Journal Description
Brain Sciences
Brain Sciences
is an international, peer-reviewed, open access journal on neuroscience published monthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, Embase, PSYNDEX, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 12.9 days after submission; acceptance to publication is undertaken in 2.5 days (median values for papers published in this journal in the first half of 2024).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
2.7 (2023);
5-Year Impact Factor:
3.0 (2023)
Latest Articles
Neural Substrates for Early Data Reduction in Fast Vision: A Psychophysical Investigation
Brain Sci. 2024, 14(8), 753; https://doi.org/10.3390/brainsci14080753 - 26 Jul 2024
Abstract
To ensure survival, the visual system must rapidly extract the most important elements from a large stream of information. This necessity clashes with the computational limitations of the human brain, so a strong early data reduction is required to efficiently process information in
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To ensure survival, the visual system must rapidly extract the most important elements from a large stream of information. This necessity clashes with the computational limitations of the human brain, so a strong early data reduction is required to efficiently process information in fast vision. A theoretical early vision model, recently developed to preserve maximum information using minimal computational resources, allows efficient image data reduction by extracting simplified sketches containing only optimally informative, salient features. Here, we investigate the neural substrates of this mechanism for optimal encoding of information, possibly located in early visual structures. We adopted a flicker adaptation paradigm, which has been demonstrated to specifically impair the contrast sensitivity of the magnocellular pathway. We compared flicker-induced contrast threshold changes in three different tasks. The results indicate that, after adapting to a uniform flickering field, thresholds for image discrimination using briefly presented sketches increase. Similar threshold elevations occur for motion discrimination, a task typically targeting the magnocellular system. Instead, contrast thresholds for orientation discrimination, a task typically targeting the parvocellular system, do not change with flicker adaptation. The computation performed by this early data reduction mechanism seems thus consistent with magnocellular processing.
Full article
(This article belongs to the Section Behavioral Neuroscience)
Open AccessArticle
Neural Dynamics of Processing Inflectional Morphology: An fMRI Study on Korean Inflected Verbs
by
Joonwoo Kim, Sangyub Kim and Kichun Nam
Brain Sci. 2024, 14(8), 752; https://doi.org/10.3390/brainsci14080752 - 26 Jul 2024
Abstract
The present study aimed to elucidate the neural mechanisms underpinning the visual recognition of morphologically complex verbs in Korean, a morphologically rich, agglutinative language with inherent polymorphemic characteristics. In an fMRI experiment with a lexical decision paradigm, we investigated whether verb inflection types
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The present study aimed to elucidate the neural mechanisms underpinning the visual recognition of morphologically complex verbs in Korean, a morphologically rich, agglutinative language with inherent polymorphemic characteristics. In an fMRI experiment with a lexical decision paradigm, we investigated whether verb inflection types (base, regular, and irregular) are processed through separate mechanisms or a single system. Furthermore, we explored the semantic influence in processing inflectional morphology by manipulating the semantic ambiguity (homonymous vs. unambiguous) of inflected verbs. The results showed equivalent activation levels in the left inferior frontal gyrus for both regular and irregular verbs, challenging the dichotomy between the two. Graded effects of verb regularity were observed in the occipitotemporal regions, with regular inflections eliciting increased activation in the fusiform and lingual gyri. In the middle occipital gyrus, homonyms showed decreased activation relative to that of unambiguous words, specifically for base and irregular forms. Furthermore, the angular gyrus exhibited significant modulation with all verb types, indicating a semantic influence during morphological processing. These findings support single-system theories and the connectionist framework, challenging the assumptions of purely orthographic morphological decomposition and dual-mechanism accounts. Furthermore, they provide evidence for a semantic influence during morphological processing, with differential reliance on semantic activation for regular and irregular inflections.
Full article
(This article belongs to the Special Issue Neuropsychology of Reading)
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Open AccessReview
Understanding the Effect of Listening to Music, Playing Music, and Singing on Brain Function: A Scoping Review of fNIRS Studies
by
Keya Ding, Jingwen Li, Xuemei Li and Hui Li
Brain Sci. 2024, 14(8), 751; https://doi.org/10.3390/brainsci14080751 - 26 Jul 2024
Abstract
Music is integrated into daily life when listening to it, playing it, and singing, uniquely modulating brain activity. Functional near-infrared spectroscopy (fNIRS), celebrated for its ecological validity, has been used to elucidate this music–brain interaction. This scoping review synthesizes 22 empirical studies using
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Music is integrated into daily life when listening to it, playing it, and singing, uniquely modulating brain activity. Functional near-infrared spectroscopy (fNIRS), celebrated for its ecological validity, has been used to elucidate this music–brain interaction. This scoping review synthesizes 22 empirical studies using fNIRS to explore the intricate relationship between music and brain function. This synthesis of existing evidence reveals that diverse musical activities, such as listening to music, singing, and playing instruments, evoke unique brain responses influenced by individual traits and musical attributes. A further analysis identifies five key themes, including the effect of passive and active music experiences on relevant human brain areas, lateralization in music perception, individual variations in neural responses, neural synchronization in musical performance, and new insights fNIRS has revealed in these lines of research. While this review highlights the limited focus on specific brain regions and the lack of comparative analyses between musicians and non-musicians, it emphasizes the need for future research to investigate the complex interplay between music and the human brain.
