Struvite and ammonium nitrate (AN), as wastewater-recovered products, are possible alternatives as raw materials for nutrient solutions. However, their impact on the rhizosphere microbiota and N₂O emissions is scarcely known. Therefore, the present research studies the ecological changes in the bulk-substrate microbiome and its correlation with N₂O emissions in a perlite-based system tomato crop under (i) conventional synthetic fertigation management; (ii) fertigation with struvite; and (iii) struvite and AN. A high bacterial diversity and the natural presence of plant-growth-promoting rhizobacteria in a soilless system are highlighted. However, the different N-NH₄⁺:N-NO₃⁻ ratios influence the ecological niches of ammonia-oxidizing archaea (AOA) and bacteria (AOB), with a stronger response by AOB community, while AOA kept constant regarding the fertilization applied. Despite this, enrichment of N-transforming bacterial phylotypes was relatively enhanced (mainly Nitrosomonas, Nitrosospira, and Nitrospira) concomitant with the production of N₂O emissions when ammonium fertilization was overapplied. In the absence of a plant, N₂O emissions were positively correlated, respectively, with Nitrosospira and AOB:AOA ratio, suggesting potential indicators for ammonium availability in the substrate. Fertilizer blends using recovered nutrients are a feasible alternative for increasing circularity in horticulture. Nevertheless, optimum fertilizer management is needed due to its influence on rhizosphere microbiota and N₂O emissions. Full article

The crucial physiological process of heme breakdown yields biliverdin (BV) and bilirubin (BR) as byproducts. BV, BR, and the enzymes involved in their production (the “yellow players—YP”) are increasingly documented as endogenous modulators of human health. Mildly elevated serum bilirubin concentration has been correlated with a reduced risk of multiple chronic pro-oxidant and pro-inflammatory diseases, especially in the elderly. BR and BV per se have been demonstrated to protect against neurodegenerative diseases, in which heme oxygenase (HMOX), the main enzyme in the production of pigments, is almost always altered. HMOX upregulation has been interpreted as a tentative defense against the ongoing pathologic mechanisms. With the demonstration that multiple cells possess YP, their propensity to be modulated, and their broad spectrum of activity on multiple signaling pathways, the YP have assumed the role of an adjustable system that can promote health in adults. Based on that, there is an ongoing effort to induce their activity as a therapeutic option, and natural compounds are an attractive alternative to the goal, possibly requiring only minimal changes in the life style. We review the most recent evidence of the potential of natural compounds in targeting the YP in the context of the most common pathologic condition of adult and elderly life. Full article

Nanotechnology is the science of creating materials at the nanoscale by using various devices, structures, and systems that are often inspired by nature. Micro- and nanoparticles (MPs, NPs) are examples of such materials that have unique properties and can be used as carriers for delivering drugs for different biomedical applications. Chitosan (CS) is a natural polysaccharide that has been widely studied, but it has a problem with low water solubility at neutral or basic pH, which limits its processability. The goal of this work was to use a chemically modified CS with poly(ethylene glycol) methyl ether acrylate (PEGA) to prepare CS micronic and submicronic particles (MPs/NPs) that can deliver different types of antibiotics, respectively, levofloxacin (LEV) and Ciprofloxacin (CIP). The particle preparation procedure employed a double crosslinking method, ionic followed by a covalent, in a water/oil emulsion. The studied process parameters were the precursor concentration, stirring speeds, and amount of ionic crosslinking agent. MPs/NPs were characterized by FT-IR, SEM, light scattering granulometry, and Zeta potential. MPs/NPs were also tested for their water uptake capacity in acidic and neutral pH conditions, and the results showed that they had a pH-dependent behavior. The MPs/NPs were then used to encapsulate two separate drugs, LEV and CIP, and they showed excellent drug loading and release capacity. The MPs/NPs were also found to be safe for cells and blood, which demonstrated their potential as suitable drug delivery systems for biomedical applications. Full article

