Journal Description
Molbank
Molbank
is an international, peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products published quarterly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 13.9 days after submission; acceptance to publication is undertaken in 3.8 days (median values for papers published in this journal in the first half of 2024).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
0.6 (2023)
Latest Articles
Crystal Structures of 9,9-Disubstituted Fluorene Derivatives Bearing Methyl, Hydroxymethyl or Pyridinylmethyl Groups
Molbank 2024, 2024(4), M1928; https://doi.org/10.3390/M1928 (registering DOI) - 3 Dec 2024
Abstract
The wide range of application possibilities of fluorene derivatives, due to their unique physical and chemical properties, has made this class of molecules important for various disciplines. The synthesis of these compounds and the study of their properties are, therefore, of great scientific
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The wide range of application possibilities of fluorene derivatives, due to their unique physical and chemical properties, has made this class of molecules important for various disciplines. The synthesis of these compounds and the study of their properties are, therefore, of great scientific interest. Due to their reactivity and sensitivity to oxidation, the 9-position of the fluorene skeleton is often double substituted, for example, to ensure the long-term stability of materials. Single crystal structure analysis, among other methods, plays a very important role in the development of various fluorene-based systems. In this paper, the crystal structures of three 9,9-disubstituted fluorene derivatives bearing methyl, hydroxymethyl or pyridinylmethyl groups are described (three solvent-free structures and one toluene solvate). A detailed evaluation of the intermolecular interactions, supported by Hirshfeld surface analysis, is the subject of this article.
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(This article belongs to the Section Structure Determination)
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Open AccessCommunication
Synthesis of N-p-Fluorothiosemicarbazone and of Bis(N-p-Fluorophenylthiourea): Crystal Structure and Conformational Analysis of N,N′-Bis(4-Fluorophenyl)Hydrazine-1,2-Bis(Carbothioamide)
by
Sirine Salhi, Dorra Kanzari-Mnallah, Isabelle Jourdain, Michael Knorr, Carsten Strohmann, Jan-Lukas Kirchhoff, Hédi Mrabet and Azaiez Ben Akacha
Molbank 2024, 2024(4), M1926; https://doi.org/10.3390/M1926 - 28 Nov 2024
Abstract
The reaction of the phosphonated hydrazone (2-hydrazineylidenepropyl) diphenylphosphine oxide 1 with p-fluorophenyl-isothiocyanate yields as a major product the thiosemicarbazone Ph2P(=O)CH2{C=N-NH(C=S)-N(H)C6H4F}CH3 (2-(1-(diphenylphosphoryl)propan-2-ylidene)-N-(4-fluorophenyl)hydrazine-1-carbothioamide) 2 along with bis(N-p-fluorophenylthiourea) 3 as
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The reaction of the phosphonated hydrazone (2-hydrazineylidenepropyl) diphenylphosphine oxide 1 with p-fluorophenyl-isothiocyanate yields as a major product the thiosemicarbazone Ph2P(=O)CH2{C=N-NH(C=S)-N(H)C6H4F}CH3 (2-(1-(diphenylphosphoryl)propan-2-ylidene)-N-(4-fluorophenyl)hydrazine-1-carbothioamide) 2 along with bis(N-p-fluorophenylthiourea) 3 as a minor product. The latter compound 3 was isolated as the main product by direct treatment of p-FC6H4N=C=S with hydrazine in a 2:1 ratio. Both 2 and 3 were characterized by NMR. Furthermore, the molecular structure of 3 was elucidated by an X-ray diffraction study, revealing both intra- and intermolecular secondary interactions. A conformational DFT study, at the B3LYP/6-311 G++ (d, p) level of theory, confirms a good match between the calculated structure and the experimental one.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
2-([1,1′-Biphenyl]-4-yl)-5-[(E)-2-(3-methoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3H-indole
by
Gabrielė Varvuolytė, Aurimas Bieliauskas, Neringa Kleizienė, Asta Žukauskaitė and Algirdas Šačkus
Molbank 2024, 2024(4), M1927; https://doi.org/10.3390/M1927 - 28 Nov 2024
Abstract
The ligandless palladium-catalyzed Heck reaction of 4-ethenyl-3-methoxy-1-phenyl-1H-pyrazole and 2-([1,1′-biphenyl]-4-yl)-5-bromo-3,3-dimethyl-3H-indole gave the previously unreported 2-([1,1′-biphenyl]-4-yl)-5-[(E)-2-(3-methoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3H-indole in 45% yield. The compound was characterized using NMR, FT-IR spectroscopy, and HRMS data. The optical properties of the
