EOG showed systematic within-session modulation in adults with ADHD on stable treatment. These preliminary findings suggest that EOG is sensitive to short-latency physiological changes occurring within a clinical timeframe. However, the present design does not establish pharmacological specificity, and further controlled studies are needed to determine whether such changes are specifically medication related and whether they have relevance for treatment monitoring and titration.
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(This article belongs to the Section Clinical Neurobiology, Precision Psychiatry and Artificial Intelligence)
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Academic Procrastination and Anxiety as Predictors of Social Media Addiction in Peruvian University Students
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Liliana Haro Sánchez, Ysabel Yvonne Marquez Rondan, Mónica Graciela Palacios Poma, Isaac Alex Conde Rodríguez, Carlos D. Abanto-Ramírez and Josué E. Turpo-Chaparro
Psychiatry Int. 2026, 7(4), 157; https://doi.org/10.3390/psychiatryint7040157 - 15 Jul 2026
Abstract
The study sought to examine the relationship between procrastination and anxiety as predictors of social media addiction among Peruvian university students. The research employed a cross-sectional predictive methodological design. A sample of 335 students, aged 21 to 69 years, comprising both females and
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The study sought to examine the relationship between procrastination and anxiety as predictors of social media addiction among Peruvian university students. The research employed a cross-sectional predictive methodological design. A sample of 335 students, aged 21 to 69 years, comprising both females and males from private and public university management, was selected through non-probabilistic sampling. The instruments utilized included the Social Media Addiction Questionnaire, the Academic Procrastination Scale, and General Anxiety Disorder-7 (GAD-7). The findings indicated that anxiety (β = 0.52, p < 0.001) and academic procrastination (β = 0.17, p = 0.040) significantly predicted social media addiction. The study concluded that there is a significant relationship between procrastination and anxiety as predictors of social media addiction in Peruvian university students.
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Open AccessArticle
Associations Between Big Five Personality Traits and Psychological Well-Being Among Polish Medical Students: A Cross-Sectional Study
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Maria Monika Nowosadko, Piotr Przymuszała, Aleksandra Jędryszek, Patrycja Marciniak-Stępak and Michał Nowicki
Psychiatry Int. 2026, 7(4), 156; https://doi.org/10.3390/psychiatryint7040156 - 15 Jul 2026
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Background: Medical training is characterized by high academic demands, repeated performance evaluation, and sustained exposure to emotionally demanding situations. Although medical student distress has been widely investigated, fewer studies have examined how broad personality traits relate to multidimensional, eudaimonic psychological well-being (PWB), particularly
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Background: Medical training is characterized by high academic demands, repeated performance evaluation, and sustained exposure to emotionally demanding situations. Although medical student distress has been widely investigated, fewer studies have examined how broad personality traits relate to multidimensional, eudaimonic psychological well-being (PWB), particularly in Central and Eastern European medical student populations. This study examined associations between Big Five personality traits and Ryff’s PWB dimensions among Polish medical students. Methods: A cross-sectional, anonymous paper-and-pencil survey was conducted among 169 Polish medical students. Personality was assessed using the Polish adaptation of the NEO Five-Factor Inventory (NEO-FFI), and PWB was measured using the 84-item Ryff Psychological Well-Being Scales. Descriptive statistics, reliability analyses, normality checks, and bivariate Spearman correlations were used. Results: The global PWB total score was 352.69 (SD = 45.55; observed range 235–450). Among PWB domains, the highest mean score was observed for personal growth (M = 62.86, SD = 8.04), followed by purpose in life (M = 61.76, SD = 10.31), positive relations with others (M = 61.25, SD = 10.94), self-acceptance (M = 57.00, SD = 11.67), autonomy (M = 55.85, SD = 10.58), and environmental mastery (M = 53.97, SD = 10.03). Internal consistency was acceptable to excellent for all PWBS domains (Cronbach’s alpha = 0.796–0.906). Neuroticism was negatively associated with all PWB domains, most strongly with environmental mastery (rho = −0.620) and self-acceptance (rho = −0.618). Conscientiousness was strongly positively associated with environmental mastery (rho = 0.627) and purpose in life (rho = 0.570). Extraversion showed positive associations with self-acceptance, positive relations, environmental mastery, purpose in life, and personal growth. Openness was positively associated with personal growth and negatively associated with environmental mastery, whereas Agreeableness was positively associated with self-acceptance, positive relations, and personal growth, but negatively associated with autonomy. Conclusions: Big Five traits showed domain-specific associations with PWB among Polish medical students. The findings support a differentiated, trait-informed perspective on student well-being, but the cross-sectional design precludes causal inference. Future longitudinal and multi-center studies should clarify temporal relationships and evaluate whether universal or optional well-being supports are differentially useful for students with distinct personality profiles.