Traditional research on apparent permeability in shale reservoirs has mainly focussed on effects such as poromechanics and porosity-assisted adsorption layers. However, for a more realistic representation of field conditions, a comprehensive multi-scale and multi-flowing mechanism model, considering the fracturing process, has not been thoroughly explored. To address this research gap, this study introduces an innovative workflow for dynamic permeability assessment. Initially, an accurate description of the pore size distribution (PSD) within three major mineral types in shale is developed using focussed ion beam-scanning electron microscopy (FIB-SEM) and nuclear magnetic resonance (NMR) data. Subsequently, an apparent permeability model is established by combining the PSD data, leading to the derivation of dynamic permeability. Finally, the PSD-related dynamic permeability model is refined by incorporating the effects of imbibition resulting from the fracturing process preceding shale gas production. The developed dynamic permeability model varies with pore and fracture pressures in the shale reservoir. The fracturing process induces water blockage, water-film formation, and water-bridging phenomena in shale, requiring additional pressure inputs to counteract capillary effects in hydrophilic minerals in shale, But also increases the overall permeability from increasing permeability at larger scale pores. Unlike traditional reservoirs, the production process commences when the fracture is depleted to 1–2 MPa exceeds the pore pressure, facilitated by the high concentration of hydrophobic organic matter pores in shale, this phenomenon explains the gas production at the intial production stage. The reduction in adsorption-layer thickness resulting from fracturing impacts permeability on a nano-scale by diminishing surface diffusion and the corresponding slip flow of gas. this phenomenon increases viscous-flow permeability from enlarged flow spacing, but the increased viscous flow does not fully offset the reduction caused by adsorbed-gas diffusion and slip flow. In addition to the phenomena arising from various field conditions, PSD in shale emerges as a crucial factor in determining dynamic permeability. Furthermore, considering the same PSD in shale, under identical pore spacing, the shape factor of slit-like clay minerals significantly influences overall permeability characteristics, much more slit-shaped pores(higher shape factor) reduce the overall permeability. The dynamic permeability-assisted embedded discrete fracture model (EDFM) showed higher accuracy in predicting shale gas production compared to the original model. Full article

People with Young Onset Dementia (YOD) can be hesitant to engage with online peer support. This work aims to explore (1) why people are hesitant to engage in online peer support, (2) how to get more people involved in online peer support, and (3) what makes online peer support work well. Nine interviews with people with YOD were conducted on MS Teams. Participants were recruited through purposive sampling. Data were analysed thematically. Reasons for being hesitant to engage with online peer support include being unsure what to expect and concerns about seeing others in more advanced stages of dementia. Additionally, it can be difficult to identify groups that suit one’s needs and interests. Group facilitators of online peer support groups should provide a detailed description of their group so that people can better assess whether the group would suit them. The insights obtained from this study will be used to develop a Best Practice Guidance on online peer support for people with YOD. Moreover, the findings can be useful for further research exploring how to support people with dementia in general in accessing online health and social care services. Full article

In underground coal gasification, as a choke regulating the formation gas lift pressure, the throttling tool can effectively reduce the production cost, the number of ground heating and insertion equipment, and gas consumption. Because in this process, the coal is transformed into composite synthetic gas through a series of technical treatments, the throttling tool is in a working environment with high temperature and pressure. In the process of transportation of combined synthetic gas, the pulverized coal parts produced by incomplete coal combination move with the gas in the throttling tool. The high temperature and high-pressure gas carrying large-diameter pressed coal parts will cause serial erosion and wear to the throttling device, resulting in failure and well-controlled safety risks. Therefore, according to the Joule–Thomson effect, this paper independently designs downhole throttling tools with single- and double-hole structures. According to actual field conditions, the erosion wear of throttling tools with different systems in high-temperature gas–solid two-phase flow was simulated and predicted, and the internal flow field characteristics of throttling means were analyzed. The difference between the wall wear distribution, wall collision position, and wall erosion effect of different structure throttling mechanisms with the change in gas velocity was investigated, which guides the practical use of the subsequent throttling tools. Full article

In many churches nowadays, there has been a standardized approach to premarital counseling for couples involving social, pastoral, and psychological perspectives. In contrast, many rabbis and other Jewish officials still concentrate on legal aspects alone. The need for resolving important issues on the verge of wedlock is too often left to secular experts in law, psychology, or counseling. However, in recent years, this lack of formal training for marriage preparation has also been acknowledged by the Jewish clergy in order to incorporate it in the preparatory period before the bond is tied. This case study focuses on Jewish and Roman Catholic conceptions of marriage, past and present. We intend to do a comparative analysis of the prerequisites of religious marriage based on the assumption that both Judaism and the Roman Catholic Church have a distinct legal framework to assess marriage preparation. Full article