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The ligandless palladium-catalyzed Heck reaction of 4-ethenyl-3-methoxy-1-phenyl-1H-pyrazole and 2-([1,1′-biphenyl]-4-yl)-5-bromo-3,3-dimethyl-3H-indole gave the previously unreported 2-([1,1′-biphenyl]-4-yl)-5-[(E)-2-(3-methoxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3H-indole in 45% yield. The compound was characterized using NMR, FT-IR spectroscopy, and HRMS data. The optical properties of the compound were investigated in tetrahydrofuran by UV-Vis and fluorescence spectroscopy.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessCommunication
3-Methyl-2-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)butan-2-ol
by
Oleg A. Mikhailov, Almira R. Kurbangalieva and Ilya D. Gridnev
Molbank 2024, 2024(4), M1925; https://doi.org/10.3390/M1925 - 27 Nov 2024
Abstract
The reactions of dialkylzinc reagents with ketones are scarcely studied. In this paper, we describe a previously unknown direct alkylation of substituted 2-acetylpyridine with diisopropyl zinc, which gave a corresponding novel alcohol with 82% yield.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Scheme 1
Open AccessShort Note
Ammonium Oxathioamidate
by
M. Carla Aragoni, David B. Cordes, Anna Pintus, Enrico Podda, Riccardo Serra, Alexandra M. Z. Slawin, J. Derek Woollins and Massimiliano Arca
Molbank 2024, 2024(4), M1924; https://doi.org/10.3390/M1924 - 26 Nov 2024
Abstract
Ammonium oxathioamidate (1) was synthesised by the reaction between O-ethyl-thioxamate (oxalic acid-1-amide-2-O-ethyl ester) and ammonium hydrogen carbonate in water solution. Compound 1 was fully characterised by both microanalytical (elemental analysis, melting point determination) and spectroscopic means (FT-IR and
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Ammonium oxathioamidate (1) was synthesised by the reaction between O-ethyl-thioxamate (oxalic acid-1-amide-2-O-ethyl ester) and ammonium hydrogen carbonate in water solution. Compound 1 was fully characterised by both microanalytical (elemental analysis, melting point determination) and spectroscopic means (FT-IR and NMR spectroscopy). Crystals suitable for single-crystal X-ray diffraction were isolated by slow evaporation of an ethanol solution of the compound. The analysis of the crystal packing reveals the prominent role exerted by intermolecular hydrogen bonding (HB) and chalcogen bonding (ChB) interactions.
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(This article belongs to the Section Structure Determination)
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Supplementary material:
Supplementary File 1 (ZIP, 140 KiB)
Supplementary File 2 (MOL, 6 KiB)
Supplementary File 3 (INCHI, 2 KiB)
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Supplementary File 6 (INCHI, 410 B)
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Supplementary File 9 (CIF, 1554 KiB)
Supplementary File 1 (ZIP, 140 KiB)
Supplementary File 2 (MOL, 6 KiB)
Supplementary File 3 (INCHI, 2 KiB)
Supplementary File 4 (MOL, 6 KiB)
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Supplementary File 6 (INCHI, 410 B)
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Supplementary File 8 (CIF, 2208 KiB)
Supplementary File 9 (CIF, 1554 KiB)
Open AccessCommunication
Coordination of O-Propyl-N-phenylthiocarbamate to HgI2 and the Crystallographic Characterization of an Anilinium Chloride Thiocarbamate Adduct
by
Wafa Arar, Nuri Ekici, Michael Knorr, Isabelle Jourdain, Carsten Strohmann and Jan-Lukas Kirchhoff
Molbank 2024, 2024(4), M1923; https://doi.org/10.3390/M1923 - 22 Nov 2024
Abstract
In order to investigate the coordination chemistry of O-alkyl N-aryl thiocarbamate ligands, HgI2 was reacted with one equivalent of PrOC(=S)N(H)Ph L in toluene solution to afford the 1D polymeric title compound [{IHg(μ-I)}{κ1-PrOC(=S)N(H)Ph}]n CP1. The formation
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In order to investigate the coordination chemistry of O-alkyl N-aryl thiocarbamate ligands, HgI2 was reacted with one equivalent of PrOC(=S)N(H)Ph L in toluene solution to afford the 1D polymeric title compound [{IHg(μ-I)}{κ1-PrOC(=S)N(H)Ph}]n CP1. The formation of this iodide-bridged coordination polymer was ascertained by a single-crystal X-ray diffraction study performed at 100 K, as well as the formation of an adduct between anilinium chloride and L forming a supramolecular ribbon of composition [L(PhNH3)(Cl)]. The occurrence of anilinium chloride is due to the partial hydrolysis of L in the presence of HCl.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one
by
Anastasia R. Kovrizhina, Dauren Tolegen, Dmitry I. Pavlov, Andrei S. Potapov and Andrei I. Khlebnikov
Molbank 2024, 2024(4), M1922; https://doi.org/10.3390/M1922 - 21 Nov 2024
Abstract
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We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one, which presents an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The structure of the compound was confirmed by the single crystal X-ray diffraction.
