Announcements

The following are the Editor’s Choice Articles in the Section “Cells of the Nervous System” of Cells (ISSN: 2073-4409) in 2020–2021: 

1. “Neuron–Glia Interactions in Neurodevelopmental Disorders”
by Kim, Y.S.; Choi, J.; Yoon, B.-E.
Cells 2020, 9(10), 2176; https://doi.org/10.3390/cells9102176 

2. “Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke”
by Santopolo, G.; Magnusson, J.P.; Lindvall, O.; Kokaia, Z.; Frisén, J.
Cells 2020, 9(7), 1732; https://doi.org/10.3390/cells9071732 

3. “Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse”
by Walker, C.D.; Risher, W.C.; Risher, M.-L.
Cells 2020, 9(2), 297; https://doi.org/10.3390/cells9020297 

4. “Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum”
by Fernando, S.; Allan, C.Y.; Mroczek, K.; Pearce, X.; Sanislav, O.; Fisher, P.R.; Annesley, S.J.
Cells 2020, 9(10), 2289; https://doi.org/10.3390/cells9102289 

5. “Linking Autism Risk Genes to Disruption of Cortical Development”
by Garcia-Forn, M.; Boitnott, A.; Akpinar, Z.; De Rubeis, S.
Cells 2020, 9(11), 2500; https://doi.org/10.3390/cells9112500 

6. “Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways”
by Preman, P.; Alfonso-Triguero, M.; Alberdi, E.; Verkhratsky, A.; Arranz, A.M.
Cells 2021, 10(3), 540; https://doi.org/10.3390/cells10030540 

7. “Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives”
by Raffaele, S.; Boccazzi, M.; Fumagalli, M.
Cells 2021, 10(3), 565; https://doi.org/10.3390/cells10030565

8. “Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease”
by Shukla, P.K.; Delotterie, D.F.; Xiao, J.; Pierre, J.F.; Rao, R.; McDonald, M.P.; Khan, M.M.
Cells 2021, 10(4), 779; https://doi.org/10.3390/cells10040779 

9. “Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models”
by Geloso, M.C.; D’Ambrosi, N.
Cells 2021, 10(3), 686; https://doi.org/10.3390/cells10030686 

10. “Regulatory Effects of Cannabidiol on Mitochondrial Functions: A Review”
by Chan, J.Z.; Duncan, R.E.
Cells 2021, 10(5), 1251; https://doi.org/10.3390/cells10051251

11. “Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy”
by Lange, F.; Hörnschemeyer, J.; Kirschstein, T.
Cells 2021, 10(5), 1226; https://doi.org/10.3390/cells10051226

“The Roles of Ubiquitin in Mediating Autophagy”
by Daniel J. Klionsky et al.
Cells 2020, 9(9), 2025; https://doi.org/10.3390/cells9092025
Available online: https://www.mdpi.com/2073-4409/9/9/2025 

“Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo”
by Sylviane Muller et al.
Cells 2020, 9(5), 1321; https://doi.org/10.3390/cells9051321
Available online: https://www.mdpi.com/2073-4409/9/5/1321 

“The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages”
by Isabelle Vergne et al.
Cells 2020, 9(3), 666; https://doi.org/10.3390/cells9030666
Available online: https://www.mdpi.com/2073-4409/9/3/666 

“p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4)”
by Ki-Young Lee et al.
Cells 2020, 9(5), 1142; https://doi.org/10.3390/cells9051142
Available online: https://www.mdpi.com/2073-4409/9/5/1142 

“VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1”
by Regine Heller et al.
Cells 2020, 9(3), 687; https://doi.org/10.3390/cells9030687
Available online: https://www.mdpi.com/2073-4409/9/3/687 

“Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond”
by Vladimir V. Rogov et al.
Cells 2020, 9(9), 2008; https://doi.org/10.3390/cells9092008
Available online: https://www.mdpi.com/2073-4409/9/9/2008

1. "Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening"
by Shan Li et al.
Cells 2021, 10(5), 1136; https://doi.org/10.3390/cells10051136
Available online: https://www.mdpi.com/2073-4409/10/5/1136 

