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Molbank

Molbank is an international, peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products published quarterly online by MDPI.

Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 13.9 days after submission; acceptance to publication is undertaken in 3.8 days (median values for papers published in this journal in the first half of 2024).
Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.

Impact Factor: 0.6 (2023)

Imprint Information Journal Flyer Open Access ISSN: 1422-8599

Latest Articles

7 pages, 243 KiB

Open AccessCommunication

The Effects of Ceric Ammonium Nitrate in the Oxidation of 2-Benzyl-1,4-dimethoxybenzene Derivatives

by Marcello Casertano, Anna Aiello, Marialuisa Menna and Concetta Imperatore

Molbank 2024, 2024(3), M1882; https://doi.org/10.3390/M1882 (registering DOI) - 16 Sep 2024

The one- or two-electron reduction in quinone compounds gives rise to semiquinones and hydroquinones, respectively, which, in turn, can be oxidized back to quinones, generating a cyclic redox system with the production of reactive oxygen species (ROS). For these reasons, quinone derivatives participate [...] Read more.

The one- or two-electron reduction in quinone compounds gives rise to semiquinones and hydroquinones, respectively, which, in turn, can be oxidized back to quinones, generating a cyclic redox system with the production of reactive oxygen species (ROS). For these reasons, quinone derivatives participate in various biological processes in metabolic pathways, such as oxidative reactions and electron transport. In addition, natural quinone compounds as well as their semisynthetic and/or synthetically produced derivatives are of great pharmacological interest for the discovery and design of new drugs. As a result, their chemical reactivity as well as new methods for their synthesis are being investigated on an ongoing basis. Herein, a mild and efficient synthesis to obtain 2-(4-benzyl substituted)-1,4-dimethoxybenzene derivatives is reported. In addition, an evaluation of the effects on the quinone/diquinone ratio in the reaction product in relation to different ways of adding the oxidant CAN to the arene solution is discussed. Full article

(This article belongs to the Section Organic Synthesis)

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Scheme 1

4 pages, 586 KiB

Open AccessShort Note

rel-(2R,3S)-2-((Diphenylmethylene)amino)-5-oxo-5-phenyl-3-(thiophen-2-yl)pentanenitrile

by Donka N. Tasheva and Vesela M. Mihaylova

Molbank 2024, 2024(3), M1881; https://doi.org/10.3390/M1881 - 11 Sep 2024

The reaction of 2-((diphenylmethylene)amino)acetonitrile with (E)-1-phenyl-3-(thiophen-2-yl)prop-2-en-1-one was performed by using 33% NaOH in CH₃CN for 30 min at 0 °C. The main product—rel-(2R,3S)-2-((diphenylmethylene)amino)-5-oxo-5-phenyl-3-(thiophen-2-yl)pentanenitrile—was isolated and characterized by IR, ¹H NMR, ¹³C NMR, ¹H-¹H COSY, and high-resolution mass spectrometry (HRMS). Full article

(This article belongs to the Section Organic Synthesis)

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Graphical abstract

7 pages, 3596 KiB

Open AccessCommunication

The Crystal Structures of Some Bromo-Derivatives of the DPPH Stable Free Radical

by Adela F. Dobre, Augustin M. Madalan and Petre Ionita

Molbank 2024, 2024(3), M1880; https://doi.org/10.3390/M1880 - 10 Sep 2024

Bromination of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical with bromine or N-bromo-succinimide (NBS) affords a complex mixture of bromo- and nitro-derivatives of the starting material. In this study, by chromatographic separation, most of the reaction products were isolated. Suitable crystals for X-ray measurements [...] Read more.

