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Tomography

Tomography is an international, peer-reviewed open access journal on imaging technologies published monthly online by MDPI.

Indexed in PubMed | Quartile Ranking JCR - Q2 (Radiology, Nuclear Medicine and Medical Imaging)

All Articles (1,003)

Background/Objectives: To assess diagnostic accuracy of two-dimensional (2D) projection methods for rapid visual quality control of automated volumetric (3D) lung segmentations compared with slice-based 3D review of segmentation results for application in large-scale studies. Methods: Segmentation of right and left lungs on T1-weighted MRI of 300 participants of the German National Cohort (NAKO) study was performed using the nnU-NET framework. Three variants of 2D projection images of segmentation masks were created: maximum intensity projection (MIP) using pseudo-chromadepth encoding with different color spectra for right and left lung (Colored_MIP) and standard deviation projection of segmentation mask outlines, encoded in black-and-white (Gray_outline) or using color-encoding (Colored_outline). The worst of two ratings by two independent raters conducting slice-based review for segmentation errors on underlying imaging data and review for mislabeling errors served as the standard of reference. All variants were evaluated by five raters each for identification of segmentation errors and the majority rating was used as index test. The time required for review was recorded and diagnostic accuracies were calculated. Results: Sensitivities of Colored_MIP, Colored_outline and Gray_outline were 88.2% [95%-CI 78.7%; 94.4%], 89.5% [80.3%; 95.3%] and 78.9% [68.1%; 87.5%]; specificities were 98.7% [96.1%; 99.7%], 96.4% [93.1%; 98.5%] and 98.7% [96.1%; 99.7%]; and F1-scores were 0.918, 0.895 and 0.863, respectively. Mean time per case and rater required for evaluation was 2.8 ± 0.9 s for Colored_outline, 1.7 ± 0.1 s for Colored_MIP, and 2.0 ± 0.4 s for Gray_outline. Conclusions: The 2D segmentation mask projection images enabled the detection of segmentation errors of automated 3D segmentations of left and right lungs based on MRI with high diagnostic accuracy, especially when using color-encoding. The method enabled evaluation within a matter of seconds per case. Segmentation mask projection images may assist in visual quality control of automated segmentations in large-scale studies.

29 November 2025

Examples of thoracic MRI data and overlying lung segmentation masks. Axial slices (left column) and coronal views (right column) of the thoracic part of axially acquired T1-weighted 3D VIBE two-point DIXON images of thorax and abdomen of two different participants of the NAKO study. Translucent overlays of right (green) and left (red) lung segmentation masks as results of deep learning-based automated segmentation are shown. The quality of the lung segmentation of the participant in the top row was deemed sufficient for further analysis (reference positive). The bottom row shows an example of erroneous segmentation according to the reference standard (reference negative). Note the exclusion of consolidated parts of the lungs (arrows) and the spatial inconsistencies (composing artifacts, arrowheads) resulting from the stitching of separate acqusitions for the lower and upper part of the scan volume.

A Question of Dose? Ultra-Low Dose Chest CT on Photon-Counting CT in People with Cystic Fibrosis

