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Molbank

Molbank is an international, peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products published bimonthly online by MDPI.

Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 12.7 days after submission; acceptance to publication is undertaken in 2.7 days (median values for papers published in this journal in the second half of 2025).
Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.

Impact Factor: 0.4 (2024)

Imprint Information Journal Flyer Open Access ISSN: 1422-8599

Latest Articles

10 pages, 1645 KB

Open AccessShort Note

1-Phenyl-4-p-tolyl-[1,2,3]triazole

by Eder Y. Nolasco-Terrón, David Gómez-Colín, Nelly González-Rivas, Diego Martínez-Otero and Erick Cuevas-Yañez

Molbank 2026, 2026(2), M2160; https://doi.org/10.3390/M2160 - 8 Apr 2026

1-Phenyl-4-p-tolyl-[1,2,3]triazole was obtained via a CuAAC reaction involving phenyl azide and 1-ethynyl-4-methylbenzene. The NMR spectra of the compound are discussed, and its crystal structure was studied by X-ray analysis. According to the latter analysis and a Hirshfeld surface analysis, the predominant intermolecular C-H⋅⋅⋅N [...] Read more.

1-Phenyl-4-p-tolyl-[1,2,3]triazole was obtained via a CuAAC reaction involving phenyl azide and 1-ethynyl-4-methylbenzene. The NMR spectra of the compound are discussed, and its crystal structure was studied by X-ray analysis. According to the latter analysis and a Hirshfeld surface analysis, the predominant intermolecular C-H⋅⋅⋅N and C-H⋅⋅⋅π interactions in this molecule are responsible for crystal packing. Full article

(This article belongs to the Section Structure Determination)

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7 pages, 381 KB

Open AccessShort Note

Synthesis of a Calix[4]semitube with a Selectively Dinitrated Face

by Roderick Abdilla, Stefano Volpi, Alessandro Casnati, Maria A. Cardona and Ruben Gatt

Molbank 2026, 2026(2), M2159; https://doi.org/10.3390/M2159 - 7 Apr 2026

This paper describes the synthesis and characterisation of the calix semitube 5. The calix[4]semitube consists of two calix[4]arenes connected through their lower rim from two phenol groups in distal positions. One calix[4]arene is unsubstituted on its upper rim, while the upper rim [...] Read more.

This paper describes the synthesis and characterisation of the calix semitube 5. The calix[4]semitube consists of two calix[4]arenes connected through their lower rim from two phenol groups in distal positions. One calix[4]arene is unsubstituted on its upper rim, while the upper rim of the other calix[4]arene has two nitro groups in the 1,3- position and two tert-butyl groups in the remaining ones. The synthesis procedure yielded an amorphous structure, which did not provide a single crystal. The final compound was comprehensively characterised by infrared spectroscopy, mass spectrometry, and ¹H and ¹³C NMR spectroscopy. The results of the ¹H NMR spectroscopy confirmed that the calix[4]arene units adopted a cone conformation. This was confirmed by COSY and ¹H-¹³C HMBC. The results obtained confirm that the compound was successfully synthesised. The IUPAC name of 5 is 2,34-di-tert-butyl-39,49-dinitro-6,7,8,9,27,28,29,30-octahydro-15H,21H,36H,42H-4,32:11,25-bis(methano [1,3]benzenomethano)-16,20:37,41-di(metheno)tetrabenzo[g,g1,p,x][1,6,18,23] tetraoxacyclotetratriacontine-43,46,54,60-tetraol. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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5 pages, 356 KB

Open AccessShort Note

(1S,2R,3aR,6S,8aS)-1-Isopropyl-3a,6-Dimethyldecahydroazulene-1,2,6-Triol from Trichoderma virens

by Desita Triana Aziz, Resky Nugraha, Marwah Wirda Ningsih, Zetryana Puteri Tachrim, Yuta Murai and Makoto Hashimoto

Molbank 2026, 2026(2), M2158; https://doi.org/10.3390/M2158 - 2 Apr 2026

A novel derivative from carotene-type sesquiterpene, (1S,2R,3aR,6S,8aS)-1-isopropyl-3a,6-dimethyldecahydroazulene-1,2,6-triol (1), was successfully isolated from filamentous fungus Trichoderma virens NBRC 31959. The structure and molecular formula of 1 were determined by interpretation of 1D [...] Read more.

