You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without javascript enabled.

Search for Articles:

Title / Keyword

Author / Affiliation / Email

Journal

Article Type

Advanced Search

Section

Special Issue

Volume

Issue

Number

Page

Logical OperatorOperator

Search Text

Search Type

Journal Description

Molbank

Molbank is an international, peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products published quarterly online by MDPI.

Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 13.5 days after submission; acceptance to publication is undertaken in 2.7 days (median values for papers published in this journal in the second half of 2024).
Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.

Impact Factor: 0.6 (2023)

Imprint Information Journal Flyer Open Access ISSN: 1422-8599

Latest Articles

8 pages, 374 KiB

Open AccessShort Note

4-(8-Propyl-2,4-dithioxo-1,3-diazaspiro[4.5]decan-3-yl)spiro[1,5-dihydro-1,5-benzodiazepine-2,3′-indoline]-2′-one)

by Dimitar Stoitsov, Marin Marinov, Plamen Penchev and Neyko Stoyanov

Molbank 2025, 2025(2), M2011; https://doi.org/10.3390/M2011 (registering DOI) - 23 May 2025

A number of 1D and 2D NMR techniques, such as ¹H, ¹³C, DEPT 135, ¹H-¹H COSY, HSQC, and HMBC, were utilized for the structure verification of 4-(8-propyl-2,4-dithioxo-1,3-diazaspiro[4.5]decan-3-yl)spiro[1,5-dihydro-1,5-benzodiazepine-2,3′-indoline]-2′-one). The NMR spectra provided evidence for the tautomeric conversion of the [...] Read more.

A number of 1D and 2D NMR techniques, such as ¹H, ¹³C, DEPT 135, ¹H-¹H COSY, HSQC, and HMBC, were utilized for the structure verification of 4-(8-propyl-2,4-dithioxo-1,3-diazaspiro[4.5]decan-3-yl)spiro[1,5-dihydro-1,5-benzodiazepine-2,3′-indoline]-2′-one). The NMR spectra provided evidence for the tautomeric conversion of the compound. The completely assigned NMR data was supported additionally by ATR. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

12 pages, 1408 KiB

Open AccessCommunication

Synthesis of Mesoionic 1,3,4-Thiadiazole-2-Thiolates

by Sean Ray Kahnert and Andreas Schmidt

Molbank 2025, 2025(2), M2010; https://doi.org/10.3390/M2010 - 22 May 2025

A reliable synthesis of C5-unsubstituted 1,3,4-thiadiazole-2-thiolates is described that avoids potentially explosive or laborious steps. This work presents a reliable method for preparing the starting material dithioformate from carbon disulfide and potassium or sodium tri-sec-butylhydroborates for the preparation of the mesoionic [...] Read more.

A reliable synthesis of C5-unsubstituted 1,3,4-thiadiazole-2-thiolates is described that avoids potentially explosive or laborious steps. This work presents a reliable method for preparing the starting material dithioformate from carbon disulfide and potassium or sodium tri-sec-butylhydroborates for the preparation of the mesoionic title compounds with potassium hydrazinecarbodithioates. New 1,3,4-thiadiazole-2-thiolates are presented, and missing structural analysis data of known derivatives are added (1D- and 2D-NMR, HR-ESI-MS, IR). Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Figure 1

7 pages, 549 KiB

Open AccessCommunication

An Alternative Method for Preparing Methyl 2-Ferrocenyl-2-oxo-acetate

by Pascal Pigeon and Hugo Hapel

Molbank 2025, 2025(2), M2009; https://doi.org/10.3390/M2009 - 21 May 2025

Because of the continuous interest in ferrocene chemistry, there is a sustained demand for various ferrocenic building blocks, especially small molecules with useful chemical functional groups, sometimes containing multiple groups. Our interest in ferrocene ketoesters (ω-ferrocenyl-ω-ketoesters) was motivated by the synthesis of esters [...] Read more.