Full article
(This article belongs to the Section Sensory and Motor Neuroscience)
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Open AccessArticle
Eye Tracking-Based Characterization of Fixations during Reading in Children with Neurodevelopmental Disorders
by
Carmen Bilbao, Alba Carrera, Sofia Otin and David P. Piñero
Brain Sci. 2024, 14(8), 750; https://doi.org/10.3390/brainsci14080750 - 26 Jul 2024
Abstract
An efficient mode of evaluation for eye movements is the use of objective eye tracking systems combined with subjective tests (NSUCO or DEM), which are easily applicable across all age groups and in eye care clinical settings. The objective of this study was
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An efficient mode of evaluation for eye movements is the use of objective eye tracking systems combined with subjective tests (NSUCO or DEM), which are easily applicable across all age groups and in eye care clinical settings. The objective of this study was to characterize fixations during reading in two groups: a group of children with neurodevelopmental disorders (NDDG, 24 children, age: 6–12 years) and a group of children with oculomotor anomalies but without NDD (OAG, 24 children, age: 6–12 years). The results obtained were compared with those from a control group (CG, 20 children, age: 6–12 years). Specifically, the outcomes obtained with two subjective score systems, the Northeastern State University College of Optometry’s Oculomotor (NSUCO) test and the Developmental Eye Movement (DEM) test, were compared with the objective analysis obtained through a commercially available eye tracker (Tobii Eye X, Tobii, Stockholm, Sweden). Specialized analysis software, namely Clinical Eye Tracker 2020 (Thomson Software Solutions, Welham Green, UK), was used. It was found that children with NDD had impaired oculomotor skills. A higher number of regressions, more fixations, and longer durations of fixations appear to be characteristic signs of this population group. Additionally, children with NDD took longer to complete the DEM test, as well as exhibiting more errors. The use of objective videoculographic systems for eye tracking and subjective tests like the NSUCO or DEM are good tools to assess saccadic movements, allowing the detection of oculomotor abnormalities in children with NDD.
Full article
(This article belongs to the Special Issue Advances in ADHD—Second Edition)
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Open AccessArticle
Effect of Spatial and Temporal Prediction on Tactile Sensitivity
by
Hiroshi Kunimura, Hitoshi Oda, Taku Kawasaki, Han Gao, Shiho Fukuda and Koichi Hiraoka
Brain Sci. 2024, 14(8), 749; https://doi.org/10.3390/brainsci14080749 - 26 Jul 2024
Abstract
The purpose of the present study was to examine whether spatial or temporal prediction of the tactile stimulus contributes to tactile sensitivity. To investigate the effect of spatial prediction on tactile sensitivity, electrical stimuli were provided for the digit nerve in one of
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The purpose of the present study was to examine whether spatial or temporal prediction of the tactile stimulus contributes to tactile sensitivity. To investigate the effect of spatial prediction on tactile sensitivity, electrical stimuli were provided for the digit nerve in one of five fingers, and advanced notice of the stimulating finger was provided before the stimulus in some trials but not in others. There was no significant effect of spatial prediction on the intensity at the perceptual threshold of the digit nerve stimulus. This indicates that spatial prediction of the tactile stimulus does not influence tactile sensitivity. To examine the effect of temporal prediction, an auditory warning cue was provided 0, 1, or 10 s before the electrical stimulus to the digit nerve. The stimulus intensity at the perceptual threshold in the trials with the 1 s warning cue was lower than those with the 0 s warning cue. This indicates that temporal prediction enhances tactile sensitivity. The stimulus intensity at the perceptual threshold in the trials with the 1 s warning cue was lower than those with the 10 s warning cue. This means that the contribution of temporal prediction to the tactile sensitivity is greater as the warning cue is closer to the time of the stimulus. This finding may be explained by a defense mechanism activated when humans predict that a tactile stimulus is coming soon.
