Molbank

Open AccessCommunication

4,4’-(Pyridin-4-ylmethylene)dibenzonitrile

by

Ben M. J. Lancaster

,

Alexander J. Nicholls

and

Ian R. Baxendale

Molbank 2021, 2021(4), M1302; https://doi.org/10.3390/M1302 - 30 Nov 2021

Abstract

This communication describes an unprecedented substitution cascade, in which 4-methylpyridine, following deprotonation with LDA, twice acts as a carbon nucleophile in an unusual S_NAr process, to form a novel triarylmethane structure. A proposed mechanism for this sequence is presented that is [...] Read more.

This communication describes an unprecedented substitution cascade, in which 4-methylpyridine, following deprotonation with LDA, twice acts as a carbon nucleophile in an unusual S_NAr process, to form a novel triarylmethane structure. A proposed mechanism for this sequence is presented that is supported by single crystal X-ray analysis of the resulting product. We believe this unique transformation is of note as it highlights a neat and efficient entry as a single step to complex triarylmethane architectures containing both substituted phenyl and pyridyl aromatics. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

Potassium (3-Methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide

by

Egor S. Zhilin

,

Dmitry B. Meerov

and

Leonid L. Fershtat

Molbank 2021, 2021(4), M1301; https://doi.org/10.3390/M1301 - 26 Nov 2021

Abstract

Furoxan derivatives enriched with explosophoric functionalities are promising compounds in the preparation of novel energetic materials. Herein, a previously unknown potassium (3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide (also referred to as potassium 4-dinitromethyl-3-methylfuroxanate) was synthesized via tandem nitration-reduction reactions of an available (furoxanyl)chloroxime. The structure of the synthesized [...] Read more.

Furoxan derivatives enriched with explosophoric functionalities are promising compounds in the preparation of novel energetic materials. Herein, a previously unknown potassium (3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide (also referred to as potassium 4-dinitromethyl-3-methylfuroxanate) was synthesized via tandem nitration-reduction reactions of an available (furoxanyl)chloroxime. The structure of the synthesized compound was established by elemental analysis, IR, ¹H, ¹³C and ¹⁴N NMR spectroscopy. Thermal stability and mechanical sensitivity of the prepared compound toward impact and friction were experimentally determined. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessCommunication

CF₃-Bis-TEMPO-Vis: New Visible Light Active Bis-Benzimidazolequinone Alkoxyamine

by

,

,

and

Molbank 2021, 2021(4), M1300; https://doi.org/10.3390/M1300 - 26 Nov 2021

Abstract

Alkoxyamines of TEMPO usually dissociate thermally at >100 °C; however, room temperature homolysis, activated by visible light, occurs with benzimidazolequinone derivatives. 1,1’-Dimethyl-2,2’-bis{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-6-(trifluoromethyl)-1H,1’H-[5,5’-bibenzimidazole]-4,4’,7,7’-tetrone (CF₃-Bis-TEMPO-Vis) is prepared in a 59% yield through NBS/H₂SO₄ oxidative [...] Read more.

Alkoxyamines of TEMPO usually dissociate thermally at >100 °C; however, room temperature homolysis, activated by visible light, occurs with benzimidazolequinone derivatives. 1,1’-Dimethyl-2,2’-bis{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-6-(trifluoromethyl)-1H,1’H-[5,5’-bibenzimidazole]-4,4’,7,7’-tetrone (CF₃-Bis-TEMPO-Vis) is prepared in a 59% yield through NBS/H₂SO₄ oxidative demethylations of the dimethoxybenzimidazole-benzimidazolequinone precursor with aqueous work up. The alternative basic work up in air gave the epoxide derivative of CF₃-Bis-TEMPO-Vis. Unlike the latter CF₃-epoxide, both alkoxyamine residues are labile under green light (470–600 nm), and the rate of TEMPO release is three times slower than Bis-TEMPO-Vis. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Open AccessShort Note

11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone

by

Anastasia R. Kovrizhina

,

Elizaveta I. Samorodova

and

Andrei I. Khlebnikov

Molbank 2021, 2021(4), M1299; https://doi.org/10.3390/M1299 - 23 Nov 2021

Abstract

11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the [...] Read more.