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Antistreptolysin O Titers, Symptom Burden, and Multidimensional Correlates in Children with Suspected Streptococcal-Associated Neuropsychiatric Presentations: A Cross-Sectional Observational Study in a Clinically Referred Cohort
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Cristina-Gabriela Schiopu, Cristina Elena Dobre, Ovidiu Alexinschi, Dan-Catalin Oprea, Alexandra Boloș, Oriana-Maria Onicescu, Carmen Gabriela Lupusoru, Adriana Gurbet, Marcel-Alexandru Gaina and Cristinel Stefanescu
Psychiatry Int. 2026, 7(4), 155; https://doi.org/10.3390/psychiatryint7040155 - 14 Jul 2026
Abstract
Pediatric acute-onset neuropsychiatric presentations occurring in the context of prior streptococcal exposure remain clinically important but diagnostically inconclusive, particularly at the interface between Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). This cross-sectional observational study examined
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Pediatric acute-onset neuropsychiatric presentations occurring in the context of prior streptococcal exposure remain clinically important but diagnostically inconclusive, particularly at the interface between Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). This cross-sectional observational study examined whether serological, psychometric, and electroencephalographic findings converged within a clinically referred pediatric psychiatric cohort at the index assessment. Children and adolescents evaluated for neuropsychiatric symptoms in the context of caregiver- or record-supported history suggestive of prior streptococcal exposure were recruited over a 12-month period through inpatient and outpatient child psychiatric services. Out of 154 screened cases, 96 with analyzable index assessment data were retained and stratified by antistreptolysin O (ASO) status. Symptom burden was quantified using the Pediatric Acute-onset Neuropsychiatric Syndrome 31-Item Symptom Rating Scale (PANS-31) which was treated primarily as a continuous dimensional outcome and examined in relation to ASO titers, time since the last reported streptococcal infection, electroencephalography (EEG) findings, and selected developmental and clinical-history variables. Higher ASO values were associated with greater PANS-31 symptom burden, whereas a shorter interval since the last reported streptococcal infection was associated with both higher ASO titers and higher symptom scores. PANS-31 showed good total scale internal consistency and meaningful domain-level convergence with age-appropriate Child Symptom Inventory-4 (CSI-4) and Adolescent Symptom Inventory-4 (ASI-4) domains. Exploratory within-cohort stratification using an operational PANS-31 threshold and alternative post hoc thresholds suggested that higher symptom burden subgroups were largely confined to the ASO-positive stratum; however, these threshold-based patterns were interpreted descriptively and not as diagnostic performance or predictive classification. These findings do not support a disease-specific biomarker model, but suggest that higher anti-streptococcal serology, more recent streptococcal exposure, and greater neuropsychiatric burden may cluster as a clinically interpretable association pattern in a selected real-world psychiatric sample.
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(This article belongs to the Section Developmental Psychiatry and Early-Life Mental Health)
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Postpartum Depression and Anxiety Co-Occurrence Among Birthing and Non-Birthing Caregivers: Evidence and Implications from a Family Systems Perspective
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Ellen Keefe, Robin Neuhaus, Shana DeVlieger and Erin O’Connor
Psychiatry Int. 2026, 7(4), 154; https://doi.org/10.3390/psychiatryint7040154 - 14 Jul 2026
Abstract
Though perinatal mental health has been frequently examined in the context of maternal depression, research has minimally explored the degree to which a partner’s perinatal mental diagnosis influences perinatal mood and anxiety disorder incidence. Drawing on Bowen’s Family Systems Theory, we examine co-occurring
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Though perinatal mental health has been frequently examined in the context of maternal depression, research has minimally explored the degree to which a partner’s perinatal mental diagnosis influences perinatal mood and anxiety disorder incidence. Drawing on Bowen’s Family Systems Theory, we examine co-occurring symptoms of postpartum depression and anxiety (PPD/A) and support dynamics within couples through a cross-sectional mixed-methods study. In the summer of 2024, birthing and non-birthing caregivers (n = 907) across the United States completed a survey including a modified Edinburgh Postnatal Depression Scale (EPDS) and additional questions about partner support, screening, and communication. Post-survey interviews (n = 17) revealed further insight into the relational dynamics of co-occurring PPD/A symptoms among couples. Survey analyses indicated correlations between birthing and non-birthing partner experiences of PPD/A. Further, co-occurrence was associated with diminished emotional support and increased distress for birthing parents. Participants who desired more partner support or felt afraid to express their feelings had significantly higher EPDS scores. Qualitative findings reinforced these patterns, highlighting the roles of relational strain, gender norms, and lack of systemic support for perinatal mental health. Findings suggest couple-based screening practices and interventions that recognize the bidirectional emotional impact of PPD/A may hold promise for improving outcomes across the entire family system.