Full article
(This article belongs to the Section Sensory and Motor Neuroscience)
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Open AccessSystematic Review
Neuromodulation Treatments Targeting Pathological Synchrony for Tinnitus in Adults: A Systematic Review
by
Derek J. Hoare, Gillian W. Shorter, Giriraj S. Shekhawat, Amr El Refaie, Bas Labree and Magdalena Sereda
Brain Sci. 2024, 14(8), 748; https://doi.org/10.3390/brainsci14080748 - 26 Jul 2024
Abstract
(1) Background: Tinnitus involves the conscious awareness of a tonal or composite noise for which there is no identifiable corresponding external acoustic source. For many people, tinnitus is a disorder associated with symptoms of emotional distress, cognitive dysfunction, autonomic arousal, behavioural changes, and
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(1) Background: Tinnitus involves the conscious awareness of a tonal or composite noise for which there is no identifiable corresponding external acoustic source. For many people, tinnitus is a disorder associated with symptoms of emotional distress, cognitive dysfunction, autonomic arousal, behavioural changes, and functional disability. Many symptoms can be addressed effectively using education or cognitive behavioural therapy. However, there is no treatment that effectively reduces or alters tinnitus-related neurophysiological activity and thus the tinnitus percept. In this systematic review, we evaluated the effectiveness of neuromodulation therapies for tinnitus that explicitly target pathological synchronous neural activity. (2) Methods: Multiple databases were searched for randomised controlled trials of neuromodulation interventions for tinnitus in adults, with 24 trials included. The risk of bias was assessed, and where appropriate, meta-analyses were performed. (3) Results: Few trials used acoustic, vagal nerve, or transcranial alternating current stimulation, or bimodal stimulation techniques, with limited evidence of neuromodulation or clinical effectiveness. Multiple trials of transcranial direct current stimulation (tDCS) were identified, and a synthesis demonstrated a significant improvement in tinnitus symptom severity in favour of tDCS versus control, although heterogeneity was high. (4) Discussion: Neuromodulation for tinnitus is an emerging but promising field. Electrical stimulation techniques are particularly interesting, given recent advances in current flow modelling that can be applied to future studies.
Full article
(This article belongs to the Special Issue Central Aspects of Tinnitus: Advances in Mechanisms and Neuromodulation)
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Open AccessArticle
Do Psoriasis and Atopic Dermatitis Affect Memory, Attention, Stress and Emotions?
by
Marcin Kuryłło, Ewa Mojs, Natalia Woźniak and Dorota Wiśniewska-Szeplewicz
Brain Sci. 2024, 14(8), 747; https://doi.org/10.3390/brainsci14080747 - 25 Jul 2024
Abstract
Background: Psoriasis and atopic dermatitis are chronic skin diseases found all over the world that cause a lot of suffering to patients. Objectives: The aim of this study was to answer the following questions: whether people suffering from psoriasis and AD have greater
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Background: Psoriasis and atopic dermatitis are chronic skin diseases found all over the world that cause a lot of suffering to patients. Objectives: The aim of this study was to answer the following questions: whether people suffering from psoriasis and AD have greater problems with recognizing emotions, the effectiveness of attention and memory processes, and whether they use different strategies of coping with stress than healthy people. Methods: This study involved 90 patients, including 30 patients with psoriasis, 30 patients with AD and 30 healthy patients, aged 21 to 63 years, including 54 women and 36 men. This study used a battery of the CANTAB Cognitive Tests, Mini-COPE Questionnaire Inventory, Toronto Alexithymia Scale TAS Questionnaire, Psoriasis Area and Severity Index, and Eczema Area and Severity Index. Results: People with psoriasis and AD had higher total scores on the alexithymia scale and had greater difficulty in identifying and verbalizing emotions. People with psoriasis and AD are less likely to choose the correct stimulus and achieve a shorter length of the sequence that should be remembered. Psoriasis patients with more severe symptoms are less likely to use the strategy of a sense of humor in stressful situations. AD patients with more severe symptoms are less likely to use strategies of operative thinking, denial and self-blame, and the strategy of seeking instrumental support is used more often. Conclusions: Patients with psoriasis and AD require a holistic approach; in addition to dermatological treatment, psychological support, psychotherapeutic support and possible psychiatric treatment are recommended.
