Journal Description
Clinics and Practice
Clinics and Practice
is an international, peer-reviewed, open access journal on clinical medicine, published monthly online by MDPI (from Volume 11, Issue 1 - 2021).
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), PubMed, PMC, Embase, and other databases.
- Journal Rank: JCR - Q1 (Medicine, General and Internal) / CiteScore - Q1 (General Medicine)
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 24 days after submission; acceptance to publication is undertaken in 2.8 days (median values for papers published in this journal in the first half of 2026).
- Recognition of Reviewers: APC discount vouchers, optional signed peer review, and reviewer names published annually in the journal.
- Journal Clusters of Surgery: Journal of Clinical Medicine, Surgical Techniques Development, Reports — Clinical Practice and Surgical Cases, Surgeries, Clinics and Practice, European Burn Journal, Complications, Osteology, Transplantology, Anesthesia Research, Emergency Care and Medicine and Journal of Aesthetic Medicine.
Impact Factor:
2.8 (2025);
5-Year Impact Factor:
2.4 (2025)
Latest Articles
Quality Assurance in Laparoscopic Gynecological Training: A Narrative Review of Standards with a Multicenter Expert Perspective on Pathways Toward Effective Education and Care
Clin. Pract. 2026, 16(9), 165; https://doi.org/10.3390/clinpract16090165 (registering DOI) - 5 Sep 2026
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Background: Quality assurance (QA) is a cornerstone of safe and effective postgraduate training in gynecological laparoscopic surgery, where clinical outcomes depend on procedural complexity, equipment sophistication, and the coordinated competence of an entire surgical team. This article is a narrative review of the
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Background: Quality assurance (QA) is a cornerstone of safe and effective postgraduate training in gynecological laparoscopic surgery, where clinical outcomes depend on procedural complexity, equipment sophistication, and the coordinated competence of an entire surgical team. This article is a narrative review of the conceptual, professional, and regulatory foundations of QA in healthcare education, complemented by a structured synthesis of the collective teaching and clinical experience of the author group. It is not an empirical study, and the sections that follow present a conceptual mapping supported by expert perspective rather than original outcome data. Methods: Sources were identified through targeted searches of PubMed/MEDLINE and Google Scholar, supplemented by hand-searching of policy and curriculum documents issued by professional bodies and by backward citation tracking, without date restriction. Approximately 480 records were screened at title and abstract level, 112 were assessed as full text, and 41 sources were retained against predefined inclusion and exclusion criteria, with five further sources added during peer review. In a second and separate step, the ten co-authors, who hold teaching and supervisory roles in gynecological laparoscopy across academic centers in Romania and Germany, each completed the same six-item written prompt on training provision, trainer development, trainee assessment, and institutional QA practice; responses were coded thematically by two authors independently and consolidated into explicit points of convergence and divergence. Results: We describe how QA principles, originally articulated in general quality-management and health-promotion literature, have been adapted by professional and regulatory bodies, including the European Board and College of Obstetrics and Gynecology (EBCOG), European Society for Gynecological Endoscopy (ESGE), American Society for Gastrointestinal Endoscopy (ASGE), and the UK General Medical Council, into concrete standards for training providers, trainers, and trainees. We outline the structures used to monitor and audit training quality, including Kirkpatrick’s four-level evaluation model and periodic institutional review cycles, alongside documentation and certification pathways such as the Gynecological Endoscopic Surgical Education and Assessment (GESEA) program, with governance and financing as cross-cutting determinants of sustainability. The author synthesis converged on a consistent gap between documented standards and their routine enforcement and diverged on whether external review and formal certification should become mandatory. Conclusions: The conceptual architecture of QA in gynecological laparoscopy is coherent and broadly fit for purpose, but we identified no study linking the implementation of a specific QA standard to measurable gains in trainee competency or patient outcomes in this field. Proposals for harmonized, outcome-oriented, and where appropriate, mandatory external review should therefore be read as reasoned positions awaiting prospective evaluation rather than as evidence-based recommendations; generating that evidence, with the trainee’s own perspective collected rather than inferred, is the principal task for future research.
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Open AccessArticle
An Alternative Biventricular Tracking Approach for Assessment of Right Ventricular Strain in Cardiac Amyloidosis
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Marina Leitman, Vladimir Tyomkin and Shmuel Fuchs
Clin. Pract. 2026, 16(9), 164; https://doi.org/10.3390/clinpract16090164 - 4 Sep 2026
Abstract
Background: Cardiac amyloidosis is characterized by progressive myocardial infiltration leading to ventricular dysfunction. While left ventricular strain assessment is well established, evaluation of right ventricular (RV) mechanics remains challenging because of the ventricle’s complex geometry and limitations of conventional speckle-tracking methods. We aimed
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Background: Cardiac amyloidosis is characterized by progressive myocardial infiltration leading to ventricular dysfunction. While left ventricular strain assessment is well established, evaluation of right ventricular (RV) mechanics remains challenging because of the ventricle’s complex geometry and limitations of conventional speckle-tracking methods. We aimed to evaluate an alternative approach for RV strain assessment based on a continuous biventricular tracking pathway within the apical four-chamber view. Methods: We retrospectively studied 32 patients with cardiac amyloidosis and 32 age-, sex-, rhythm-, and ejection fraction–matched controls. RV free-wall longitudinal strain was measured using a novel investigational biventricular tracking approach from the basal RV free wall through the apex to the basal lateral left ventricular wall and compared with conventional RV strain. Investigational biventricular strain (BVS) was also obtained automatically as a surrogate marker of global ventricular function. Reproducibility was assessed in a subset of 20 patients using intraclass correlation coefficients (ICC), coefficient of variation (CV), and Bland–Altman analysis. Results: Investigational RV free-wall strain was significantly reduced in patients with cardiac amyloidosis compared with controls (−15.3 ± 4.1% vs. −21.2 ± 5.4%, p < 0.001). Compared with conventional RV strain, the investigational biventricular tracking approach yielded more negative global RV strain values in both patients with amyloidosis (−15.3 ± 4.1% vs. −13.8 ± 4.8%, p = 0.003) and controls (−21.2 ± 5.4% vs. −17.4 ± 5.8%, p < 0.001). The greatest differences were observed at the apical RV segment. Bland–Altman analysis demonstrated a mean bias of −2.64 percentage points with 95% limits of agreement from −8.41 to +3.12 percentage points. A significant regional deformation pattern along the investigational tracking contour was observed in patients with cardiac amyloidosis (p < 0.001), whereas no significant regional variation was observed in controls. BVS correlated strongly with LV global longitudinal strain (r = 0.83 in amyloidosis; r = 0.58 in controls; r = 0.84 overall; all p < 0.001). Inter- and intra-observer reproducibility of investigational RV free-wall strain was excellent (ICC 0.976 and 0.985, respectively). Conclusions: The investigational biventricular tracking approach is a feasible and highly reproducible method for assessing ventricular longitudinal deformation using a single continuous contour. It provides complementary information while remaining an exploratory investigational technique. Further studies are required to validate its anatomical specificity, clinical applicability, and prognostic value.