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(This article belongs to the Section Clinical Psychiatry and Psychotherapy)
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Exploring the Interface Between Gamma Oscillations and Psychological Resilience: A Multimodal EEG Pilot Study
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Damian Rocks, Christopher Sharpley and Ian Evans
Psychiatry Int. 2026, 7(4), 153; https://doi.org/10.3390/psychiatryint7040153 - 10 Jul 2026
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While psychological resilience (PR) is critical for adaptive stress responses, its neurophysiological substrates remain unclear. Given that gamma activity (30–130 Hz) is implicated in the sensory integration and cognitive control necessary for emotion regulation, this study utilized multimodal EEG and psychometric assessments (
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While psychological resilience (PR) is critical for adaptive stress responses, its neurophysiological substrates remain unclear. Given that gamma activity (30–130 Hz) is implicated in the sensory integration and cognitive control necessary for emotion regulation, this study utilized multimodal EEG and psychometric assessments (N = 100) to evaluate resting-state eyes-open (EO) and eyes-closed (EC) oscillatory dynamics in three experimental stages. Resilience was quantified using the Connor–Davidson Resilience Scale (CDRISC-25). Following a hierarchical signal-discovery protocol, a whole-head survey was conducted to identify sites of interest, providing independent data for hypothesis formation. Following rigorous artifact control (EOG-verified ICA; 90% mean epoch retention) and statistical adjustment for multiple comparisons (Benjamini–Hochberg FDR), a robust spectral cluster was identified at the left frontopolar site (FP1), showing consistent inverse correlations with resilience across 30–50 Hz, 50–70 Hz, and 70–90 Hz sub-bands (all p FDR = 0.043). Crucially, findings were strictly lateralized, with the adjacent FP2 site remaining non-significant. Results highlight a lateralized neurophysiological signature of resilience at the left frontal pole, arguing against diffuse myogenic contamination. Next, source localization (eLORETA) and functional connectivity (Lagged Linear Coherence) were utilized to characterize spatial dynamics. Source analysis revealed noteworthy activity near the left anterior cingulate and medial prefrontal cortex. Furthermore, functional connectivity analysis showed significant coherence correlates across nodes linked with the default mode network (DMN). Notably, the 70–90 Hz sub-band emerged as a consistent correlate across all three experimental stages. Prioritizing statistical parsimony over complex mediation, these preliminary, hypothesis-generating findings suggest that site-dependent and frequency-specific gamma activity may provide neurophysiological insight toward adaptive flexibility. In particular, the 30–90 Hz spectral cluster at the left frontopolar region appears to be associated with the resting-state profile of resilient individuals in complex, as-yet-unspecified ways. These pilot data suggest further investigation is warranted, potentially providing a foundational target for future longitudinal research into the oscillatory signatures of adaptive flexibility.
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Development and Preliminary Evaluation of a Behavior-Analytic Family Intervention for Adolescents with Anorexia Nervosa and Their Parents: A Four-Case Series
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Felipe Alckmin Carvalho, Guilherme Welter Wendt, Iara Teixeira, Maria Cristina Triguero Veloz Teixeira and Márcia Helena da Silva Melo
Psychiatry Int. 2026, 7(4), 152; https://doi.org/10.3390/psychiatryint7040152 - 9 Jul 2026
Abstract
Anorexia nervosa (AN) in adolescence is associated with substantial morbidity and complex family processes. Family-based approaches are the best-established psychosocial treatments, but remission rates remain modest and broader family and emotional processes are often only partly addressed. This case series describes the development
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Anorexia nervosa (AN) in adolescence is associated with substantial morbidity and complex family processes. Family-based approaches are the best-established psychosocial treatments, but remission rates remain modest and broader family and emotional processes are often only partly addressed. This case series describes the development and preliminary evaluation of a behavior-analytic family intervention combining parent-led refeeding with structured work on parental socioemotional and educational skills. Eight families were screened, five entered treatment, and four completed a 20-session outpatient protocol delivered weekly over approximately six months, with assessments at baseline, post-treatment, and three-month follow-up. Outcomes included anthropometric indicators, menstrual status, eating-disorder psychopathology, adolescent and caregiver functioning, parenting style, perceived family support, and parent satisfaction. Among completer families, attendance was 100%. Mean BMI increased from 16.72 at baseline to 18.91 post-treatment and 19.03 at follow-up; mean EDE-Q total score decreased from 4.25 to 1.40 and 0.73, respectively. All four adolescents achieved physiological remission and reliable EDE-Q improvement by follow-up; three also met multidimensional remission criteria. The intervention was feasible, acceptable, and clinically promising, but larger studies with independent assessment and comparison conditions are needed.
