The gut microbiota plays a pivotal role in the balance between host health and obesity. The composition of the gut microbiota can be influenced by external factors, among which diet plays a key role. As the source of dietary protein is important to achieve weight loss and gut microbiota modulation, in the literature there is increasing evidence to suggest consuming more plant proteins than animal proteins. In this review, a literature search of clinical trials published until February 2023 was conducted to examine the effect of different macronutrients and dietary patterns on the gut microbiota in subjects with overweight and obesity. Several studies have shown that a higher intake of animal protein, as well as the Western diet, can lead to a decrease in beneficial gut bacteria and an increase in harmful ones typical of obesity. On the other hand, diets rich in plant proteins, such as the Mediterranean diet, lead to a significant increase in anti-inflammatory butyrate-producing bacteria, bacterial diversity and a reduction in pro-inflammatory bacteria. Therefore, since diets rich in fiber, plant protein, and an adequate amount of unsaturated fat may help to beneficially modulate the gut microbiota involved in weight loss, further studies are needed. Full article

Wheat (Triticum aestivium L.) and barley (Hordeum vulgare L.) are two commonly grown cereal crops in the northern Great Plains. Adding other crops such as field pea (Pisum Sativum L.), canola (Brassica napus L.), or camelina (Camelina sativa L.) to wheat or barley cropping systems may improve soil quality. However, little is known about the effects of including oilseeds in small grain cropping systems on soil physical properties. We sampled an 8-year dryland study with 10 different cropping systems including continuous spring wheat, continuous winter wheat, continuous barley, pea–spring wheat, pea–barley, pea–winter wheat, pea–barley–camelina–spring wheat, pea–barley–canola–spring wheat, pea–winter wheat–camelina–spring wheat and pea–winter wheat–canola–spring wheat. We measured dry aggregate stability, wet aggregate stability, water retention, hydraulic conductivity, bulk density and total carbon. Continuous barley and winter wheat had a higher fraction of large dry soil aggregates, whereas the pea–barley–canola–spring wheat and pea–spring wheat cropping systems had a higher fraction of small aggregates in the 0–15 cm depth. However, wet aggregate stability, water retention, bulk density, hydraulic conductivity and soil carbon concentration were not affected by the cropping system in the 0–15 cm depth. Diversifying small grain cropping systems by adding canola or camelina oil seeds and peas generally did not affect soil physical properties at this location. Full article

The aim of this work is to present an efficient procedure for growing large metallic single crystals that associates a classical growth technique (namely, the critical strain-annealing—CSA—method) with advanced methods of accurate full-field strain measurements based on digital image correlation (DIC) technique and of sample geometry design using finite element analysis. Measuring the critical plastic strains with an accuracy better than 0.1% resulted in a significantly improved construction of the recrystallization diagram. Applying this “DIC-assisted CSA method” to an A1050 commercially pure aluminum allowed obtaining in less than two days (26 h to 30 h) large multi-crystal samples with a half dozen of large grains. Their length between 35 mm and 100 mm was in full agreement with the obtained recrystallization diagram. Full article

Methane (CH₄) is the second most significant contributor to climate change after carbon dioxide (CO₂), accounting for approximately 20% of the contributions from all well-mixed greenhouse gases. Understanding the spatiotemporal distributions and the relevant long-term trends is crucial to identifying the sources, sinks, and impacts on climate. Hyperspectral thermal infrared (TIR) sounders, including the Atmospheric Infrared Sounder (AIRS), the Cross-track Infrared Sounder (CrIS), and the Infrared Atmospheric Sounding Interferometer (IASI), have been used to measure global CH₄ concentrations since 2002. This study analyzed nearly 20 years of data from AIRS and CrIS and confirmed a significant increase in CH₄ concentrations in the mid-upper troposphere (around 400 hPa) from 2003 to 2020, with a total increase of approximately 85 ppb, representing a +4.8% increase in 18 years. The rate of increase was derived using global satellite TIR measurements, which are consistent with in situ measurements, indicating a steady increase starting in 2007 and becoming stronger in 2014. The study also compared CH₄ concentrations derived from the AIRS and CrIS against ground-based measurements from NOAA Global Monitoring Laboratory (GML) and found phase shifts in the seasonal cycles in the middle to high latitudes of the northern hemisphere, which is attributed to the influence of stratospheric CH₄ that varies at different latitudes. These findings provide insights into the global budget of atmospheric composition and the understanding of satellite measurement sensitivity to CH₄. Full article