  • Marcel Opitz,
  • Matthias Welsner and
  • Halil I. Tazeoglu
  • + 14 authors

Objective: Chest computed tomography (CT) is a key component of the diagnostic assessment of people with cystic fibrosis (PwCF) and is increasingly replacing chest radiography. Due to improvements in life expectancy, radiation exposure has become a growing concern in PwCF. Photon-counting CT (PCCT) has the potential to reduce the risk of radiation-induced malignancies while maintaining diagnostic accuracy. This study aimed to compare the radiation dose and image quality of low-dose high-resolution (LD-HR) and ultra-low-dose high-resolution (ULD-HR) CT protocols using PCCT in PwCF. Methods: This retrospective study included 72 PwCF, with 36 undergoing a LD-HR chest CT protocol and 36 receiving an ULD-HR protocol on a PCCT. The radiation dose and image quality were assessed by comparing the effective dose and signal-to-noise ratio (SNR). Three blinded radiologists evaluated the overall image quality, sharpness, noise, and assessability of the bronchi, bronchial wall thickening, and bronchiolitis using a five-point Likert scale. Results: The ULD-HR PCCT protocol reduced radiation exposure by approximately 65% compared with the LD-HR PCCT protocol (median effective dose: 0.19 vs. 0.55 mSv, p < 0.001). While LD-HR images were consistently rated higher than ULD-HR images (p < 0.001), both protocols maintained diagnostic significance (median image quality rating of “4-good”). The average SNR of the lung parenchyma was significantly lower with ULD-HR PCCT compared to LD-HR PCCT (p < 0.001). Conclusions: ULD-HR PCCT significantly reduced radiation exposure while maintaining good diagnostic image quality in PwCF. The effective dose of ULD-HR PCCT is only twice that of a two-plane chest X-ray, making it a viable low-radiation alternative for routine imaging in PwCF.

27 November 2025

Comparison of Mean and Standard Deviation in Quantitative Image Quality Analysis. HU Hounsfield units, LD-HR low-dose high-resolution, Std standard deviation, ULD-HR ultra-low-dose high-resolution.

Quantitative Ultrasound Grayscale Analysis and Size of Benign and Malignant Solid Thyroid Nodules

  • Salahaden R. Sultan,
  • Faisal Albin Hajji and
  • Abdulrahman Alhazmi
  • + 11 authors

Background: Ultrasound is the primary imaging modality for evaluating thyroid nodules, with echogenicity and nodule size serving as parameters for malignancy risk stratification. Though the TI-RADS classification system is standardized, interpretation varies among observers due to subjectivity, and can affect diagnostic consistency. This study aimed to evaluate the diagnostic and interobserver agreement of quantitative ultrasound gray-scale analysis and nodule area in differentiating benign from malignant solid thyroid nodules. Methods: This retrospective study reviewed 600 patients who underwent thyroid ultrasound at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, in 2023 and 2024. Of these 600, 107 adult patients with 116 solid thyroid nodules (96 benign and 20 malignant) who subsequently underwent ultrasound-guided fine-needle aspiration were included in the final analysis. From B-mode ultrasound images, the grayscale median (GSM) values of each nodule and adjacent normal thyroid tissue were measured using Adobe Photoshop. The GSM ratio (GSMr) was calculated by dividing nodule GSM by normal tissue GSM. Nodule size, taken as cross-sectional area, was assessed using ImageJ software version 1.53. The Mann–Whitney U test was used to compare GSMr and the area between benign and malignant nodules. Inter-observer agreement was evaluated using the intraclass correlation coefficient (ICC). Results: Malignant nodules had significantly lower GSMr compared to benign nodules (malignant: median 0.76, IQR 0.27; benign: median 0.88, IQR 0.55, p = 0.02). Malignant nodules were also significantly larger than benign nodules (malignant: median 2.77 cm2, IQR: 5.08; benign: median 1.78 cm2, IQR 1.65, p = 0.02). Inter-observer reproducibility was excellent for both GSMr (ICC = 0.998) and area (ICC = 0.997). Conclusions: Quantitative ultrasound assessment of grayscale echogenicity and nodule area provides valuable diagnostic information for differentiating benign from malignant solid thyroid nodules. These objective measures may enhance diagnostic confidence and support more precise clinical decision-making in thyroid nodule evaluation.

27 November 2025

Measurement of echogenicity. Gray-scale median of thyroid nodules (1) and normal thyroid tissues (2).

Lung nodules are a common radiological finding that can be caused by a variety of reasons, ranging from benign granulomas and scarring to the early stages of primary lung malignancies and metastases [...]

26 November 2025

Flowchart illustrating the study process.

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Editors: Karolina Nurzynska, Michał Strzelecki, Adam Piórkowski, Rafał Obuchowicz
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Editors: Karolina Nurzynska, Michał Strzelecki, Adam Piórkowski, Rafał Obuchowicz

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Tomography - ISSN 2379-139X