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    • Article
    • Open Access

    Delayed density dependence is a significant process in insect population dynamics; nonetheless, its identification and resulting dynamical implications remain subjects of substantial contention. Motivated by this controversy, we investigate a two-generation discrete-time model of the form where . This model integrates both instantaneous and one-generation-lagged density dependence via a weighted amalgamation of successive population densities. Based on general assumptions regarding the diminishing recruitment function f, we delineate the local asymptotic stability of the positive equilibrium and demonstrate that the ratio ab, which quantifies the relative influence of direct versus delayed density dependence, plays a crucial role in determining stability and its structure. The stability region is maximized when a=3b; if a<3b, stability may be compromised by a Neimark–Sacker bifurcation, whereas for a>3b, it may be compromised through a period-doubling bifurcation. We also investigate strong local asymptotic stability and identify additional parameter regimes satisfying this criterion after the first expansion. Separately, we establish global asymptotic stability under explicit sufficient conditions by constructing enveloping maps. As prototypes, we consider Ricker- and logistic-type models. We implement the overarching theory, derive explicit invariant regions, establish bifurcation criteria, and obtain global stability results. The examination underscores that the balance between direct and delayed density dependence can significantly alter the qualitative behavior of insect populations.

    Symmetry

    27 October 2026

    • Article
    • Open Access

    In this study, comparative experiments on picosecond laser drilling were conducted in three different environments: air, water-based, and underwater. By varying the laser power (11–15 W), the effects of different water-assisted methods on hole diameter, taper, sidewall morphology, and oxidation degree were analyzed, and the laser drilling mechanisms operating under these conditions were revealed. The experimental results showed that both water-based and underwater assistance significantly improved laser drilling quality. In the underwater environment, the water thickness was greater than in the water-based case. Laser energy attenuation became more pronounced when the beam reached the bottom of the hole, further reducing the material removal rate. This resulted in a smaller exit diameter than under the water-based conditions and thus a larger taper. However, since the workpiece was fully submerged throughout the process, almost no molten material was observed at the entrance. The roughness at the entrance and middle of the hole was lower than in the water-based environment. Nevertheless, the water layer in the underwater environment isolated the workpiece from air, enabling drilling under near oxygen-free conditions. The oxygen content of the sidewalls was significantly reduced compared to the air environment.

    Metals

    27 October 2026

    • Article
    • Open Access

    Whether advances in global weather forecasting translate into local forecast skill requires regional verification. Using observations at 117 stations in Inner Mongolia during the June–August 2026 flood season, we compared three publicly distributed forecast fields at 6–84 h lead times: the Integrated Forecasting System control forecast (IFS-Control), the Artificial Intelligence Forecasting System (AIFS), and WeatherNext 2’s 64-member ensemble mean (WN2). Because WN2 is an ensemble mean and the others are single deterministic forecasts, this compares operational products, not the underlying models. Verification of 2 m temperature and precipitation used Murphy error decomposition and block-bootstrap sensitivity tests. Temperature mean absolute error was approximately 15.7% lower for AIFS and 13.1% lower for WN2 than for IFS-Control, mainly through smaller correlation-error terms, though IFS-Control had the smallest systematic bias. Both AI products outperformed IFS-Control for 6 h moderate rain (≥4 mm). IFS-Control robustly outperformed AIFS for 6 h heavy rain (≥13 mm), but its advantage over WN2 did not survive the stricter multiple-comparison correction. Both AI products under-forecast heavy-rain frequency and extremes; a limited member experiment suggests ensemble averaging may contribute, though not separably from model differences. Findings apply only to the product versions, region, and season evaluated.