Bromination of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical with bromine or N-bromo-succinimide (NBS) affords a complex mixture of bromo- and nitro-derivatives of the starting material. In this study, by chromatographic separation, most of the reaction products were isolated. Suitable crystals for X-ray measurements were obtained and characterized for the compounds 2-p-bromophenyl-2-phenyl-1-picrylhydrazyl free radical (Br-DPPH), 2-p-bromophenyl-2-phenyl-1-picrylhydrazine (Br-DPPH-H), and 2,2-(p-bromophenyl)-1-(2-bromo-4,6-dinitrophenyl)hydrazine (Br₂-DPPBr-H). Full article

(This article belongs to the Section Structure Determination)

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Figure 1

5 pages, 778 KiB

Open AccessCommunication

Synthesis of Novel Sulfonamide Derivatives Featuring 1-(Methylsulfonyl)-4-(2,3,4-trimethoxybenzyl)piperazine Core Structures

by Iliyan Ivanov, Stanimir Manolov, Dimitar Bojilov, Diyana Dimitrova and Paraskev Nedialkov

Molbank 2024, 2024(3), M1879; https://doi.org/10.3390/M1879 - 9 Sep 2024

Herein we report the synthesis of three novel sulfonamide derivatives of trimetazidine—medication primarily used to treat angina pectoris. The new compounds have been fully characterized with their melting point, ¹H- and ¹³C-NMR, UV, and mass spectrometry. The collected data confirm the [...] Read more.

Herein we report the synthesis of three novel sulfonamide derivatives of trimetazidine—medication primarily used to treat angina pectoris. The new compounds have been fully characterized with their melting point, ¹H- and ¹³C-NMR, UV, and mass spectrometry. The collected data confirm the successful synthesis and structural integrity of the new molecules. Full article

(This article belongs to the Section Organic Synthesis)

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Figure 1

6 pages, 1565 KiB

Open AccessCommunication

2,3-Dihydrobenzo[e][1,3]oxazin-4-one

by R. Alan Aitken, David B. Cordes, Mhairi R. Kinahan and Aidan P. McKay

Molbank 2024, 2024(3), M1878; https://doi.org/10.3390/M1878 - 5 Sep 2024

The title compound and its hydroxymethyl precursor have been fully characterised for the first time. The IR spectra, fully assigned ¹H and ¹³C NMR spectra, and X-ray structures are presented for both compounds. Both compounds form hydrogen-bonded dimers in the crystal structures. Full article

(This article belongs to the Section Structure Determination)

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Graphical abstract

6 pages, 1741 KiB

Open AccessCommunication

Attempted Synthesis of the Pseudomonas aeruginosa Metabolite 2-Benzyl-4(1H)-quinolone and Formation of 3-Methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an Unexpected Product

by Plamen Angelov, Yordanka Mollova-Sapundzhieva and Paraskev Nedialkov

Molbank 2024, 2024(3), M1877; https://doi.org/10.3390/M1877 - 29 Aug 2024

The unusual reactivity of key enamine intermediates led to the formation of 3-methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an unexpected product in an attempted synthesis of the P. aeruginosa metabolite 2-benzyl-4(1H)-quinolone. Although the synthesis of the natural product has not been successful, this [...] Read more.

The unusual reactivity of key enamine intermediates led to the formation of 3-methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an unexpected product in an attempted synthesis of the P. aeruginosa metabolite 2-benzyl-4(1H)-quinolone. Although the synthesis of the natural product has not been successful, this methodology allows for the easy preparation of novel derivatives carrying a carboxamide moiety at the C3 position. Full article

(This article belongs to the Section Organic Synthesis)

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Figure 1

8 pages, 1286 KiB

Open AccessCommunication

Synthesis of Diastereomeric 2,6-bis{[3-(2-Hydroxy-5-substitutedbenzyl)octahydro-1H-benzimidazol-1-yl]methyl}-4-substituted Phenols (R = Me, OMe) by Mannich-Type Tandem Reactions

by Diego Quiroga, Jaime Ríos-Motta and Augusto Rivera

Molbank 2024, 2024(3), M1876; https://doi.org/10.3390/M1876 - 28 Aug 2024

The synthesis and characterization of two novel diastereomeric Mannich bases was carried out from the reaction of the cyclic aminal (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo[8.8.1.1.^8,170.^2,70.^11,16]icosane 1 and p-cresol 2a and 4-methoxyphenol 2b [...] Read more.