This study numerically investigates the effects of diluent gas proportion, the overdrive factor, and throat width on the wave structure and thrust performance of a ram accelerator operating in super-detonative mode. For premixed gas of a high energy density, a typical unstart oblique detonation wave system is observed due to the ignition on the front wedge of the projectile, and the detonation waves move downstream to the shoulder as the energy density decreases. In the start range of the overdrive factor, the wave position also shows a tendency to move downstream as the projectile velocity increases, accompanied by oscillations of the wave surface and thrust. As the throat width increases, the wave standing position changes non-monotonously, with an interval of upstream movement and Mach reflection. The typical wave structure of a ram accelerator in super-detonative mode is identified, as well as the unstart stable wave features and the unstable process for choking, which can provide theoretical guidance for avoiding unstart issues in ram accelerators and optimizing their performance. Full article

Civil infrastructure monitoring with the aim of early damage detection and acquiring the data required for urban management not only prevents sudden infrastructure collapse and increases service life and sustainability but also facilitates the management of smart cities including smart transportation sectors. In this context, smart geosynthetics can act as vital arteries for extracting and transmitting information about the states of the strain, stress, damage, deformation, and temperature of the systems into which they are incorporated in addition to their traditional infrastructural roles. This paper reviews the wide range of technologies, manufacturing techniques and processes, materials, and methods that have been used to date to develop smart geosynthetics to provide rational arguments on the current trends and utilise the operational trends as a guide for predicting what can be focused on in future researches. The various multifunctional geosynthetic applications and future challenges, as well as operational solutions, are also discussed and propounded to pave the way for developing applicable smart geosynthetics. This critical review will provide insight into the development of new smart geosynthetics with the contribution to civil engineering and construction industries. Full article

A natural gas combined cooling, heating, and power (CCHP) system is a typical integrated energy supply method that optimizes end−use energy. However, how to achieve economically feasible natural gas CCHP in severe cold regions with low−grade heat demand reaching 50% is still a pressing issue. This paper establishes a typical natural gas CCHP system model for severe cold regions and conducts the system. Based on the climate conditions of Harbin, the economic optimization of independent gas turbine systems, internal combustion engines, and gas turbine systems is still a pressing issue. Based on the climate conditions of Harbin, the economic optimization of independent gas turbine systems, internal combustion engine systems, and steam boiler systems under different cooling and heating load ratios was carried out. The combination of “internal combustion engine + steam boiler” has the most optimal cost of RMB 1.766 million (USD 0.255 million), saving 10.7%, 7.8%, and 18.3% compared to the three single equipment subsystems respectively. This provides good theoretical support for the construction of multi−energy heterogeneous energy systems. Full article

Over time, human beings have built increasingly large astronomical observatories to increase the number of discoveries related to celestial objects. However, the amount of collected elements far exceeds the human capacity to analyze findings without help. For this reason, researchers must now turn to machine learning to analyze such data, identifying and classifying transient objects or events within extensive observations of the firmament. Algorithms from the family of random forests (an ensemble of decision trees) have become a powerful tool that can be used to classify astronomical events and objects. This work aims to illustrate the versatility of machine learning algorithms, such as decision trees, to facilitate the identification and classification of celestial bodies by manipulating hyperparameters and studying the attributes of celestial body datasets. By applying a random forest algorithm to a well-known dataset that includes three types of celestial bodies, its effectiveness was compared against some supervised classifiers of the most important approaches (Bayes, nearest neighbors, support vector machines, and neural networks). The results show that random forests are a good alternative for data analysis and classification in astronomical observations. Full article