11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia–reperfusion injury. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

2,2′-(1,4-Phenylene)bis(7-nitro-1H-benzimidazole 3-oxide)

by

Fabrizio Politano

,

Ana K. Gran-Magano

and

Nicholas E. Leadbeater

Molbank 2021, 2021(4), M1297; https://doi.org/10.3390/M1297 - 22 Nov 2021

Abstract

Bis(benzimidazol-2-yl-3-oxide)benzene derivatives have potential applications as energetic or photoactive materials. By using a two-step one-pot approach employing microwave heating as a tool, 2,2′-(1,4-phenylene)bis(7-nitro-1H-benzimidazole 3-oxide) (1) has been prepared in 94% yield. In the first step an S_NAr [...] Read more.

Bis(benzimidazol-2-yl-3-oxide)benzene derivatives have potential applications as energetic or photoactive materials. By using a two-step one-pot approach employing microwave heating as a tool, 2,2′-(1,4-phenylene)bis(7-nitro-1H-benzimidazole 3-oxide) (1) has been prepared in 94% yield. In the first step an S_NAr reaction is performed using p-xylylenediamine as the central building block. Without isolating the intermediate, a base-mediated cyclization reaction follows in the second step. The product was isolated in analytically pure form by means of a pH-controlled precipitation. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

Bis(pyrazol-1-yl)methane-4,4′-dicarboxylic Acid

by

Elizaveta A. Pershina

,

Dmitry I. Pavlov

,

Nikita P. Burlutskiy

and

Andrei S. Potapov

Molbank 2021, 2021(4), M1298; https://doi.org/10.3390/M1298 - 22 Nov 2021

Abstract

The molecular structure of bis(pyrazol-1-yl)methane-4,4′-dicarboxylic acid (H₂bpmdc) was determined by single crystal X-Ray diffraction analysis. The compound crystallizes in a monoclinic crystal system; the unit cell contains four formula units. The molecules of H₂bpmdc are linked into zig-zag chains [...] Read more.

The molecular structure of bis(pyrazol-1-yl)methane-4,4′-dicarboxylic acid (H₂bpmdc) was determined by single crystal X-Ray diffraction analysis. The compound crystallizes in a monoclinic crystal system; the unit cell contains four formula units. The molecules of H₂bpmdc are linked into zig-zag chains by intermolecular carboxyl–carboxyl hydrogen bonds. Other types of supramolecular interactions, namely, CH···N and CH···O short contacts, CH–π interactions and carbonyl–carbonyl interactions were detected in the crystal structure. Full article

(This article belongs to the Section Structure Determination)

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Open AccessCommunication

Regioselective Synthesis of 4-Bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide

by

Sukanta Bar

and

Maxwell Israel Martin

Molbank 2021, 2021(4), M1296; https://doi.org/10.3390/M1296 - 16 Nov 2021

Abstract

We synthesized 4-bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide by using three successive direct lithiations and a bromination reaction starting from thiophene. All these lithiation reactions were carried out at −78 °C to RT over a period of 1 to 24 h based on the reactivity of [...] Read more.

We synthesized 4-bromo-3-formyl-N-phenyl-5-propylthiophene-2-carboxamide by using three successive direct lithiations and a bromination reaction starting from thiophene. All these lithiation reactions were carried out at −78 °C to RT over a period of 1 to 24 h based on the reactivity of electrophile. This is a four-step protocol starting from thiophene with an overall yield of 47%. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Open AccessShort Note

4,7-Bis(1,2,3,4,4a,9a-Hexahydro-9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine

by

Timofey N. Chmovzh

,

Karim S. Gaisin

and

Oleg A. Rakitin

Molbank 2021, 2021(4), M1295; https://doi.org/10.3390/M1295 - 05 Nov 2021

Abstract

New donor-acceptor-donor (D-A-D)-type structures are widely used to design effective organic light-emitting diodes (OLEDs). In this communication, 4,7-bis(1,2,3,4,4a,9a-hexahydro-9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine was obtained in a 65% yield by the treatment of 4,7-dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide with 2,3,4,4a,9,9a-hexahydro-1H-carbazole. The structure of [...] Read more.