    Atmosphere

    27 October 2026

    • Article
    • Open Access

    Influence of Donor Cells on the Efficiency of Cloned Ỉ Pig Production

    • Au Thi Hoang,
    • Vu Thi Thu Huong and
    • Van Khanh Nguyen
    • + 11 authors

    In this study, we investigated the effects of donor cell on the efficiency of producing cloned Ỉ pigs, an endangered Vietnamese breed. Cloned Ỉ pig embryos were generated using somatic cell nuclear transfer technology (SCNT). The results demonstrated that pregnancy, farrowing, and piglet production rates of Ỉ pig fibroblasts (ID:6004) at the 5th and 6th passages were significantly higher compared with those observed at the 4th and 7th passages. Under the conditions of this study, no significant effect of donor cell sex or cell lines on the efficiency of cloned Ỉ pig embryo transfer was observed. The pregnancy, farrowing, and piglet production rates did not differ significantly between donor cell groups of male and female origin (p > 0.05). Similarly, no significant differences were observed in pregnancy rates, farrowing outcomes, or one-week survival of live cloned piglets among the three donor cell lines (IDs: 6004, 9154, and 9157) (p > 0.05). These findings contribute to improving the efficiency of the somatic cell nuclear transfer (SCNT) technique in efforts to conserve the critically endangered Vietnamese Ỉ pig.

    Animals

    27 October 2026

    • Article
    • Open Access

    Commercial nonionic sucrose ester surfactants (SEs) contain varying ratios of monoesters and polyesters. In our previous study, we found that when the mono-to-polyester (MP) ratio is close to 1, SE dispersions can form hydrogels at very low surfactant and electrolyte concentrations. In the current study, we systematically investigate how the MP ratio and particle size affect the salt-induced gelation process. We reveal that SE dispersions form hydrogels only within a certain MP range. At low MP ratios (<0.4), micrometer-sized particles form and sediment, preventing gel formation, whereas at high MP ratios (≳3), particle concentration decreases, confining gelation to a very narrow electrolyte region. Sonication significantly reduces particle size across all dispersions, expanding the gelation domain down to MP ≈ 0.3. The critical salt concentration required for hydrogel formation exhibits a maximum as a function of MP ratio at MP ≈ 0.43, which is explained with the highest measured zeta potential for these particles. The obtained results support the hypothesis that increasing the monoester content enhances surface mobility, suppresses hydroxide ion adsorption, and reduces particle charge, thereby lowering the threshold electrolyte concentration. Finally, particle size reduction enhances overall gel strength and lowers the minimum surfactant concentration required for gelation. These findings enable the rational design of simple, biodegradable hydrogels with tunable properties for future applications in food, pharmaceutical, and cosmetic formulations.

    Gels

    27 October 2026

    • Systematic Review
    • Open Access

    Student support in open and distance e-learning (ODeL) higher education remains unevenly governed, particularly for historically disadvantaged, low-income, rural, and disabled students. This systematic review compares how governance structures shape equitable student support in the United States and South Africa, two systems marked by histories of racial segregation and apartheid and by persistent racial, socioeconomic, technological, and disability-related inequalities. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the review searched five databases and relevant policy repositories, screening 773 records and appraising 123 full-text reports. Twenty-one sources met the inclusion criteria, comprising 13 empirical studies and eight governance and policy documents published mainly between 2013 and 2025. Because the corpus was deliberately bounded to governance evidence from two national systems, the review is a focused comparative synthesis rather than an exhaustive account of distance education provision in either country. A thematic synthesis examined legislation, funding, disability provisions, quality assurance, and institutional accountability. Findings show that both countries articulate strong equity commitments but experience persistent implementation, monitoring, and accountability gaps, with the digital divide undermining support for rural and low-income learners. Contextual differences in funding models and regulatory design generate transferable lessons. The review proposes an equity-oriented governance framework that links foundational equity values, four governance pillars, and continuous monitoring to strengthen inclusive, accountable, and sustainable student support.

    Educ. Sci.