Oral cancer has traditionally been treated with surgery, radiotherapy, chemotherapy, or a combination of these therapies. Although cisplatin, a chemotherapy drug, can effectively kill oral cancer cells by forming DNA adducts, its clinical use is limited due to adverse effects and chemo-resistance. Therefore, there is a need to develop new, targeted anticancer drugs to complement chemotherapy, allowing for reduced cisplatin doses and minimizing adverse effects. Recent studies have shown that 3,5-Bis (4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidine (PAC), a new curcumin analog, possesses anticancer properties and could be considered a complementary or alternative therapy. In this study, we aimed to assess the potential complementary effects of PAC in combination with cisplatin for treating oral cancer. We conducted experiments using oral cancer cell lines (Ca9-22) treated with different concentrations of cisplatin (ranging from 0.1 μM to 1 μM), either alone or in conjunction with PAC (2.5 and 5 μM). Cell growth was measured using the MTT assay, while cell cytotoxicity was evaluated using an LDH assay. Propidium iodide and annexin V staining were employed to examine the impact on cell apoptosis. Flow cytometry was used to investigate the effects of the PAC/cisplatin combination on cancer cell autophagy, oxidative stress, and DNA damage. Additionally, a Western Blot analysis was performed to assess the influence of this combination on pro-carcinogenic proteins involved in various signaling pathways. The results demonstrated that PAC enhanced the efficacy of cisplatin in a dose-dependent manner, leading to a significant inhibition of oral cancer cell proliferation. Importantly, treatment with PAC (5 μM) alongside different concentrations of cisplatin reduced the IC50 of cisplatin tenfold. Combining these two agents increased apoptosis by further inducing caspase activity. In addition, the concomitant use of PAC and cisplatin enhances oral cancer cell autophagy, ROS, and MitoSOX production. However, combined PAC with cisplatin inhibits the mitochondrial membrane potential (ΔΨm), which is a marker for cell viability. Finally, this combination further enhances the inhibition of oral cancer cell migration via the inhibition of epithelial-to-mesenchymal transition genes, such as E-cadherin. We demonstrated that the combination of PAC and cisplatin markedly enhanced oral cancer cell death by inducing apoptosis, autophagy, and oxidative stress. The data presented indicate that PAC has the potential to serve as a powerful complementary agent to cisplatin in the treatment of gingival squamous cell carcinomas. Full article

Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and apoptosis, the role of total glutathione depletion in inducing tumor cell apoptosis via nSMase2 activation is still under investigation. Conversely, glutathione-mediated inhibition of reactive oxygen species (ROS) accumulation is necessary for the enzymatic activity of nSMase1 and nSMase3, increased ceramide levels, and cell apoptosis. This study evaluated the effects of depleting total glutathione in HepG2 cells using buthionine sulfoximine (BSO). The study assessed nSMases RNA levels and activities, intracellular ceramide levels, and cell proliferation using RT-qPCR, Amplex red neutral sphingomyelinase fluorescence assay, and colorimetric assays, respectively. The results indicated a lack of nSMase2 mRNA expression in treated and untreated HepG2 cells. Depletion of total glutathione resulted in a significant increase in mRNA levels but a dramatic reduction in the enzymatic activity of nSMase1 and nSMase3, a rise in ROS levels, a decrease in intracellular levels of ceramide, and an increase in cell proliferation. These findings suggest that total glutathione depletion may exacerbate liver cancer (HCC) and not support using total glutathione-depleting agents in HCC management. It is important to note that these results are limited to HepG2 cells, and further studies are necessary to determine if these effects will also occur in other cell lines. Additional research is necessary to explore the role of total glutathione depletion in inducing tumor cell apoptosis. Full article

Environmental remediation in the presence of robust semiconductor photocatalysts by utilizing renewable energy sources is of keen interest among researchers. In this study, we synthesize a BiVO₄/P-g-C₃N₄ semiconductor heterojunction photocatalytic system through a hydrothermal route followed by utilizing a total-solvent evaporation method. The optical and electronic properties of the as-prepared heterojunction are characterized via various spectroscopic techniques. Rhodamine B (RhB) and Congo Red (CR) are used as synthetic colorants to evaluate the photocatalytic performances of BiVO₄/P-g-C₃N₄. In addition, the chemical environment of the photocatalyst and its mechanistic pathways are confirmed through X-ray photoelectron spectroscopy and electrochemical Mott–Schottky analysis. The BiVO₄/P-g-C₃N₄ photocatalyst shows higher photodegradation (96.94%) of the mixed synthetic dyes under simulated solar-light irradiation. The as-synthesized BiVO₄/P-g-C₃N₄ heterojunction significantly promotes the quick separation of photoexcited carriers due to the excellent synergetic properties, the extended light absorption, and the photoelectrochemical response. Furthermore, a possible type-II charge transfer mechanism is adopted for the BiVO₄/P-g-C₃N₄ system after investigating the band potentials, active species, and charge carrier migration over the heterojunction interface. Full article