New donor-acceptor-donor (D-A-D)-type structures are widely used to design effective organic light-emitting diodes (OLEDs). In this communication, 4,7-bis(1,2,3,4,4a,9a-hexahydro-9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine was obtained in a 65% yield by the treatment of 4,7-dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide with 2,3,4,4a,9,9a-hexahydro-1H-carbazole. The structure of the newly synthesized compounds was established by means of an elemental analysis, ¹H, ¹³C NMR, IR and UV spectroscopy, and HRMS and LR mass-spectrometry. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Open AccessShort Note

6-(Chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

by

Vladimir A. Ogurtsov

and

Oleg A. Rakitin

Molbank 2021, 2021(4), M1294; https://doi.org/10.3390/M1294 - 01 Nov 2021

Abstract

Functionally 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines are important compounds with various pharmacological activities. 1-Substituted 4-chloro-6-(chloromethyl)-1H-pyrazolo[3,4-d]pyrimidines are practically unexplored derivatives in this series. In this paper, it was shown that the nucleophilic substitution of 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine [...] Read more.

Functionally 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines are important compounds with various pharmacological activities. 1-Substituted 4-chloro-6-(chloromethyl)-1H-pyrazolo[3,4-d]pyrimidines are practically unexplored derivatives in this series. In this paper, it was shown that the nucleophilic substitution of 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine with methylamine produced selectively 4-substituted product, 6-(chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. The structure of the synthesized compound was established by elemental analysis, high resolution mass-spectrometry, ¹H, ¹³C-NMR, and IR spectroscopy, mass-spectrometry, and X-ray analysis. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Open AccessCommunication

Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one

by

Andrey N. Komogortsev

,

Boris V. Lichitsky

and

Valeriya G. Melekhina

Molbank 2021, 2021(4), M1292; https://doi.org/10.3390/M1292 - 29 Oct 2021

Abstract

A simple one-pot approach was developed for the synthesis of furan-2(5H)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid. The synthetic utility of the prepared furan-2(5H)-one was demonstrated by condensation [...] Read more.

A simple one-pot approach was developed for the synthesis of furan-2(5H)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid. The synthetic utility of the prepared furan-2(5H)-one was demonstrated by condensation with 4-methoxybenzaldehyde. The advantages of this method include the employment of readily accessible starting materials, atom economy, process simplicity, and the easy isolation of the target products. The structure of the synthesized furanones was confirmed by ¹H and ¹³C-NMR spectroscopy and high-resolution mass spectrometry with electrospray ionization (ESI-HRMS). Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

by

Irina Ihnatenko

,

Peter G. Jones

and

Conrad Kunick

Molbank 2021, 2021(4), M1293; https://doi.org/10.3390/M1293 - 29 Oct 2021

Abstract

(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one was prepared by a condensation reaction from 3,4-dihydro-1H-benzo[b]azepin-2,5-dione and O-methylhydroxylamine. The configuration at the C=N double bond was determined by X-ray crystallography. Full article

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Open AccessShort Note

4,7-Bis(dodecylthio)-[1,2,5]thiadiazolo[3,4-c]pyridine

by

Timofey N. Chmovzh

,

Timofey A. Kudryashev

and

Oleg A. Rakitin

Molbank 2021, 2021(4), M1291; https://doi.org/10.3390/M1291 - 25 Oct 2021

Abstract

Bis(alkylsulfanyl) derivatives of 1,2,5-thiadiazoles fused with aromatic and heteroaromatic rings containing long alkyl chains are of interest as compounds with liquid crystalline properties. In this communication, 4,7-bis(dodecylthio)-[1,2,5]thiadiazolo[3,4-c]pyridine 1 was obtained from 4,7-dibromo-[1,2,5]thiadiazolo[3,4-c]pyridine 2 by a combination of two reactions—aromatic [...] Read more.