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(This article belongs to the Section Cardiac and Cardiovascular Systems)
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Cariogenic Risk Modifies the Effect of Marginal Adaptation on Caries Adjacent to Posterior Composite Restorations: A Stratified Multivariate Analysis
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Andrei Georgescu, Sorin Andrian, Cristina-Angela Ghiorghe, Galina Pancu, Claudiu Topoliceanu, Ionuţ Tărăboanţă, Irina Nica, Răzvan Brânzan, Cristina Dascălu, Maria-Alexandra Mârţu and Mihaela Sălceanu
Clin. Pract. 2026, 16(9), 163; https://doi.org/10.3390/clinpract16090163 (registering DOI) - 3 Sep 2026
Abstract
Background/Objectives: Caries adjacent to restorations or sealants (CARS) is among the most frequent biological causes of composite restoration failure, resulting from the interplay between the patient’s cariogenic risk and restoration-related factors such as marginal adaptation. The study aimed to investigate whether cariogenic risk
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Background/Objectives: Caries adjacent to restorations or sealants (CARS) is among the most frequent biological causes of composite restoration failure, resulting from the interplay between the patient’s cariogenic risk and restoration-related factors such as marginal adaptation. The study aimed to investigate whether cariogenic risk modifies the effect of marginal adaptation on the occurrence of caries adjacent to posterior composite restorations (CARS), using risk-stratified univariate analysis and a clustering-adjusted approach, to identify associated clinical, socio-demographic, and local risk factors. Methods: This retrospective cross-sectional study evaluated 453 posterior direct composite resin restorations (Class I, Class II) in 88 patients at the Faculty of Dental Medicine, “Grigore T. Popa” University, Iași, Romania. CARS and marginal adaptation were assessed using FDI Criteria. Patients were classified as high or low cariogenic risk using a multifactorial institutional protocol. Univariate analysis and Generalized Estimating Equations (GEE) accounting for within-patient clustering were performed. Results: CARS prevalence was 27.9% in high cariogenic risk patients versus 3.15% in low cariogenic risk patients. Univariate analysis identified high cariogenic risk (OR = 11.904), deficient marginal adaptation (OR = 25.929–69.475), restoration age of 3–5 years (OR = 3.045), and Class II configuration (OR = 2.597) as significant risk factors. GEE analysis, adjusted for clustering of restorations within patients, confirmed high cariogenic risk (OR = 12.597) and deficient marginal adaptation (OR = 121.320) as independent correlates of CARS. A significant interaction between the two (p < 0.001) showed that marginal adaptation remained the dominant local risk factor in low cariogenic risk patients, while its association with CARS was largely attenuated in high-risk patients. Conclusions: GEE analysis confirmed high cariogenic risk and deficient marginal adaptation as independent correlates of CARS, with marginal adaptation acting as the dominant local risk factor only in low-risk patients.
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Open AccessArticle
Stable-Phase Peyronie’s Disease: Have Perilesional Injections of Hyaluronic Acid Come of Age?
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Tommaso Cai, Daniele Tiscione, Marco Puglisi, Daniele Mattevi, Simone Botti, Tommaso Ceccato and Truls Erik Bjerklund Johansen
Clin. Pract. 2026, 16(9), 162; https://doi.org/10.3390/clinpract16090162 - 31 Aug 2026
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Background: Peyronie’s Disease (PD) is a complex andrological condition that severely compromises patients’ quality of life. While a novel formulation of hyaluronic acid (HA) has recently gained traction for treating the acute inflammatory phase, clinical evidence regarding its role in stable-phase (chronic)
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Background: Peyronie’s Disease (PD) is a complex andrological condition that severely compromises patients’ quality of life. While a novel formulation of hyaluronic acid (HA) has recently gained traction for treating the acute inflammatory phase, clinical evidence regarding its role in stable-phase (chronic) PD is lacking. We aimed to assess the therapeutic outcomes and safety profile of Perovial®, a specialized HA formulation, in patients with stable disease. Methods: A cohort of 47 patients with stable-phase PD was treated at a single andrological center between June and December 2025. The treatment protocol consisted of eight weekly injections targeted around the tunica albuginea plaque. Clinical efficacy was assessed 3 months post-treatment by comparing baseline data with the following outcome measures: change in penile curvature (Δ°), the international index of erectile function (IIEF-5) score, Peyronie’s Disease Questionnaire (PDQ) and Global Assessment of Peyronie’s Disease (GAPD). Results: At the 3-month follow-up visit, a statistically significant improvement in penile curvature was registered in 35 out of 47 patients (Δ° − 16) (p < 0.001). All patients had a significant improvement from baseline in terms of IIEF (20 vs. 24; p < 0.001) and in all PDQ domains. No major adverse events or complications were observed during the study period. At the GAPD questionnaire, 43 patients (91.2%) reported subjective improvement of penile curvature. Conclusions: Perilesional injection of Perovial® seems a promising intervention in patients with stable-phase PD in terms of penile curvature reduction and patient-reported quality of life improvement.