Background: With the emergence of therapies for mantle cell lymphoma (MCL), understanding the treatment patterns and burden of illness among older patients with MCL in Canada is essential to inform decision making. Methods: A retrospective study using administrative data matched individuals aged ≥65 who were newly diagnosed with MCL between 1 January 2013 and 31 December 2016 with general population controls. Cases were followed for up to 3 years in order to assess healthcare resource utilization (HCRU), healthcare costs, time to next treatment or death (TTNTD), and overall survival (OS); all were stratified according to first-line treatment. Results: This study matched 159 MCL patients to 636 controls. Direct healthcare costs were highest among MCL patients in the first year following diagnosis (Y1: CAD 77,555 ± 40,789), decreased subsequently (Y2: CAD 40,093 ± 28,720; Y3: CAD 36,059 ± 36,303), and were consistently higher than the costs for controls. The 3-year OS after MCL diagnosis was 68.6%, with patients receiving bendamustine + rituximab (BR) experiencing a significantly higher OS compared to patients treated with other regimens (72.4% vs. 55.6%, p = 0.041). Approximately 40.9% of MCL patients initiated a second-line therapy or died within 3 years. Conclusion: Newly diagnosed MCL presents a substantial burden to the healthcare system, with almost half of all patients progressing to a second-line therapy or death within 3 years. Full article

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly immunosuppressive tumor microenvironment (TME). The aim of this study is to determine the potential significant TME immune markers of long-term survival. Methods: We retrospectively included patients with a diagnosis of resectable PDAC having undergone upfront surgery. Immunohistochemical (IHC) staining using tissue microarray for PD-L1, CD3, CD4, CD8, FOXP3, CD20, iNOS and CD163 was performed in order to characterize the TME. The primary endpoint was long-term survival, defined as the Overall Survival > 24 months from surgery. Results: A total of 38 consecutive patients were included, and 14 (36%) of them were long-term survivors. Long-term survivors showed a higher density of CD8+ lymphocytes intra- and peri-acinar (p = 0.08), and a higher CD8/FOXP3 intra- and peri-tumoral ratio (p = 0.05). A low density of intra- and peri-tumoral FOXP3 infiltration is a good predictor of long-term survival (p = 0.04). A significant association of the low density of intra- and peri-tumoral tumor-associated macrophages (TAMs) iNOS+ with long-term survival was detected (p = 0.04). Conclusions: Despite the retrospective nature and small sample size, our study showed that the high infiltration of CD8+ lymphocytes and low infiltration of FOXP3+ and TAMs iNOS+ are predictors of good prognosis. A preoperative assessment of these potential immune markers could be useful and determinant in the staging process and in PDAC management. Full article

The target group of this study—people with disabilities who work and who are cared for in institutions that offer occupational therapy—is largely absent from the discussions about urban agriculture. When implementing the UN Convention on the Rights of People with Disabilities, education and work are essential aspects, especially for the self-determination of people with disabilities. However, people with disabilities are currently often prevented from truly participating in society. The main research objective of this study lies on the identification on systemic barriers to inclusion into horticultural working life as well as possible solutions. The aim of this study was to find out how inclusion processes could be facilitated in the field of urban agriculture in Vienna. A pilot project was carried out for this purpose during May and October 2019. A university, three social institutions with seven employees, two horticultural farms with two farm managers and fifteen people with disabilities took part in this pilot project. During the tomato harvest, action research was applied, evaluated and modified. At the same time, the authors tried to contribute to Grounded Theory. One of the results of this study is the suggestion that offers in the field of urban agriculture should go beyond pure cooperation between social institutions and horticultural farms. A social-ecological scenario with agro-ecological inclusion farms is elaborated. It is concluded that the establishment of such farms in terms of the UN Convention on the Rights of People with Disabilities in Vienna could bring the city closer to reaching the Sustainable Development Goals. This is exemplified in a new framework on social-ecological inclusion processes in the world of work. Full article

