Graphene combined with fractal structures would probably be a promising candidate design of an antenna for a wireless communication system. However, the thermal transport properties of fractal graphene, which would influence the properties of wireless communication systems, are unclear. In this paper, the thermal transport properties of graphene with a Sierpinski fractal structure were investigated via the reverse non-equilibrium molecular dynamics simulation method. Simulation results indicated that the thermal conductivity of graphene with fractal defects decreased from 157.62 to 19.60 (W m⁻¹ K⁻¹) as the fractal level increased. Furthermore, visual display and statistical results of fractal graphene atomic heat flux revealed that with fractal levels increasing, the real heat flux paths twisted, and the angle distributions of atomic heat flux vectors enlarged from about (−30°, 30°) to about (−45°, 45°). In fact, the fractal structures decreased the real heat flow areas and extended the real heat flux paths, and enhanced the phonon scattering in the defect edges of the fractal graphene. Analyses of fractal graphene thermal transport characters in our work indicated that the heat transfer properties of fractal graphene dropped greatly as fractal levels increased, which would provide effective guidance to the design of antennae based on fractal graphene. Full article

The capture and storage of solar energy is a promising option to overcome current energy issues. To put such systems into practice, molecular photosensitizers should be based on abundant metals and possess a strong absorption capability for visible light. Therefore, a systematic series of four novel heteroleptic Cu(I) complexes of the type [(P^P)Cu(N^N)]⁺ (with P^P = xantphos and N^N = different diimine ligands) has been prepared. As an essential feature, these copper photosensitizers contain an imidazole moiety at the backbone of the diimine ligand, which increases the aromatic π-system compared to phenanthroline type ligands. Moreover, 2-(4-bromophenyl)-1-phenyl-1H-imidazo-[4,5-f][1,10]phenanthroline was used as a starting point and modular platform for gradually extended diimine ligands. Suzuki cross-coupling was applied to introduce different kind of substituents in the back of this ligand. Afterwards, a combination of NMR spectroscopy, mass spectrometry, X-ray analysis, cyclic voltammetry, UV/vis and emission spectroscopy was used to investigate the structural, electrochemical and photophysical properties of these compounds. As a result, a reversible reduction, strongly increased extinction coefficients and significantly redshifted absorption maxima (>20 nm) were found compared to traditional Cu(I) photosensitizers without an imidazo moiety. Moreover, these compounds show a bright emission in the solid state. Full article

A nuclear fusion reactor requires a radiation-hardened sensor readout integrated circuit (IC), whose operation should be tolerant against harsh radiation effects up to MGy or higher. This paper proposes radiation-hardening circuit design techniques for an instrumentation amplifier (IA), which is one of the most sensitive circuits in the sensor readout IC. The paper studied design considerations for choosing the IA topology for radiation environments and proposes a radiation-hardened IA structure with total-ionizing-dose (TID) effect monitoring and adaptive reference control functions. The radiation-hardened performance of the proposed IA was verified through model-based circuit simulations by using compact transistor models that reflected the TID effects into complementary metal–oxide–semiconductor (CMOS) parameters. The proposed IA was designed with the 65 nm standard CMOS process and provides adjustable voltage gain between 3 and 15, bandwidth up to 400 kHz, and power consumption of 34.6 μW, while maintaining a stable performance over TID effects up to 1 MGy. Full article

Skin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic stresses, including telomere shortening, overproduction of reactive oxygen species, diet, and sunlight exposure. Epigenetic mechanisms directly regulate skin homeostasis and regeneration, but they also mark cell senescence and the natural and pathological aging processes. Progeroid syndromes represent a group of clinical and genetically heterogeneous pathologies characterized by the accelerated aging of various tissues and organs, including skin. Skin cells from progeroid patients display molecular hallmarks that mimic those associated with naturally occurring aging. Thus, investigations on progeroid syndromes strongly contribute to disclose the causal mechanisms that underlie the aging process. In the present review, we discuss the role of epigenetic pathways in skin cell regulation during physiologic and premature aging. Full article

As part of the Pr55^Gag polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature HIV-1 p6 protein. Recently, we showed that p6 is a bona fide substrate of the insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease. This phenomenon appears to be specific for HIV-1, since p6 homologs of HIV-2, SIV and EIAV were IDE-insensitive. Furthermore, abrogation of the IDE-mediated degradation of p6 reduces the replication capacity of HIV-1 in an Env-dependent manner. However, it remained unclear to which extent the IDE mediated degradation is phylogenetically conserved among HIV-1. Here, we describe two HIV-1 isolates with IDE resistant p6 proteins. Sequence comparison allowed deducing one single amino acid regulating IDE sensitivity of p6. Exchanging the N-terminal leucine residue of p6 derived from the IDE sensitive isolate HIV-1_NL4-3 with proline enhances its stability, while replacing Pro-1 of p6 from the IDE insensitive isolate SG3 with leucine restores susceptibility towards IDE. Phylogenetic analyses of this natural polymorphism revealed that the N-terminal leucine is characteristic for p6 derived from HIV-1 group M except for subtype A, which predominantly expresses p6 with an N-terminal proline. Consequently, p6 peptides derived from subtype A are not degraded by IDE. Thus, IDE mediated degradation of p6 is specific for HIV-1 group M isolates and not occasionally distributed among HIV-1. Full article