    27 October 2026

    • Article
    • Open Access

    Background/Objectives: Undernutrition remains an important contributor to morbidity and mortality among children under five years of age, particularly in rural and low-resource settings. This study determined the proportion of children with documented readmission for undernutrition and identified associated factors at Bela-Bela District Hospital, Limpopo Province, South Africa. Methods: A retrospective analytical hospital record review covering January 2018 to December 2025 was conducted. Of 538 medical records identified, 94 were excluded, 444 remained eligible, and 222 were selected through systematic random sampling. Clinical, caregiver/household conditions, healthcare-related and post-discharge data were extracted. The primary outcome was documented readmission for undernutrition at Bela-Bela District Hospital following discharge. Multivariable logistic regression was used to identify independently associated factors. Results: Of 222 children, 54 (24.3%) had documented readmission. Previous admission for undernutrition was strongly associated with documented readmission (AOR = 4.12; 95% CI: 2.00–8.50; p < 0.001). Lack of documented caregiver nutrition education (AOR = 3.10; 95% CI: 1.40–6.90; p = 0.005), absence of a documented follow-up date (AOR = 2.20; 95% CI: 1.05–4.60; p = 0.036), and failure to attend follow-up according to schedule (AOR = 1.95; 95% CI: 1.05–3.60; p = 0.030) were also associated with documented readmission. Conclusions: Documented readmission was associated with previous admission for undernutrition and gaps in documented post-discharge care. These findings highlight the importance of strengthening post-discharge planning, documentation of caregiver nutrition education, documentation of follow-up appointments, and continuity of nutritional support.

    Nutrients

    27 October 2026

    • Article
    • Open Access

    Nature reserves serve as core areas for maintaining ecological functions in karst regions, and their conservation efficacy and surrounding influence are crucial to ecological security. However, knowledge gaps remain regarding spillover effects, driving mechanisms, and key areas around nature reserves across landform types in the Southern China Karst. This study examines conservation effectiveness, spillover effects in surrounding buffer zones (5–10 km), and driving mechanisms across NRs of different landform types. Results show that ecosystem services decline along the gradient of “nature reserves–5 km buffer zone–10 km buffer zone”. The 5 km buffer shows stronger potential spillover patterns than the 10 km zone, particularly for carbon storage and soil conservation. The karst fault basin exhibits higher protection efficiency in the 5 km buffer zone than within nature reserves, indicating ecological feedback. Environmental variables are direct positive drivers of integrated ecosystem services; vegetation variables exert the strongest positive mediating effect via environmental variables; degradation variables show region-dependent mediating effects; and the negative direct effect of human-activity variables weakens with distance, alongside positive mediating effects. This study fills knowledge gaps concerning the spatial differentiation of conservation effectiveness and ecological key areas, offering support for ecological protection and restoration.

    Land

    27 October 2026

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Highly Accessed Articles

  • Article
  • Open Access

I argue that the emerging sciences of synthetic morphology and diverse intelligence suggest non-physicalist models of mind and show how they can be empirically investigated. Whence the anatomical, physiological, molecular-biological, and behavioral properties of engineered new beings that have never before existed, and do not have a history of selection? Understanding, predicting, and guiding new forms of life and mind requires characterizing a structured latent space of patterns. Developmental, synthetic, and behavioral biology should take seriously, and exploit, the kinds of non-physicalist ideas that are already a staple of Platonist mathematics. I propose the following hypotheses. (1) Patterns in this space span a highly variable degree of agency, comprising a spectrum ranging from static truths studied by mathematicians to active ones studied by behavioral scientists (i.e., some patterns on the same spectrum as mathematical truths are kinds of minds). (2) The relationship between mind and body is the same as the relationship between causally instructive mathematical facts and physics. (3) Living beings have no monopoly on the “free lunches” provided by the ingression of these patterns into the physical world. While traditional computationalist views of living and cognitive systems are insufficient, my framework erases artificial distinctions between organisms and machines, framing all physical constructs (natural or engineered) as being, to various degrees, in-formed by patterns from the latent space. I sketch a research program, already begun, inspired by these ideas. Such frameworks, while contradicting long-held assumptions of both mechanists and organicists, could have many implications for evolutionary biology, regenerative medicine, AI, and the ethics of synthbiosis with the forthcoming immense diversity of morally important beings.

