Molbank

A new fused triazinobenzimidazole derivative, 4-(3,5-dimethoxyphenyl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-amine, was synthesized via one-step cyclocondensation reaction. The target compound was obtained in good yield and characterized by ¹H NMR, ¹³C NMR, and HRMS. This work expands the library of aryl-substituted 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazines, a class of fused nitrogen-containing heterocycles of interest in medicinal chemistry.

This research aimed to develop a new semisynthetic piperine compound derived from black pepper (Piper nigrum, Piperaceae), commonly known as “King of Spices”. Piperine was isolated from the ethanolic extract of Piper nigrum by the Soxhlet extraction method. In this, 5(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (Piperine) is used as a starting material to form (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienoic acid (2). After that, ethyl (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienoate (3) will be formed by the esterification process. The (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienehydrazide (4) was formed by using hydrazine and ethanol. In the final step, the hydrazide was reacted with p-aminobenzoic acid to form 4-(5-((1E,3E)-4-(benzo[d][1,3]dioxol-5-yl)buta-1,3-dien-1-yl)-1,3,4-oxadiazol-2-yl)aniline (5). The novel synthesized compound was characterized by IR, ¹H NMR, ¹³C NMR, and mass spectroscopy.

The reaction of Cd(NO₃)₂·4H₂O with the fluorescent ditopic N-donor ligand 2,5-bis[(pyridin-3-yl)ethynyl]thiophene (L) afforded the new coordination polymer {[Cd(L)(H₂O)₂(NO₃)₂]∙1.25H₂O}_n (1). Single-crystal X-ray diffraction analysis revealed that the Cd^II centre is heptacoordinated and adopts a distorted pentagonal-bipyramidal coordination geometry, with two bridging L ligands in the axial positions and water molecules and nitrate anions occupying the equatorial plane. The antiperiplanar conformation of L promotes the formation of zigzag polymeric chains, which are further assembled through O–H···O hydrogen bonds and π–π stacking interactions into a 3D supramolecular network containing solvent-accessible channels. Compound 1 was further characterised by FT-IR spectroscopy, melting point determination, and solid-state absorption and emission spectroscopy.