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Clinical Relevance of Calcifications in Osteosarcoma Lung Metastases: Correlations Among Radiological Patterns, Histological Subtypes, and Chemotherapy Responses
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Paolo Spinnato, Mario Simonetti, Maria Carpenzano, Gabriele Bilancia, Nicola Marrone, Annamaria Chiesa, Maddalena Di Carlo, Emanuela Palmerini, Luca Cevolani, Marco Colangeli, Marco Gambarotti, Alberto Righi and Alessandra Longhi
Clin. Pract. 2026, 16(9), 161; https://doi.org/10.3390/clinpract16090161 - 28 Aug 2026
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Background/Objectives: Osteosarcoma is a rare malignancy and the most common primary malignant bone tumor. Metastases commonly affect the lungs and are associated with reduced life expectancy. Calcifications can be present within a metastatic nodule at baseline or can appear during follow-up. We aimed
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Background/Objectives: Osteosarcoma is a rare malignancy and the most common primary malignant bone tumor. Metastases commonly affect the lungs and are associated with reduced life expectancy. Calcifications can be present within a metastatic nodule at baseline or can appear during follow-up. We aimed to assess the clinical significance of calcifications in lung metastases, particularly in relation to radiological pattern, histopathological subtype, and treatment response. Methods: A retrospective cohort of patients with osteosarcoma and lung metastases at diagnosis was evaluated for the period 2000–2018. The presence of calcifications inside pulmonary lesions on baseline lung CT and/or follow-up was assessed and recorded. Radiological data were then checked against histopathological data (i.e., osteosarcoma subtypes and chemotherapy response with necrosis percentage) and the radiological pattern of the primary tumor (i.e., osteolytic, sclerotic, or mixed pattern). Results: Of a cohort of 92 patients, 14 were excluded due to having no baseline or follow-up chest CT. Of the 78 patients with an osteosarcoma diagnosis, lung metastases at diagnosis, and chest CT who were enrolled (42 men and 36 women; mean age: 23.8 years [range, 6–73 years]), 70 (89.7%) had a baseline imaging study of the primary tumor (osteosarcoma). The presence of calcifications in lung metastases at both baseline and follow-up was significantly associated with the radiological pattern of the primary lesion (p < 0.0001). Calcifications were not present in the lung metastases of any of the 18 patients (0%) with a lytic radiological pattern at any stage, whereas all 32 patients (100%) with a purely sclerotic pattern had calcifications within lung metastases at baseline or during follow-up; of the 20 patients with a mixed radiological pattern, 11 (55%) had no calcifications and 9 (45.0%) had detectable calcifications. No statistically significant association was found between histopathological subtype and calcification. Osteoblastic osteosarcoma was more frequently associated with calcification (66.0%). During induction chemotherapy, five poor responders and three good responders (necrosis > 90%) developed calcifications (p = 0.72; OR = 0.67; 95% CI, 0.10–3.86). Conclusions: In patients with osteosarcoma, calcifications within pulmonary metastases are strongly associated with the radiological pattern of the primary tumor, and this association is greatest for a pure sclerotic pattern, followed by the mixed one. We found no statistically significant association between the occurrence of calcifications during follow-up and chemotherapy response measured by necrosis percentage of the surgical specimen in our limited cohort; further research is needed.
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Neurobiological Effects of Non-Invasive Behavioural Management Strategies in Paediatric Dentistry: A Scoping Review
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Love Bukola Ayamolowo, Idayat Adetoun Raji, Bukola Abimbola Adesoji, Dorcas Oluwatola Adelakun and Moréniké Oluwátóyìn Foláyan
Clin. Pract. 2026, 16(9), 160; https://doi.org/10.3390/clinpract16090160 - 27 Aug 2026
Abstract
Behavioural management strategies used in paediatric dentistry have neurobiological effects. This scoping review aimed to map the existing literature on the neurobiological effects of non-invasive behavioural management strategies used in paediatric dentistry. The study protocol was registered on the Open Science Framework (registration
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Behavioural management strategies used in paediatric dentistry have neurobiological effects. This scoping review aimed to map the existing literature on the neurobiological effects of non-invasive behavioural management strategies used in paediatric dentistry. The study protocol was registered on the Open Science Framework (registration number: OSF.IO/9EZVT). A search was conducted on PubMed, Web of Science, Scopus, Google Scholar, and African Journals Online (AJOL) for studies published up to May 2025. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Studies were included if they assessed non-invasive behavioural strategies in children aged 0–17 years undergoing dental procedures and reported at least one neurobiological or physiological outcome. The data were summarised descriptively, and key findings were thematically synthesised to identify trends in behavioural strategy types and neurobiological outcomes measured. Out of 1720 records retrieved, 35 studies met the inclusion criteria. These included randomised and non-randomised controlled trials and observational studies conducted in 13 countries on five continents involving 2919 children. The behaviour management strategies identified were 18 in number, with distraction (n = 19) and tell–show–do (n = 17) being the most frequently applied. The neurobiological outcomes assessed included anxiety (n = 36), pain perception (n = 8), fear (n = 7), and stress response (n = 1). Their physiological regulation was assessed using heart rate (n = 26), oxygen saturation (n = 10), blood pressure (n = 8), pulse rate (n = 6), cortisol (n = 4), respiratory rate (n = 1), and oxytocin (n = 1). Behavioural assessment tools used were classified into Child-Reported Anxiety and Fear Instruments (n = 23), Pain Perception Instruments (n = 9), Clinician/Observer-Rated Behavioural and Anxiety Scales (n = 18), and Parental and Proxy Reports (n = 2). This review underscores the emerging evidence that non-invasive behavioural strategies may be linked to neurobiology in paediatric dentistry. More studies are needed in new countries to be able to map the possible impact of context and culture on study findings.
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(This article belongs to the Section Dentistry and Oral Medicine)
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Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy
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Vittorio Gebbia, Sergio Rizzo, Dario Piazza, Daniela Sambataro, Giuseppa Scandurra and Maria Rosaria Valerio
Clin. Pract. 2026, 16(9), 159; https://doi.org/10.3390/clinpract16090159 - 27 Aug 2026
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Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clinical trial scientific publication output, citation impact, research
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Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clinical trial scientific publication output, citation impact, research funding, and collaboration networks in medical oncology between northern and southern Italy. Methods: A narrative bibliometric analysis was conducted using data from PubMed and other institutional databases of Italian Scientific Institutes for Hospitalization and Care. Data from the Italian National Agency for the Evaluation of Universities and Research Institutes, the Alliance Against Cancer, and the Italian Association for Cancer Research were also reviewed. Regional output was compared across two macro-areas, namely north and south Italy. Results: Northern Italian institutions account for a disproportionate share of publications, high-impact citations, and funded research projects. Northern Italy produces an estimated four to six times more medical oncology papers than southern Italy, driven by a higher concentration of cancer institutes, better-funded university hospitals, and stronger multidisciplinary infrastructure than in the south. Clinical trial density is highest in the north compared to the south (0.53 versus 0.02 per 100,000 inhabitants). Conclusions: The north–south divide in Italian oncology research productivity is real, multi-factorial, and persistent. The analysis reveals a substantial gap in research productivity, institutional capacity, and access to clinical trials between the two macro-regions. Targeted policy interventions, including decentralized trial models, dedicated funding streams for southern institutions, and stronger infrastructure for inter-regional collaboration, are urgently needed to ensure representativeness in oncology evidence generation and equitable scientific progress.