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(This article belongs to the Special Issue Advances and Innovations in Child and Adolescent Mental Health)
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Academic Motivation of Canadian Undergraduate Students: Mental Health, Sociodemographic and COVID Predictors
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Max J. Marshall, Kesaan Kandasamy and Lixia Yang
Psychiatry Int. 2026, 7(4), 151; https://doi.org/10.3390/psychiatryint7040151 - 8 Jul 2026
Abstract
In the context of the COVID-19 pandemic, the relationship between academic motivation and mental health remains unclear among Canadian undergraduate students. This study examined associations between academic motivation and mental health, sociodemographic, and COVID-related factors in Canadian undergraduate students during the period of
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In the context of the COVID-19 pandemic, the relationship between academic motivation and mental health remains unclear among Canadian undergraduate students. This study examined associations between academic motivation and mental health, sociodemographic, and COVID-related factors in Canadian undergraduate students during the period of returning back to in-person learning (third stage of the pandemic from January–March 2022). A sample of 1868 undergraduates across British Columbia, Ontario, and Quebec completed a cross-sectional online survey in Winter 2022. Regression models revealed that depression was associated with lower academic motivation (βs ≥ 0.12, ps < 0.001), whereas stress and resilience were associated with higher academic motivation (βs ≥ 0.07, ps ≤ 0.001), controlling for related sociodemographic or COVID-related factors. Results also identified some sociodemographic (e.g., year of study, gender, English as first language status) and COVID-related factors (e.g., preference for in-person vs. online learning) for academic motivation. Results highlight factors associated with the academic motivation of students when returning back to in-person learning.
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(This article belongs to the Section Mental Health)
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Emotion Regulation Difficulties and Coping Strategies in Substance Use Disorders: Effects of Severity, Impulsivity, and Social Support in a Clinical Sample
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Cornelia Rada and Robert-Andrei Lunga
Psychiatry Int. 2026, 7(4), 150; https://doi.org/10.3390/psychiatryint7040150 - 7 Jul 2026
Abstract
(1) Background. Substance use disorders are frequently associated with difficulties in emotion regulation and the use of ineffective coping strategies. (2) Methods. A total of 201 participants undergoing specialized treatment for substance use disorders in Romania completed the Difficulties in Emotion Regulation Scale
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(1) Background. Substance use disorders are frequently associated with difficulties in emotion regulation and the use of ineffective coping strategies. (2) Methods. A total of 201 participants undergoing specialized treatment for substance use disorders in Romania completed the Difficulties in Emotion Regulation Scale (DERS) and the Strategic Approach to Coping Scale (SACS). Statistical analyses included independent samples t-tests, Pearson correlations, path analysis, and linear regression. (3) Results. Participants with more severe substance use (history of hospitalization, detoxification treatment, and polysubstance use) exhibited significantly higher levels of emotion regulation difficulties. The latent factor DIFFICULTY was predicted by two correlated SACS predictors: Assertive Action (AA) and Antisocial Action (AS). Substance type differentially influenced DERS dimensions. The strongest correlation with the total DERS score was observed for antisocial action. (4) Conclusions. Emotion regulation and coping optimization are key targets in the treatment of substance use disorders, reflecting persistent difficulties in effectively managing emotions despite cognitive awareness. Social support may function as both an adaptive and maladaptive mechanism in this clinical context.
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(This article belongs to the Section Addiction Psychiatry)
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Relationship Between Salivary Cortisol and Psychological Scales in the Stress Assessment of Shift Workers: A Narrative Review
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Yuka Kumagai, Naoko Kudo, Tomomi Suda, Yoshimi Narita and Masato Yoshioka
Psychiatry Int. 2026, 7(4), 149; https://doi.org/10.3390/psychiatryint7040149 - 7 Jul 2026
Abstract
Background/Objectives: Cortisol, a stress-related protein found in saliva, is occupying an increasingly crucial role in stress research. While stress was previously assessed solely using psychological scales, the addition of cortisol as a biomarker has enabled more accurate stress assessment. Previously, stress among shift
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Background/Objectives: Cortisol, a stress-related protein found in saliva, is occupying an increasingly crucial role in stress research. While stress was previously assessed solely using psychological scales, the addition of cortisol as a biomarker has enabled more accurate stress assessment. Previously, stress among shift workers was evaluated both subjectively and objectively using psychological scales and cortisol levels. However, the variety of available psychological scales led to a lack of consensus on which ones should be used. This study reviewed papers investigating the relationship between cortisol and psychological scales to determine which ones should be used together. Methods: We searched for original research papers examining the relationship between psychological scales and cortisol levels among shift workers during a 20-year period from 1 January 2006 to 31 December 2025. The data were organized using psychological scales. Results: In total, 308 papers were selected, and after excluding those that met the exclusion criteria, 19 were chosen. Across the 19 studies, 10 different psychological scales were associated with cortisol. The most frequently associated psychological scales with cortisol were the Maslach Burnout Inventory (MBI), which appeared in four out of seven studies, followed by the Visual Analog Scale and Zung Self-Rating Depression Scale, which appeared in one out of two studies. Conclusions: We believe that the MBI is the most appropriate stress scale to evaluate in conjunction with cortisol; however, further evaluation is needed, particularly research that measures salivary cortisol and stress-related psychological scales using appropriate sampling methods.