Full article
(This article belongs to the Section Neuropsychology)
Open AccessSystematic Review
A Meta-Analysis of the Reliability of Second Language Listening Tests (1991–2022)
by
Yuxin Shang, Vahid Aryadoust and Zhuohan Hou
Brain Sci. 2024, 14(8), 746; https://doi.org/10.3390/brainsci14080746 - 25 Jul 2024
Abstract
To investigate the reliability of L2 listening tests and explore potential factors affecting the reliability, a reliability generalization (RG) meta-analysis was conducted in the present study. A total number of 122 alpha coefficients of L2 listening tests from 92 published articles were collected
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To investigate the reliability of L2 listening tests and explore potential factors affecting the reliability, a reliability generalization (RG) meta-analysis was conducted in the present study. A total number of 122 alpha coefficients of L2 listening tests from 92 published articles were collected and submitted to a linear mixed effects RG analysis. The papers were coded based on a coding scheme consisting of 16 variables classified into three categories: study features, test features, and statistical results. The results showed an average reliability of 0.818 (95% CI: 0.803 to 0.833), with 40% of reliability estimates falling below the lower bound of CI. The presence of publication bias and heterogeneity was found in the reliability of L2 listening tests, indicating that low reliability coefficients were likely omitted from some published studies. In addition, two factors predicting the reliability of L2 listening tests were the number of items and test type (standardized and researcher- or teacher-designed tests). The study also found that reliability is not a moderator of the relationship between L2 listening scores and theoretically relevant constructs. Reliability induction was identified in reporting the reliability of L2 listening tests, too. Implications for researchers and teachers are discussed.
Full article
(This article belongs to the Section Neurolinguistics)
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Open AccessArticle
Gruppo Otologico’s Experience in Managing the So-Called Inoperable Tympanojugular Paraganglioma
by
Mario Sanna, Mohammed Al-Khateeb, Melcol Hailu Yilala, Mohanad Almashhadani and Giuseppe Fancello
Brain Sci. 2024, 14(8), 745; https://doi.org/10.3390/brainsci14080745 - 25 Jul 2024
Abstract
Objective: to identify advanced or “so-called inoperable” cases of tympanojugular paragangliomas (PGLs) and analyze how each case is surgically managed and followed afterward. Study Design: a retrospective case series study. Methods: Out of 262 type C and D TJPs and more
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Objective: to identify advanced or “so-called inoperable” cases of tympanojugular paragangliomas (PGLs) and analyze how each case is surgically managed and followed afterward. Study Design: a retrospective case series study. Methods: Out of 262 type C and D TJPs and more than 10 cases of advanced or so-called inoperable cases, files of 6 patients with a diagnosis of advanced tympanojugular PGLs who were referred to an otology and skull-base center between 1996 and 2021 were reviewed to analyze management and surgical outcomes. The criteria for choosing these cases involve having one or more of the following features: (1) a large-sized tumor; (2) a single ipsilateral internal carotid artery (ICA); (3) involvement of the vertebral artery; (4) a considerable involvement of the ICA; (5) an extension to the clivus, foramen magnum, and cavernous sinus; (6) large intradural involvement (IDE); and (7) bilateral or multiple PGLs. Results: The age range at presentation was 25–43 years old, with a mean of 40.5 years: two females and four males. The presenting symptoms were glossal atrophy, hearing loss, pulsatile tinnitus, dysphonia, shoulder weakness, and diplopia. The modified Infratemporal Fossa Approach (ITFA) with a transcondylar–transtubercular extension is the principal approach in most cases, with additional approaches being used accordingly. Conclusions: The contemporary introduction of carotid artery stenting with the direct and indirect embolization of PGLs has made it possible to operate on many cases, which was otherwise considered impossible to treat surgically. Generally, the key is to stage the removal of the tumor in multiple stages during the management of complex PGLs to decrease surgical morbidities. A crucial aspect is to centralize the treatment of PGLs in referral centers with experienced surgeons who are trained to plan the stages and manage possible surgical complications.
Full article
(This article belongs to the Special Issue Advances in Skull Base Tumor Surgery: The Practical Pearls)
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Open AccessArticle
The Interplay between Gender and Duration of Hospitalization Modulates Psychiatric Symptom Severity in Subjects with Long COVID-19
by
Alessio Simonetti, Antonio Restaino, Claudia Calderoni, Emanuela De Chiara, Antonio Maria D’Onofrio, Salvatore Lioniello, Giovanni Camardese, Delfina Janiri, Matteo Tosato, Francesco Landi and Gabriele Sani
Brain Sci. 2024, 14(8), 744; https://doi.org/10.3390/brainsci14080744 - 25 Jul 2024
Abstract
Long COVID-19 is characterized by ongoing symptoms or prolonged or long-term complications of SARS-CoV-2 contraction which persist beyond 4 weeks from the initial onset of symptoms. Gender and duration of hospitalization (DH) are key risk factors for developing long COVID-19 syndrome, but their
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Long COVID-19 is characterized by ongoing symptoms or prolonged or long-term complications of SARS-CoV-2 contraction which persist beyond 4 weeks from the initial onset of symptoms. Gender and duration of hospitalization (DH) are key risk factors for developing long COVID-19 syndrome, but their impact and interplay need further study. This research involved 996 long COVID-19 patients, and we compared the levels of general psychopathology, depression, agitated depression, anxiety, and medication use between hospitalized and non-hospitalized males and females. In the hospitalized patients, multivariate regressions assessed the impact of gender, DH, and the interaction of these variables. The females had higher levels of long COVID-19 symptoms, psychotropic drug use, depression, anxiety, and general psychopathology than the males. The non-hospitalized females exhibited more severe agitated depression than the non-hospitalized males. In females, DH was more strongly correlated with the number of psychotropic medications used during long COVID-19. A negative correlation was found between DH and severity of agitated depression in the female patients only. These results highlight that the gender-specific relationship between DH and agitated depression severity should be explored further.