The synthesis and characterization of two novel diastereomeric Mannich bases was carried out from the reaction of the cyclic aminal (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo[8.8.1.1.^8,170.^2,70.^11,16]icosane 1 and p-cresol 2a and 4-methoxyphenol 2b in a water/dioxane mixture. The title compounds (4a–b) are interesting because bearing two 3-(2-hydroxy-5-substitutedbenzyl)octahydro-1H-benzimidazol-1-yl]methyl} substituents joined to an arenol ring. The formation of these new Mannich bases in the reaction mixture can be explained by aminomethylation of previously reported di-Mannich base 2,2′-((hexahydro-1H-benzo[d]imidazole-1,3(2H)-diyl)bis(methylene))bis(4-substituentphenol) 3a–b. NMR analysis demonstrated that compounds 4a–b were formed as diastereomeric mixtures. Subsequent experiments revealed that at longer reaction times, the percentage yield of these new products increased considerably (yield percentages up to 22–27%), suggesting a nucleophilic competition between the p-substituted phenols and Mannich bases of type 3 for aminal 1. Full article

(This article belongs to the Section Organic Synthesis)

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Graphical abstract

5 pages, 870 KiB

Open AccessShort Note

(R/S)-Ethyl 2-Acetoxy-4-phenyl-4H-chromene-3-carboxylate

by Nevena I. Petkova-Yankova, Ana I. Koleva and Rositca D. Nikolova

Molbank 2024, 2024(3), M1875; https://doi.org/10.3390/M1875 - 26 Aug 2024

A simple protocol for the preparation of O-acylated enol form (R/S)-ethyl-2-acetoxy-4-phenyl-4H-chromene-3-carboxylate 5 was presented. The compound was characterized by ¹H-, ¹³C-and DEPT135 NMR spectra, including {¹H,¹H} COSY, {¹H,¹³C} HSQC, {¹ [...] Read more.

A simple protocol for the preparation of O-acylated enol form (R/S)-ethyl-2-acetoxy-4-phenyl-4H-chromene-3-carboxylate 5 was presented. The compound was characterized by ¹H-, ¹³C-and DEPT135 NMR spectra, including {¹H,¹H} COSY, {¹H,¹³C} HSQC, {¹H,¹³C} HMBC, and 2D-NOESY spectra. The preferred regioselectivity for O-acylation of 3,4-dihydrocoumarin 5 in the presence of substituent in the 4th position in the chroman ring and accounting for the steric hindrance of the ester group in the 3rd place was confirmed. Full article

(This article belongs to the Section Organic Synthesis)

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Figure 1

10 pages, 3300 KiB

Open AccessShort Note

8-(2-Methoxyphenyl)-6-methyl-2-(1-methyl-1H-benzo[d]imidazol-2-yl)quinoline

by Maria Ivanova, Joana Zaharieva, Martin Tsvetkov, Vesela Lozanova, Bernd Morgenstern and Rumen Lyapchev

Molbank 2024, 2024(3), M1874; https://doi.org/10.3390/M1874 - 21 Aug 2024

For very first time, we report the synthesis of 8-(2-methoxyphenyl)-6-methyl-2-(1-methyl-1H-benzo[d]imidazol-2-yl)quinoline 1. This was achieved in several steps, including usage of the Suzuki reaction for functionalization of 2-(1H-benzo[d]imidazol-2-yl)quinoline moiety. The new compound exhibits blue fluorescence. Its structure was confirmed [...] Read more.

For very first time, we report the synthesis of 8-(2-methoxyphenyl)-6-methyl-2-(1-methyl-1H-benzo[d]imidazol-2-yl)quinoline 1. This was achieved in several steps, including usage of the Suzuki reaction for functionalization of 2-(1H-benzo[d]imidazol-2-yl)quinoline moiety. The new compound exhibits blue fluorescence. Its structure was confirmed with 1D and 2D NMR spectroscopy, IR spectroscopy, high-resolution mass spectrometry and X-ray analysis. Full article

(This article belongs to the Section Organic Synthesis)

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Figure 1

9 pages, 433 KiB

Open AccessCommunication

Synthesis and Antimicrobial Evaluation of 2-[2-(9H-Fluoren-9-ylidene)hydrazin-1-yl]-1,3-thiazole Derivatives

by Kazimieras Anusevičius, Ignė Stebrytė and Povilas Kavaliauskas

Molbank 2024, 2024(3), M1872; https://doi.org/10.3390/M1872 - 19 Aug 2024

Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shorten the reaction time. The [...] Read more.

Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shorten the reaction time. The antimicrobial properties of all synthesized compounds were screened for multidrug-resistant microorganism strains. The minimum inhibitory concentration of the tested compounds against Gram-positive bacteria and fungi was higher than 256 μg/mL, but several compounds had activity against Gram-positive strains. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Graphical abstract

4 pages, 553 KiB

Open AccessShort Note

3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic Acid

by Edoardo Armano, Alessandro Giraudo, Camillo Morano, Marco Pallavicini and Cristiano Bolchi

Molbank 2024, 2024(3), M1873; https://doi.org/10.3390/M1873 - 19 Aug 2024

3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic acid, a novel 2,3-disubstituted benzodioxin, was prepared from readily available 1,4-benzodioxin-2-carboxylic acid by lithiation at C(3) and a reaction with the electrophile ethyl chloroformate. The analytical characterization of the product was performed via IR, ¹H-NMR, ¹³C-NMR, HRMS, and HPLC-UV. Due [...] Read more.

3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic acid, a novel 2,3-disubstituted benzodioxin, was prepared from readily available 1,4-benzodioxin-2-carboxylic acid by lithiation at C(3) and a reaction with the electrophile ethyl chloroformate. The analytical characterization of the product was performed via IR, ¹H-NMR, ¹³C-NMR, HRMS, and HPLC-UV. Due to the unsymmetrically disubstituted unsaturation, the obtained monoester of 1,4-benzodioxin-2,3-dicarboxylic acid is a building block of great potential in the synthesis of a variety of compounds containing the benzodioxin or benzodioxane scaffold. Full article

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Figure 1

6 pages, 1523 KiB

Open AccessShort Note

3-((λ³-Oxidanylidene)(propylamino)methyl)-2-ethoxybenzo[e]-[1,2]oxaphosphinine-2-oxide

by Ana I. Koleva, Nevena I. Petkova-Yankova and Rositca D. Nikolova

Molbank 2024, 2024(3), M1870; https://doi.org/10.3390/M1870 - 19 Aug 2024

A method for the simple preparation of 2-ethoxy-N-propylbenzo[e][1,2]oxaphosphinine-3-carboxamide 2-oxide via an ultrasound technique using catalytic amounts of CuI is reported. The formation of the amide could indicate the isomerization of the formed E-alkene intermediate to its Z-form, assisted by the sonication [...] Read more.

A method for the simple preparation of 2-ethoxy-N-propylbenzo[e][1,2]oxaphosphinine-3-carboxamide 2-oxide via an ultrasound technique using catalytic amounts of CuI is reported. The formation of the amide could indicate the isomerization of the formed E-alkene intermediate to its Z-form, assisted by the sonication irradiation, and such transformation under the presented conditions has not been previously reported in the literature. Full article

(This article belongs to the Section Organic Synthesis)

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Scheme 1

8 pages, 494 KiB

Open AccessShort Note

8-Iodo-4-methyl-2-oxo-2H-chromen-7-yl Benzenesulfonate

by Luis Pulido-Moreno, Andrés Parra-Tibocha, Alexander Ladino-Bejarano, Mario A. Macías, Diana Becerra and Juan-Carlos Castillo

Molbank 2024, 2024(3), M1869; https://doi.org/10.3390/M1869 - 19 Aug 2024

We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2H-chromen-7-yl benzenesulfonate (3a) and 8-iodo-4-methyl-2-oxo-2H-chromen-7-yl benzenesulfonate (3b) in good yields through an O-sulfonylation reaction of 7-hydroxy-2H-chromen-2-ones 1a and 1b with benzenesulfonyl chloride 2 mediated [...] Read more.