This limited-scope study demonstrates the application of probabilistic risk assessment (PRA) methodologies to a spent fuel storage system for spent pebble-filled dry cask with a focus only on the necessary PRA technical elements sufficient to risk-inform the spent fuel storage system design. A dropping canister scenario in a silo of the spent fuel storage system is analyzed through an initiating event (IE) identification from the Master Logic Diagram (MLD); event sequence analysis (ES) by establishing the event tree; data analysis (DA) for event sequence quantification (ESQ) with uncertainty quantification; mechanistic source term (MST) analysis by using ORIGEN; radiological consequence analysis (RC) by deploying MicroShield, and risk integration (RI) by showing the Frequency-Consequence (F-C) target curve in the emergency area boundary (EAB). Additionally, a sensitivity study is conducted using the ordinary least square (OLS) regression method to assess the impact of variables such as failed pebble numbers, their location in the canister, and building wall thickness. Furthermore, the release categories grouped from the end states in the event tree are verified as safety cases through the F-C curve. This study highlights the implementation of PRA elements in a logical and structured manner, using appropriate methodologies and computational tools, thereby showing how to risk-inform the design of a dry cask system for storing spent pebble-filled fuel. Full article

The cross-sectional study examines minority stress and depression symptoms regarding various sexual and gender minority (SGM) identities in lesbian, gay, bisexual, transgender, queer, and asexual (LGBTQA) individuals from Poland. The online survey was conducted among 509 people. Participants aged between 18 and 47 (M = 22.39, SD = 4.78). Gender identity included 262 cisgender women, 74 cisgender men, 31 transgender women, 53 transgender men, and 89 nonbinary individuals. Sexual identity comprises 197 bisexual, 150 homosexual, 78 pansexual, 33 asexual, 21 undefined, 14 heterosexual, 9 demisexuals, 6 queer, and 1 sapiosexual individual. The Daily Heterosexist Experiences Questionnaire (DHEQ) and the Center for Epidemiologic Studies Depression Scale—Revised (CESD-R) were used to measure minority stress and depression symptoms, respectively. Among LGBTQA participants, 99.80% declared minority stress at least once during the past year. In particular, vicarious trauma was experienced in 99.80% of participants, vigilance in 95.87%, harassment and discrimination in 80.35%, stress related to the family of origin in 69.16%, and to gender expression in 68.76% of respondents. Depression symptoms were found in 62.50% of respondents. Significantly higher rates of depression and minority stress were presented in dual than single SGM individuals. Binomial logistic regression showed that such sources of minority stress as vigilance, harassment, and gender expression could predict depression symptoms. Therefore, prevention and intervention programs should be designed for the LGBTQA population focusing on coping with these sources of minority stress, especially among those of dual SGM identity. Full article

With the increasing availability and diversity of satellite imagery, the multisensor fusion of data can more effectively address the improved monitoring of temporary water bodies. This study supports the attempt to apply well established methods to detect spatial and temporal changes in ephemeral shallow lakes in lowland karst terrain, as well as to improve the understanding concerning the dynamics of water storage and hydrological mechanisms during extreme precipitation events. Based on the joint analysis of Copernicus Sentinel SAR and optical mission data, as well as soil moisture and EO-based rainfall observations over the period of 2015–2020, we demonstrated the control of the karst system on the ephemeral lake appearances in the broader area of Chalkida (Evvia, Greece). A connection between the prolonged and extended water coverage in the ephemeral lakes and flooding in the area is documented. Our EO-supported findings may serve as indicators for flood alerts in future extreme precipitation events, improving responses in cases of emergencies. Full article

To increase the thermocyclic resistance of material, multilayer coatings with alternating layers of Zr-Y-O and Si-Al-N were obtained via magnetron sputtering. It was established that a coating layer based on Zr-Y-O has a columnar structure; the height of the columns is determined by the thickness of the layer. The Si-Al-N-based layer is amorphous. There were monoclinic and tetragonal phases with a large lattice parameter in the composition of the Zr-Y-O-based coating layer. After high-temperature annealing, a tetragonal phase with a small lattice parameter appeared in the microscope column. In the “in situ” mode, a change in the structural state of the Zr-Y-O coating layer was detected in the temperature range of 450–500 °C; namely, a change in the grain size and coherent scattering regions, and an increase in internal elastic stresses. It was found that the thermocyclic resistance increased by more than two times for multilayer samples compared to the single-layer ones we studied earlier. Full article