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Clinical Characteristics, Treatment Patterns, and Survival Outcomes of Right-Sided RAS/RAF Wild-Type Metastatic Colorectal Cancer: A Real-World Multicenter Cohort Study
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Nur Deniz Yildiz, Çağatay Arslan, İlker Nihat Okten, Umut Kefeli, Mahmut Emre Yildirim, Nuri Karadurmus, Tuba Baydas, Bülent Karabulut, Irfan Cicin, Cemil Bilir, Melike Ozcelik, Timucin Cil, Sinemis Celik, Oktay Bozkurt, Hakan Harputluoglu, Bala Başak Oven, Mehmet Artaç, Hacı Mehmet Türk, Ahmet Alacacıoğlu, Mahmut Gumus and Şuayib Yalcinadd
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Clin. Pract. 2026, 16(9), 158; https://doi.org/10.3390/clinpract16090158 - 24 Aug 2026
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Background: Right-sided metastatic colon cancer represents a clinically distinct subgroup with inferior outcomes and uncertain optimal biologic treatment selection, even among patients with RAS wild-type disease. Real-world data focusing specifically on right-sided RAS wild-type metastatic colon cancer remain limited. This study aimed
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Background: Right-sided metastatic colon cancer represents a clinically distinct subgroup with inferior outcomes and uncertain optimal biologic treatment selection, even among patients with RAS wild-type disease. Real-world data focusing specifically on right-sided RAS wild-type metastatic colon cancer remain limited. This study aimed to describe clinicopathologic characteristics, metastatic patterns, treatment approaches, and survival outcomes in this population using a national multicenter registry. Methods: This retrospective multicenter cohort study was conducted using data from the ONKO-KOLON Türkiye registry. Patients with pathologically confirmed KRAS/NRAS wild-type metastatic colorectal cancer and available primary tumor localization were evaluated. The main analytic cohort included patients with right-sided metastatic colon cancer, defined as right colon or transverse colon tumors. Left-sided colon cancer patients were used as a contextual comparator, while rectal cancer patients were excluded from sidedness-based colon comparisons. Survival outcomes were estimated using the Kaplan–Meier method, and prognostic factors were evaluated using Cox regression analyses. Results: Among 1079 patients in the source cohort, primary tumor localization was available in 1065 patients. Of these, 213 had right-sided colon cancer, 464 had left-sided colon cancer, and 388 had rectal cancer. In the right-sided cohort, median age was 61.5 years, 64.3% were male, and 66.7% had synchronous/de novo metastatic disease. Liver metastasis was the most common metastatic site (63.4%), followed by lymph node (31.0%), lung (21.1%), and peritoneal metastases (15.5%). First-line anti-VEGF-based treatment was used in 46.0% of patients, while anti-EGFR-based treatment was used in 40.8%. Among evaluable patients, the objective response rate was 46.8% and the disease control rate was 79.2%. Median progression-free survival was 10.0 months, and median overall survival was 24.0 months. In unadjusted exploratory analysis, median OS was 27.0 months with anti-EGFR-based treatment and 17.0 months with anti-VEGF-based treatment (log-rank p = 0.022), whereas median PFS was 10.0 months in both groups. In an extended covariate-adjusted multiple-imputation sensitivity model, the anti-EGFR OS estimate did not meet statistical significance (adjusted HR 0.66, 95% CI 0.43–1.00; p = 0.051). In a secondary contextual comparison, median overall survival was shorter in the right-sided than in the left-sided colon cancer group (24.0 vs. 28.0 months; HR 1.47, 95% CI 1.19–1.82; p < 0.001), whereas progression-free survival did not differ significantly. Conclusions: This study provides a descriptive account of metastatic patterns, treatment approaches, and outcomes in a dedicated right-sided RAS wild-type metastatic colon cancer cohort. The unadjusted OS difference between biological treatment groups was not confirmed after measured covariate adjustment and should not be interpreted as evidence of comparative treatment effectiveness. Because molecular profiling was incomplete, this study cannot identify biomarker-defined treatment subgroups. Prospective studies with complete, predefined molecular characterization are needed before molecularly informed treatment selection hypotheses can be evaluated in this population.
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Exploring the Role of Resistance Training in the Prevention and Management of Chronic Conditions: A Narrative Review
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Anu M. Räisänen
Clin. Pract. 2026, 16(8), 157; https://doi.org/10.3390/clinpract16080157 - 21 Aug 2026
Abstract
Physical activity is widely recognized as a fundamental component of health promotion and chronic disease prevention. Historically the focus has primarily been on aerobic exercise, while resistance training has received comparatively less attention. This imbalance underestimates the critical role of muscular performance in
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Physical activity is widely recognized as a fundamental component of health promotion and chronic disease prevention. Historically the focus has primarily been on aerobic exercise, while resistance training has received comparatively less attention. This imbalance underestimates the critical role of muscular performance in supporting physical health, functional capacity, long-term mobility, and overall quality of life. Current physical activity guidelines for Americans recommend that adults engage regularly in both aerobic and muscle-strengthening activities. However, only approximately one-quarter of adults in the United States meet these recommendations, despite nearly half achieving recommended levels of aerobic activity alone. Although any form of physical activity can confer health benefits, participation in both aerobic exercise and muscle-strengthening, such as resistance training, produces more comprehensive and substantial health outcomes. As research on resistance training has evolved beyond its traditional focus on athletic performance, a growing body of evidence has demonstrated its effectiveness in the prevention and management of numerous chronic conditions. This narrative review summarizes the role of resistance training in the prevention and management of several prevalent lifestyle-related chronic conditions, including type 2 diabetes, obesity, hypertension, cardiovascular disease, dyslipidemia, and osteoporosis.
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(This article belongs to the Special Issue Exercise and Sports for Chronic Diseases)
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Threshold Validity of N3 Criteria in Nasopharyngeal Carcinoma: A Narrative Methodological Review of Pragmatic Cutoffs and Biologically Defensible Risk Boundaries
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Erkan Topkan, Efsun Somay, Melis Selek and Ugur Selek
Clin. Pract. 2026, 16(8), 156; https://doi.org/10.3390/clinpract16080156 - 21 Aug 2026
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This narrative methodological review aims to critically assess whether current AJCC/UICC N3-defining criteria for nasopharyngeal carcinoma (NPC) represent validated biological and statistical thresholds or pragmatic staging boundaries. Specifically, it examines the evidential basis of the >6 cm nodal-size threshold, extension below the caudal
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This narrative methodological review aims to critically assess whether current AJCC/UICC N3-defining criteria for nasopharyngeal carcinoma (NPC) represent validated biological and statistical thresholds or pragmatic staging boundaries. Specifically, it examines the evidential basis of the >6 cm nodal-size threshold, extension below the caudal border of the cricoid cartilage, and advanced radiologic extranodal extension (rENE), with emphasis on the distinction between prognostic-variable validity and threshold validity. The >6 cm criterion is a historically inherited threshold that predates contemporary MRI-based staging and may insufficiently capture the three-dimensional complexity of nodal tumor burden. Similarly, defining inferior nodal extension by the caudal border of the cricoid cartilage improves anatomical reproducibility compared with earlier lower-neck definitions, yet it remains a pragmatic imaging landmark rather than a validated biological boundary for lymphatic dissemination. By contrast, advanced rENE is more biologically informative because it reflects invasive tumor behavior; nonetheless, its staging utility depends on standardized imaging definitions, interobserver reliability, external validation, and incremental clinical utility. Emerging imaging-derived descriptors—including MRI-based nodal diameter, nodal volume, middle-neck involvement, total tumor volume, and integrated imaging–biological models—underscore the limitations of relying exclusively on single categorical thresholds. Future N3 refinement should move beyond substituting one cutoff for another by characterizing nodal descriptors in continuous, ordinal, volumetric, or severity-graded forms before adopting simplified categories. Future refinement of NPC nodal staging will likely require approaches that move beyond isolated anatomical thresholds and better account for the multidimensional nature of nodal disease, including tumor burden, spatial distribution, invasive characteristics, and biological risk.