Philosophies

9 September 2026

76,780 Views
Bodies and minds self-assemble from single cells as a process of alignment and autopoiesis. (A) Most complex biological forms begin as one cell—a fertilized oocyte, commonly thought to be well-described by the laws of physics and chemistry. (B) A gradual, slow process of developmental morphogenesis results in the final form of the organism, which may have complex structure and a mind which may not believe it is a “machine”. Our transformation from a chemical soup into an active embodied mind is continuous but heterogeneous: (C) while we commonly think of ourselves as a unified intelligence with a “centralized” brain, the fact is that even the pineal gland, of which there is only one in the brain, is made of cells (C′) and those cells in turn are made of myriad other active components (C″)—we are a collective intelligence at all scales. (D) The creation of an “individual” out of an excitable medium such as an embryonic blastoderm with hundreds of thousands of cells is a dynamic process that is not hardwired: scratches made in that blastoderm would result in independent self-organization in each island, resulting in multiple embryos forming. This reveals the potentiality for some non-pre-determined number of minds to arise out of the same substrate. Images in (A,B,D) courtesy of Jeremy Guay of Peregrine Creative, used previously in [29]. Image (B) used with permission from [30]. Image in (C′) courtesy of Jose Calvo, Science Photo Library. Image in (C″) courtesy of Evan Ingersoll and Gaël McGill. Image (D) used with permission from [31].
  • Article
  • Open Access

Digital Facial Approximation of Jebel Irhoud Composite Skull (~315,000 BP)

  • Cicero Moraes,
  • Elena Varotto and
  • Johari Yap Abdullah
  • + 3 authors

The archeological site of Jebel Irhoud, Morocco, houses the oldest fossils attributed to Homo sapiens, dated to approximately 315,000 years before present (BP). This study presents a forensic facial approximation based on data from a three-dimensional composite skull derived from Layer 7 of the site, with structural predominance of the Irhoud 1 fossil. The methodology employed open-source software tools, combining anatomical projections and the constrained anatomical deformation technique. Endocast segmentation yielded a volume of 1364 mL, a result fully compatible with measurements and segmentations obtained in previous studies directly from the fossil, while also aligning with the variation observed in modern populations. Two sets of images were produced: an objective approximation in grayscale, focused on osteological correspondence, and a colored artistic version featuring skin pigmentation and facial hair for scientific communication. The results reinforce the feasibility and reproducibility of open-access methodologies applied to paleoanthropology, offering an anatomically coherent representation of this Middle Pleistocene hominin.

Heritage

13 September 2026

18,245 Views
(A) Photogrammetry performed from video (credit: Philipp Gunz, MPI EVA Leipzig, License: CC-BY-SA 2.0). (B) One of the scale adjustments based on images of the findings. (C) Adjustment of the virtual donor to the endocranial structure (credit: Philipp Gunz, MPI EVA Leipzig, License: CC-BY-SA 2.0). (D) Segmentation of the endocranium from the anatomical deformation of the virtual donor. References available in [3].
  • Review
  • Open Access

Background: Chlorine dioxide (ClO2), formulated as an aqueous solution (CDS), has been proposed as a therapeutic agent, yet its classification among oxidizing compounds is frequently confounded with chemically distinct species—sodium chlorite (NaClO2) and sodium hypochlorite (NaOCl). Objective: This study aimed to synthesize the physicochemical, mechanistic and cellular basis of ClO2 action and to delineate the distinctions between ClO2 and related oxidants, with explicit separation of established data from hypothesized data. Methods: The methodology includes a narrative synthesis of electrochemical data, primary toxicological and clinical literature (PubMed) and the redox-biology literature on low-dose oxidant signaling. Results: ClO2 is a neutral free radical that acts via one-electron transfer (E°′ = +0.95 V vs. SHE for the half-reaction ClO2 + e− → ClO2−, essentially pH-independent over pH 4–8, pH-independent) without chlorination. Its antimicrobial action is attributable to oxidation of thiol-dependent enzymes and membrane constituents and to the inhibition of bacterial respiratory metabolism; host-cell sparing is consistent with differential glutathione-dependent buffering. Controlled human ingestion studies at low concentrations report a favorable short-term safety profile; conversely, the principal metabolite (chlorite) is associated with documented developmental toxicity in animals and regulatory caution by EPA/WHO. Low-dose ClO2 exposure is hypothesized—but not yet directly demonstrated—to elicit dose-dependent adaptive redox responses and redox-regulatory modulation. Conclusions: The one-electron, non-chlorinating chemistry of ClO2 provides a coherent mechanistic framework. The translation of this framework into clinical application requires prospective trials and direct mechanistic measurement, ideally conducted by independent investigators. The following mechanisms are hypothesized and have not yet been directly demonstrated in vivo: modulation of oxidative phosphorylation, mitochondrial oxygenation, and associated redox-regulatory signaling. Reported antimicrobial efficacy typically occurs in the low-ppm range (0.1–5 ppm), whereas adverse effects on mammalian cells in the reviewed literature are reported at concentrations at least one order of magnitude higher; direct head-to-head cytotoxicity comparisons remain scarce and are identified as a priority for future work. This differential thiol buffering—in particular, the higher glutathione content of many mammalian cells relative to many pathogens—has been proposed as a contributing basis for host-cell sparing; direct quantitative confirmation in vivo is not yet available. Bacterial species possess their own thiol-based defense systems (e.g., mycothiol in actinomycetes, bacillithiol in Firmicutes), and the interplay between ClO2 and these systems requires further investigation.

