Advancing Open Science

Digital platform innovation has become increasingly complex as platforms enable product-service innovation, business process transformation, and ecosystem-level value creation simultaneously. However, existing research remains fragmented regarding how governance configurations shape different innovation pathways across digital platform ecosystems. This study addresses this gap by synthesizing research on product and service innovation (PSI), business process innovation (BPI), and hybrid innovation (HI) through an integrated Antecedents–Decisions–Outcomes (ADO) and Theories–Contexts–Methods (TCM) perspective. Based on a PRISMA-guided systematic literature review of 57 peer-reviewed studies published between 2015 and 2026, this study identifies recurring governance configurations linking ecosystem conditions, managerial decisions, and innovation outcomes. The findings suggest that governance configurations provide an analytical lens for explaining how ecosystem conditions correspond to differentiated innovation pathways. PSI is primarily characterized by openness, modularity, complementor participation, and market-facing value creation, whereas BPI emphasizes coordination, standardization, scalability, and process optimization. HI emerges when product-service, process, and ecosystem innovation logics intersect, requiring governance configurations that balance openness and control, exploration and exploitation, and multiple levels of value creation. This study contributes by reconceptualizing ADO as a configuration-based framework for explaining platform innovation pathways beyond linear antecedent–outcome relationships. The findings provide insights into how platform managers can align governance choices with ecosystem conditions and innovation objectives. By integrating ADO and TCM perspectives, this review advances a contingent governance view of digital platform innovation and identifies directions for future research and managerial practice.

Steroid-induced osteonecrosis of the femoral head (SONFH) develops with early microvascular injury, but the systemic signals connecting glucocorticoid exposure to the femoral head remain incompletely defined. We examined whether intestinal epithelial Piezo1–TPH1–serotonin signaling contributes to this process. A glucocorticoid-induced SONFH model was studied in male C57BL/6 mice (8–10 weeks old), using pharmacological inhibition of peripheral serotonin synthesis, intestinal epithelial-specific Piezo1 deletion, micro-computed tomography, histological and vascular analyses, bone microvascular endothelial cell (BMEC) assays, and independent public transcriptomic datasets. Glucocorticoid exposure increased intestinal Piezo1 and TPH1 expression and circulating serotonin, together with loss of CD31^hiEMCN^hi type H vessels and trabecular deterioration. Inhibiting peripheral serotonin synthesis reduced vascular and structural injury. Intestinal epithelial Piezo1 deletion blunted TPH1 upregulation, preserved femoral-head microvasculature, and improved trabecular architecture. In BMECs, serotonin impaired tube formation and increased Bax-, Caspase-3-, and NLRP3-associated signaling; intestinal Piezo1 deletion reduced the corresponding injury signals in vivo. Intestinal epithelial Piezo1–TPH1–serotonin signaling therefore contributes to SONFH-associated microvascular injury in this model.

The use of virtual platforms to search for information about a tourism destination has become increasingly relevant in developing regions, posing a challenge for Destination Management Organizations (DMOs). This study aims to explore how tourist motivation and behavioral orientations are expressed in relation to destination imagination across the digital platforms of Mexico, Brazil, and the Dominican Republic. The procedure involved a 20 s exposure to standardized static stimuli from official digital platforms and a 2 min free exploration of each official destination website, followed by in-depth interviews with 40 participants. Data analysis employed thematic content analysis using an abductive approach. The findings support an interpretive framework that analytically orders digital interaction and cognitive processing in relation to destination imagination and anticipatory evaluation, including expectancy of success, outcome expectations, and value appraisal. These processes are subsequently associated with motivation and future-oriented behavioral orientations. The study contributes to Expectancy–Value Theory by showing how subjective value is experienced in digital tourism through affective, symbolic, aesthetic, and social meanings that enrich the interpretation of intrinsic value, attainment value, utility value, and cost within pre-travel destination experiences.