This work presents the first development of an analytical turbidimetric method for the determination of legal alcohols in alcohol-based hand sanitizer products. A typical iodoform reaction is exploited to form a yellow product in the form of precipitates. An iodoform test shows a positive result as yellow precipitates in the presence of ethanol and isopropanol; therefore, the test can only be used to distinguish between methanol and those legal alcohols. In the presence of molecular iodine (I₂) and a strong alkaline solution, the legal alcohol is converted to the corresponding carbonyl compound (i.e., ethanol to acetaldehyde, isopropanol to acetone). The susceptibility of this intermediate towards the reaction with hydroxide ions (strong alkaline condition) results in formations of yellow precipitation of iodoform (CHI₃) and a water-soluble carboxylate salt in the solution. Therefore, this change allows for the detection of legal alcohols through either naked-eye observation (as semi-quantitative analysis) or a common benchtop/portable photometer/spectrophotometer (as quantitative analysis) by means of turbidimetric analysis. In this work, turbidimetry is employed, which is a useful alternative detection method in analytical practice, especially with colored samples in hand sanitizing products. This is because they can employ wavelengths at which the colored solution does not absorb light. As a result of our developed method, the calibration plots are in the range of 30 to 100% (v/v) for both ethanol and isopropanol. The limit of detection (LOD) (3SD of y-intercept/slope) was found to be 7.4% (v/v) ethanol and 6.5% (v/v) isopropanol. Direct analysis of the non-pretreatment of the sample is achieved. The results indicate that our new proposed analytical method is fit for purpose and valid to detect the legal alcohols in alcohol-based hand sanitizing products for both international and Thai regulations (at least 70% (v/v)). Our quantitative results were also comparable to a standard analytical method, such as the use of a gas chromatography-flame ionization detector (GC-FID). Our developed method and analytical operation could potentially be developed into a practically portable analysis. Full article

Ni/Pd co-modified graphene hydrogen storage materials were successfully prepared by a solvothermal method using NiCl₂·6H₂O and Pd(OAc)₂ and reduced graphene oxide (rGO). By adjusting the hydrothermal temperature, Pd–Ni is successfully alloyed, and the size of the obtained nanoparticles is uniform. The electronic structure of Pd was changed by alloying, and the center of the D-band moved down, which promoted the adsorption of hydrogen. The NiPd-rGO-180 sample, in which 180 represents the solvothermal temperature in centigrade (°C), has the highest hydrogen storage capacity of 2.65 wt% at a moderate condition (RT/4MPa). The excellent hydrogen storage performance benefits from the synergistic hydrogen spillover effect of Pd–Ni bimetal. The calculated hydrogen adsorption energies of Ni₂Pd₂-rGO are within the ideal range (−0.20 to −0.60 eV) of hydrogen ads/desorption; however, the introduction of substrate defects and the cluster orientation alter the hydrogen adsorption energy. This work provides an effective reference for the design and optimization of carbon-based hydrogen storage materials. Full article

This pilot study explored the effectiveness of tailored informational interventions to reduce the surplus and waste of fruits and vegetables at the distribution level in Chile. Stalls from a fresh food market were randomized to intervention (n = 5 selling fruits, n = 5 selling vegetables) or control (n = 4 selling fruits, n = 4 selling vegetables) groups. The causes of surplus and waste were estimated by questionnaires. Surplus, avoidable waste, and unavoidable waste were measured using direct quantification before and after the intervention, and were expressed relative to the initial stock. Before the intervention, the surplus was (median [25th–75th percentile]) 46.2% [33.3–51.2] for fruits and 51.5% [41.3–55.0] for vegetables; avoidable waste was 0.1% [0.0–0.8] for fruits and 1.8% [0.7–5.3] for vegetables; and unavoidable waste was 0.0% [0.0–1.0] for fruits and 0.0% [0.0–1.3] for vegetables. Planning and storage represented the main causes explaining surplus and waste. After the intervention, the intervention group decreased the surplus of fruits compared to the control group (−17.8% [−29.0–−11.0] vs. 5.8% [−0.6–7.8], respectively; p = 0.016), without other differences. In conclusion, tailored informational interventions based on the causes of surplus and waste may reduce the surplus of fruits in a fresh food market. Interventions might also include management strategies for the surplus to improve grocers’ business operations. Full article

Gastrointestinal (GI) disorders comprise a diverse range of conditions that can significantly reduce the quality of life and can even be life-threatening in serious cases. The development of accurate and rapid detection approaches is of essential importance for early diagnosis and timely management of GI diseases. This review mainly focuses on the imaging of several representative gastrointestinal ailments, such as inflammatory bowel disease, tumors, appendicitis, Meckel’s diverticulum, and others. Various imaging modalities commonly used for the gastrointestinal tract, including magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission computed tomography (SPECT), and photoacoustic tomography (PAT) and multimodal imaging with mode overlap are summarized. These achievements in single and multimodal imaging provide useful guidance for improved diagnosis, staging, and treatment of the corresponding gastrointestinal diseases. The review evaluates the strengths and weaknesses of different imaging techniques and summarizes the development of imaging techniques used for diagnosing gastrointestinal ailments. Full article