Biophysica

21 September 2026

13,053 Views
Mechanistic overview. ClO2 acts via one-electron oxidation of microbial targets (thiol oxidation, envelope and nucleic acid damage, respiratory inhibition); host cells are spared through glutathione-dependent redox buffering. The proposed low-dose hormetic response is a hypothesis requiring direct experimental confirmation, as discussed in Section 4.2.
  • Article
  • Open Access

Nanoconfinement-Enhanced CO2 Retention in Fenamate-Loaded Silica Aerogels

  • Konstantin Belov,
  • Maria Ikim and
  • Ilya Khodov
  • + 6 authors

The interaction between carbon dioxide and molecularly confined pharmaceutical compounds can result in CO2 retention that exceeds that achieved through conventional physical adsorption. This study investigates CO2 retention following sorption in hydrophilic and hydrophobic silica aerogels containing the fenamates mefenamic acid and flufenamic acid. The Thermal stability of the retained CO2 was characterized using temperature-programmed oxidation and temperature-programmed desorption measurements. Concurrently, single-point nitrogen adsorption measurements monitored relative changes in the apparent accessible surface area of the porous matrix. Untreated silica aerogels did not exhibit a significant CO2 desorption peak at elevated temperatures. In contrast, all composites containing fenamates exhibited an additional high-temperature desorption step beginning at approximately 225 °C, indicating enhanced CO2 retention after sorption once the external CO2 layer was removed. This characteristic persisted following preliminary thermal treatment, suggesting it is not solely attributable to residual volatile substances. Surface-area measurements indicated minimal changes in the original aerogels after the CO2 cycle, whereas composites with flufenamic acid demonstrated more pronounced alterations. Considering previous nuclear magnetic resonance, spectroscopic, and computational studies, these findings suggest a combined effect of nanoconfinement, surface-dependent interfacial phenomena, and specific interactions involving the fenamate-containing phase. Reversible chemical interactions may contribute to the observed retention, although the current measurements do not allow for quantitative separation of their effects from those of physical confinement.

Molecules

14 September 2026

13,073 Views
TPO (black) and TPD (red) curves for AG-H-Phil (a) and AG-H-Phob (b) recorded over the temperature range from 30 °C to 500 °C.

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Editor's Choice Articles

  • Review
  • Open Access

Cistus creticus, a perennial shrub native to the Mediterranean region, has attracted considerable scientific attention due to its rich phytochemical profile and associated health-promoting properties. This review provides a comprehensive analysis of the antioxidant activity of C. creticus, examining the various extraction methods that influence the bioavailability and efficacy of its active compounds. The plant’s antioxidant properties are primarily attributed to its high content of flavonoids, phenolic acids, and other bioactive constituents, which play a key role in mitigating oxidative stress and reducing the risk of chronic diseases. The review further discusses the effectiveness of different extraction techniques—mainly maceration and ultrasound-assisted extraction—in maximizing the yield and potency of antioxidants from the plant. By synthesizing current research findings, this review aims to highlight the therapeutic potential of C. creticus and provide a basis for future studies on its application in nutraceuticals and functional foods.