Heritage building information modelling requires deciding which scanned points form which element. This single-case study encodes the typological reading of Alaca Çeşmesi, an Ottoman square fountain, as readable point-classification rules carried into IFC4 elements with heritage property sets. The rules, calibrated on a complete manual segmentation of the same cloud, were compared with two independent blind annotations. The annotators agreed on 97.0%, the unmodified rules with them on 86.3% and 87.0%. These values measure encoding fidelity on one structure, not performance on unseen buildings. Most of the gap is a class-definition difference between calibration and the reference: whether the niche belongs to an arch or a façade. An exploratory post hoc mask for the annotators’ definition raised agreement to 96.7% and 98.1%; this is not an independent validation. A template filled from 16 picked points reached a mean intersection over the union of 0.726 (rules: 0.764); a co-author blind to the earlier landmark values and scores reached 0.713, differing mainly in the interpretation of the niche opening, represented by two picked points. The classification stage was exchangeable for a Random Forest; both IFC files linked into Revit, showing technical, not semantic, validity. Class definitions should be fixed before calibration and checked against a second reference.

The Lokbatan field, located in the Absheron Peninsula, represents an important example of the spatial and genetic association between hydrocarbon reservoirs and active mud volcanism. This study investigates the long-term evolution of Horizon VIII of the Lokbatan field and examines the relationship between reservoir development, production dynamics, and mud volcano activity. Historical production and reservoir data covering 1934–2024 were integrated with documented eruptive events. The dynamics of oil production, water production, liquid production, and gas production, together with gas factor and water cut, were evaluated using Shewhart statistical control charts to identify long-term shifts in the production regime and deviations from established control ranges. The results reveal a pronounced transition from an early stage of intensive hydrocarbon production to a mature stage characterized by strongly depleted production conditions. Oil production reached exceptionally high values during the initial development period but subsequently declined and remained close to or below the lower control limit during the later decades. Liquid and water production also showed a long-term reduction, whereas water cut evolved toward a persistently high, water-dominated production regime, reaching a maximum of 94.9% in 1993 and remaining above 80% during most of the recent development period. Gas production and gas factor exhibited an overall decline, although the gas factor showed an exceptional increase during 1995–1997, reaching 871 m³/t in 1996. The analysis further indicates that intensive hydrocarbon extraction was associated with changes in the frequency and character of mud volcanic eruptions, whereas available monitoring data show no clear short-term abrupt effect of individual eruptions on reservoir pressure or well productivity. The novelty of this study lies in integrating long-term reservoir performance indicators with Shewhart statistical process control and historical mud-volcano activity within a single analytical framework. This approach makes it possible to identify major transitions in the development regime of a mature hydrocarbon field while assessing its interaction with an active mud-volcanic system. The Lokbatan field thus provides a valuable case study of long-term reservoir depletion, increasing water dominance, changing gas behavior, and reservoir–mud volcano interaction in a tectonically active petroleum system.

Phase change materials can exhibit markedly different thermal responses during cooling, ranging from narrow single-stage transitions to broad or multistage behaviour, which requires the analysis procedure to account for differences in response structure. This study applies a common water-referenced T-history framework to the enthalpy–temperature characterisation of six organic phase change materials: RT35HC, RT45HC, lauric acid, beeswax, palmitic acid and soy wax. Five experiments were reported for each material. The enthalpy was obtained from small, matched temperature intervals in the same way for every material, while the low-temperature calorimetric boundary was derived from the measured cooling response rather than imposed as a fixed temperature criterion. Thermal responses were described by cumulative temperatures at the 5%, 50% and 95% levels of the detected thermal effect. The T-history enthalpy changes were 207.35 ± 32.31, 197.59 ± 23.31, 224.11 ± 32.48, 200.38 ± 17.47, 191.50 ± 15.16 and 109.37 ± 13.33 J/g for RT35HC, RT45HC, lauric acid, beeswax, palmitic acid and soy wax, respectively. Comparison with differential scanning calorimetry measurements of the tested samples, independent calorimetric studies, manufacturer data and published thermal data supported the identified temperature regions and response structures. The enthalpy values were interpreted separately, taking into account differences in calorimetric definitions and temperature intervals. Changing the detector settings changed the mean primary midpoint temperature by less than 0.03 K for every material, while changing the matched temperature interval from the nominal 0.250 K to 0.125 K or 0.500 K changed the mean enthalpy by at most 2.29%. The results show that a common T-history framework can characterise substantially different cooling behaviours of the phase change materials when calorimetric boundaries are derived from the measured thermal response. The resulting characteristics also provide material-level information relevant to the selection of PCMs for electronic thermal management applications.