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Gross Total Resection and Recurrence-Free Survival in Diffuse Gliomas: A Single-Center Cohort Study from Eastern Europe
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Teodor Cristian Blidaru, Marius Cristian Zaharia, Dan Mitrea, Raluca Maria Marin, Natalia Blidaru, Manuela Ghica, Maria Sinziana Matei, Raluca Papacocea, Stefan Strilciuc and Dragos Nicolae Garofil
Clin. Pract. 2026, 16(8), 155; https://doi.org/10.3390/clinpract16080155 - 20 Aug 2026
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Background/Objectives: The independent contribution of extent of resection (EOR) to early recurrence in diffuse gliomas remains debated, as crude analyses are confounded by tumor biology, and real-world data from Eastern European centers are scarce. Methods: We retrospectively studied 283 consecutive adults with surgically
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Background/Objectives: The independent contribution of extent of resection (EOR) to early recurrence in diffuse gliomas remains debated, as crude analyses are confounded by tumor biology, and real-world data from Eastern European centers are scarce. Methods: We retrospectively studied 283 consecutive adults with surgically treated diffuse gliomas (2021–2024) at a Romanian tertiary center. Primary endpoints were recurrence-free survival (RFS) at 1 and 2 years, evaluated as landmark endpoints; secondary endpoints were overall recurrence, reoperation, and reirradiation. Clinical, histopathological, surgical, imaging, and treatment variables were analyzed with complete-case Firth-penalized logistic regression. Results: Among evaluable patients, 70.6% (132/187) were recurrence-free at 1 year and 64.2% (120/187) at 2 years; overall recurrence occurred in 53.7% (139/259). After adjustment, gross total resection (GTR) was independently associated with higher odds of remaining recurrence-free at 1 year (OR 12.37, 95% CI 3.23–52.58; p < 0.001) and 2 years (OR 10.56; p < 0.001), as was subtotal resection (STR) at both time points (OR 4.15, 95% CI 1.17–16.16, p = 0.027; and OR 3.93, p = 0.027), versus partial resection/biopsy. Conclusions: EOR was independently associated with early RFS, supporting maximal safe resection as a primary surgical objective. The landmark endpoints were not evaluable in 96 of 283 patients, almost all of whom underwent biopsy or partial resection, so the odds ratios indicate the direction of the effect and not its precise magnitude. Overall recurrence, evaluable in 91.5% of the cohort, showed a concordant gradient. External validation is needed.
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Beyond Disease Categories: The Adaptive Hierarchical Domain Network (AHDN) for Precision Phenotyping and Personalized Management of Chronic Orofacial Pain
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Takahiko Nagamine
Clin. Pract. 2026, 16(8), 154; https://doi.org/10.3390/clinpract16080154 - 20 Aug 2026
Abstract
Background/Objectives: Chronic orofacial pain disorders are highly heterogeneous and therapeutically challenging. Although current classifications such as the International Classification of Orofacial Pain (ICOP) and the concept of nociplastic pain have improved diagnostic consistency, patients with the same diagnosis may show substantial differences in
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Background/Objectives: Chronic orofacial pain disorders are highly heterogeneous and therapeutically challenging. Although current classifications such as the International Classification of Orofacial Pain (ICOP) and the concept of nociplastic pain have improved diagnostic consistency, patients with the same diagnosis may show substantial differences in symptom severity, underlying biology, and treatment response. This suggests that disease classifications may describe clinical phenotypes more effectively than the biological mechanisms sustaining persistent pain. This article proposes the Adaptive Hierarchical Domain Network (AHDN) as a conceptual framework for understanding chronic orofacial pain from a precision medicine perspective. Conceptual Framework: AHDN integrates concepts from systems biology, network neuroscience, predictive processing, biomarker research, and precision medicine. It organizes chronic pain across five hierarchically related but dynamically interacting layers: biological susceptibility, peripheral nociceptive drivers, central adaptive plasticity, behavioral adaptation, and social embedding. The framework is intended to complement, rather than replace, established diagnostic classifications. Implications: The proposed framework suggests that burning mouth syndrome, persistent dentoalveolar pain disorder, persistent idiopathic facial pain, occlusal dysesthesia, and subsets of temporomandibular disorders may represent different mechanistic configurations within a shared adaptive network. AHDN provides a hypothesis-generating structure for mechanistic phenotyping, biomarker development, and individualized management. However, the framework remains conceptual and requires prospective clinical validation, standardized assessment methods, and evaluation of its clinical utility before routine implementation.