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(This article belongs to the Section Mental Health)
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Complex Clinical Profile in Adult Female Survivors of Childhood Sexual Abuse: Dissociation, Psychopathology, and Somatic Comorbidity
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Milagros Molero-Zafra, María Jesús Hernández-Jiménez, Olga Fernández-García and Marián Pérez-Marín
Psychiatry Int. 2026, 7(4), 148; https://doi.org/10.3390/psychiatryint7040148 - 2 Jul 2026
Abstract
Background: Childhood sexual abuse (CSA) is associated with long-term psychological and somatic consequences in adulthood. However, detailed clinical characterisations of female survivors remain limited from a public health perspective. Methods: This exploratory cross-sectional study was conducted in Spain (March 2022–June 2023) with 31
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Background: Childhood sexual abuse (CSA) is associated with long-term psychological and somatic consequences in adulthood. However, detailed clinical characterisations of female survivors remain limited from a public health perspective. Methods: This exploratory cross-sectional study was conducted in Spain (March 2022–June 2023) with 31 adult women (18–58 years) with a history of CSA. Participants were recruited through non-probabilistic sampling from clinical services and a survivors’ association. Sociodemographic and clinical variables were assessed using validated instruments, including the EGS-R, SCL-90-R, DERS, DES, RSE, and PID-5-BF, administered in structured online guided sessions. Descriptive statistics, Pearson correlations, and independent samples t-tests were performed. Results: The sample reported early-onset CSA (mean age = 7.17 years), predominantly intrafamilial, repeated, and prolonged, with high rates of revictimization and low disclosure. Participants reported clinically relevant levels of post-traumatic, psychological, and dissociative symptoms. The mean DES score was 11.89 (SD = 7.75). Women reporting a current somatic illness showed significantly higher levels of post-traumatic symptoms, general psychological distress, and dissociation, together with lower self-esteem. Earlier age of CSA onset and younger current age were associated with several indicators of greater symptom severity. Conclusions: In this exploratory clinical sample, adult female survivors of childhood sexual abuse reported substantial psychological distress, dissociative symptoms, and frequent somatic illness. The observed associations between trauma-related variables and clinical outcomes should be interpreted cautiously and require replication in larger and more diverse samples. Nevertheless, the findings support the potential relevance of trauma-informed and multidisciplinary approaches when working with clinically vulnerable survivors of childhood sexual abuse.
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(This article belongs to the Section Clinical Psychiatry and Psychotherapy)
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Autonomic Arousal and Perseverative Cognition Are Associated with Depression and Suicidal Ideation: A Moderated-Mediation Model
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Sara Guidotti, Alice Fiduccia, Daniele Chirco, Emma Carli and Carlo Pruneti
Psychiatry Int. 2026, 7(4), 147; https://doi.org/10.3390/psychiatryint7040147 - 2 Jul 2026
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Perseverative cognition—frequently expressed through obsessive–compulsive symptoms—is a recognized trans-diagnostic risk factor for psychopathology, with documented links to depression and suicidal ideation. While the literature suggests that altered autonomic arousal in depression may relate to suicidal risk, the conditional architecture linking these variables remains
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Perseverative cognition—frequently expressed through obsessive–compulsive symptoms—is a recognized trans-diagnostic risk factor for psychopathology, with documented links to depression and suicidal ideation. While the literature suggests that altered autonomic arousal in depression may relate to suicidal risk, the conditional architecture linking these variables remains insufficiently explored. This study examined whether suicidal ideation mediates the association between depression and autonomic arousal and whether obsessive–compulsive symptoms moderate the initial pathways within this mechanism. A sample of 120 university students (61.8% female; Mage = 28.6, SDage = 10.71) completed the Symptom Checklist-90-Revised (SCL-90-R), from which the depression, obsessive–compulsive, and suicidal ideation scores were derived; notably, the suicidal ideation score was calculated from specific items (15 and 59) embedded within the depression subscale. All participants underwent a psychophysiological evaluation to record baseline Electrodermal Activity (EDA) as an index of tonic autonomic arousal. Results indicated that depression significantly predicted suicidal ideation (B = 0.05, SE = 0.006, p < 0.001, 95% CI [0.03, 0.06]), which, in turn, was a significant predictor of autonomic arousal (B = 0.17, SE = 0.08, p = 0.03, 95% CI [0.02, 0.33]). Additionally, the mediation analysis revealed that depression showed an indirect statistical association with autonomic arousal through suicidal ideation (Bootstrapped 95% CI [0.01, 0.12]). Concurrently, obsessive–compulsive symptoms significantly moderated the psychological link between depression and suicidal ideation (B = 0.20, SE = 0.04, p < 0.001, 95% CI [0.04, 0.37]), accounting for 38.40% of the variance (F (4, 115) = 22.17, p < 0.001). Sensitivity analyses, conducted by re-calculating the models after excluding items 15 and 59 from the depression score, confirmed the robustness of these findings against potential psychometric overlap. However, the formal Index of Moderated Mediation was not statistically significant (0.0000 (95% Boot CI [−0.0001, 0.0001]), explicitly demonstrating that this psychological moderation did not translate into a significant conditional indirect effect on peripheral autonomic arousal. These findings suggest that while obsessive cognitive patterns significantly intensify the psychological burden of depression into thoughts of death, their concurrent association with peripheral physiological parameters remains strictly exploratory in non-clinical cohorts, underscoring a nuanced underscoring a nuanced ‘blocking’ effect—both emotional and behavioral—where obsessive rigidity functions as a mechanism of paralysis that, while generating profound subjective distress, fails to translate into a corresponding reactive physiological response of the autonomic nervous system.
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Open AccessSystematic Review
Variables of Negative Impact on Mental Health in the LGBT Population: Identification of Measurement Scales—A Systematic Review
by
José-Rufino García-Sánchez, Francisco-Javier Gago-Valiente, Andrés Arana-Rodríguez and Emilia Moreno-Sánchez
Psychiatry Int. 2026, 7(4), 146; https://doi.org/10.3390/psychiatryint7040146 - 1 Jul 2026
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The scientific literature was reviewed to systematically identify and characterize validated scales measuring homophobia, lesbophobia, biphobia, and transphobia, as well as the biopsychosocial consequences derived from these attitudes in sexual and gender minority (SGM) populations. The search was conducted in the WOS, Scopus,
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The scientific literature was reviewed to systematically identify and characterize validated scales measuring homophobia, lesbophobia, biphobia, and transphobia, as well as the biopsychosocial consequences derived from these attitudes in sexual and gender minority (SGM) populations. The search was conducted in the WOS, Scopus, and Medline databases, limited to studies published between January 2015 and January 2024. This review was registered in the International Prospective Register of Systematic Reviews, and its quality was evaluated using the Effective Public Health Practice Project instrument. The criteria of the PRISMA declaration for systematic reviews were applied. Among the 78 articles initially selected, 9 met the established eligibility criteria. In these 9 articles, 13 validated scales were identified, covering attitudes toward sexual and gender minorities, internalised stigma, minority stress and resilience, parental acceptance, and experiences of bullying and cyberbullying in SGM populations. The findings reveal substantial fragmentation in the available measurement landscape, with most instruments lacking cross-cultural validation, measurement invariance testing, and construct coverage beyond Western, English- or Spanish-speaking contexts. These results should be interpreted with caution given the limited number of included studies and the absence of meta-analytic quantification. This review proposes the development of a novel intermodular measurement system as a priority research agenda and identifies key implications for specialized psychiatric and clinical practice, public health surveillance, and future research.