A novel derivative from carotene-type sesquiterpene, (1S,2R,3aR,6S,8aS)-1-isopropyl-3a,6-dimethyldecahydroazulene-1,2,6-triol (1), was successfully isolated from filamentous fungus Trichoderma virens NBRC 31959. The structure and molecular formula of 1 were determined by interpretation of 1D and 2D NMR and HRMS data. The absolute configuration was established unambiguously by single-crystal X-ray diffraction, with the Flack parameter supporting the assignment. This study adds to the chemical diversity of sesquiterpene-type CAF603 derivatives of Trichoderma virens. Full article

(This article belongs to the Section Natural Product Chemistry)

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4 pages, 407 KB

Open AccessShort Note

(+)-(3S)-8-(3-Methylbut-2-en-1-yl)-7-Methoxy-6,2′,4′-Trihydroxyisoflavan

by Hye Jin Kim, Kye Jung Shin, Khin Myo Htwe and Kee Dong Yoon

Molbank 2026, 2026(2), M2157; https://doi.org/10.3390/M2157 - 2 Apr 2026

Phytochemical investigation of Millettia racemosa Benth. led to the identification of an undescribed isoflavan, (+)-(3S)-8-(3-methylbut-2-en-1-yl)-7-methoxy-6,2′,4′-trihydroxyisoflavan, namely milletiaisoflavan (1). The structure of the isolate was elucidated by spectroscopic evidence (one- and two-dimensional nuclear magnetic resonance, ultraviolet, mass spectrometry, and circular dichroism spectra). Full article

(This article belongs to the Section Natural Product Chemistry)

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6 pages, 293 KB

Open AccessShort Note

(E)-3-(3,4-Di-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyloxy)phenyl) Acrylic Acid

by Sara Ghazi and Mohamed Touaibia

Molbank 2026, 2026(2), M2156; https://doi.org/10.3390/M2156 - 1 Apr 2026

Phenolic acids are widely known for their antioxidant and biological properties, which make them attractive scaffolds for structural modification. In this short note, we report the synthesis of a new 3,4-di-glucosylated caffeic acid analogue. The (E)-3-(3,4-di-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyloxy)phenyl) acrylic [...] Read more.

Phenolic acids are widely known for their antioxidant and biological properties, which make them attractive scaffolds for structural modification. In this short note, we report the synthesis of a new 3,4-di-glucosylated caffeic acid analogue. The (E)-3-(3,4-di-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyloxy)phenyl) acrylic acid was obtained through a two-step synthesis, starting with a phase-transfer-catalyzed glycosylation of 3,4-dihydroxybenzaldehyde with 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl bromide followed by a Dobner-modified Knoevenagel condensation. Consistent with the 2-O-acetyl neighbouring participation and the resulting Walden-type inversion at the anomeric centre, both glucopyranosyl units were assigned the β-configuration. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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8 pages, 1081 KB

Open AccessShort Note

1-(2-Aminophenyl)-3-(4-pyridyl)-3-hydroxy-1-propanone

by Yahaira Cuenú Ibargüen, Fernando Cuenú-Cabezas and Jovanny A. Gómez Castaño

Molbank 2026, 2026(2), M2155; https://doi.org/10.3390/M2155 - 25 Mar 2026

This work reports the isolation and structural characterization of 1-(2-aminophenyl)-3-(4-pyridyl)-3-hydroxy-1-propanone (1), a β-hydroxyketone intermediate that crystallized unexpectedly during the base-catalyzed aldol condensation of 2-aminoacetophenone with pyridine-4-carbaldehyde, a reaction intended to afford the corresponding pyridyl chalcone (2). The formation of [...] Read more.