Extracellular biophysical properties have particular implications for a wide spectrum of cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene expression, cell–matrix and cell–cell adhesion, and signal transduction including mechanotransduction. Cells not only react to unambiguously mechanical cues from the extracellular matrix (ECM), but can occasionally manipulate the mechanical features of the matrix in parallel with biological characteristics, thus interfering with downstream matrix-based cues in both physiological and pathological processes. Bidirectional interactions between cells and (bio)materials in vitro can alter cell phenotype and mechanotransduction, as well as ECM structure, intentionally or unintentionally. Interactions between cell and matrix mechanics in vivo are of particular importance in a variety of diseases, including primarily cancer. Stiffness values between normal and cancerous tissue can range between 500 Pa (soft) and 48 kPa (stiff), respectively. Even the shear flow can increase from 0.1–1 dyn/cm² (normal tissue) to 1–10 dyn/cm² (cancerous tissue). There are currently many new areas of activity in tumor research on various biological length scales, which are highlighted in this review. Moreover, the complexity of interactions between ECM and cancer cells is reduced to common features of different tumors and the characteristics are highlighted to identify the main pathways of interaction. This all contributes to the standardization of mechanotransduction models and approaches, which, ultimately, increases the understanding of the complex interaction. Finally, both the in vitro and in vivo effects of this mechanics–biology pairing have key insights and implications for clinical practice in tumor treatment and, consequently, clinical translation. Full article

Accurate estimates of intermolecular interaction energy, , are crucial for modeling the properties of organic electronic materials and many other systems. For a diverse set of 50 dimers comprising up to 50 atoms (Set50-50, with 7 of its members being models of single-stacking junctions), benchmark data were compiled. They were obtained by the focal-point strategy, which involves computations using the canonical variant of the coupled cluster theory with singles, doubles, and perturbative triples [CCSD(T)] performed while applying a large basis set, along with extrapolations of the respective energy components to the complete basis set (CBS) limit. The resulting data were used to gauge the performance for the Set50-50 of several density-functional theory (DFT)-based approaches, and of one of the localized variants of the CCSD(T) method. This evaluation revealed that (1) the proposed “silver standard” approach, which employs the localized CCSD(T) method and CBS extrapolations, can be expected to provide accuracy better than two kJ/mol for absolute values of ∆E, and (2) from among the DFT techniques, computationally, by far, the cheapest approach (termed “ωB97X-3c/vDZP” by its authors) performed remarkably well. These findings are directly applicable in cost-effective yet reliable searches of the potential energy surfaces of noncovalent complexes. Full article

In this paper, an intelligent weather conditions fuzzy adjustment based on spatial features (IWeCASF) is developed. It is indispensable for our regional soil moisture estimation approach, complementing a point estimation model of soil moisture from the literature. The point estimation model requires the weather conditions at the point where an estimate is made. Therefore, IWeCASF’s aim is to determine these weather conditions. The procedure begins measuring them at only one checkpoint, called the primary checkpoint. The model determines the weather conditions anywhere within a region through image processing algorithms and fuzzy inference systems. The results are compared with the measurement records and with a spatial interpolation method. The performance is similar to or better than interpolation, especially in the rain, where the model developed is more accurate due to the certainty of replication. Additionally, IWeCASF does not require more than one measurement point. Therefore, it is a more appropriate approach to complement the point estimation model for enabling a regional soil moisture estimation. Full article