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Open AccessSystematic Review
Gender Bias in ASD Diagnostic and Screening Tools: A Systematic Review and Meta-Analysis
by
Ana Muiño Tato, Albert Marquès-Donoso and Juan Carlos Sánchez-Huete
Psychiatry Int. 2026, 7(4), 145; https://doi.org/10.3390/psychiatryint7040145 - 1 Jul 2026
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(1) Background: ASD diagnostic and screening instruments were historically developed on predominantly male samples, raising concerns about their differential validity across sexes. (2) Objective: This meta-analysis quantified the magnitude of gender bias in ASD diagnostic and screening tools and examined its consistency across
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(1) Background: ASD diagnostic and screening instruments were historically developed on predominantly male samples, raising concerns about their differential validity across sexes. (2) Objective: This meta-analysis quantified the magnitude of gender bias in ASD diagnostic and screening tools and examined its consistency across instruments, age groups, and clinical contexts. (3) Method: A systematic search was conducted in APA PsycINFO, ERIC, Dialnet, and PsicoDoc (2015–2025) following PRISMA 2020 guidelines. Fourteen empirical studies were included (N = 55 to ~3,000,000). Effect sizes were computed as Fisher r-to-z transformed coefficients and pooled using a random-effects model. Heterogeneity was assessed via Cochran’s Q and I2; methodological quality was assessed via the CRF-QS. (4) Results: The pooled effect size was = 0.29 (95% CI: 0.11–0.47, z = 3.11, p = 0.001), indicating systematic bias favoring detection of externalizing, prototypically male profiles. Substantial heterogeneity was observed (I2 = 99.93%, Q(13) = 11,417.61, p < 0.001, τ2 = 0.11), with a prediction interval of −0.40 to 0.97. Funnel plot asymmetry suggested possible publication bias (p = 0.01). (5) Conclusions: ASD diagnostic instruments systematically underperform in identifying female presentations of autism. Bias operates across screening and formal evaluation stages, is not corrected by specialist assessment, and is associated with diagnostic delay and increased psychopathological burden. Revision of diagnostic tools and clinical training is urgently warranted.
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Open AccessArticle
Dynamics of the Use of Addiction Treatment Services in Poland Before and During the COVID-19 Pandemic: An Analysis of National Health Fund Data from 2018 to 2023
by
Mateusz Grajek, Paweł Juraszek, Joanna Kobza, Mariusz Geremek, Beata Nowak, Tomasz Jurys and Mateusz Rozmiarek
Psychiatry Int. 2026, 7(4), 144; https://doi.org/10.3390/psychiatryint7040144 - 1 Jul 2026
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Alcohol and psychoactive substance use disorders are major public health challenges in Poland. The COVID-19 pandemic affected both mental health and the organization of addiction treatment services. This study assessed changes in the utilization of publicly funded addiction treatment services in Poland before,
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Alcohol and psychoactive substance use disorders are major public health challenges in Poland. The COVID-19 pandemic affected both mental health and the organization of addiction treatment services. This study assessed changes in the utilization of publicly funded addiction treatment services in Poland before, during, and after the pandemic, with attention to regional differences. National Health Fund data from 2018 to 2023 were analyzed for alcohol use disorder treatment and treatment of other substance use disorders. Indicators included the number of patients, services provided, and total financial value of services. ANOVA, linear regression, and Pearson correlation analyses were performed. In 2020, the number of patients and services declined, particularly for non-alcohol substance treatment, followed by gradual recovery in 2021–2023. Significant regional differences were observed (p < 0.001), while differences between years were not significant. The financial value of services increased significantly over time, and strong positive correlations were found between patients, services, and costs. The pandemic temporarily reduced access to addiction treatment services in Poland. Although service utilization recovered over time, regional inequalities and increasing treatment costs persisted, highlighting the need to improve accessibility and resilience of addiction care systems.
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Open AccessArticle
Temporal Fluctuations of Suicide Mortality and Their Attributed Motives in Governmental Databases of Student Suicides in Japan from 2009 to 2025
by
Ryusuke Matsumoto, Yuki Ito, Tomoka Oka, Eishi Motomura and Motohiro Okada
Psychiatry Int. 2026, 7(4), 143; https://doi.org/10.3390/psychiatryint7040143 - 1 Jul 2026
Abstract
National crude suicide mortality rates (CMRs) in Japan trended downward throughout the 2010s, yet the CMR for the youth population moved in the opposite direction, rising from the mid-2010s onwards. To clarify the risk groups and underlying mechanisms of increasing student suicides, the
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National crude suicide mortality rates (CMRs) in Japan trended downward throughout the 2010s, yet the CMR for the youth population moved in the opposite direction, rising from the mid-2010s onwards. To clarify the risk groups and underlying mechanisms of increasing student suicides, the temporal fluctuations of CMRs of students in middle school, high school, special vocational school, and university were analyzed by joinpoint regression analysis, and identification of high CMR groups were detected by a linear mixed-effect model using government suicide databases. CMRs of female students in all school categories increased from the mid-2010s. CMRs of male students in middle and high schools increased, whereas those in university and special vocational school moved from a decreasing to a stable level. Among the average of CMRs from 2022 to 2025, the highest CMR was observed in part-time high school students, which was approximately fivefold higher than the average of all students overall. The major leading suicide motives for all student subgroups were concerned with underachievement and career-path-associated problems within school-related problems. Family-related problems, such as conflict with parents and parental reprimands, were leading suicide motives for middle school students, but these impacts attenuated with age. Instead, the impacts of psychiatric disorders, including depression and other psychiatric disorders, enhanced with age. Student suicides attributed in the government suicide database to these leading suicide motives showed an upward inflexion, moving from a decreasing or stable pattern to a rising one, beginning in the mid-2010s. Taken together, these patterns indicate that mental health concerns among students have re-emerged as a substantial motive behind student suicide from the mid-2010s.