Because of the continuous interest in ferrocene chemistry, there is a sustained demand for various ferrocenic building blocks, especially small molecules with useful chemical functional groups, sometimes containing multiple groups. Our interest in ferrocene ketoesters (ω-ferrocenyl-ω-ketoesters) was motivated by the synthesis of esters and subsequently alcohols of ferrociphenols. However, from a bibliographic survey, only one publication dated from 1964 reports the two-step synthesis (six-step synthesis from ferrocene) of methyl 2-ferrocenyl-2-oxoacetate, the simplest member of this family of compounds, with no further developments since. We hypothesized that a simpler method might exist, such as the Friedel–Crafts method. By focusing on our experiments to use aluminum trichloride as the catalyst, we managed to achieve the synthesis of FcCOCOOMe in a single step, albeit with a very low yield, regardless of reaction time, temperature, amount of aluminum chloride and reagents concentration. Nevertheless, considering the time saved, simplicity, and the use of less hazardous and less expensive reagents, this method offers certain advantages for synthesizing this building block. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Scheme 1

8 pages, 4572 KiB

Open AccessCommunication

Crystal Structure and Hirshfeld Surface Analysis of Hexakis(acetoxymethyl)benzene

by Manuel Stapf, Wilhelm Seichter and Monika Mazik

Molbank 2025, 2025(2), M2008; https://doi.org/10.3390/M2008 - 16 May 2025

Representatives of the hexasubstituted benzene derivatives, also known as hexa-hosts, have been the subject of extensive studies in solution and in the solid state, including the investigation of their ability to act as artificial receptors for various substrates, as well as detailed conformational [...] Read more.

Representatives of the hexasubstituted benzene derivatives, also known as hexa-hosts, have been the subject of extensive studies in solution and in the solid state, including the investigation of their ability to act as artificial receptors for various substrates, as well as detailed conformational analyses. In this paper, we describe the X-ray crystal structure of hexakis(acetoxymethyl)benzene (1), a member of the above class of compounds. The molecules of 1 adopt an aaabbb conformation, in which three side-arms point to the same face of the central benzene ring, while the other three point in the opposite direction. As the compound lacks strong hydrogen bond donors, C–H···O hydrogen bonds connect the molecules to a three-dimensional supramolecular network. According to the Hirshfeld surface analysis, the H∙∙∙O/O∙∙∙H interactions represent the major contribution of the molecular Hirshfeld surface. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Graphical abstract

7 pages, 2295 KiB

Open AccessShort Note

2′,7′-Dimethyl-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

by Brian A. Chalmers, Aidan P. McKay, David B. Cordes, Iain L. J. Patterson, Nadiia Vladymyrova and Iain A. Smellie

Molbank 2025, 2025(2), M2007; https://doi.org/10.3390/M2007 - 14 May 2025

A synthetic route to 2′,7′-dimethyl-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one has been described using methanesulfonic acid in place of reagents described in protocols from the early 20th century. A full NMR assignment has been made and X-ray crystallography has been used to characterise the title compound [...] Read more.

A synthetic route to 2′,7′-dimethyl-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one has been described using methanesulfonic acid in place of reagents described in protocols from the early 20th century. A full NMR assignment has been made and X-ray crystallography has been used to characterise the title compound for the first time. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

8 pages, 17118 KiB

Open AccessShort Note

(Z)-4-(Azulen-1-ylmethylene)-2-phenyloxazol-5(4H)-one

by Mihaela Cristea, Alexandru C. Razus, Sergiu Shova, Marcel-Mirel Popa, Mihai Răducă and Florea Dumitrascu

Molbank 2025, 2025(2), M2006; https://doi.org/10.3390/M2006 - 8 May 2025

The title compound, i.e., (Z)-4-(azulen-1-ylmethylene)-2-phenyloxazol-5(4H)-one (3), has previously been synthesized in a good yield (56%) using the Erlenmeyer–Plöchl procedure. The crystal structure of 3 is described herein along with the results of a Hirshfeld surface analysis. Crystals of [...] Read more.