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(This article belongs to the Topic Advances in Chronic Disease Management)
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Open AccessReview
Interventional Endoscopic Ultrasound in Gastroenterology: A Comprehensive Bibliometric Analysis (2001–2024)
by
Koji Takahashi, Noa Minami, Kohei Horie, Taiga Sudo, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma and Hidehiro Kamezaki
Clin. Pract. 2026, 16(8), 153; https://doi.org/10.3390/clinpract16080153 - 20 Aug 2026
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Background/Objectives: Interventional endoscopic ultrasound (I-EUS) has evolved from a diagnostic imaging modality into a transformative therapeutic platform encompassing biliary drainage, pancreatic interventions, luminal bypass, pain management, and ablative therapies. Despite the rapid proliferation of I-EUS research, a comprehensive bibliometric analysis characterizing the
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Background/Objectives: Interventional endoscopic ultrasound (I-EUS) has evolved from a diagnostic imaging modality into a transformative therapeutic platform encompassing biliary drainage, pancreatic interventions, luminal bypass, pain management, and ablative therapies. Despite the rapid proliferation of I-EUS research, a comprehensive bibliometric analysis characterizing the global intellectual architecture of this field is lacking. Methods: A Web of Science Core Collection search identified 4340 records, of which 2237 were included (2001–2024), analyzed with R bibliometrix (version 5.0) and VOSviewer (version 1.6.20). Results: Publication output demonstrated three distinct phases with pronounced acceleration from 2017. The United States led global output (n = 625, 27.9%), followed by Japan (n = 435, 19.4%) and Italy (n = 166, 7.42%). At the continental level, Asia collectively produced the largest share of output (n = 884, 39.5% of the total corpus), exceeding the Americas (n = 687, 30.7%) and Europe (n = 492, 22.0%). Gastrointestinal Endoscopy was the most productive journal (n = 173). Tokyo Medical University was the most productive institution (n = 93, 4.16%). Four thematic clusters were identified: EUS-guided biliary and pancreatic ductal drainage; diagnostic, ablative, and injection EUS for pancreatic tumors; LAMS-enabled luminal bypass and gallbladder drainage; and pancreatic fluid collections and necrotizing pancreatitis. Temporal overlay confirmed EUS-guided gastroenterostomy, EUS-guided gallbladder drainage, and EUS-guided radiofrequency ablation as the leading research frontiers. Annual output showed no discernible contraction during the COVID-19 pandemic period (2020–2021). Conclusions: The United States led global I-EUS research output with higher rates of international collaboration compared with East Asian nations, although Asia as a continent generated the largest aggregate volume of publications. EUS-guided biliary drainage and pancreatic fluid collection management constitute the established, high-volume core of the field, while EUS-guided gastroenterostomy and novel ablative technologies represent the most dynamic investigative frontiers.
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Open AccessArticle
Association Between General Practitioner’s Sex and Documented Diagnoses of Female-Specific Disorders in German Primary Care: A Large Matched Cross-Sectional Study
by
Karel Kostev, Ira Rodemer, Marcel Konrad and Matthias Kalder
Clin. Pract. 2026, 16(8), 152; https://doi.org/10.3390/clinpract16080152 - 20 Aug 2026
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Background/Objectives: In Germany, women have direct access to gynaecologists without GP referral, making the GP’s role in female-specific conditions largely secondary. It has not previously been examined whether the sex of the GP is nonetheless associated with the documented prevalence of these conditions
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Background/Objectives: In Germany, women have direct access to gynaecologists without GP referral, making the GP’s role in female-specific conditions largely secondary. It has not previously been examined whether the sex of the GP is nonetheless associated with the documented prevalence of these conditions in primary care records. Methods: This retrospective cross-sectional study used data from the IQVIA™ Disease Analyzer. All women aged ≥18 years with at least one visit to one of 1183 GPs in Germany in 2025 were included. Women attending female and male GPs were matched 1:1 by propensity score on age, statutory health insurance, practice size, consultation frequency in 2025, and the van Walraven comorbidity score (excluding malignancy), yielding 661,485 women per group. Associations between GP sex and the documented prevalence of eight female-specific conditions were examined using conditional logistic regression within the age strata clinically relevant to each condition (from 18–30 to >75 years), with the age × GP-sex interaction tested in a single model per condition and E-values calculated to assess robustness to unmeasured confounding. Results: The association between GP sex and documented prevalence was strongly age-dependent, with a significant age × GP-sex interaction for seven of eight conditions (all p < 0.001). Female GP sex was associated with higher documented prevalence in mid-life, including menopausal and perimenopausal disorders (46–60 years: OR 1.37, 95% CI 1.28–1.46), endometriosis (31–45 years: OR 1.15, 1.03–1.28) and benign neoplasm of the female breast and genital organs (46–60 years: OR 1.16, 1.04–1.29); in the oldest women, the pattern attenuated or reversed (menopausal disorders > 75 years: OR 0.81, 0.72–0.90). No association was observed for breast cancer or female genital organ cancer at any age. Conclusions: In German primary care, the association between GP sex and the documented prevalence of female-specific disorders is age-dependent—most pronounced for conditions that require active clinical recognition and patient disclosure in mid-life, and absent for specialist-managed malignancies.
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Open AccessCase Report
Awake Prone Positioning in Moderate ARDS: A Case Report
by
Kapilan Kalaruban, Aristomenis Exadaktylos, Vincent Ribordy and Mairi Ziaka
Clin. Pract. 2026, 16(8), 151; https://doi.org/10.3390/clinpract16080151 - 17 Aug 2026
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Background: Legionella pneumophila is a rare but severe cause of community-acquired pneumonia and can lead to acute respiratory distress syndrome (ARDS). Awake prone positioning (APP) has been recognized as an effective adjunct for non-intubated patients with hypoxemic respiratory failure, primarily studied in coronavirus
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Background: Legionella pneumophila is a rare but severe cause of community-acquired pneumonia and can lead to acute respiratory distress syndrome (ARDS). Awake prone positioning (APP) has been recognized as an effective adjunct for non-intubated patients with hypoxemic respiratory failure, primarily studied in coronavirus disease 2019 (COVID-19) and other ARDS etiologies. Its application in Legionella-associated ARDS remains poorly documented. Therefore, in this work, we present a case of Legionella-associated ARDS successfully managed with APP, high-flow nasal cannula (HFNC), non-invasive ventilation (NIV), levofloxacin, and corticosteroids. Case presentation: A 62-year-old male with multiple comorbidities, including type 2 diabetes mellitus (T2DM) and a history of coronary artery bypass surgery, presented with a 3-day history of productive cough, exertional dyspnea, and general malaise. Oxygen saturation on admission was 90%, with fever and tachycardia. Inflammatory markers were markedly elevated. Chest computed tomography (CT) revealed extensive bilateral pulmonary infiltrates. Despite a negative urinary Legionella antigen test, sputum polymerase chain reaction (PCR) confirmed Legionella pneumophila on day 2. A Horowitz index of 147 mmHg on day 2 established moderate ARDS. The patient was treated with HFNC oxygen therapy, NIV, and APP for up to 12 h daily. Antibiotic therapy was initiated with amoxicillin/clavulanic acid and clarithromycin, subsequently streamlined to levofloxacin upon microbiological confirmation. Methylprednisolone 40 mg/day was administered for 8 days as adjunctive ARDS therapy. The patient demonstrated gradual clinical and respiratory improvement without requiring endotracheal intubation. Follow-up chest CT on day 7 showed regression of bilateral consolidations and ground-glass opacities (GGOs). The patient was transferred to pulmonary rehabilitation on day 11 and completed antibiotic therapy as an outpatient. Conclusions: This case illustrates the successful use of APP combined with HFNC and NIV alongside standard medical therapies, including appropriate antibiotics and corticosteroids, to avoid intubation in moderate ARDS secondary to Legionella pneumonia. Early initiation of APP may be a valuable strategy in Legionella-associated ARDS in carefully selected patients.