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(This article belongs to the Special Issue Advances and Innovations in Child and Adolescent Mental Health)
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Open AccessArticle
The Dominant Role of Depression over Cognitive Impairment in Determining Quality of Life Among Hemodialysis Patients: Evidence from Mediation Analysis
by
Sonja Golubović, Jovan Milatović, Milana Okanović, Nikola Glogonjac, Slobodan Šajinović, Danilo Medin, Ivana Đuran, Violeta Knežević and Boris Golubović
Psychiatry Int. 2026, 7(4), 142; https://doi.org/10.3390/psychiatryint7040142 - 1 Jul 2026
Abstract
Background and Aims: Cognitive impairment (CI) and depression are frequent comorbidities in chronic hemodialysis (HD) patients with substantial impact on health-related quality of life (HRQoL). This study examined their prevalence, predictors, and independent associations with HRQoL. Methods: A cross-sectional study enrolled 70 adult
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Background and Aims: Cognitive impairment (CI) and depression are frequent comorbidities in chronic hemodialysis (HD) patients with substantial impact on health-related quality of life (HRQoL). This study examined their prevalence, predictors, and independent associations with HRQoL. Methods: A cross-sectional study enrolled 70 adult maintenance HD patients. Cognitive functioning was assessed with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA); depressive symptoms with the Beck Depression Inventory (BDI); and HRQoL with the Kidney Disease Quality of Life instrument (KDQOL-SF). Logistic regression, multiple linear regression, and mediation analysis were applied. Results: CI (MoCA ≤ 24) was present in 54.3% of patients; clinically significant depressive symptoms (BDI ≥ 14) were present in 44.4%. BDI was not correlated with MoCA (p = 0.656) or MMSE (p = 0.880), confirming independence of the two dimensions in cross-section. Older age (OR = 1.106, p = 0.001) and male sex (OR = 4.523, p = 0.022) were independent predictors of CI. BDI significantly correlated with 15 of 19 KDQOL domains and was the dominant predictor across 10 domains in multiple linear regression (Adj. R2 up to 0.358). MoCA correlated with only two KDQOL domains. Mediation analysis confirmed that MoCA does not mediate the BDI–HRQoL relationship (indirect effect: −0.004, 95% bootstrap CI: −0.106 to +0.097). Conclusions: CI and depression are highly prevalent and clinically distinct dimensions in HD patients, though subtle longitudinal interactions cannot be excluded. Depression is the dominant determinant of impaired HRQoL, acting through a direct, cognitively independent pathway, and represents the primary modifiable target for improving quality of life in this population.
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Open AccessSystematic Review
A Systematic Review of Attitudes Toward Suicide Among University Students
by
Shirlyn Ming Hui Lee, Shazli Ezzat Ghazali, Noraziah Mohamad Zin, Shanthi Krishnasamy, Choy Qing Cham and Ching Sin Siau
Psychiatry Int. 2026, 7(4), 141; https://doi.org/10.3390/psychiatryint7040141 - 25 Jun 2026
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Background: Suicide is a major mental health concern, particularly among university students facing unique stressors. Understanding their attitudes toward suicide is essential for effective prevention, yet the existing literature lacks a systematic review on this population. This review synthesises and evaluates the literature
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Background: Suicide is a major mental health concern, particularly among university students facing unique stressors. Understanding their attitudes toward suicide is essential for effective prevention, yet the existing literature lacks a systematic review on this population. This review synthesises and evaluates the literature on attitudes toward suicide among university students. Methods: A systematic search was conducted on four databases (MEDLINE, Web of Science, Scopus, and PubMed) using Medical Subject Headings terms and keywords identified from previous studies. The search, conducted in February 2024, included studies published between 2014 and 2024. One researcher screened the titles and abstracts, while two independent researchers extracted the data. Twenty-one articles (N participants = 13,424) were selected for further assessment. Quantitative designs were the most common (n = 18), followed by qualitative (n = 2) and mixed-method designs (n = 1), spanning multiple regions. Themes were derived by organising findings into thematic categories based on recurring patterns across the studies. Results: Two core themes emerged: Factors associated with attitudes toward suicide and their associations with suicide outcomes. Conclusions: The review underscores the need for culturally sensitive approaches to address negative attitudes toward suicide and promote help-seeking among university students, highlighting the importance of further research in this area.
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