The title compound, i.e., (Z)-4-(azulen-1-ylmethylene)-2-phenyloxazol-5(4H)-one (3), has previously been synthesized in a good yield (56%) using the Erlenmeyer–Plöchl procedure. The crystal structure of 3 is described herein along with the results of a Hirshfeld surface analysis. Crystals of compound 3 were obtained through the slow evaporation of a mixture of petroleum ether/dichloromethane = 1:1 (vol.) at room temperature. This compound has a monoclinic system: a P2₁/n space group at room temperature. Its crystal packing is driven by π-π interactions between neighboring molecules in the range of 3.60–3.71 Å and by hydrogen bonds (D-H···A = 2.58 Å). Full article

► Show Figures

Graphical abstract

9 pages, 2127 KiB

Open AccessCommunication

Synthesis of Vanillic Acid—Meldrum’s Acid Conjugate

by Laima Bērziņa and Inese Mieriņa

Molbank 2025, 2025(2), M2005; https://doi.org/10.3390/M2005 - 7 May 2025

A vanillic acid—Meldrum’s acid conjugate with a 1,2,3-triazole linker is synthesized. The reaction sequence foresees the Huisgen reaction and the Knoevenagel condensation as the key-steps. Full article

► Show Figures

Graphical abstract

5 pages, 486 KiB

Open AccessCommunication

Synthesis and Characterization of New Monosubstituted Pillar[5]arene with Terminal Carboxyl Group

by Luidmila Yakimova, Darya Filimonova, Anastasia Nazarova and Ivan Stoikov

Molbank 2025, 2025(2), M2004; https://doi.org/10.3390/M2004 - 6 May 2025

The subject of this article is a new monosubstituted pillar[5]arene with a terminal carboxylic group. Previously, it was shown that monosubstituted pillar[5]arene forms solid lipid nanoparticles with various morphologies depending on the nature of the terminal group. The present work is devoted to [...] Read more.

The subject of this article is a new monosubstituted pillar[5]arene with a terminal carboxylic group. Previously, it was shown that monosubstituted pillar[5]arene forms solid lipid nanoparticles with various morphologies depending on the nature of the terminal group. The present work is devoted to the synthesis of monosubstituted pillar[5]arene with an anionic carboxylic group for the further creation of drug–carrier systems based on them. The chemical structure of the product obtained was established based on ¹H and ¹³C NMR, IR spectroscopy, MALDI TOF mass spectrometry, and elemental analysis. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Scheme 1

6 pages, 1653 KiB

Open AccessCommunication

Stereoselective Preparation of (4S)-1-Methyl-4-propyl-L-proline Commencing from (cis)-4-Hydroxy-L-proline

by Gour Hari Mandal, Shifali Choudhary, Steven P. Kelley and Shyam Sathyamoorthi

Molbank 2025, 2025(2), M2003; https://doi.org/10.3390/M2003 - 5 May 2025

We present a recipe for the stereoselective conversion of commercial (cis)-4-hydroxy-L-proline into (4S)-1-methyl-4-propyl-L-proline, an analog of the amino acid fragment found in the clinically used antibacterial antibiotic lincomycin. The single-crystal X-ray diffraction analysis of the final target’s hydrochloride salt [...] Read more.

We present a recipe for the stereoselective conversion of commercial (cis)-4-hydroxy-L-proline into (4S)-1-methyl-4-propyl-L-proline, an analog of the amino acid fragment found in the clinically used antibacterial antibiotic lincomycin. The single-crystal X-ray diffraction analysis of the final target’s hydrochloride salt confirms its identity and absolute stereochemistry. Full article

► Show Figures

Graphical abstract

9 pages, 1682 KiB

Open AccessCommunication

Synthesis of Dimethyl (Z)-((3-oxoindolin-2-ylidene) (aryl)methyl)phosphonates Through Tandem Cadogan and Arbuzov Reactions

by Nicolai A. Aksenov, Dmitrii A. Aksenov, Daniil D. Ganusenko, Alexander E. Kurlikov, Alexander P. Barbolin, Polina S. Karaseva and Alexander V. Aksenov

Molbank 2025, 2025(2), M2002; https://doi.org/10.3390/M2002 - 5 May 2025

A novel method employing a tandem Cadogan and Arbuzov reaction sequence has been developed, providing access to a series of previously unreported dimethyl (Z)-((3-oxoindolin-2-ylidene)(aryl)methyl)phosphonates. Restricted rotation of the aryl substituent, particularly in the presence of ortho substituents, gives axial chirality to these compounds. [...] Read more.