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We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one, which presents an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The structure of the compound was confirmed by the single crystal X-ray diffraction. Molecular docking analysis revealed that 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one may effectively intercalate with DNA. The synthesized indenoquinoline derivative thus represents a promising lead compound for developing targeted anticancer and anti-inflammatory drugs.
Full article
Figure 1
Open AccessShort Note
Cyclo[Tri(thiomethyl-1,2-phenylmethylene)]
by
Pablo Simón Marqués, Nicolas Bréfuel and Claire Kammerer
Molbank 2024, 2024(4), M1921; https://doi.org/10.3390/M1921 - 21 Nov 2024
Abstract
During the purification of a reported compound named 1,3-dihydrobenzo[c]thiophene, we isolated an unexpected molecule in one of the chromatography fractions by serendipity. Structural elucidation using common techniques such as 1D and 2D NMR, and mass spectrometry revealed the nature of this
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During the purification of a reported compound named 1,3-dihydrobenzo[c]thiophene, we isolated an unexpected molecule in one of the chromatography fractions by serendipity. Structural elucidation using common techniques such as 1D and 2D NMR, and mass spectrometry revealed the nature of this novel product characterized as cyclo[tri(thiomethyl-1,2-phenylmethylene)].
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
trans-11-(3,4-Dimethoxyphenyl)-2,3,8,9-tetramethoxy-6-oxo-11,12-dihydro-6H-dibenzo[c,h]chromene-12-carboxylic Acid
by
Victor Angelov, Savina Stoyanova and Milen G. Bogdanov
Molbank 2024, 2024(4), M1920; https://doi.org/10.3390/M1920 - 19 Nov 2024
Abstract
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The title compound, trans-11-(3,4-Dimethoxyphenyl)-2,3,8,9-tetramethoxy-6-oxo-11,12-dihydro-6H-dibenzo[c,h]chromene-12-carboxylic acid (4), was synthesized for the first time via a two-step protocol from 3,4-dimethoxyhomophthalic anhydride (1) and 3,4-dimethoxybenzaldehyde (DMBA). In the first step, 1 reacts with DMBA to give
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The title compound, trans-11-(3,4-Dimethoxyphenyl)-2,3,8,9-tetramethoxy-6-oxo-11,12-dihydro-6H-dibenzo[c,h]chromene-12-carboxylic acid (4), was synthesized for the first time via a two-step protocol from 3,4-dimethoxyhomophthalic anhydride (1) and 3,4-dimethoxybenzaldehyde (DMBA). In the first step, 1 reacts with DMBA to give trans-3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-oxo-3,4-dihydro-1H-2-benzopyran-4-carboxylic acid (2), which further reacts with two additional equivalents of 1 to give 4. Compound 4 was characterized by means of spectral methods—1H-, 13C-, DEPT-135-NMR, and HRMS.