Full article
(This article belongs to the Topic Multifaceted Efforts from Basic Research to Clinical Practice in Controlling COVID-19 Disease)
Open AccessArticle
Multiple Types of Developmental Dyslexias in a Shallow Orthography: Principles for Diagnostic Screening in Italian
by
Daniela Traficante, Claudio Luzzatti and Naama Friedmann
Brain Sci. 2024, 14(8), 743; https://doi.org/10.3390/brainsci14080743 - 25 Jul 2024
Abstract
A new dyslexia screening test for Italian, Tiltan-IT, is presented. The test was developed based on an integrated dual-route model of reading, which describes in detail specific mechanisms underpinning early visual processes as well as the lexical and the sublexical routes. The
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A new dyslexia screening test for Italian, Tiltan-IT, is presented. The test was developed based on an integrated dual-route model of reading, which describes in detail specific mechanisms underpinning early visual processes as well as the lexical and the sublexical routes. The principle according to which the test was developed is that each dyslexia type is manifested in different kinds of errors and in different kinds of stimuli, and we therefore included stimuli sensitive to each dyslexia type in the test. Tiltan-IT is a reading aloud test that includes word, nonword, and word pair lists. The test was administered to 618 Italian-speaking children (2nd–8th grade). Each error produced by the children was classified through the coding scheme developed to detect the different types of dyslexias described by the reading model. The Tiltan-IT was able to identify 110 children with dyslexia. The identified dyslexia types included letter position dyslexia, attentional dyslexia, letter identity dyslexia, surface dyslexia, vowel dyslexia, consonant conversion dyslexia, multi-letter phonological dyslexia, voicing dyslexia. The results confirm that the selection of items in the Tiltan-IT enabled the detection of the wide variety of dyslexias in Italian, some of them for the first time, adding evidence for the cross-linguistic validity of multiple types of developmental dyslexias and for the dual-route model of reading.
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(This article belongs to the Special Issue Neuropsychology of Reading)
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Open AccessArticle
Resting-State Functional Connectivity Profile of Insular Subregions
by
Jimmy Ghaziri, Phillip Fei, Alan Tucholka, Sami Obaid, Olivier Boucher, Isabelle Rouleau and Dang K. Nguyen
Brain Sci. 2024, 14(8), 742; https://doi.org/10.3390/brainsci14080742 - 25 Jul 2024
Abstract
The insula is often considered the fifth lobe of the brain and is increasingly recognized as one of the most connected regions in the brain, with widespread connections to cortical and subcortical structures. As a follow-up to our previous tractography work, we investigated
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The insula is often considered the fifth lobe of the brain and is increasingly recognized as one of the most connected regions in the brain, with widespread connections to cortical and subcortical structures. As a follow-up to our previous tractography work, we investigated the resting-state functional connectivity (rsFC) profiles of insular subregions and assessed their concordance with structural connectivity. We used the CONN toolbox to analyze the rsFC of the same 19 insular regions of interest (ROIs) we used in our prior tractography work and regrouped them into six subregions based on their connectivity pattern similarity. Our analysis of 50 healthy participants confirms the known broad connectivity of the insula and shows novel and specific whole-brain and intra-connectivity patterns of insular subregions. By examining such subregions, our findings provide a more detailed pattern of connectivity than prior studies that may prove useful for comparison between patients.
Full article
(This article belongs to the Section Neurosurgery and Neuroanatomy)
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Open AccessReview
The Role of the Thalamus in Nociception: Important but Forgotten
by
Giovane Galdino, Flavio Protasio Veras and Tayllon dos Anjos-Garcia
Brain Sci. 2024, 14(8), 741; https://doi.org/10.3390/brainsci14080741 - 25 Jul 2024
Abstract
Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons. These second-order neurons carry the nociceptive stimulus
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Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons. These second-order neurons carry the nociceptive stimulus to supraspinal regions, notably the thalamus. Although extensive research has focused on spinal-level nociceptive mechanisms (e.g., neurotransmitters, receptors, and glial cells), the thalamus is still poorly elucidated. The role of the thalamus in relaying sensory and motor responses to the cortex is well known. However, a comprehensive understanding of the mechanisms in the synapse between the second-order and third-order neurons that transmit this impulse to the somatosensory cortex, where the response is processed and interpreted as pain, is still lacking. Thus, this review investigated the thalamus’s role in transmitting nociceptive impulses. Current evidence indicates the involvement of the neurotransmitters glutamate and serotonin, along with NMDA, P2X4, TLR4, FGR, and NLRP3 receptors, as well as signaling pathways including ERK, P38, NF-κB, cytokines, and glial cells at nociceptive synapses within the thalamus.