A novel method employing a tandem Cadogan and Arbuzov reaction sequence has been developed, providing access to a series of previously unreported dimethyl (Z)-((3-oxoindolin-2-ylidene)(aryl)methyl)phosphonates. Restricted rotation of the aryl substituent, particularly in the presence of ortho substituents, gives axial chirality to these compounds. Full article

► Show Figures

Figure 1

5 pages, 1105 KiB

Open AccessShort Note

6,7,8,9-Tetrafluoro-11H-indeno[1,2-b]quinoxalin-11-one

by Anastasia R. Kovrizhina, Irina Yu. Bagryanskaya, Andrey V. Zibarev and Andrei I. Khlebnikov

Molbank 2025, 2025(2), M2001; https://doi.org/10.3390/M2001 - 28 Apr 2025

Fluorinated aza-heterocycles are important in organic and medicinal chemistry. Currently, a quarter of the drugs on the global market contain fluorine. We report the synthesis of the title compound and its single-crystal XRD structure. Full article

► Show Figures

Figure 1

5 pages, 350 KiB

Open AccessShort Note

5,7-Diiodoquinolin-8-yl (E)-3-(3,4-dihydroxyphenyl)acrylate

by Marcin Cybulski, Michał Zieliński, Marek Kubiszewski and Olga Michalak

Molbank 2025, 2025(2), M2000; https://doi.org/10.3390/M2000 - 28 Apr 2025

We report the synthesis of 5,7-diiodoquinolin-8-yl ester of caffeic acid and its O,O-diallyl-protected analogue. The compounds from the hybrid class were fully characterised using NMR spectroscopy and high-resolution mass spectrometry. Full article

► Show Figures

Scheme 1

8 pages, 644 KiB

Open AccessShort Note

4,4′-(Anthracene-9,10-diylbis(ethyne-2,1-diyl))bis(1-benzyl-1-pyridinium) Bromide

by Valentina Novelli, Andrea D’Annibale, Fabrizio Casano, Alessandro Latini and Lorenza Romagnoli

Molbank 2025, 2025(2), M1998; https://doi.org/10.3390/M1998 - 27 Apr 2025

Viologens, i.e., quaternary 4,4′-bipyridinum salts, are a well-known class of functional organic compounds that have attracted in the past few decades a great deal of attention for their peculiar chemical and electrochemical properties and have therefore found numerous applications ranging from herbicides to [...] Read more.

Viologens, i.e., quaternary 4,4′-bipyridinum salts, are a well-known class of functional organic compounds that have attracted in the past few decades a great deal of attention for their peculiar chemical and electrochemical properties and have therefore found numerous applications ranging from herbicides to electrochromic devices. In this paper, the synthesis and characterization of a novel viologen derivative are described. In the reported compound, the pyridinium nitrogen atoms have been quaternarized with the benzyl group and an additional unsaturated moiety, namely a 9,10-diethynylanthracene core, has been inserted between the charged pyridinium rings to extend the conjugation. Characterization by means of absorbance and diffuse reflectance UV–visible spectroscopy suggested intriguing optical and electronic properties, making this extended viologen a potential candidate for different optoelectronic applications. Full article

► Show Figures

Figure 1

11 pages, 1782 KiB

Open AccessCommunication

1-(Pyrrolidin-1-yl)naphtho[1,2-d]isoxazole

by Ioannis E. Gerontitis, Abdul kadar Shaikh, Dimitrios Alivertis, Panteleimon G. Takis, Anastassios N. Troganis, Petros G. Tsoungas and George Varvounis

Molbank 2025, 2025(2), M1999; https://doi.org/10.3390/M1999 - 27 Apr 2025

In this study, we examined the oxidation of (E)-2-hydroxy-1-naphthaldehyde oxime with lead tetraacetate in tetrahydrofuran that produced novel (E)-7a,8,9,10-tetrahydro-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazin-12-one oxime and 1-(pyrrolidin-1-yl)naphtho[1,2-d]isoxazole and known 7a,8,9,10-tetrahydro-12H-naphtho[1,2-e]pyrrolo-[2,1-b][1,3]oxazin-12-one [...] Read more.