Full article
Scheme 1
Open AccessShort Note
5,5’-Selenobis(1-benzyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde)
by
Emeline Grosjean, Julien Rizet, Shekoufeh Arabi Aliabadi, Joelle Azéma-Despeyroux, Pascal Hoffmann and Christian Lherbet
Molbank 2024, 2024(4), M1919; https://doi.org/10.3390/M1919 - 18 Nov 2024
Abstract
Selenium compounds have garnered significant attention in the field of medicinal chemistry due to their unique biochemical properties and potential therapeutic applications for different pathologies. In this study, we report the synthesis of a new selenylated bis-pyridone compound using SeO2 as the
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Selenium compounds have garnered significant attention in the field of medicinal chemistry due to their unique biochemical properties and potential therapeutic applications for different pathologies. In this study, we report the synthesis of a new selenylated bis-pyridone compound using SeO2 as the source of selenium. Detailed 1H and 13C NMR characterizations and mass spectral analysis are given.
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(This article belongs to the Collection Heterocycle Reactions)
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Supplementary material:
Supplementary File 1 (PDF, 2088 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 723 B)
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Supplementary File 6 (INCHI, 751 B)
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Supplementary File 1 (PDF, 2088 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 723 B)
Supplementary File 4 (MOL, 2 KiB)
Supplementary File 5 (MOL, 2 KiB)
Supplementary File 6 (INCHI, 751 B)
Supplementary File 7 (MOL, 2 KiB)
Supplementary File 8 (MOL, 2 KiB)
Supplementary File 9 (INCHI, 751 B)
Supplementary File 10 (MOL, 2 KiB)
Supplementary File 11 (MOL, 2 KiB)
Supplementary File 12 (INCHI, 749 B)
Supplementary File 13 (MOL, 2 KiB)
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Supplementary File 15 (INCHI, 750 B)
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Supplementary File 18 (INCHI, 750 B)
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Supplementary File 21 (INCHI, 749 B)
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Open AccessCommunication
A Gram Scale Synthesis of 3,4-Dihalogen Substituted 1,8-Naphthalimides
by
Denitsa Anastasova, Monika Mutovska, Natali Simeonova, Irena Zagranyarska, Zlatina Vlahova, Stanimir Stoyanov and Yulian Zagranyarski
Molbank 2024, 2024(4), M1918; https://doi.org/10.3390/M1918 - 18 Nov 2024
Abstract
A general protocol for the synthesis of 3,4-dihalogen substituted 1,8-naphthalimides is proposed, starting from available and cheap 1,8-naphthalic anhydride. The reported new compounds have only bromine or chlorine atoms as substituents, in contrast to the known iodo-containing analogues. This is an advantage in
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A general protocol for the synthesis of 3,4-dihalogen substituted 1,8-naphthalimides is proposed, starting from available and cheap 1,8-naphthalic anhydride. The reported new compounds have only bromine or chlorine atoms as substituents, in contrast to the known iodo-containing analogues. This is an advantage in possible aryl nucleophilic substitution or cross-coupling modifications, making them interesting and important building-block molecules in naphthalimide chemistry. Although the procedure includes five synthetic steps, they are quick and straightforward. The overall yields are relatively high (48–62%), and only one column of chromatographic purification is needed. All the reactions were carried out on a multigram scale to allow the target building-block compounds to be obtained in sufficient amounts for further derivatizations.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
9,10-Bis(5H-dibenzo[b,f]azepino)anthracene
by
Himeko Kawaguchi and Takuya Kuwabara
Molbank 2024, 2024(4), M1917; https://doi.org/10.3390/M1917 - 15 Nov 2024
Abstract
The title compound with a donor–π–donor (D–π–D) type triad structure was synthesized by Buchwald–Hartwig amination using 9,10-dibromoanthracene and 5H-dibenzo[b,f]azepine, and characterized by 1H, 13C{1H} NMR, HRMS, and X-ray diffraction analysis. The azepine–anthracene–azepine units
[...] Read more.