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(This article belongs to the Special Issue Advances in Neuroinflammation and Pain Medicine)
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Open AccessSystematic Review
Exploring Pathways for Pain Relief in Treatment and Management of Lumbar Foraminal Stenosis: A Review of the Literature
by
Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Medet Dosanov, Abakirov Medetbek, Stepan Kudryakov, Gervith Reyes Soto, Claudia B. Ponce Espinoza, Jeff Natalaja Mukengeshay, Tshiunza Mpoyi Cherubin, Vladimir Nikolenko, Artem Gushcha, Salman Sharif and Nicola Montemurro
Brain Sci. 2024, 14(8), 740; https://doi.org/10.3390/brainsci14080740 - 24 Jul 2024
Abstract
Background: Lumbar foraminal stenosis (LFS) involves the narrowing of neural foramina, leading to nerve compression, significant lower back pain and radiculopathy, particularly in the aging population. Management includes physical therapy, medications and potentially invasive surgeries such as foraminotomy. Advances in diagnostic and treatment
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Background: Lumbar foraminal stenosis (LFS) involves the narrowing of neural foramina, leading to nerve compression, significant lower back pain and radiculopathy, particularly in the aging population. Management includes physical therapy, medications and potentially invasive surgeries such as foraminotomy. Advances in diagnostic and treatment strategies are essential due to LFS’s complexity and prevalence, which underscores the importance of a multidisciplinary approach in optimizing patient outcomes. Method: This literature review on LFS employed a systematic methodology to gather and synthesize recent scientific data. A comprehensive search was conducted across PubMed, Scopus and Cochrane Library databases using specific keywords related to LFS. The search, restricted to English language articles from 1 January 2000 to 31 December 2023, focused on peer-reviewed articles, clinical trials and reviews. Due to the heterogeneity among the studies, data were qualitatively synthesized into themes related to diagnosis, treatment and pathophysiology. Results: This literature review on LFS analyzed 972 articles initially identified, from which 540 remained after removing duplicates. Following a rigorous screening process, 20 peer-reviewed articles met the inclusion criteria and were reviewed. These studies primarily focused on evaluating the diagnostic accuracy, treatment efficacy and pathophysiological insights into LFS. Conclusion: The comprehensive review underscores the necessity for precise diagnostic and management strategies for LFS, highlighting the role of a multidisciplinary approach and the utility of a unified classification system in enhancing patient outcomes in the face of this condition’s increasing prevalence.
Full article
(This article belongs to the Special Issue New Trends and Technologies in Modern Neurosurgery)
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Open AccessArticle
You’re Beautiful When You Smile: Event-Related Brain Potential (ERP) Evidence of Early Opposite-Gender Bias in Happy Faces
by
Jonas Schmuck, Emely Voltz and Henning Gibbons
Brain Sci. 2024, 14(8), 739; https://doi.org/10.3390/brainsci14080739 - 24 Jul 2024
Abstract
Studies of social cognition have shown gender differences regarding human face processing. One interesting finding is the enhanced processing of opposite-gender faces at different time stages, as revealed by event-related brain potentials. Crucially, from an evolutionary perspective, such a bias might interact with
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Studies of social cognition have shown gender differences regarding human face processing. One interesting finding is the enhanced processing of opposite-gender faces at different time stages, as revealed by event-related brain potentials. Crucially, from an evolutionary perspective, such a bias might interact with the emotional expression of the face. To investigate this, 100 participants (50 female, 50 male) completed an expression-detection task while their EEG was recorded. In three blocks, fearful, happy and neutral faces (female and male) were randomly presented, with participants instructed to respond to only one predefined target expression level in each block. Using linear mixed models, we observed both faster reaction times as well as larger P1 and late positive potential (LPP) amplitudes for women compared to men, supporting a generally greater female interest in faces. Highly interestingly, the analysis revealed an opposite-gender bias at P1 for happy target faces. This suggests that participants’ attentional templates may include more opposite-gender facial features when selectively attending to happy faces. While N170 was influenced by neither the face nor the participant gender, LPP was modulated by the face gender and specific combinations of the target status, face gender and expression, which is interpreted in the context of gender-emotion stereotypes. Future research should further investigate this expression and attention dependency of early opposite-gender biases.