Background/Objectives: Glioblastoma multiforme (GBM) remains the most aggressive and treatment-refractory primary brain tumor, with current therapeutic modalities providing minimal survival improvement. Chimeric antigen receptor (CAR)-based immunotherapies succeeded in hematologic malignancies but are constrained in solid tumors by tumor heterogeneity, immunosuppressive microenvironment, and delivery challenges. CD276 (B7-H3), a pan-cancer antigen overexpressed in gliomas and correlated with poor patient outcomes, represents a compelling immunotherapeutic target. Methods: Here, we developed a non-viral lipid nanoparticle (LNP)-based platform for transient CAR mRNA delivery to T cells and evaluated its application for generating CD276 (B7-H3)-targeted CAR-T cells against GBM. An in-house-assembled T-mixer incorporating polyether ether ketone (PEEK) tubing was integrated with a dual-syringe-pump system for controlled LNP production. Results: LNPs formulated with clinically relevant ionizable lipids, SM-102 and DLin-MC3-DMA, demonstrated high encapsulation efficiency and effective mRNA delivery. Cell-type-dependent expression kinetics were further characterized following LNP-mediated reporter mRNA delivery in K562, NK, NK92, and T cells, revealing differences in transgene expression across cell populations. LNP-mediated delivery of CD276 CAR mRNA enabled generation of CAR-expressing T cells that exhibited antigen-specific cytotoxicity against CD276-positive LN229 GBM cells in vitro. Conclusions: Collectively, this study demonstrates the feasibility of an adaptable LNP-based platform for non-viral CAR mRNA engineering of T cells and CD276-targeted cytotoxicity against GBM cells in vitro. The combination of transient CAR expression and LNP-mediated mRNA delivery provides a foundation for further optimization and evaluation in preclinical in vivo models.

This prospective, single-center, randomized, split-face controlled trial evaluated whether a multicomponent investigational cosmetic serum (ISCE) applied immediately after radiofrequency microneedling (RF-MN) provides additional benefit over RF-MN alone. In 22 healthy Korean women aged 40–69 years, one hemiface was randomly assigned by a computer-generated sequence to RF-MN plus ISCE and the other to RF-MN alone, in two sessions 3 weeks apart; outcome assessors and statisticians were blinded. Primary endpoints were transepidermal water loss (TEWL) and procedure-induced erythema; secondary endpoints were hydration, elastic recoil, elasticity, density, wrinkles, pores, and pigmentation. Twenty participants were analyzed. TEWL decreased more on the combination side from the first session (between-side difference −0.50 g/m²·h, 95% CI −0.68 to −0.33; p < 0.001), and the procedure-induced increase in erythema was smaller after the second session (−1.07 A.U., 95% CI −2.08 to −0.05; nominal p = 0.041). After the second session, all exploratory secondary endpoints favored the combination side (unadjusted p < 0.05). No adverse events occurred. ISCE after RF-MN yielded a greater short-term reduction in TEWL than RF-MN alone, whereas the erythema finding is preliminary and requires confirmation; because no vehicle control was included, the TEWL benefit is attributable to the formulation as a whole. The trial was not registered in a trial registry.