We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2H-chromen-7-yl benzenesulfonate (3a) and 8-iodo-4-methyl-2-oxo-2H-chromen-7-yl benzenesulfonate (3b) in good yields through an O-sulfonylation reaction of 7-hydroxy-2H-chromen-2-ones 1a and 1b with benzenesulfonyl chloride 2 mediated by triethylamine in dichloromethane at ambient temperature. The aryl sulfonyl esters were characterized using spectroscopic, spectrometric, and thermal analyses. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Scheme 1

4 pages, 1012 KiB

Open AccessShort Note

1-(Dicyanomethylene)-3-hydroxy-1H-indene-2-carboxylic Acid

by Sofia D. Usova, Ekaterina A. Knyazeva and Oleg A. Rakitin

Molbank 2024, 2024(3), M1871; https://doi.org/10.3390/M1871 - 19 Aug 2024

Bulk heterojunction solar cells are among the most promising organic solar cells (OSCs). One of the two important parts of OSCs are acceptors, and the development of the design and synthesis of non-fullerene acceptors involves an electron-deficient heterocyclic central core and anchor acceptor [...] Read more.

Bulk heterojunction solar cells are among the most promising organic solar cells (OSCs). One of the two important parts of OSCs are acceptors, and the development of the design and synthesis of non-fullerene acceptors involves an electron-deficient heterocyclic central core and anchor acceptor malonitrile derivatives of 3-methylene-2,3-dihydro-1H-inden-1-ones. In this communication, an intermediate for the synthesis of this compound, 1-(dicyanomethylene)-3-hydroxy-1H-indene-2-carboxylic acid, was prepared by the Perkin reaction of 2-(3-oxoisobenzofuran-1(3H)-ylidene)malononitrile with tert-butyl acetoacetate in the presence of acetic anhydride and triethylamine. The structure of the newly synthesized compound was established by means of elemental analysis, high-resolution mass spectrometry, ¹H NMR, ¹³C NMR and IR spectroscopy, and mass spectrometry. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Scheme 1

8 pages, 1461 KiB

Open AccessShort Note

2-(2,6-Diisopropylphenyl)-1-methylimidazo[1,5-a]quinolin-2-ium Tetrafluoroborate

by Lyuben Borislavov, Iskra Z. Koleva, Vesela Lozanova, Maria Ivanova and Rumen Lyapchev

Molbank 2024, 2024(3), M1868; https://doi.org/10.3390/M1868 - 15 Aug 2024

A new heterocyclic compound, 2-(2,6-diisopropylphenyl)-1-methylimidazo[1,5-a]quinolin-2-ium tetrafluoroborate 1 was obtained from its precursor, N-(2,6-diisopropylphenyl)-N-(quinolin-2-ylmethyl)acetamide 2, by POCl₃-mediated cyclization. For the first time, tertiary acetamide 2, the precursor of 1, was synthesized by using commercially [...] Read more.

A new heterocyclic compound, 2-(2,6-diisopropylphenyl)-1-methylimidazo[1,5-a]quinolin-2-ium tetrafluoroborate 1 was obtained from its precursor, N-(2,6-diisopropylphenyl)-N-(quinolin-2-ylmethyl)acetamide 2, by POCl₃-mediated cyclization. For the first time, tertiary acetamide 2, the precursor of 1, was synthesized by using commercially available starting materials. The structure of 1 was unquestionably confirmed by ¹H, ¹³C, 2D-NMR, and IR spectroscopies and mass spectrometry. Its optical properties were also studied. Full article

(This article belongs to the Section Organic Synthesis)

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Figure 1

7 pages, 1581 KiB

Open AccessShort Note

Bis(3-(((4-methoxybenzyl)oxy)methyl)-5,6-dihydro-1,4-dithiin-2-yl)methanol

by Anna Esposito and Annalisa Guaragna

Molbank 2024, 2024(3), M1867; https://doi.org/10.3390/M1867 - 14 Aug 2024

An organolithium reagent containing a 5,6-dihydro-1,4-dithiin moiety has been herein used as homologating agent to build up a fully protected divinylcarbinol by two different synthetic procedures, respectively, based on a step-by-step approach or a tandem process. The resulting molecule contains two double bonds [...] Read more.