The title compound with a donor–π–donor (D–π–D) type triad structure was synthesized by Buchwald–Hartwig amination using 9,10-dibromoanthracene and 5H-dibenzo[b,f]azepine, and characterized by 1H, 13C{1H} NMR, HRMS, and X-ray diffraction analysis. The azepine–anthracene–azepine units are nearly orthogonal to each other, with a torsion angle of 88°. A broad and weak absorption band around 410–480 nm and the low emission character (ΦF = 0.01) suggest the weak intramolecular charge transfer from the azepine to the anthracene unit due to the twisted structure.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
2,2′-[2,4-Bis(4-chlorophenyl)cyclobutane-1,3-diyl]bis(8-bromo-6-chloro-3-nitroimidazo[1,2-a]pyridine)
by
Inès Jacquet, Romain Paoli-Lombardo, Caroline Castera-Ducros, Patrice Vanelle and Nicolas Primas
Molbank 2024, 2024(4), M1916; https://doi.org/10.3390/M1916 - 14 Nov 2024
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In the context of our ongoing studies on 3-nitroimidazo[1,2-a]pyridine derivatives as potent antileishmanial compounds, we isolated a new unexpected compound from the spontaneous cycloaddition of N-[2-(8-bromo-6-chloro-3-nitroimidazo[1,2-a]pyridin-2-yl)-1-(4-chlorophenyl)ethyl]-4-methylbenzenesulfonamide. The molecular structure was fully characterized by using 1H and 13C NMR, X-ray crystallography, and HRMS.
Full article
Figure 1
Open AccessCommunication
Water-Mediated Synthesis of (E)-3-(1-Methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue
by
Muppidi Subbarao and Sean M. Kerwin
Molbank 2024, 2024(4), M1915; https://doi.org/10.3390/M1915 - 12 Nov 2024
Abstract
Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with diverse biological activities, notably anticancer properties. However, its ester group is metabolically unstable. The amide derivative, CAPA, offers improved metabolic stability to esterases but still possesses a metabolically liable catechol group. In
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Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with diverse biological activities, notably anticancer properties. However, its ester group is metabolically unstable. The amide derivative, CAPA, offers improved metabolic stability to esterases but still possesses a metabolically liable catechol group. In this work, we describe the synthesis of a novel CAPA analogue in which the catechol is replaced with a benzimidazole bioisostere via a water-mediated Wittig reaction.
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(This article belongs to the Section Natural Product Chemistry)
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Supplementary material:
Supplementary File 1 (PDF, 1223 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 609 B)
Supplementary File 4 (MOL, 2 KiB)
Supplementary File 5 (MOL, 2 KiB)
Supplementary File 6 (INCHI, 579 B)
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Supplementary File 9 (INCHI, 788 B)
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Supplementary File 1 (PDF, 1223 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 609 B)
Supplementary File 4 (MOL, 2 KiB)
Supplementary File 5 (MOL, 2 KiB)
Supplementary File 6 (INCHI, 579 B)
Supplementary File 7 (MOL, 2 KiB)
Supplementary File 8 (MOL, 3 KiB)
Supplementary File 9 (INCHI, 788 B)
Supplementary File 10 (MOL, 3 KiB)
Supplementary File 11 (MOL, 3 KiB)
Supplementary File 12 (INCHI, 856 B)
Supplementary File 13 (MOL, 3 KiB)
Supplementary File 14 (MOL, 3 KiB)
Supplementary File 15 (INCHI, 761 B)
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Supplementary File 17 (MOL, 3 KiB)
Supplementary File 18 (INCHI, 826 B)
Supplementary File 19 (MOL, 3 KiB)
Open AccessCommunication
One Pot Synthesis of New Powerful Building Blocks in 1,8-Naphthalimide Chemistry
by
Monika Mutovska, Denitsa Anastasova, Natali Simeonova, Irena Zagranyarska, Zlatina Vlahova, Iva Ugrinova, Stanimir Stoyanov and Yulian Zagranyarski
Molbank 2024, 2024(4), M1914; https://doi.org/10.3390/M1914 - 11 Nov 2024
Abstract
This communication reports a reliable one-pot synthetic protocol for preparation on a multigram scale of 3-bromo- and 3,4-dibromo-6-nitro-1,8-naphthalic anhydride from commercially available and economical 1,8-naphthalic anhydride. The synthetic steps used were nitration and selective bromination in sulfuric acid at room temperature. The reaction
[...] Read more.