Bis(alkylsulfanyl) derivatives of 1,2,5-thiadiazoles fused with aromatic and heteroaromatic rings containing long alkyl chains are of interest as compounds with liquid crystalline properties. In this communication, 4,7-bis(dodecylthio)-[1,2,5]thiadiazolo[3,4-c]pyridine 1 was obtained from 4,7-dibromo-[1,2,5]thiadiazolo[3,4-c]pyridine 2 by a combination of two reactions—aromatic nucleophilic substitution S_NAr and Buchwald–Hartwig cross-coupling. The structure of the newly synthesized compounds was established by means of elemental analysis; high-resolution mass spectrometry; ¹H, ¹³C NMR, IR and UV spectroscopy; and mass spectrometry. Full article

(This article belongs to the Special Issue Heteroatom Rich Organic Heterocycles)

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Open AccessShort Note

N,N-Bis(4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)thiophen-2-amine

by

Timofey N. Chmovzh

and

Oleg A. Rakitin

Molbank 2021, 2021(4), M1290; https://doi.org/10.3390/M1290 - 21 Oct 2021

Abstract

N,N-Diarylthiophen-2-amine units are of great interest for the synthesis of optoelectronic devices. In this communication, N,N-bis (4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)thiophen-2-amine was obtained by means of a Buchwald–Hartwig cross-coupling reaction of bis(4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)amine and 2-bromothiophene in the presence of tris(dibenzylideneacetone)dipalladium(0), tri-tert [...] Read more.

N,N-Diarylthiophen-2-amine units are of great interest for the synthesis of optoelectronic devices. In this communication, N,N-bis (4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)thiophen-2-amine was obtained by means of a Buchwald–Hartwig cross-coupling reaction of bis(4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)amine and 2-bromothiophene in the presence of tris(dibenzylideneacetone)dipalladium(0), tri-tert-butyl phosphine and sodium tert-butanolate. The structure of newly synthesized compounds was established by means of elemental analysis, high-resolution mass spectrometry, ¹H, ¹³C NMR, IR and UV spectroscopy and mass-spectrometry. Full article

(This article belongs to the Special Issue Metal-Catalyzed Synthesis)

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Open AccessCommunication

Regioselective Synthesis of 5-Propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde

by

Sukanta Bar

Molbank 2021, 2021(4), M1289; https://doi.org/10.3390/M1289 - 14 Oct 2021

Cited by 1

Abstract

5-propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde was synthesized by using the concept of chemo- and regioselective Br/Li exchange reaction from 3-bromo-5-propyl-2-((trityloxy)methyl)thiophene. This is a five-step protocol starting from thiophene with an overall yield of 33%. These lithium/halogen exchange reactions were carried out at −78 °C to rt over [...] Read more.

5-propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde was synthesized by using the concept of chemo- and regioselective Br/Li exchange reaction from 3-bromo-5-propyl-2-((trityloxy)methyl)thiophene. This is a five-step protocol starting from thiophene with an overall yield of 33%. These lithium/halogen exchange reactions were carried out at −78 °C to rt over the period of 1 to 18 h depending on the reactivity of electrophiles. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessCommunication

Novel Synthesis of N-Acetylcysteine Medicine Using an Effective Method

by

Farzaneh Ziaee

and

Mohammad Ziaee

Molbank 2021, 2021(4), M1288; https://doi.org/10.3390/M1288 - 13 Oct 2021

Abstract

N-acetylcysteine (NAC) is mainly administrated as a mucolytic medication, antioxidant supplement, antidote in paracetamol overdose, and a drug for the prevention of diabetic kidney disease. Its effect has been investigated for the treatment of several diseases such as COVID-19. In this work, [...] Read more.

N-acetylcysteine (NAC) is mainly administrated as a mucolytic medication, antioxidant supplement, antidote in paracetamol overdose, and a drug for the prevention of diabetic kidney disease. Its effect has been investigated for the treatment of several diseases such as COVID-19. In this work, an effective method for high-yield synthesis of N-acetylcysteine is proposed. This drug can be synthesized in a single-batch step instead of using a multi-stage process. The proposed method has shown the potential to be considered as an alternative method for producing NAC. The purification process was carried out using suitable solvents to reach a high level of purity. The characterization of the synthesized drug was undertaken through Elemental analysis, Proton Nuclear Magnetic Resonance (¹H NMR), High Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectroscopy (FT-IR), and melting point analyses. Full article

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Open AccessShort Note

3-[N-(4-Methoxybenzyl)amino]benzo[de]anthracen-7-one

by

,

,

and

Molbank 2021, 2021(4), M1287; https://doi.org/10.3390/M1287 - 11 Oct 2021

Abstract

Herein, we describe the synthesis of 3-[N-(4-methoxybenzyl)amino]benzo[de]anthracen-7-one via a two-step procedure including 3-aminobenzanthrone condensation with anisaldehyde and following reduction of obtained imine to appropriate amine by sodium borohydride. The structure of the synthesized compounds was established by elemental analysis, [...] Read more.