Long-term health consequences are influenced by circumstances that occur during pregnancy. The convergence of the maternal and fetal circulations occurs in the placenta, which is the first organ to develop. Placental pathology provides an accurate diagnosis of amniotic sac inflammation, and pathological alterations in preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospective study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department at our institution. Thirty-seven male and forty-seven female placentas were collected following full-term delivery, and the grading and staging of any evident inflammatory responses were evaluated and correlated with the babies’ sex. Full-thickness placental samples that were considered normal and not sent to the histopathology department were obtained from the central and marginal regions of placental discs. Morphological examination of the fresh placenta was conducted, and fetal and maternal inflammatory response syndromes were assessed. In addition, placental villitis of unknown etiology (VUE) and chronic deciduitis were evaluated. Immunohistochemistry was performed to evaluate the patterns of inflammation in the placenta using anti-CD8 and anti-CD68 antibodies. The correlation between silent pathologies and clinical complications or the development of fetal inflammatory response syndrome was measured. In this study, 17 (20%) maternal and 10 (12%) fetal samples showed inflammatory responses. The frequencies of chronic deciduitis and VUE were higher among pregnant Saudi women than previously reported, probably because fetal inflammatory response syndrome goes unnoticed in Saudi Arabia. In addition, the prevalence of fetal and maternal inflammatory responses was higher in the placentas of the mothers of males than in those of females, suggesting that differences occur in the inflammatory response in the placenta depending on the sex of the newborn. Grading placental inflammation (in cases of VUE) typically predicts the degree of maternal anti-fetal cellular rejection; therefore, increasing the number of placental samples sent for microscopic inspection may be preferable because of their significance in identifying the causes of chronic disorders. Full article

Our objective was to identify variations in gene expression that could help elucidate the pathways for the development of prostate cancer (PCa) in men with Benign Prostatic Hyperplasia (BPH). We included 98 men with BPH, a positive prostate MRI (Prostate Imaging Reporting and Data System; PIRADS ≥ 4), and a negative biopsy from November 2014 to January 2018. RNA sequencing (RNA-Seq) was performed on tissue cores from the MRI lesion and a geographically distant region (two regions per patient). All patients were followed for at least three years to identify who went on to develop PCa. We compared the gene expressions of those who did not develop PCa (“BPH-only”) vs. those who did (“BPH/PCa”). Then, we identified the subset of men with BPH who had the highest American Urological Association (AUA) symptom scores (“symptomatic BPH”) and compared their gene expression to the BPH/PCa group. At a median follow-up of 47.5 months, 15 men had developed PCa while 83 did not. We compared gene expressions of 14 men with symptomatic BPH (AUAss ≥ 18) vs. 15 with BPH/PCa. We found two clusters of genes, suggesting the two groups had distinctive molecular features. Differential analysis revealed genes that were upregulated in BPH-only and downregulated in BPH/PCa, and vice versa. Symptomatic BPH men had upregulation of T-cell activation markers (TCR, CD3, ZAP70, IL-2 and IFN-γ and chemokine receptors, CXCL9/10) expression. In contrast, men with BPH/PCa had upregulation of NKX3-1 and HOXB13 transcription factors associated with luminal epithelial progenitors but depleted of immune cells, suggesting a cell-autonomous role in immune evasion. Symptomatic BPH with immune-enriched landscapes may support anti-tumor immunity. RNA sequencing of benign prostate biopsy tissue showing upregulation of NKX3-1 and HOXB13 with the absence of T-cells might help in identifying men at higher risk of future PCa development, which may be useful in determining ongoing PCa screening. Full article

Since the reform and opening up, China’s urbanization level has increased rapidly, with the urbanization rate rising from 17.92% in 1978 to 63.89% in 2020. At the same time, the extreme expansion of urban space has gradually become a common phenomenon, and the problem of urban sprawl has become a stumbling block to the high-quality development of Chinese cities. The traditional single-indicator method and multi-indicator method have obvious shortcomings in the richness of index dimension and the subjectivity of indicator selection, respectively, when measuring urban sprawl quantitatively. In this study, based on the weighted urban proliferation (WUP) model, we integrated the three independent dimensions of urban permeation (UP), dispersion of built-up areas (DIS), and utilization density (UD) to verify the applicability and feasibility of the model for quantifying the spatiotemporal pattern of urban sprawl, taking the Bohai Rim region in China as an example. There were four main results. Most cities in the Bohai Rim region had a moderate-to-high level of urban sprawl, with obvious spatial heterogeneity by province. The average WUP of cities in the Bohai Rim region increased by 61.83% from 2000 to 2020, and cities with moderate urban sprawl became cities with high sprawl. The urban sprawl process in the Bohai Rim region accelerated during 2010−2015 and stabilized thereafter. The increase in WUP caused by the growth of built-up areas is the main driver of urban sprawl in the Bohai Rim region. This study found that the WUP model can be effectively applied to the Bohai Rim region of China, where it reflects the multidimensional features of urban sprawl and provides new insight into its spatiotemporal pattern. Full article