Full article
(This article belongs to the Special Issue EEG and Event-Related Potentials)
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Open AccessArticle
Individual Deviation-Based Functional Hypergraph for Identifying Subtypes of Autism Spectrum Disorder
by
Jialong Li, Weihao Zheng, Xiang Fu, Yu Zhang, Songyu Yang, Ying Wang, Zhe Zhang, Bin Hu and Guojun Xu
Brain Sci. 2024, 14(8), 738; https://doi.org/10.3390/brainsci14080738 - 24 Jul 2024
Abstract
Heterogeneity has been one of the main barriers to understanding and treatment of autism spectrum disorder (ASD). Previous studies have identified several subtypes of ASD through unsupervised clustering analysis. However, most of them primarily depicted the pairwise similarity between individuals through second-order relationships,
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Heterogeneity has been one of the main barriers to understanding and treatment of autism spectrum disorder (ASD). Previous studies have identified several subtypes of ASD through unsupervised clustering analysis. However, most of them primarily depicted the pairwise similarity between individuals through second-order relationships, relying solely on patient data for their calculation. This leads to an underestimation of the complexity inherent in inter-individual relationships and the diagnostic information provided by typical development (TD). To address this, we utilized an elastic net model to construct an individual deviation-based hypergraph (ID-Hypergraph) based on functional MRI data. We then conducted a novel community detection clustering algorithm to the ID-Hypergraph, with the aim of identifying subtypes of ASD. By applying this framework to the Autism Brain Imaging Data Exchange repository data (discovery: 147/125, ASD/TD; replication: 134/132, ASD/TD), we identified four reproducible ASD subtypes with roughly similar patterns of ALFF between the discovery and replication datasets. Moreover, these subtypes significantly varied in communication domains. In addition, we achieved over 80% accuracy for the classification between these subtypes. Taken together, our study demonstrated the effectiveness of identifying subtypes of ASD through the ID-hypergraph, highlighting its potential in elucidating the heterogeneity of ASD and diagnosing ASD subtypes.
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(This article belongs to the Special Issue Deep into the Brain: Artificial Intelligence in Brain Diseases)
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Open AccessReview
DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?
by
Hanieh Gholamalizadeh, Maedeh Amiri-Shahri, Fatemeh Rasouli, Arina Ansari, Vafa Baradaran Rahimi and Vahid Reza Askari
Brain Sci. 2024, 14(8), 737; https://doi.org/10.3390/brainsci14080737 - 23 Jul 2024
Abstract
Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disabilities with persistent impairments in cognition, communication, and social behavior. Although environmental factors play a role in ASD etiopathogenesis, a growing body of evidence indicates that ASD is highly inherited. In the last
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Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disabilities with persistent impairments in cognition, communication, and social behavior. Although environmental factors play a role in ASD etiopathogenesis, a growing body of evidence indicates that ASD is highly inherited. In the last two decades, the dramatic rise in the prevalence of ASD has interested researchers to explore the etiologic role of epigenetic marking and incredibly abnormal DNA methylation. This review aimed to explain the current understanding of the association between changes in DNA methylation signatures and ASD in patients or animal models. We reviewed studies reporting alterations in DNA methylation at specific genes as well as epigenome-wide association studies (EWASs). Finally, we hypothesized that specific changes in DNA methylation patterns could be considered a potential biomarker for ASD diagnosis and prognosis and even a target for pharmacological intervention.
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(This article belongs to the Section Environmental Neuroscience)
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Open AccessArticle
Identifying the Shared and Dissociable Neural Bases between Self-Worth and Moral Ambivalence
by
Jiwen Li, Shuai Wang, Tengfei Du, Jianchao Tang and Juan Yang
Brain Sci. 2024, 14(7), 736; https://doi.org/10.3390/brainsci14070736 - 22 Jul 2024
Abstract
Self-ambivalence, a prevalent phenomenon in daily life, has been increasingly substantiated by research. It refers to conflicting self-views and evaluations, primarily concerning self-worth and morality. Previous behavioral research has distinguished self-worth and moral ambivalence, but it remains unclear whether they have separable neural
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Self-ambivalence, a prevalent phenomenon in daily life, has been increasingly substantiated by research. It refers to conflicting self-views and evaluations, primarily concerning self-worth and morality. Previous behavioral research has distinguished self-worth and moral ambivalence, but it remains unclear whether they have separable neural bases. The present study addressed this question by examining resting-state brain activity (i.e., the fractional amplitude of low-frequency fluctuations, fALFF) and connectivity (i.e., resting-state functional connectivity, RSFC) in 112 college students. The results found that self-worth ambivalence was positively related to the fALFF in the orbitofrontal cortex (OFC) and left superior parietal lobule (SPL). The RSFC strength between the SPL and precuneus/posterior cingulate cortex (PCC) was positively related to self-worth ambivalence. Moral ambivalence was positively associated with the fALFF in the left SPL (extending into the temporoparietal junction) and right SPL. The RSFC strengths between the left SPL/TPJ and OFC, as well as the RSFC strengths between the right SPL as a seed and the bilateral middle and inferior temporal gyrus, were associated with moral ambivalence. Overall, the neural bases of self-worth and moral ambivalence are associated with the SPL and OFC, involved in attentional alertness and value representation, respectively. Additionally, the neural basis of moral ambivalence is associated with the TPJ, responsible for mentalizing.