In this study, we examined the oxidation of (E)-2-hydroxy-1-naphthaldehyde oxime with lead tetraacetate in tetrahydrofuran that produced novel (E)-7a,8,9,10-tetrahydro-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazin-12-one oxime and 1-(pyrrolidin-1-yl)naphtho[1,2-d]isoxazole and known 7a,8,9,10-tetrahydro-12H-naphtho[1,2-e]pyrrolo-[2,1-b][1,3]oxazin-12-one in 15, 18, and 10% yields, respectively. The oxime is partially hydrolyzed to its corresponding ketone. Modifying the oxidants and reaction conditions did not improve the product yields. Based on previous studies in our laboratory, we proposed that the reactions proceed via the formation of an o-naphthoquinone nitrosomethide intermediate; 1D and 2D NMR, HRMS, IR, and UV-VIS spectra provided information that supported the structure of the products. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Figure 1

7 pages, 958 KiB

Open AccessShort Note

(E)-4,2′,4′-Trimethoxychalcone (Z)-N-Tosyl Hydrazone

by Sonia Berenguel Gómez, Irene Moreno-Gutiérrez, Manuel Muñoz-Dorado, Míriam Álvarez-Corral and Ignacio Rodríguez-García

Molbank 2025, 2025(2), M1997; https://doi.org/10.3390/M1997 - 27 Apr 2025

The synthesis and structural characterization of (E)-4,2′,4′-trimethoxychalcone (Z)-N-tosyl hydrazone, a conjugated tosylhydrazone derivative, is described. The compound was obtained via the condensation of (E)-1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one with p-toluenesulfonylhydrazide in methanol under mild conditions, yielding a yellow [...] Read more.

The synthesis and structural characterization of (E)-4,2′,4′-trimethoxychalcone (Z)-N-tosyl hydrazone, a conjugated tosylhydrazone derivative, is described. The compound was obtained via the condensation of (E)-1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one with p-toluenesulfonylhydrazide in methanol under mild conditions, yielding a yellow solid in a 66% yield. The structure of the product was confirmed through ¹H NMR, ¹³C NMR, IR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction analysis, which revealed a non-planar molecular conformation and a Z configuration for the C=N double bond. This work is part of our ongoing research on carbene-mediated transformations. Full article

► Show Figures

Graphical abstract

6 pages, 1255 KiB

Open AccessShort Note

(3a,8b)-5-Acetyl-3a-fluoro-6,8-dihydroxy-7,8b-dimethyl-3,3a-dihydrofuro[3,2-b]benzofuran-2(8bH)-one

by Aleksandr S. Filimonov, Stepan P. Zernov, Olga A. Luzina and Nariman F. Salakhutdinov

Molbank 2025, 2025(2), M1995; https://doi.org/10.3390/M1995 - 24 Apr 2025

Usnetic acid is a dibenzofuran-2-ylacetic acid that can be obtained by alkaline degradation of a secondary lichen metabolite—usnic acid. In the present paper, the product of the reaction of usnetic acid with a mild fluorinating agent, Selectfluor^®, was obtained. The structure [...] Read more.

Usnetic acid is a dibenzofuran-2-ylacetic acid that can be obtained by alkaline degradation of a secondary lichen metabolite—usnic acid. In the present paper, the product of the reaction of usnetic acid with a mild fluorinating agent, Selectfluor^®, was obtained. The structure of the product was proved by a set of physical methods, including ¹H, ¹³C, ¹⁹F NMR, HMBC, HSQC, HRMS and IR spectroscopy. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Figure 1

6 pages, 1285 KiB

Open AccessShort Note

2,2′-((5,5′,6,6′-Tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(methanylylidene))dimalononitrile

by David Gendron and Josée Labrecque

Molbank 2025, 2025(2), M1996; https://doi.org/10.3390/M1996 - 24 Apr 2025

This report discusses the synthesis of a biosourced divanillin derivative obtained by Knoevenagel condensation. The compound was fully characterized by proton (¹H), carbon (¹³C), heteronuclear single quantum coherence (HSQC), homonuclear correlation spectroscopy (COSY), and heteronuclear multiple bond correlation (HMBC) [...] Read more.