Leveraging recent advances in graph neural networks, our study introduces an application of graph convolutional networks (GCNs) within a correlation-based population graph, aiming to enhance Alzheimer’s disease (AD) prognosis and illuminate the intricacies of AD progression. This methodological approach leverages the inherent structure and correlations in demographic and neuroimaging data to predict amyloid-beta (A$\beta$) positivity. To validate our approach, we conducted extensive performance comparisons with conventional machine learning models and a GCN model with randomly assigned edges. The results consistently highlighted the superior performance of the correlation-based GCN model across different sample groups in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset, suggesting the importance of accurately reflecting the correlation structure in population graphs for effective pattern recognition and accurate prediction. Furthermore, our exploration of the model’s decision-making process using GNNExplainer identified unique sets of biomarkers indicative of A$\beta$ positivity in different groups, shedding light on the heterogeneity of AD progression. This study underscores the potential of our proposed approach for more nuanced AD prognoses, potentially informing more personalized and precise therapeutic strategies. Future research can extend these findings by integrating diverse data sources, employing longitudinal data, and refining the interpretability of the model, which potentially has broad applicability to other complex diseases. Full article

Synthetic organic pigments from the direct discharge of textile effluents are considered as colossal global concern and attract the attention of scholars. The efficient construction of heterojunction systems involving precious metal co-catalysis is an effective strategy for obtaining highly efficient photocatalytic materials. Herein, we report the construction of a Pt-doped BiFeO₃/O-g-C₃N₄ ([email protected]/O-CN) S-scheme heterojunction system for photocatalytic degradation of aqueous rhodamine B (RhB) under visible-light irradiation. The photocatalytic performances of [email protected]/O-CN and BFO/O-CN composites and pristine BiFeO₃ and O-g-C₃N₄ were compared, and the photocatalytic process of the [email protected]/O-CN system was optimized. The results exhibit that the S-scheme [email protected]/O-CN heterojunction has superior photocatalytic performance compared to its fellow catalysts, which is due to the asymmetric nature of the as-constructed heterojunction. The as-constructed [email protected]/O-CN heterojunction reveals high performance in photocatalytic degradation of RhB with a degradation efficiency of 100% achieved after 50 min of visible-light irradiation. The photodegradation fitted well with pseudo-first-order kinetics proceeding with a rate constant of 4.63 × 10⁻² min⁻¹. The radical trapping test reveals that h⁺ and ^•O₂⁻ take the leading role in the reaction, while the stability test reveals a 98% efficiency after the fourth cycle. As established from various interpretations, the considerably enhanced photocatalytic performance of the heterojunction system can be attributed to the promoted charge carrier separation and transfer of photoexcited carriers, as well as the strong photo-redox ability established. Hence, the S-scheme [email protected]/O-CN heterojunction is a good candidate in the treatment of industrial wastewater for the mineralization of organic micropollutants, which pose a grievous threat to the environment. Full article

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that occurs in susceptible individuals in response to various inhaled antigens. The fibrotic phenotype of HP is characterized by disease progression and can lead to pulmonary hypertension (PH). The aim of this study was to estimate the prevalence of PH and to identify predictors of PH in patients with chronic HP. Methods: We conducted an observational longitudinal study that included 85 patients with an established diagnosis of HP. Clinical examination, quality of life questionnaires, high-resolution computed tomography (HRCT) of the chest, arterial blood gases analyses, six-minute walking test (6-MWT), pulmonary function tests, and echocardiography were performed. Results: Patients were divided into groups with fibrotic (71.8%) and nonfibrotic phenotype (28.2%). PH was detected in 41 (48.2%) patients. Patients with PH had the predominant fibrotic phenotype of HP, were older, more symptomatic, and had a higher FVC/DLco ratio. The most significant predictors of PH were CT signs of fibrosis, finger clubbing, FVC/DLco, decreased distance, and SpO₂ at the end of 6-MWT, as well as the presence of cardiovascular diseases. Conclusions: PH is a common condition in patients with chronic HP, especially with the fibrotic phenotype. Early detection of the PH predictors is necessary for the timely diagnosis of this complication of HP. Full article