Since the main attenuation of solar irradiance reaching the earth’s surface is due to clouds, it has been hypothesized that global horizontal irradiance attenuation and its temporal variability at a given location could be characterized simply by cloud properties at that location. This hypothesis is tested using global horizontal irradiance measurements at two stations in San Antonio, Texas, and satellite estimates of cloud types and cloud layers from the Geostationary Operational Environmental Satellite (GOES) Surface and Insolation Product. A modified version of an existing solar attenuation variability index, albeit having a better physical foundation, is used. The analysis is conducted for different cloud conditions and solar elevations. It is found that under cloudy-sky conditions, there is less attenuation under water clouds than those under opaque ice clouds (optically thick ice clouds) and multilayered clouds. For cloud layers, less attenuation was found for the low/mid layers than for the high layer. Cloud enhancement occurs more frequently for water clouds and less frequently for mixed phase and cirrus clouds and it occurs with similar frequency at all three levels. The temporal variability of solar attenuation is found to decrease with an increasing temporal sampling interval and to be largest for water clouds and smallest for multilayered and partly cloudy conditions. This work presents a first step towards estimating solar energy potential in the San Antonio area indirectly using available estimates of cloudiness from GOES satellites. Full article

This paper presents a robotic platform, PiBot, which was developed to improve the teaching of robotics with vision to secondary students. Its computational core is the Raspberry Pi 3 controller board, and the greatest novelty of this prototype is the support developed for the powerful camera mounted on board, the PiCamera. An open software infrastructure written in Python language was implemented so that the student may use this camera as the main sensor of the robotic platform. Furthermore, higher-level commands were provided to enhance the learning outcome for beginners. In addition, a PiBot 3D printable model and the counterpart for the Gazebo simulator were also developed and fully supported. They are publicly available so that students and schools without the physical robot or that cannot afford to obtain one, can nevertheless practice, learn and teach Robotics using these open platforms: DIY-PiBot and/or simulated-PiBot. Full article

A new triterpenoid saponin, named oleiferasaponin A₂, was isolated and identified from Camellia oleifera defatted seeds. Oleiferasaponin A₂ exhibited anti-hyperlipidemic activity on HepG2 cell lines. Further study of the hypolipidemic mechanism showed that oleiferasaponin A₂ inhibited fatty acid synthesis by significantly down-regulating the expression of SREBP-1c, FAS and FAS protein, while dramatically promoting fatty acid β-oxidation by up-regulating the expression of ACOX-1, CPT-1 and ACOX-1 protein. Our results demonstrate that the oleiferasaponin A₂ possesses potential medicinal value for hyperlipidemia treatment. Full article

Over the past few years, power quality (PQ) monitoring has become of paramount importance for utilities and users since poor PQ generates negative consequences. In monitoring, fast detection and accurate classification of PQ disturbances (PQDs) are desirable features. In this work, a new method to detect and classify PQDs is proposed. The proposal takes advantage of the low computational resources of both a phasor measurement unit (PMU)-based signal processing scheme and the homogeneity approach. To classify the PQDs, if–then–else rules are used. To validate and test the proposal, synthetic and real signals of sags, swells, interruptions, notching, spikes, harmonics, and oscillatory transients are considered. For the generation of real signals, a PQD generator based on a power inverter is used. In the proposed method, the PMU information is directly used to classify sags, swells, and interruptions, whereas the homogeneity index is used to distinguish among the remaining PQDs. Results show that the proposal is an effective and suitable tool for PQ monitoring. Full article

In-vehicle applications that are based on Vehicle-to-Everything (V2X) communication technologies need to be evaluated under lab-controlled conditions before performing field tests. The need for a tailored platform to perform specific research on the cooperative Advanced Driving Assistance System (ADAS) to assess the effect on driver behavior and driving performance motivated the development of a driver-centric traffic simulator that is built over a 3D graphics engine. The engine creates a driving situation as it communicates with a traffic simulator as a means to simulate real-life traffic scenarios. The TraCI as a Service (TraaS) library was implemented to perform the interaction between the driver-controlled vehicle and the Simulation of Urban MObility (SUMO). An extension of a previous version, this work improves simulation performance and realism by reducing computational demand and integrating a tailored scenario with the ADAS to be tested. The usability of the implemented simulation platform was evaluated by means of an experiment related to the efficiency of a Traffic Light Assistant (TLA), showing the analysis of the answer that 80% of the participants were satisfied with the simulator and the TLA system implemented. Full article