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(This article belongs to the Section Neurotechnology and Neuroimaging)
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Open AccessArticle
An Unavoidable Mind-Set Reversal: Consciousness in Vision Science
by
Liliana Albertazzi
Brain Sci. 2024, 14(7), 735; https://doi.org/10.3390/brainsci14070735 - 22 Jul 2024
Abstract
In recent decades, the debate on consciousness has been conditioned by the idea of bottom-up emergence, which has influenced scientific research and raised a few obstacles to any attempt to bridge the explanatory gap. The analysis and explanation of vision conducted according to
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In recent decades, the debate on consciousness has been conditioned by the idea of bottom-up emergence, which has influenced scientific research and raised a few obstacles to any attempt to bridge the explanatory gap. The analysis and explanation of vision conducted according to the accredited methodologies of scientific research in terms of physical stimuli, objectivity, methods, and explanation has encountered the resistance of subjective experience. Moreover, original Gestalt research into vision has generally been merged with cognitive neuroscience. Experimental phenomenology, building on the legacy of Gestalt psychology, has obtained new results in the fields of amodal contours and color stratifications, light perception, figurality, space, so-called perceptual illusions, and subjective space and time. Notwithstanding the outcomes and the impulse given to neuroscientific analyses, the research carried out around these phenomena has never directly confronted the issue of what it means to be conscious or, in other words, the nature of consciousness as self-referentiality. Research has tended to focus on the percept. Therefore, explaining the non-detachability of parts in subjective experience risks becoming a sort of impossible achievement, similar to that of Baron Munchausen, who succeeds in escaping unharmed from this quicksand by pulling himself out by his hair. This paper addresses how to analyze seeing as an undivided whole by discussing several basic dimensions of phenomenal consciousness on an experimental basis and suggesting an alternative way of escaping this quicksand. This mind-set reversal also sheds light on the organization and dependence relationships between phenomenology, psychophysics, and neuroscience.
Full article
(This article belongs to the Special Issue From Visual Perception to Consciousness)
Open AccessArticle
Emotional and Cognitive “Route” in Decision-Making Process: The Relationship between Executive Functions, Psychophysiological Correlates, Decisional Styles, and Personality
by
Davide Crivelli, Carlotta Acconito and Michela Balconi
Brain Sci. 2024, 14(7), 734; https://doi.org/10.3390/brainsci14070734 - 22 Jul 2024
Abstract
Studies on decision-making have classically focused exclusively on its cognitive component. Recent research has shown that a further essential component of decisional processes is the emotional one. Indeed, the emotional route in decision-making plays a crucial role, especially in situations characterized by ambiguity,
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Studies on decision-making have classically focused exclusively on its cognitive component. Recent research has shown that a further essential component of decisional processes is the emotional one. Indeed, the emotional route in decision-making plays a crucial role, especially in situations characterized by ambiguity, uncertainty, and risk. Despite that, individual differences concerning such components and their associations with individual traits, decisional styles, and psychophysiological profiles are still understudied. This pilot study aimed at investigating the relationship between individual propensity toward using an emotional or cognitive information-processing route in decision-making, EEG and autonomic correlates of the decisional performance as collected via wearable non-invasive devices, and individual personality and decisional traits. Participants completed a novel task based on realistic decisional scenarios while their physiological activity (EEG and autonomic indices) was monitored. Self-report questionnaires were used to collect data on personality traits, individual differences, and decisional styles. Data analyses highlighted two main findings. Firstly, different personality traits and decisional styles showed significant and specific correlations, with an individual propensity toward either emotional or cognitive information processing for decision-making. Secondly, task-related EEG and autonomic measures presented a specific and distinct correlation pattern with different decisional styles, maximization traits, and personality traits, suggesting different latent profiles.
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(This article belongs to the Section Social Cognitive and Affective Neuroscience)
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