2. "Insights into Plant Programmed Cell Death Induced by Heavy Metals—Discovering a Terra Incognita"
by Klaudia Sychta et al.
Cells 2021, 10(1), 65; https://doi.org/10.3390/cells10010065
Available online: https://www.mdpi.com/2073-4409/10/1/65

3. "The Relationship between the Antioxidant System and Proline Metabolism in the Leaves of Cucumber Plants Acclimated to Salt Stress"
by Marcin Naliwajski et al.
Cells 2021, 10(3), 609; https://doi.org/10.3390/cells10030609
Available online: https://www.mdpi.com/2073-4409/10/3/609 

4. “Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance”
by Rubén Alcázar et al.
Cells 2020, 9(11), 2373; https://doi.org/10.3390/cells9112373
Available online: https://www.mdpi.com/2073-4409/9/11/2373 

5. “Microautophagy in Plants: Consideration of Its Molecular Mechanism”
by Katarzyna Sieńko et al.
Cells 2020, 9(11), 2373; https://doi.org/10.3390/cells9112373
Available online: https://www.mdpi.com/2073-4409/9/4/887

6. “Stress Reshapes the Physiological Response of Halophile Fungi to Salinity”
by Yordanis Pérez-Llano et al.
Cells 2020, 9(3), 525; https://doi.org/10.3390/cells9030525
Available online: https://www.mdpi.com/2073-4409/9/3/525 

7. “Overexpression of the Selective Autophagy Cargo Receptor NBR1 Modifies Plant Response to Sulfur Deficit”
by Leszek Tarnowski et al.
Cells 2020, 9(3), 669; https://doi.org/10.3390/cells9030669
Available online: https://www.mdpi.com/2073-4409/9/3/669

The 2021 citation metrics have been released in the Journal Citation Reports (JCR), and we’re pleased to announce the following results for MDPI journals:

For more information on Impact Factors and what it means to index academic journals, please visit our related blog posts.

* Journals given their first Impact Factor in 2022

Source: 2021 Journal Impact Factors, Journal Citation Reports ^TM (Clarivate, 2022)

1. “How Soon Hath Time… A History of Two “Seminal” Publications”
by Parker, Geoff A. et al.
Cells 2021, 10(2), 287; https://doi.org/10.3390/cells10020287
Available online: https://www.mdpi.com/2073-4409/10/2/287 

2. “PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia”
by Bergman, Lina et al.
Cells 2021, 10(4), 959; https://doi.org/10.3390/cells10040959
Available online: https://www.mdpi.com/2073-4409/10/4/959

3. “ACE2 Is Expressed in Immune Cells That Infiltrate the Placenta in Infection-Associated Preterm Birth”
by Lye, Phetcharawan et al.
Cells 2021, 10(7), 1724; https://doi.org/10.3390/cells10071724
Available online: https://www.mdpi.com/2073-4409/10/7/1724 

4. “The Role of Mitochondria in Oocyte Maturation”
by Kirillova, Anastasia et al.
Cells 2021, 10(9), 2484; https://doi.org/10.3390/cells10092484
Available online: https://www.mdpi.com/2073-4409/10/9/2484

5. “In Vitro Fertilisation of Mouse Oocytes in L-Proline and L-Pipecolic Acid Improves Subsequent Development”
by Treleaven, Tamara et al.
Cells 2021, 10(6), 1352; https://doi.org/10.3390/cells10061352
Available online: https://www.mdpi.com/2073-4409/10/6/1352

6. “The Origin of the Cyathea delgadii Sternb. Somatic Embryos Is Determined by the Developmental State of Donor Tissue and Mutual Balance of Selected Metabolites”
by Mikuła, Anna et al.
Cells 2021, 10(6), 1388; https://doi.org/10.3390/cells10061388
Available online: https://www.mdpi.com/2073-4409/10/6/1388 

7. “Generation of a Highly Biomimetic Organoid, Including Vasculature, Resembling the Native Immature Testis Tissue”
by Cham, Tat-Chuan et al.
Cells 2021, 10(7), 1696; https://doi.org/10.3390/cells10071696
Available online: https://www.mdpi.com/2073-4409/10/7/1696