In the era of digital information, online platforms play a crucial role in shaping public opinion. However, the extensive spread of misinformation and fake news poses a significant challenge, largely fueled by non-credible users. Detecting user credibility is vital for ensuring the reliability of information on these platforms. This study employs supervised machine learning algorithms, leveraging key user features to enhance credibility detection. Feature selection methods, specifically SelectKBest and correlation-based algorithms, are explored for their impact on X-Platform user credibility detection. Utilizing various classifiers, including support vector machine, logistic regression, and XGBoost, experiments are conducted on the ArPFN dataset, which is a labeled, balanced, publicly available dataset. The evaluation includes measures like accuracy, precision, recall, and F1-score to assess efficiency. This research considers feature categories and selection methods with SML to detect their impact on the accuracy of X-Platform user credibility detection, making this research a reference for researchers and practitioners working in the field of SML, feature engineering, and social media analysis. We aim to advance the field’s understanding of effective strategies for mitigating the spread of fake news. The novelty of this study lies in the comprehensive exploration of feature selection methods and their influence on credibility detection, contributing valuable insights for future research in this domain. Full article

This study aimed to characterize the latest antimicrobial resistance patterns and genetic diversity of Campylobacter spp. isolated from patients with acute diarrhea in Korea. In total, 371 clinical isolates (361 Campylobacter jejuni and 10 Campylobacter coli) were collected from patients with diarrhea in 106 medical institutions of six provinces during the seasonal peak (April–September 2022) in South Korea. We then assessed their antimicrobial susceptibility to eight antimicrobial agents and performed multilocus sequence typing (MLST). This study investigated the antimicrobial resistance (AMR) profiles to tetracycline (32.3%), nalidixic acid (64.9%), and ciprofloxacin (83.3%), confirming high levels of the latter even after its Korean ban in 2010. However, tetracycline resistance displayed a decreasing trend. Alternatively, significantly lower resistance rates to clindamycin (0.8%), azithromycin (0.53%), erythromycin (0.53%), and gentamicin (0.53%) as well as absolute susceptibility to florfenicol (0%) were observed. Four C. jejuni and three C. coli isolates (7/371, 1.88%) were classified as multidrug-resistant (MDR) to at least three antimicrobial classes. MLST identified a high genetic diversity with 21 clonal complexes (CCs) and sixty-six sequence types (STs), including eight novel STs. The high CC frequency of C. jejuni comprised CC21 (37.7%), CC22 (13.8%), and CC206 (9.4%), while C. coli was predominated by CC828 (90%). The high CC21 and CC828 strain prevalence in this study was consistent with their worldwide distribution. This study highlights that quinolone- and tetracycline-resistant Campylobacter circulate in Korea with diverse genotypes, providing important information that could contribute to controlling and preventing increasing antimicrobial resistance in patients. Full article

About 40% of cedar pollinosis patients living in the Yamagata Prefecture showed pollinosis symptoms before the first day of the pollen season, which was determined by Durham samplers, the standard sampler for pollen information in Japan. The amount of Cry j 1 (major cedar pollen allergen) per cedar pollen is reported to be six pg. This amount is difficult to measure using the ELISA method, so we applied the highly sensitive ESR radical immunoassay method to measure the allergen; now we can provide information for sensitive patients. It revealed that Cry j 1 exists in orbicles and tapetum. It is presumed that it is smaller than pollen, so it comes from a place where cedar are already in bloom. It is desirable to obtain real-time information on an hourly basis. Currently, information from automatic cedar pollen monitors is becoming main-stream. However, this monitor may count during snowfalls, Asian dust flying, etc., even when there was no apparent pollen examined with a microscope. This paper describes the current status of automatic cedar pollen monitors, their usefulness, and their advantages and disadvantages in comparison with results obtained by other methods of measurement. Lastly, the paper describes expectations for cedar pollen information in the future. Full article