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Open AccessArticle
Severe Dengue and Dengue–Malaria Coinfection: A Case Series from a Referral Hospital in Montería, Colombia
by
Paula A. Avilés-Vergara, Dina Ricardo-Caldera, Osnamir Elias Bru-Cordero, Juan Alberto Miranda, Angie Paola Martínez Villera, Kevin Alexander Angulo Álvarez and María Carolina Geney Caro
Clin. Pract. 2026, 16(8), 150; https://doi.org/10.3390/clinpract16080150 - 15 Aug 2026
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Background/Objectives: Severe dengue and dengue–malaria coinfection represent major diagnostic and therapeutic challenges in tropical endemic settings, where overlapping clinical manifestations may delay recognition of deterioration. This study aimed to describe the clinical and epidemiological characteristics of patients with severe dengue, dengue with warning
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Background/Objectives: Severe dengue and dengue–malaria coinfection represent major diagnostic and therapeutic challenges in tropical endemic settings, where overlapping clinical manifestations may delay recognition of deterioration. This study aimed to describe the clinical and epidemiological characteristics of patients with severe dengue, dengue with warning signs, and dengue–malaria coinfection treated at a referral hospital in Montería, Córdoba, Colombia. Methods: A retrospective case series was conducted by reviewing medical records of patients diagnosed with dengue between 2018 and 2023. Cases classified as dengue without warning signs were excluded. The final analysis included patients with dengue-warning signs, severe dengue, and dengue–malaria coinfection. Dengue classification followed the 2009 World Health Organization criteria, and malaria was confirmed by thick blood smear. Sociodemographic, clinical, laboratory, geographic, and outcome-related variables were collected. Descriptive analyses were performed, and selected categorical variables were compared using Fisher’s exact test. Results: Fifty-three patients were included: 25 (47.17%) with severe dengue, 14 (26.42%) with dengue with warning signs, and 14 (26.42%) with dengue–malaria coinfection. Severe dengue was more frequent among females, whereas dengue with warning signs and coinfection predominated in males. Children accounted for the highest proportion of severe dengue cases, while coinfected cases were mainly distributed between childhood and adolescence. Fever was documented in all patients. Edema, elevated hematocrit, severe plasma leakage, and hemodynamic compromise were more frequent among severe dengue cases, whereas myalgia differed significantly across clinical groups. Ten deaths were recorded, six occurring in coinfected patients. Conclusions: Severe dengue and dengue–malaria coinfection are clinically complex conditions with overlapping manifestations and potentially fatal outcomes, highlighting the need for early recognition, differential diagnosis, and close monitoring.
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Open AccessArticle
Development and Preliminary Assessment of a Mortality Risk Score in Patients with Coronary Artery Disease Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
by
Friba Nurmukhammad, Sholpan Zhangelova, Akhmetzhan Sugraliyev, Alexander Arutyunov, Yermagambet Kuatbayev, Zhanetta Mukanova and Dina Kapsultanova
Clin. Pract. 2026, 16(8), 149; https://doi.org/10.3390/clinpract16080149 - 14 Aug 2026
Abstract
Background: Patients with coronary artery disease (CAD) receiving dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remain at risk of early adverse outcomes, including in-hospital mortality. Simple risk stratification based on routinely available variables may help identify higher-risk patients, but a
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Background: Patients with coronary artery disease (CAD) receiving dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remain at risk of early adverse outcomes, including in-hospital mortality. Simple risk stratification based on routinely available variables may help identify higher-risk patients, but a limited number of outcome events constrains robust prediction-model development and validation. Aim: This exploratory study aimed to derive a preliminary, interpretable clinical score based on routinely available variables for risk stratification of all-cause in-hospital mortality in CAD patients receiving DAPT after PCI. In the clopidogrel-dominant practice setting of the participating centers, the score was conceived as a hypothesis-generating risk-enrichment framework rather than a validated treatment-selection tool or a surrogate measure of platelet reactivity. Methods: We analyzed a retrospective cohort of 1600 adults with CAD admitted between 2022 and 2024; 36 in-hospital deaths occurred. Twenty demographic, clinical, laboratory, and instrumental variables were evaluated. The primary outcome was all-cause in-hospital mortality during the index hospitalization. For exploratory score derivation, the dataset was randomly divided into a derivation subset (75%; n = 1200) and a hold-out assessment subset (25%; n = 400). Predictors were explored using univariable and multivariable logistic regression with stepwise selection. Continuous variables were categorized using Weight of Evidence binning, and an integer point score was derived. Performance was summarized using ROC analysis, AUC, sensitivity, specificity, and accuracy. Given the small number of deaths and the data-driven modelling workflow, all performance estimates were considered preliminary rather than definitive internal validation. Results: The exploratory six-variable score included age ≥ 57 years, estimated glomerular filtration rate < 45 mL/min/1.73 m2, body mass index ≥ 25 kg/m2, troponin I ≥ 100, prior myocardial infarction, and current smoking. In the derivation subset, each additional point was associated with higher odds of mortality (OR 1.39; 95% CI 1.29–1.51; p < 0.001), and the AUC was 0.654. A Youden-index threshold of approximately 6 points yielded sensitivity of 0.41, specificity of 0.80, and accuracy of 0.72. In the hold-out assessment subset, sensitivity was 0.53, specificity was 0.70, accuracy was 0.70, and AUC was 0.61. These estimates indicate modest discrimination and should be interpreted cautiously because only 36 outcome events were available. Conclusions: This exploratory clinical score showed modest discrimination for all-cause in-hospital mortality and should be regarded as a preliminary, hypothesis-generating risk-stratification approach. It is not sufficiently validated for routine prognostic classification, platelet-reactivity triage, or antiplatelet treatment selection. Model redevelopment using event-efficient methods, resampling-based internal validation, and subsequent external validation are required before clinical implementation.