8. “Cerebral Organoids—Challenges to Establish a Brain Prototype”
by Eremeev, Artem V. et al.
Cells 2021, 10(7), 1790; https://doi.org/10.3390/cells10071790
Available online: https://www.mdpi.com/2073-4409/10/7/1790

9. “Longer Sperm Swim More Slowly in the Canary Islands Chiffchaff”
by Cramer, Emily R. A. et al.
Cells 2021, 10(6), 1358; https://doi.org/10.3390/cells10061358
Available online: https://www.mdpi.com/2073-4409/10/6/1358

10. “Vascular Dysfunction in Preeclampsia”
by Opichka, Megan A. et al.
Cells 2021, 10(11), 3055; https://doi.org/10.3390/cells10113055
Available online: https://www.mdpi.com/2073-4409/10/11/3055

1. “Precision Medicine: Steps along the Road to Combat Human Cancer”
by Nassar, Samuel F. et al.
Cells 2020, 9(9), 2056; https://doi.org/10.3390/cells9092056
Available online: https://www.mdpi.com/2073-4409/9/9/2056 

2. “Development of Artificial Plasma Membranes Derived Nanovesicles Suitable for Drugs Encapsulation”
by Martinelli, Carolina et al.
Cells 2020, 9(7), 1626; https://doi.org/10.3390/cells9071626
Available online: https://www.mdpi.com/2073-4409/9/7/1626 

3. “Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses”
by Humphries, Brock et al.
Cells 2020, 9(10), 2167; https://doi.org/10.3390/cells9102167
Available online: https://www.mdpi.com/2073-4409/9/10/2167 

4. “NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells”
by Kim, Beom Su
Cells 2020, 9(9), 2122; https://doi.org/10.3390/cells9092122
Available online: https://www.mdpi.com/2073-4409/9/9/2122 

5. “Rho Family of Ras-Like GTPases in Early-Branching Animals”
by Beljan, Silvestar et al.
Cells 2020, 9(10), 2279; https://doi.org/10.3390/cells9102279
Available online: https://www.mdpi.com/2073-4409/9/10/2279 

6. “Development of Radiotracers for Breast Cancer—The Tumor Microenvironment as an Emerging Target”
by Heesch, Amelie et al.
Cells 2020, 9(10), 2334; https://doi.org/10.3390/cells9102334
Available online: https://www.mdpi.com/2073-4409/9/10/2334

For further reading, please follow the link to the Editor's Choice Articles website: https://www.mdpi.com/journal/cells/editors_choice.

1. “Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia”
by Mone, Pasquale et al.
Cells 2021, 10(8), 2115; https://doi.org/10.3390/cells10082115
Available online: https://www.mdpi.com/2073-4409/10/8/2115 

2. “Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies”
by Brás, Inês C. et al.
Cells 2021, 10(2), 375; https://doi.org/10.3390/cells10020375
Available online: https://www.mdpi.com/2073-4409/10/2/375 

3. “The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging”
by Schank, Madison et al.
Cells 2021, 10(1), 174; https://doi.org/10.3390/cells10010174
Available online: https://www.mdpi.com/2073-4409/10/1/174 

4. “Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease”
by Casali, Brad T. et al.
Cells 2021, 10(4), 957; https://doi.org/10.3390/cells10040957
Available online: https://www.mdpi.com/2073-4409/10/4/957 

5. “Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis”
by Agarwal, Nikhil et al.
Cells 2021, 10(6), 1365; https://doi.org/10.3390/cells10061365
Available online: https://www.mdpi.com/2073-4409/10/6/1365 

6. “Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation”
by Loving, Bailey A. et al.
Cells 2021, 10(2), 198; https://doi.org/10.3390/cells10020198
Available online: https://www.mdpi.com/2073-4409/10/2/198 

7. “The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease”
by Vos, Melissa et al.
Cells 2021, 10(3), 579; https://doi.org/10.3390/cells10030579
Available online: https://www.mdpi.com/2073-4409/10/3/579 

8. “Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review”
by Edler, Melissa K. et al.
Cells 2021, 10(5), 1138; https://doi.org/10.3390/cells10051138
Available online: https://www.mdpi.com/2073-4409/10/5/1138 