Background: Superficial venous thrombosis (SVT) is a common clinical condition caused by inflammation and the presence of a thrombus inside a superficial vein. It has traditionally been considered a benign and banal disorder, although it can progress or can be associated with thromboembolic disease of deep territories in up to 20%, asymptomatic or symptomatic pulmonary embolism (PE), especially if it affects the main trunk of the internal saphenous vein. The impact of deep vein thrombosis on the quality of life and its sequelae have long been described in the literature; however, they have not been studied in superficial vein thrombosis. Objectives: We aimed to evaluate the risk factors, management, and complications of SVT and its impact on the quality of life of our patients. Methods: Observational, prospective, single-center study to evaluate the management of SVT. The ultrasound (US) was performed initially on symptomatic patients, during treatment with low-molecular-weight heparin (LMWH), at a follow-up, and at the end of 45 days of treatment. A quality-of-life questionnaire was administered to determine the risk factors, management, and complications of SVT at the moment of diagnosis and at the end of treatment. We included patients referred from the emergency department to a monographic consultation for thromboembolic disease, over 18 years of age with a diagnosis of acute SVT symptomatic, without contraindication to initiate anticoagulation. Results: In total, 63 patients were evaluated between October 2020 and April 2022. The mean age was 65.8 years (SD 13.5), of which 35 were women (55.6%), 39 presented cardiovascular risk factors (61.9%), 25 had a history of previous personal venous thromboembolism (VTE) (39.7%), and 10 had obesity (15.9%), 47 had chronic venous insufficiency or varicose veins (74.9%). During follow-up with ultrasound, 39.7% had partial revascularization, and at discharge, 63.5% had permeabilized the thrombosis against 19% who had residual thrombosis or progression of thrombosis. There was a positive correlation between mobility parameters and improvement in the performance of daily activities (rho = 0.35; p = 0.012) and with improvement in pain/discomfort (rho = 0.37; p = 0.007). An improvement in pain parameters was statistically significantly related to a global assessment health perception (rho = 0.48; p < 0.001). Anxiety and depression parameters were related to a global assessment health perception (rho = 0.462; p = 0.001) and to an overall improvement at 12 months (rho = 0.45; p = 0.001). CONCLUSIONS: Superficial venous thrombosis (SVT) is a highly prevalent disease, which is traditionally considered banal and has good evolution, with heterogeneous management in clinical practice and limited information on patient selection for therapies, current treatment routes, and drug use, as well as outcomes. In recent years, the importance of this entity has become evident due to its frequency in clinical practice, its risk of complications, and the impact it has on the quality of life. This study’s results emphasize the importance of the diagnosis, treatment, and follow-up of superficial venous thrombosis. Full article

An accurate prediction of house prices is a fundamental requirement for various sectors, including real estate and mortgage lending. It is widely recognized that a property’s value is not solely determined by its physical attributes but is significantly influenced by its surrounding neighborhood. Meeting the diverse housing needs of individuals while balancing budget constraints is a primary concern for real estate developers. To this end, we addressed the house price prediction problem as a regression task and thus employed various machine learning (ML) techniques capable of expressing the significance of independent variables. We made use of the housing dataset of Ames City in Iowa, USA to compare XGBoost, support vector regressor, random forest regressor, multilayer perceptron, and multiple linear regression algorithms for house price prediction. Afterwards, we identified the key factors that influence housing costs. Our results show that XGBoost is the best performing model for house price prediction. Our findings present valuable insights and tools for stakeholders, facilitating more accurate property price estimates and, in turn, enabling more informed decision making to meet the housing needs of diverse populations while considering budget constraints. Full article

Automated software testing is a crucial yet resource-intensive aspect of software development. This burden on resources affects widespread adoption, with expertise and cost being the primary challenges preventing adoption. This paper focuses on automated testing driven by manually created test cases, acknowledging its advantages while critically analysing its implications across various development stages that are affecting its adoption. Additionally, it analyses the differences in perception between those in nontechnical and technical roles, where nontechnical roles (e.g., management) predominantly strive to reduce costs and delivery time, whereas technical roles are often driven by quality and completeness. This study investigates the difference in attitudes toward automated testing (AtAT), specifically focusing on why it is not adopted. This article presents a survey conducted among software industry professionals that spans various roles to determine common trends and draw conclusions. A two-stage approach is presented, comprising a comprehensive descriptive analysis and the use of Principal Component Analysis. In total, 81 participants received a series of 22 questions, and their responses were compared against job role types and experience levels. In summary, six key findings are presented that cover expertise, time, cost, tools and techniques, utilisation, organisation, and capacity. Full article