This work reports the isolation and structural characterization of 1-(2-aminophenyl)-3-(4-pyridyl)-3-hydroxy-1-propanone (1), a β-hydroxyketone intermediate that crystallized unexpectedly during the base-catalyzed aldol condensation of 2-aminoacetophenone with pyridine-4-carbaldehyde, a reaction intended to afford the corresponding pyridyl chalcone (2). The formation of (1) highlights the sensitivity of Claisen–Schmidt reactions to the electronic and steric features of the substrates and to the applied reaction conditions. Single-crystal X-ray diffraction unambiguously confirmed the molecular structure of (1), revealing a hydrogen-bonding network involving the amino, carbonyl, and β-hydroxyl functionalities. These interactions contribute to the solid-state stabilization of the β-hydroxyketone and hinder its dehydration to chalcone (2). The present results provide experimental insight into the mechanistic landscape of aldol condensations and emphasize the relevance of isolable intermediates as structurally defined precursors for further synthetic transformations. Full article

(This article belongs to the Collection Molecules from Side Reactions)

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7 pages, 704 KB

Open AccessShort Note

3a-Phenylhexahydropentalene-1,6-dione

by Yongyao Li, Hongtao Kong, Xiaoying Huang, Maxwell Ampomah-Wireko, Cedric Dzidzor Kodjo Amengor, En Zhang and Yihong Zhao

Molbank 2026, 2026(2), M2154; https://doi.org/10.3390/M2154 - 18 Mar 2026

Bicyclo[3.3.0]skeleton is a common structural motif present in many natural products and pharmaceutical agents. Here we have synthesized a rigid 3a-arylhexahydropentalene-1,6-dione from cyclopent-2-en-1-one which is an easy and readily available starting material. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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8 pages, 1978 KB

Open AccessCommunication

Naphthalene-Based Schiff Base Compounds

by Jocelyn Pradegan, Aurélien Crochet and Katharina M. Fromm

Molbank 2026, 2026(2), M2153; https://doi.org/10.3390/M2153 - 17 Mar 2026

The synthesis of a salen-type ligand functionalized with naphthalene moieties, as well as its precursor, are reported. The compounds were characterized by ¹H and ¹³C NMR, ESI-MS spectrometry and single crystal X-ray diffraction. Full article

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5 pages, 586 KB

Open AccessShort Note

N-(3,4-Dimethoxyphenethyl)-2-propylpentanamide

by Diyana Dimitrova, Nikol Dimova, Dimitrina Velikova, Iliyan Ivanov, Dimitar Bojilov and Stanimir Manolov

Molbank 2026, 2026(2), M2152; https://doi.org/10.3390/M2152 - 13 Mar 2026

In this Short Note type article, we report the synthesis of a new hybrid molecule, N-(3,4-dimethoxyphenethyl)-2-propylpentanamide, using a solvent-minimized mechanochemical method that provides a simple and efficient synthetic approach. The process achieved high yield. The compound was confirmed by melting-point analysis, ¹ [...] Read more.

In this Short Note type article, we report the synthesis of a new hybrid molecule, N-(3,4-dimethoxyphenethyl)-2-propylpentanamide, using a solvent-minimized mechanochemical method that provides a simple and efficient synthetic approach. The process achieved high yield. The compound was confirmed by melting-point analysis, ¹H and ¹³C NMR, IR spectroscopy, and mass spectrometry. Full article

(This article belongs to the Section Structure Determination)

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6 pages, 1246 KB

Open AccessShort Note

Synthesis, Structural Characterization, and SHG Behavior of a Lanthanum/β-d-Fructose-Based Metal–Organic Framework

by Domenica Marabello and Paola Benzi

Molbank 2026, 2026(2), M2151; https://doi.org/10.3390/M2151 - 13 Mar 2026

Interest in non-centrosymmetric crystalline materials exhibiting second harmonic generation (SHG) has increased due to their potential applications in optical sensing and biosensing. Saccharide-based metal complexes are particularly attractive systems, as chiral sugars can promote non-centrosymmetric crystal packing. In this work, a new lanthanum–β- [...] Read more.