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(This article belongs to the Section Cardiac and Cardiovascular Systems)
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Open AccessArticle
Calcaneal Insufficiency Fracture: An Underrecognized Cause of Atraumatic Heel Pain in Older Adults
by
Koji Nozaka and Naohisa Miyakoshi
Clin. Pract. 2026, 16(8), 148; https://doi.org/10.3390/clinpract16080148 - 13 Aug 2026
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Background/Objectives: Calcaneal insufficiency fractures may be overlooked in older adults presenting with atraumatic heel-region pain because early radiographic findings can be absent or inconclusive. Evidence regarding how often these fractures are identified in routine outpatient practice remains limited. This study aimed to
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Background/Objectives: Calcaneal insufficiency fractures may be overlooked in older adults presenting with atraumatic heel-region pain because early radiographic findings can be absent or inconclusive. Evidence regarding how often these fractures are identified in routine outpatient practice remains limited. This study aimed to describe the observed frequency, diagnostic pathway, clinical characteristics, treatment, and documented clinical course of calcaneal insufficiency fractures in an orthopaedic outpatient cohort. Methods: We retrospectively reviewed consecutive patients aged 60 years or older who presented with atraumatic pain localised to the heel or calcaneal region between April 2012 and March 2020. All patients underwent initial plain radiography. Follow-up radiography and MRI were performed selectively when weight-bearing heel pain persisted, radiographic findings remained negative or equivocal, and clinical suspicion of an occult fracture remained. Observed fracture frequencies and exact 95% confidence intervals (CIs) were calculated. Results: Among 123 included patients, calcaneal insufficiency fractures were identified in 10, corresponding to an observed frequency of 8.1% (95% CI, 4.0–14.4%). Among 89 independently ambulatory patients, 9 fractures were identified, corresponding to an observed subgroup frequency of 10.1% (95% CI, 4.7–18.3%). These subgroup findings were descriptive and were not adjusted for potential confounders. All 10 fracture cases occurred in women, with a mean age of 78.4 years. Osteoporosis was newly identified in all fracture cases; the mean femoral-neck T-score was −3.42. Four fractures were identified on radiographic findings, whereas six required MRI to establish the diagnosis after radiographs remained negative or inconclusive. All cases were managed non-operatively. The mean interval from symptom onset to the first documented clinical improvement or resolution of heel pain was 28.4 days, and no displacement or subsequent surgical intervention was documented during the available follow-up. Conclusions: In this retrospective single-centre cohort, calcaneal insufficiency fractures were identified in a subset of older adults presenting with atraumatic heel-region pain. The observed frequencies should be interpreted as descriptive estimates rather than population prevalence figures. Calcaneal insufficiency fracture may be considered when focal heel pain persists despite normal or equivocal initial radiographs, with repeat radiography and MRI considered according to the clinical context. Prospective studies using standardised imaging and follow-up protocols are needed.
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Open AccessReview
Vitamin D and Postpartum Depression: A Narrative Review
by
Afra Almashghouni, Haydar Hasan and Dimitrios Papandreou
Clin. Pract. 2026, 16(8), 147; https://doi.org/10.3390/clinpract16080147 - 8 Aug 2026
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Background/objective: Postpartum depression (PPD) is a significant public health issue affecting about 19% of mothers globally. It has well-documented impacts on maternal well-being, mother–infant relationships, and child developmental outcomes. At the same time, the level of vitamin D deficiency in women of reproductive
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Background/objective: Postpartum depression (PPD) is a significant public health issue affecting about 19% of mothers globally. It has well-documented impacts on maternal well-being, mother–infant relationships, and child developmental outcomes. At the same time, the level of vitamin D deficiency in women of reproductive age is very high (affecting 60–87 percent of pregnant women globally). The review aims to synthesize current evidence and highlight priority research areas to improve maternal mental health outcomes. Methods: A systematic literature search of PubMed, Scopus, and Google Scholar (2015–2026) was conducted, followed by narrative synthesis of mechanistic, observational, and interventional evidence. Results: Adequate vitamin D status may contribute to a reduced risk of postpartum depression through multiple interacting pathways, including serotonin synthesis and metabolism (via tryptophan hydroxylase 2 (TPH2) and monoamine oxidase-A (MAO-A) regulation), neuroplasticity via brain-derived neurotrophic factor (BDNF) signaling, and suppression of the pro-inflammatory cytokine cascade. Dose–response meta-analyses and large prospective cohort studies indicate consistent negative relationships between maternal vitamin D levels and postpartum depressive and anxiety symptoms with optimal serum 25-hydroxyvitamin D (25(OH)D) levels of 90–110 nmol/L. Conclusions: There is still limited evidence on the intervention; it is still methodologically diverse, and only a few randomized controlled trials have been carried out on specifically postpartum populations.
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Open AccessArticle
Guselkumab Every 4 Weeks as a Real-World Therapeutic Option for Psoriatic Arthritis Patients at High Risk of Joint Damage
by
Nicoletta Bernardini, Giorgio Marotta, Nevena Skroza, Dario Graceffa, Maria Consiglia Bragazzi, Lucia Finistauri Guacci, Ersilia Tolino, Francesca Paola Sasso, Umberto Gallo, Antonio Giovanni Richetta and Annunziata Dattola
Clin. Pract. 2026, 16(8), 146; https://doi.org/10.3390/clinpract16080146 - 7 Aug 2026
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Background: Guselkumab, a monoclonal antibody selectively targeting the p19 subunit of interleukin-23, is typically administered with an induction phase at weeks 0 and 4 followed by maintenance dosing every 8 weeks for the treatment of psoriatic arthritis (PsA). In Europe, a four-week regimen
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Background: Guselkumab, a monoclonal antibody selectively targeting the p19 subunit of interleukin-23, is typically administered with an induction phase at weeks 0 and 4 followed by maintenance dosing every 8 weeks for the treatment of psoriatic arthritis (PsA). In Europe, a four-week regimen (Q4W) has recently been approved for patients at high risk of joint damage progression; however, real-world evidence on this intensified schedule remains limited. This study aimed to evaluate the effectiveness and safety of guselkumab Q4W in routine clinical practice. Methods: This retrospective observational study included 18 PsA patients at high risk of structural damage treated with guselkumab Q4W at two psoriasis referral centers in the Lazio region of Italy. Baseline and 24-week clinical data were collected from medical records. Outcome measures included Disease Activity Index for Psoriatic Arthritis (DAPSA), Minimal Disease Activity (MDA), pain Visual Analog Scale (VAS), Dermatology Life Quality Index (DLQI), and Psoriasis Area and Severity Index (PASI). Results: After 24 weeks, mean DAPSA decreased from 34.3 ± 7.6 to 3.7 ± 3.0; 55.6% of patients achieved DAPSA remission and 77.8% achieved MDA. Significant improvements were observed in pain VAS, DLQI, and PASI scores. All patients achieved PASI 75, while 83.3% achieved PASI 90 and PASI 100. Treatment was generally well tolerated, with no adverse events or new safety signals documented during follow-up. Conclusions: In our study, guselkumab Q4W showed marked multidomain effectiveness and a favorable safety profile, supporting its use in PsA patients at high risk of joint damage progression.
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