AppliedChem

2 October 2026

Conceptual overview of extraction methods, polyphenolic classes, biological activities, and food applications of Cistus creticus extracts.
  • Review
  • Open Access

Technology-mediated sexual behaviours, including cybersex and technosex, are becoming increasingly prevalent as digital technologies, virtual reality, artificial intelligence, and interactive devices continue to develop. Although these behaviours may offer numerous benefits, such as facilitating sexual exploration, supporting individuals with disabilities, and enabling long-distance intimacy, they may also contribute to problematic patterns of use in some individuals. This review synthesises current knowledge on the psychological and neurobiological mechanisms underlying cybersex and technosexual behaviour. The article discusses conceptual and definitional issues, epidemiological data, and theoretical frameworks, including the Triple A model and the “quasi-necrophilia” framework, to explain the characteristics and motivations behind technology-mediated sexual activities. Furthermore, it summarises psychological factors associated with both adaptive and maladaptive use, emphasising the role of emotion regulation, personality traits, neurodevelopmental conditions, mental health, and sexual motivations. The review also presents current evidence on the neurobiology of cybersex and technosex, highlighting the involvement of dopaminergic reward pathways and similarities to other reward-related behaviours. Finally, available approaches to the treatment of problematic technology-mediated sexual behaviour are discussed, including pharmacotherapy, as well as psychoeducation and psychotherapy, with particular attention to the importance of addressing underlying psychological conditions. The article argues that cybersex and technosex should not be inherently pathologised—instead, they should be understood within a biopsychosocial framework that distinguishes between healthy sexual expression and clinically significant impairment.

Brain Sci.

9 October 2026

  • Review
  • Open Access

Wearable and attachable healthcare devices provide valuable insights across a broad range of applications, from health monitoring and disease diagnosis to the assessment of daily human activities. For these devices, both the formation of high-performance electrodes and mechanical, electrical, and physiological stability at human-device interfaces are critically important. Conductive gels, which combine deformable polymer networks with electrical conductivity, show considerable potential as functional materials for such applications. However, existing reviews have often considered material properties, interfacial behavior, and device reliability separately. This review examines hydrogels, ionogels, and organogels by linking material design, stimulus- and analyte-responsive sensing, biological and device interfaces, and healthcare applications. This integrated perspective emphasizes evaluating conductive gels within complete healthcare devices, where material properties, biological interfaces, and device integration jointly determine practical performance. Such evaluation needs to address signal quality and the stability of the assembled system during deformation, environmental exposure, and prolonged use. Future progress will require reproducible device fabrication and standardized validation tailored to the intended application, with systematic assessment of long-term biosafety and alignment with relevant regulatory requirements. Integration with flexible electronics, intelligent data processing, and feedback control may further enable reliable and responsive healthcare platforms.

Gels

30 September 2026

  • Review
  • Open Access

Accelerating the low-carbon transition of transport is essential to addressing global climate change. Although the rapid growth of the electric vehicle (EV) fleet highlights the environmental benefits of electrified mobility, carbon-intensive upstream electricity generation and energy-intensive battery production continue to constrain the life-cycle emissions reduction potential of EVs. Focusing on China, this structured narrative review examines 121 core references from 2004 to 2026 to synthesize carbon-accounting methods and emissions across the manufacturing, use, and end-of-life stages. A supplementary keyword co-occurrence analysis of 1180 Web of Science records provides an overview of the research field. The reviewed evidence indicates that embodied emissions from manufacturing account for more than 30% of total life-cycle emissions, making this stage important to life-cycle decarbonization. The use stage offers the greatest emissions reduction potential and is closely linked to regional grid carbon intensity and vehicle-to-grid (V2G) scheduling. At the end of life, second-life battery use and closed-loop recycling can reduce the burden associated with initial production and support material circularity. Drawing on these findings and the development of China’s EV industry, this review proposes decarbonization pathways for enterprises and policymakers to support the coordinated development of the transport and energy sectors.

World Electr. Veh. J.

30 September 2026