Interest in non-centrosymmetric crystalline materials exhibiting second harmonic generation (SHG) has increased due to their potential applications in optical sensing and biosensing. Saccharide-based metal complexes are particularly attractive systems, as chiral sugars can promote non-centrosymmetric crystal packing. In this work, a new lanthanum–β-d-fructose compound, [La(C₆H₁₂O₆)(H₂O)₅]Cl₃ (LaFRUCl), was synthesized using a simple and low-cost method and characterized by single-crystal X-ray diffraction. The compound crystallizes in the orthorhombic space group P2₁2₁2₁ and consists of infinite (La³⁺–fructose)_n chains extending along the [001] direction, forming a one-dimensional Metal–Organic Framework. The nonlinear optical response was evaluated using the Kurtz–Perry powder technique with a Nd:YAG laser (1064 nm) and compared to a sucrose reference. The measured SHG efficiency is comparable to that of previously reported alkaline earth metal–sugar analogs. While the compound’s SHG emission is significant, evaluation of its structural stability under aqueous or physiological conditions is be required before considering biological applications. Full article

(This article belongs to the Section Structure Determination)

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7 pages, 679 KB

Open AccessCommunication

HAT-Initiated Fragmentation of 4-(Dimethylamino)-1-((3-methylbut-2-en-1-yl)oxy)-3-phenylbut-3-en-2-one

by Andrej Bogataj, Luka Ciber, Nejc Petek, Franc Požgan, Jurij Svete, Bogdan Štefane and Uroš Grošelj

Molbank 2026, 2026(2), M2149; https://doi.org/10.3390/M2149 - 11 Mar 2026

An alkene-tethered enaminone 7 was synthesized in four steps from bromoacetic acid and 3,3-dimethylallyl alcohol. The enaminone was fully characterized, including UV-Vis spectra. TBADT-catalyzed HAT of the alkene-tethered enaminone initiated a fragmentation that yielded the literature-known phenylacetone-derived enaminone. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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Graphical abstract

6 pages, 462 KB

Open AccessCommunication

Two-Stage Synthesis of 3-(4-Hydroxyphenyl)-1′,3′,6-trimethyl-2′H,3H,4H-spiro[furo[3,2-c]pyran-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H)-tetraone

by Michail N. Elinson, Varvara M. Kalashnikova, Yuliya E. Ryzhkova and Oleg A. Rakitin

Molbank 2026, 2026(2), M2148; https://doi.org/10.3390/M2148 - 11 Mar 2026

Spirocyclic compounds are experiencing a research surge due to their unique 3D structure, offering enhanced pharmacological, industrial, and material applications. They are increasingly used in medicinal chemistry to improve drug-like properties, such as solubility and target binding, and are also being utilized for [...] Read more.

Spirocyclic compounds are experiencing a research surge due to their unique 3D structure, offering enhanced pharmacological, industrial, and material applications. They are increasingly used in medicinal chemistry to improve drug-like properties, such as solubility and target binding, and are also being utilized for advanced material applications, including electronics and photonics. In this communication, 3-(4-hydroxyphenyl)-1′,3′,6-trimethyl-2′H,3H,4H-spiro[furo[3,2-c]pyran-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H)-tetraone was prepared via a two-stage transformation including a tandem Knoevenagel–Michael reaction and NBS-induced cyclization. At the first stage, a previously unknown ionic scaffold, morpholin-4-ium 5-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)(4-hydroxyphenyl)methyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate was also isolated. Structures of the newly synthesized compounds were established by ¹H and ¹³C NMR, IR spectroscopy, high-resolution mass spectrometry, and elemental analysis. Full article

(This article belongs to the Collection Heterocycle Reactions)

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6 pages, 422 KB

Open AccessCommunication

Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one

by Andreas S. Kalogirou and Panayiotis A. Koutentis

Molbank 2026, 2026(2), M2150; https://doi.org/10.3390/M2150 - 11 Mar 2026

Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield. Another nucleophilic substitution reaction of 3-chloro-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one with 2-ethylhexan-1-amine at ca. 100 °C gave 3-[(2-ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one in 93% yield. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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7 pages, 574 KB

Open AccessCommunication

Synthesis of 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one Derivatives

by Yong-Yao Li, Zhi-Hao Li, Xiao-Ying Huang, Maxwell Ampomah-Wireko, Cedric Dzidzor Kodjo Amengor, En Zhang and Yi-Hong Zhao

Molbank 2026, 2026(2), M2146; https://doi.org/10.3390/M2146 - 10 Mar 2026

Owing to their distinctive physicochemical features, their structural analogues of benzene ring bioisosteres, and their strong affinity for biomacromolecules, pyridine derivatives function both as core structural scaffolds in pharmacologically active compounds and as versatile elements for optimizing key drug-like properties, such as water [...] Read more.