This communication reports a reliable one-pot synthetic protocol for preparation on a multigram scale of 3-bromo- and 3,4-dibromo-6-nitro-1,8-naphthalic anhydride from commercially available and economical 1,8-naphthalic anhydride. The synthetic steps used were nitration and selective bromination in sulfuric acid at room temperature. The reaction takes place under mild conditions and is completely controllable depending on the equivalents of the brominating reagent used. Both anhydrides are powerful building blocks in naphthalimide chemistry. In addition, their imides and esters were also synthesized.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
Dichloro-bis[(Z)-1-styryl-benzimidazole]-zinc(II)
by
Neslihan Şahin, İsmail Özdemir and David Sémeril
Molbank 2024, 2024(4), M1913; https://doi.org/10.3390/M1913 - 5 Nov 2024
Abstract
We have successfully synthesized the dichloro-bis[(Z)-1-styryl-benzimidazole]-zinc(II) complex, which was fully characterized by IR, elemental analysis, and mass and NMR spectroscopy. The solid-state structure definitively shows that two benzimidazole moieties are coordinated to the zinc atom, which adopts a tetrahedral geometry.
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(This article belongs to the Section Structure Determination)
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Open AccessCommunication
Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
by
Aleksandr Filimonov, Anastasia Diveikina, Yuri Gatilov, Olga Luzina and Nariman Salakhutdinov
Molbank 2024, 2024(4), M1912; https://doi.org/10.3390/M1912 - 1 Nov 2024
Abstract
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Diffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reaction of diffractaic acid with
[...] Read more.
Diffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reaction of diffractaic acid with amidoximes.
Full article
Figure 1
Open AccessShort Note
Dichloro-Bis(1-cinnamyl-benzimidazole)-Cobalt(II)
by
Neslihan Şahin, İsmail Özdemir and David Sémeril
Molbank 2024, 2024(4), M1911; https://doi.org/10.3390/M1911 - 31 Oct 2024
Abstract
Dichloro-bis(1-cinnamyl-benzimidazole)-cobalt(II) was prepared in one step using a cobalt precursor CoCl2 and corresponding substituted benzimidazole. The complex was fully characterized using IR, elemental analysis, and mass- and NMR spectroscopy. In the solid state, the cobalt atom displays a typical tetrahedral geometry and
[...] Read more.
Dichloro-bis(1-cinnamyl-benzimidazole)-cobalt(II) was prepared in one step using a cobalt precursor CoCl2 and corresponding substituted benzimidazole. The complex was fully characterized using IR, elemental analysis, and mass- and NMR spectroscopy. In the solid state, the cobalt atom displays a typical tetrahedral geometry and is coordinated to two chlorine atoms and two benzimidazole moieties.
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(This article belongs to the Section Structure Determination)
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Open AccessEditorial
Molbank—Aims and Scope Update
by
Nicholas E. Leadbeater
Molbank 2024, 2024(4), M1909; https://doi.org/10.3390/M1909 - 30 Oct 2024
Abstract
Molbank is a unique journal, bringing together one-compound-per-paper short notes on synthetic compounds and natural products [...]
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Open AccessCommunication
A Novel Approach for the Synthesis of 3,3′-((4-Methoxyphenyl)methylene)bis(4-hydroxyfuran-2(5H)-one) Employing Natural Deep Eutectic Solvents and Microwave Irradiation
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Maria-Anna Karadendrou, Ioanna Kostopoulou, Afroditi Christodoulou, Andromachi Tzani and Anastasia Detsi
Molbank 2024, 2024(4), M1910; https://doi.org/10.3390/M1910 - 30 Oct 2024
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Tetronic acid, a five-membered heterocyclic moiety present in various natural products, has emerged as a significant building block for many pharmaceutically active compounds. In this study, a novel protocol for the synthesis of the bis-tetronic acid 3,3′-((4-methoxyphenyl)methylene)bis(4-hydroxyfuran-2(5H)-one) (3) via
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Tetronic acid, a five-membered heterocyclic moiety present in various natural products, has emerged as a significant building block for many pharmaceutically active compounds. In this study, a novel protocol for the synthesis of the bis-tetronic acid 3,3′-((4-methoxyphenyl)methylene)bis(4-hydroxyfuran-2(5H)-one) (3) via a domino Knoevenagel–Michael reaction is presented. The natural deep eutectic solvent L-proline/glycerol 1:2 molar ratio was utilized as a solvent and catalyst, while the reaction was further promoted via microwave irradiation, providing the desired product in high yield (83%). The solvent was successfully recycled and reused up to three times.
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