This report discusses the synthesis of a biosourced divanillin derivative obtained by Knoevenagel condensation. The compound was fully characterized by proton (¹H), carbon (¹³C), heteronuclear single quantum coherence (HSQC), homonuclear correlation spectroscopy (COSY), and heteronuclear multiple bond correlation (HMBC) NMR, as well as high-resolution mass spectroscopy (HRMS). We also investigated the optical properties through UV-visible spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. At last, the thermal properties of this divanillin derivative were evaluated by thermogravimetric analysis (TGA) as well as differential scanning calorimetry (DSC). Full article

► Show Figures

Figure 1

7 pages, 603 KiB

Open AccessShort Note

6-(7,8-Dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)hexyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

by Simona Marincean, Diana Nichols, Rachael Schulz, Travis Branscum and Marilee Benore

Molbank 2025, 2025(2), M1994; https://doi.org/10.3390/M1994 - 23 Apr 2025

Herein we report the synthesis of 6-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)hexyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate. The compound was fully characterized by melting point, ¹H-, ¹³C-NMR spectroscopy, IR spectroscopy, UV-VIS spectroscopy, mass spectrometry, and elemental analysis. The obtained data confirmed the successful synthesis and structure of the novel molecule. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Graphical abstract

4 pages, 482 KiB

Open AccessShort Note

N-(2,2-Diphenylethyl)furan-2-carboxamide

by Iliyan Ivanov, Diyana Dimitrova and Stanimir Manolov

Molbank 2025, 2025(2), M1993; https://doi.org/10.3390/M1993 - 16 Apr 2025

We report the synthesis of N-(2,2-diphenylethyl)furan-2-carboxamide. The compound was fully characterized by melting point determination, ¹H and ¹³C NMR spectroscopy, infrared spectroscopy, and mass spectrometry. The combined analytical data confirm both the successful synthesis and the structural integrity of the target molecule. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

5 pages, 932 KiB

Open AccessShort Note

N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-4-methyl-N-tosylbenzenesulfonamide

by Diana Becerra and Juan-Carlos Castillo

Molbank 2025, 2025(2), M1992; https://doi.org/10.3390/M1992 - 15 Apr 2025

N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-4-methyl-N-tosylbenzenesulfonamide was efficiently synthesized in good yield through a triethylamine-mediated sulfonamidation reaction of 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine with 4-methylbenzenesulfonyl chloride in acetonitrile at room temperature. The pyrazole-based benzenesulfonamide was fully characterized using FT-IR, NMR, and HMRS techniques. Full article

(This article belongs to the Collection Heterocycle Reactions)

► Show Figures

Figure 1

More Articles...

Submit to Molbank Review for Molbank

Journal Menu

Journal Browser

► Journal Browser

Highly Accessed Articles

View More...

Latest Books

More Books and Reprints...

E-Mail Alert

News

30 April 2025
Richard DiMarchi and Rolf Müller Share the 2024 Tu Youyou Award

15 May 2025
Interview with Dr. Atsushi Ueda—Winner of the Molbank 2024 Outstanding Reviewer Award

14 May 2025
Meet Us at the EPF European Polymer Congress 2025, 22–27 June 2025, Groningen, the Netherlands

More News & Announcements...

Topics

Propose a Topic

Topic in Catalysts, Chemistry, Molbank, Molecules, Sustainable Chemistry

Towards the Sustainable Synthesis of Biologically Active Molecules in Green Solvents Topic Editors: Antonio Salomone, Serena Perrone
Deadline: 31 December 2025

Conferences

Announce Your Conference

More Conferences...

Special Issues

Propose a Special Issue

Topical Collections

Topical Collection in Molbank

Molecules from Catalytic Processes Collection Editor: Nicola Della Ca’

Topical Collection in Molbank

Heterocycle Reactions Collection Editor: Fawaz Aldabbagh

Topical Collection in Molbank

Molecules from Side Reactions Collection Editor: Stefano D’Errico

Back to TopTop