Owing to their distinctive physicochemical features, their structural analogues of benzene ring bioisosteres, and their strong affinity for biomacromolecules, pyridine derivatives function both as core structural scaffolds in pharmacologically active compounds and as versatile elements for optimizing key drug-like properties, such as water solubility, membrane permeability, and metabolic stability. In this study, we synthesized five pyridine-fused heterocyclic compounds using common synthetic intermediates as precursors. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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6 pages, 724 KB

Open AccessShort Note

N-(3,6-Dimethoxy-2-nitrophenyl)acetamide

by Lina A. Al-Dulaimi, Joseph C. Bear, Jeremy K. Cockcroft, Giuseppe Trigiante and Fawaz Aldabbagh

Molbank 2026, 2026(2), M2147; https://doi.org/10.3390/M2147 - 10 Mar 2026

1,4-Dimethoxy-2,3-dinitrobenzene (1) reduction using sodium hydrosulfite resulted in 3,6-dimethoxybenzene-1,2-diamine (2) and 3,6-dimethoxy-2-nitroaniline (3) in 24% and 59% yields, respectively. Nitroaniline 3 was acetylated with acetyl chloride to give N-(3,6-dimethoxy-2-nitrophenyl)acetamide (4) in a 65% yield [...] Read more.

1,4-Dimethoxy-2,3-dinitrobenzene (1) reduction using sodium hydrosulfite resulted in 3,6-dimethoxybenzene-1,2-diamine (2) and 3,6-dimethoxy-2-nitroaniline (3) in 24% and 59% yields, respectively. Nitroaniline 3 was acetylated with acetyl chloride to give N-(3,6-dimethoxy-2-nitrophenyl)acetamide (4) in a 65% yield and with acetic anhydride to give N-acetyl-N-(3,6-dimethoxy-2-nitrophenyl)acetamide (5) in 78% yield. Novel compounds 4 and 5 were characterized by FT-IR, ¹H and ¹³C-NMR, and HRMS. The X-ray crystal structure of acetamide 4 is also presented. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Graphical abstract

8 pages, 1322 KB

Open AccessCommunication

Synthesis, Crystal Structure, and Properties of a Dinuclear Zinc(II) Complex Featuring a Bromo-Functionalized Semicarbazone Schiff Base Ligand

by Cuicui Wang, Jinhua Wang, Yunkai Zhang, Azura A. Rashid and Siew Kooi Ong

Molbank 2026, 2026(2), M2145; https://doi.org/10.3390/M2145 - 5 Mar 2026

This study investigates the rational design of a dinuclear zinc(II) coordination polymer, (C₃₆H₃₄Br₂N₈O₄S₂Zn₂), to explore how halogen substitution and ligand choice modulate structural architecture, contributing to the development of [...] Read more.

This study investigates the rational design of a dinuclear zinc(II) coordination polymer, (C₃₆H₃₄Br₂N₈O₄S₂Zn₂), to explore how halogen substitution and ligand choice modulate structural architecture, contributing to the development of functional coordination polymers with tailored properties. The complex was synthesized from a bromo-substituted semicarbazone Schiff base ligand (L1) and a rigid bipyridine linker (L2) under solvothermal conditions, and its structure was elucidated using single-crystal X-ray diffraction (SCXRD), complemented by characterization via powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and infrared (IR) spectroscopy. Crystallographic analysis reveals that the complex crystallizes in the triclinic space group P-1, forming discrete dinuclear units where each Zn(II) center adopts a distorted square–pyramidal geometry; these units are extended into one-dimensional chains by bridging L2 ligands and further assembled into a three-dimensional supramolecular network through hydrogen-bonding interactions. PXRD confirms the high phase purity of the bulk material, TGA indicates notable thermal stability up to 130 °C, and IR spectroscopy validates the coordination modes and hydrogen-bonding network. This work elucidates the critical role of the bromo substituent and rigid ancillary ligands in modulating the solid-state structure of the zinc(II) complex. The revealed structure-directing principles provide a valuable reference for the rational design of functional coordination polymers. Full article