Herein, we describe the synthesis of 3-[N-(4-methoxybenzyl)amino]benzo[de]anthracen-7-one via a two-step procedure including 3-aminobenzanthrone condensation with anisaldehyde and following reduction of obtained imine to appropriate amine by sodium borohydride. The structure of the synthesized compounds was established by elemental analysis, nuclear magnetic resonance spectroscopy, mass spectrometry (EI-MS), and infrared spectroscopy (FT-IR) and confirmed by single-crystal X-ray diffraction. The title compound was analyzed by thermal gravimetric analysis, UV/vis, and fluorescence spectroscopy. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

8-[4-(2-Hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene

by

Anastasiya Zobnina

,

Alexander Moskalensky

and

Aleksey Vorob’ev

Molbank 2021, 2021(4), M1286; https://doi.org/10.3390/M1286 - 08 Oct 2021

Abstract

During recent years, the BODIPY core became a popular scaffold for designing photoremovable protecting groups (PPG). In this paper, we report the synthesis of a new molecule—8-[4-(2-hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene—by the treatment of meso-(4-CO₂Me-phenyl)-BODIPY with excess of [...] Read more.

During recent years, the BODIPY core became a popular scaffold for designing photoremovable protecting groups (PPG). In this paper, we report the synthesis of a new molecule—8-[4-(2-hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene—by the treatment of meso-(4-CO₂Me-phenyl)-BODIPY with excess of MeMgI. The product was characterized by ¹H, ¹³C NMR and HRMS. The combination of BODIPY core with tertiary benzilyc alcohol might be promising for utilizing this molecule as visible light removable PPG. Full article

(This article belongs to the Section Organic Synthesis)

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Open AccessShort Note

Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate

by

Serigne Abdou Khadir Fall

,

Sara Hajib

,

Oumaima Karai

,

Salaheddine Boukhssas

,

,

,

,

and

Molbank 2021, 2021(4), M1285; https://doi.org/10.3390/M1285 - 04 Oct 2021

Abstract

We have previously published new biheterocyclic phospohonic α-amino esters of the 1,2,3-triazole-benzimidazole and 1,2,3-triazole-carbazole type. The aim of the present paper was to describe a new phosponic aminoester bearing a triazole ring substituted in position 5 by an ester group. Thus, according to [...] Read more.

We have previously published new biheterocyclic phospohonic α-amino esters of the 1,2,3-triazole-benzimidazole and 1,2,3-triazole-carbazole type. The aim of the present paper was to describe a new phosponic aminoester bearing a triazole ring substituted in position 5 by an ester group. Thus, according to the same catalytic process used previously, the compound naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate was synthesized with an excellent yield and high regioselectivity via the copper (I)-catalyzed alkyne–azide cycloaddition reaction (CuAAC), using diethyl (α-azido(benzamido)methyl)phosphonate (1) as a dipole and 2- naphthyl propiolate as a dipolarophile (2). The structure of the new compound was fully characterized by 1D (³¹P, ¹H-, ¹³C-) and 2D (¹H-¹H and ¹H-, ¹³C-) NMR spectroscopy, IR, and HRMS. Full article

(This article belongs to the Special Issue Metal-Catalyzed Synthesis)

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Open AccessShort Note

Synthesis and Characterization of Novel Thiazolidinones and Thioxothiazolidinones Derived from Substituted Indole

by

Nawel Rekiba

,

Abdelmadjid Benmohammed

,

Sofiane Khanoussi

,

Ayada Djafri

and

Jérôme Thibonnet

Molbank 2021, 2021(4), M1284; https://doi.org/10.3390/M1284 - 30 Sep 2021

Abstract

Based on recent discoveries concerning the numerous biological properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives have been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or thiosemicarbazone. Thus, a series of new thioxothiazolidinone, thiazolidinone, or thiosemicarbazone derivatives bearing indole-based [...] Read more.

Based on recent discoveries concerning the numerous biological properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives have been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or thiosemicarbazone. Thus, a series of new thioxothiazolidinone, thiazolidinone, or thiosemicarbazone derivatives bearing indole-based moiety have been designed, synthesized, and developed in good yields. Full article

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