The following differential quadratic polynomial differential system  $\frac{dx}{dt}=y-x, \frac{dy}{dt}=2y-\frac{y}{\gamma -1}\left(2-\gamma y-\frac{5\gamma -4}{\gamma -1}x\right),$ when the parameter $\gamma \in (1,2]$ models the structure equations of an isotropic star having a linear barotropic equation of state, being $x=m\left(r\right)/r$ where $m\left(r\right)\ge 0$ is the mass inside the sphere of radius r of the star, $y=4\pi r^2\rho$ where $\rho$ is the density of the star, and $t=ln(r/R)$ where R is the radius of the star. First, we classify all the topologically non-equivalent phase portraits in the Poincaré disc of these quadratic polynomial differential systems for all values of the parameter $\gamma \in \mathbb{R}\setminus \left\{1\right\}$. Second, using the information of the different phase portraits obtained we classify the possible limit values of $m\left(r\right)/r$ and $4\pi r^2\rho$ of an isotropic star when r decreases. Full article

Under the Climate Change scenario, the occurrence of Harmful Cyanobacterial Blooms (HCBs) is an increasingly concerning problem. Particularly for inland freshwaters, that have human populations depending on them for consumption or recreation, HCBs can lead to serious ecological damages and socio-economic impacts, but also to health risks for local communities. From satellite imagery to molecular data, there is an increasing number of methodological approaches that can help improve the monitoring and prediction of cyanobacterial blooms. However, although each methodology has its own strengths and limitations, generally there is a lack of data addressing specific and intraspecific information, which has implications for the modelling and prediction of the real dynamics and toxicity of HCBs. The present review intends to make a quick overview on current approaches to monitor cyanobacterial blooms and provide a tier-based integrative perspective for their application. A transversal monitoring at a wide scale should be enhanced but cannot rely only on pigment levels but rather include the specific and intraspecific diversity information that can be obtained from modern molecular tools. This is crucial to achieve the effective prediction, monitoring and management of HCBs under their increasing occurrence and severity trends in freshwaters. Full article

Peripheral nerve injuries inflict severe consequences, necessitating innovative therapeutic strategies. This study investigates the potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in mitigating the consequences of peripheral nerve injury. The existing treatment methods for such injuries underscore the importance of ongoing translational research efforts. Thirty adult Wistar rats underwent sciatic nerve dissection and repair surgery. The nerves were surgically transected using micro scissors at a precise location located 1.5 cm proximal to the trifurcation site. The study included a control group and two experimental groups, one treated with saline (placebo group) and the other with liraglutide (experimental group) for 12 weeks. Motor function, electromyography (EMG), and biochemical and histopathological analyses were performed after 12 weeks of treatment. Electrophysiological assessments revealed that liraglutide improved the compound muscle action potential (CMAP) amplitude and motor function compared to the saline-treated group. Histological and immunohistochemical analyses demonstrated increased NGF expression, total axon number, and diameter and reduced fibrosis in the liraglutide group. Biochemical analyses illustrated liraglutide’s antioxidative properties, evidenced by reduced malondialdehyde (MDA) levels. Galectin-3 levels were suppressed and GDF-11 levels were modulated by liraglutide, indicating anti-inflammatory and anti-apoptotic effects. Liraglutide is a promising therapeutic intervention for peripheral nerve injuries, promoting functional recovery and histopathological improvement. Its multifaceted positive impact, beyond glycemic control, suggests constructive effects on the acute and chronic inflammatory processes associated with peripheral neuropathy. These findings warrant further research to elucidate molecular mechanisms and facilitate clinical translation. The study contributes valuable insights to the growing understanding of GLP-1 receptor agonists’ neuroprotective properties in the context of peripheral nerve injuries. Full article