(This article belongs to the Section Structure Determination)

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7 pages, 458 KB

Open AccessCommunication

Synthesis of Ethyl 2-Amino-6-hydroxy-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate and Ethyl 6-(Acetyloxy)-2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

by Andrii Yu. Myshastyi, Sergiy V. Vlasov, Hanna I. Severina, Georgiy G. Yakovenko and Andrii R. Khairulin

Molbank 2026, 2026(2), M2144; https://doi.org/10.3390/M2144 - 4 Mar 2026

An effective one-step synthetic procedure for preparation of hydroxylated analogues of ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate as novel promising multifunctional building blocks for drug discovery based on the Gewald procedure was developed. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

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Graphical abstract

6 pages, 1117 KB

Open AccessShort Note

(4S*,10aS*,11S*)-4-Hydroxy-2,7,7-trimethyl-11-(4-methylbenzoyl)-7,8-dihydro-10H-4,10a-methano[1,4]oxazino[3,4-d][1,3,5]thiadiazepine-5,10(4H)-dione

by Nikita A. Tretyakov and Andrey N. Maslivets

Molbank 2026, 2026(2), M2143; https://doi.org/10.3390/M2143 - 3 Mar 2026

The reaction of 4,4-dimethyl-8-(4-methylbenzoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,6,7-trione with thioacetamide in a 1:1 ratio when refluxed in dichloromethane gives (4S*,10aS*,11S*)-4-hydroxy-2,7,7-trimethyl-11-(4-methylbenzoyl)-7,8-dihydro-10H-4,10a-methano[1,4]oxazino[3,4-d][1,3,5]thiadiazepine-5,10(4H)-dione with a good yield. This compound was fully characterized. Full article

(This article belongs to the Section Structure Determination)

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9 pages, 837 KB

Open AccessShort Note

8-Phenyl-13a-(trifluoromethyl)-13aH-benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine-6-carbonitrile

by Dmitry V. Osipov, Pavel E. Krasnikov and Vitaly A. Osyanin

Molbank 2026, 2026(1), M2142; https://doi.org/10.3390/M2142 - 23 Feb 2026

A DABCO-catalyzed one-pot synthesis of a novel pentacyclic heterocycle featuring an unprecedented benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine scaffold from 2-(cyanomethyl)benzimidazole and 3-trifluoroacetyl-4-phenyl-4H-chromene has been developed. This hybrid architecture merges three privileged pharmacophores—benzimidazole, chromene, and pyridine—into a rigid, nearly planar π-extended system [...] Read more.

A DABCO-catalyzed one-pot synthesis of a novel pentacyclic heterocycle featuring an unprecedented benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine scaffold from 2-(cyanomethyl)benzimidazole and 3-trifluoroacetyl-4-phenyl-4H-chromene has been developed. This hybrid architecture merges three privileged pharmacophores—benzimidazole, chromene, and pyridine—into a rigid, nearly planar π-extended system decorated with trifluoromethyl and nitrile groups. The structure of 8-phenyl-13a-(trifluoromethyl)-13aH-benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine-6-carbonitrile was unambiguously confirmed through NMR spectroscopy and X-ray diffraction analysis. A plausible mechanism involves Michael addition, hemiaminal formation, ring opening, recyclization, and oxidation. Full article

(This article belongs to the Collection Heterocycle Reactions)

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6 pages, 733 KB

Open AccessShort Note

(E)-Methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate

by Jorge Trilleras, Efraín Polo-Cuadrado and Jairo Quiroga

Molbank 2026, 2026(1), M2141; https://doi.org/10.3390/M2141 - 16 Feb 2026

The synthesis of methyl (E)-3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate 3 was accomplished using a Schlosser-modified Wittig reaction. Complete ¹H and ¹³C NMR signal assignments confirm the formation of E-alkene. Full article

(This article belongs to the Collection Heterocycle Reactions)

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Topical Collection in Molbank

Molecules from Side Reactions Collection Editor: Stefano D’Errico

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