An organolithium reagent containing a 5,6-dihydro-1,4-dithiin moiety has been herein used as homologating agent to build up a fully protected divinylcarbinol by two different synthetic procedures, respectively, based on a step-by-step approach or a tandem process. The resulting molecule contains two double bonds masked by two dithiodimethylene bridges that can be stereoselectively removed to give a E,E- or Z,Z-configured divinylcarbinol. These products could then be conveniently functionalized, for example, with hydroxyl or amino functions, for the construction of the skeleton of more complex systems. Full article

(This article belongs to the Collection Molecules from Side Reactions)

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8 pages, 386 KiB

Open AccessCommunication

Synthesis of Tetrahydroberberine N,N-Derived O-Acetamides

by Ivan Vasil’evich Nechepurenko, Nina Ivanovna Komarova and Nariman Faridovich Salakhutdinov

Molbank 2024, 2024(3), M1865; https://doi.org/10.3390/M1865 - 13 Aug 2024

The reaction of berberine derivatives containing at the O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol at 0 °C leads to a mild reduction of the “C” cycle with the formation of corresponding tetrahydroberberine derivatives with moderate to good yields. Full article

(This article belongs to the Section Natural Products)

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Graphical abstract

4 pages, 347 KiB

Open AccessShort Note

(E)-5-(3-Oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzo[d]oxazol-2(3H)-one

by Yordanka B. Ivanova, Filip E. Svetoslavov and Ognyan I. Petrov

Molbank 2024, 2024(3), M1866; https://doi.org/10.3390/M1866 - 13 Aug 2024

The title compound, (E)-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzo[d]oxazol-2(3H)-one, was synthesized by the acid- and base-catalyzed aldol condensation of 2-oxo-2,3-dihydrobenzo[d]oxazole-5-carbaldehyde and 3,4,5-trimethoxyacetophenone. The structure of the target compound was confirmed using ¹H NMR, ¹³C NMR, HRMS, and elemental analysis. Full article

(This article belongs to the Section Organic Synthesis)

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Scheme 1

5 pages, 390 KiB

Open AccessShort Note

5′-Oxospiro-(fluorene-9,4′-imidazolidine)-2′-thione

by Dimitar Stoitsov, Marin Marinov, Plamen Penchev, Petya Marinova and Neyko Stoyanov

Molbank 2024, 2024(3), M1864; https://doi.org/10.3390/M1864 - 8 Aug 2024

The structure verification of 5′-oxospiro-(fluorene-9,4′-imidazolidine)-2′-thione by NMR is reported. Toward this aim, 2D NMR techniques including ¹H-¹H COSY, HMQC, and HMBC experiments were used to assist with the assignment of the ¹H and ¹³C chemical shifts for the [...] Read more.

The structure verification of 5′-oxospiro-(fluorene-9,4′-imidazolidine)-2′-thione by NMR is reported. Toward this aim, 2D NMR techniques including ¹H-¹H COSY, HMQC, and HMBC experiments were used to assist with the assignment of the ¹H and ¹³C chemical shifts for the corresponding structure. The mutual interpretation of the 1D and 2D NMR spectra ensured a complete and accurate ¹H and ¹³C NMR data assignment for 5′-oxospiro-(fluorene-9,4′-imidazolidine)-2′-thione. Full article

(This article belongs to the Section Structure Determination)

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Figure 1

5 pages, 950 KiB

Open AccessShort Note

3-((2-(4-Chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate

by Rosalba Leuci, Daniela Dininno, Marco Paparella and Luca Piemontese

Molbank 2024, 2024(3), M1863; https://doi.org/10.3390/M1863 - 5 Aug 2024

In this study, we report the synthesis of 3-((2-(4-chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate, designed on the basis of the structures of the commercial acetylcholinesterase inhibitor drug rivastigmine and a substituted aryloxyacetic acid, aiming at a multi-target approach to the therapy of Alzheimer’s disease. The hybrid was obtained [...] Read more.

In this study, we report the synthesis of 3-((2-(4-chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate, designed on the basis of the structures of the commercial acetylcholinesterase inhibitor drug rivastigmine and a substituted aryloxyacetic acid, aiming at a multi-target approach to the therapy of Alzheimer’s disease. The hybrid was obtained thanks to a synthesized intermediate by-product. The compound was fully characterized by using ¹H and ¹³C NMR, FT-IR and HRMS. Full article

(This article belongs to the Collection Molecules from Side Reactions)

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