9. “Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review”
by Bielach-Bazyluk, Angelika et al.
Cells 2021, 10(4), 813; https://doi.org/10.3390/cells10040813
Available online: https://www.mdpi.com/2073-4409/10/4/813 

10. “Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8+ EMRA Cells in the Elderly”
by Boßlau, Tim K. et al.
Cells 2021, 10(5), 998; https://doi.org/10.3390/cells10050998
Available online: https://www.mdpi.com/2073-4409/10/5/998

1. “Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy”
by Yoshida, Tadashi et al.
Cells 2020, 9(9), 1970; https://doi.org/10.3390/cells9091970
Available online: https://www.mdpi.com/2073-4409/9/9/1970 

2. “Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases”
by Song, Ping et al.
Cells 2020, 9(3), 671; https://doi.org/10.3390/cells9030671
Available online: https://www.mdpi.com/2073-4409/9/3/671 

3. “Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats”
by Malavolta, Marco et al.
Cells 2020, 9(4), 909; https://doi.org/10.3390/cells9040909
Available online: https://www.mdpi.com/2073-4409/9/4/909 

4. “Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy”
by Triana-Martínez, Francisco et al.
Cells 2020, 9(2), 346; https://doi.org/10.3390/cells9020346
Available online: https://www.mdpi.com/2073-4409/9/2/346 

5. “Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease”
by Cianflone, Eleonora et al.
Cells 2020, 9(6), 1558; https://doi.org/10.3390/cells9061558
Available online: https://www.mdpi.com/2073-4409/9/6/1558 

6. “IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer”
by Cai, Qing et al.
Cells 2020, 9(5), 1261; https://doi.org/10.3390/cells9051261
Available online: https://www.mdpi.com/2073-4409/9/5/1261 

7. “The Histone Code of Senescence”
by Paluvai, Harikrishnareddy et al.
Cells 2020, 9(2), 466; https://doi.org/10.3390/cells9020466
Available online: https://www.mdpi.com/2073-4409/9/2/466 

8. “The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence”
by Heath, John J. et al.
Cells 2020, 9(3), 766; https://doi.org/10.3390/cells9030766
Available online: https://www.mdpi.com/2073-4409/9/3/766 

9. “New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations”
by Janssen, Joseph A.M.J.L. et al.
Cells 2020, 9(4), 862; https://doi.org/10.3390/cells9040862
Available online: https://www.mdpi.com/2073-4409/9/4/862 

10. “The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology”
by da Costa, Cristine Alves et al.
Cells 2020, 9(11), 2495; https://doi.org/10.3390/cells9112495
Available online: https://www.mdpi.com/2073-4409/9/11/2495

“Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma”
by Francesca Ida Montalto et al.
Cells 2020, 9(12), 2648; https://doi.org/10.3390/cells9122648
Available online: https://www.mdpi.com/2073-4409/9/12/2648

“CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate”
by Lenka Stolarova et al.
Cells 2020, 9(12), 2675; https://doi.org/10.3390/cells9122675
Available online: https://www.mdpi.com/2073-4409/9/12/2675

“The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer”
by Marina Andrade-Tomaz et al.
Cells 2020, 9(9), 2140; https://doi.org/10.3390/cells9092140
Available online: https://www.mdpi.com/2073-4409/9/9/2140

“A Comparative Analysis of Oocyte Development in Mammals”
by Rozenn Dalbies-Tran et al.
Cells 2020, 9(4), 1002; https://doi.org/10.3390/cells9041002
Available online: https://www.mdpi.com/2073-4409/9/4/1002

“Diversity of RNA-Binding Proteins Modulating Post-Transcriptional Regulation of Protein Expression in the Maturing Mammalian Oocyte”
by Marie Christou-Kent et al.
Cells 2020, 9(3), 662; https://doi.org/10.3390/cells9030662
Available online: https://www.mdpi.com/2073-4409/9/3/662

“Microtubule-Based Mechanisms of Pronuclear Positioning”
by Johnathan L. Meaders et al.
Cells 2020, 9(2), 505; https://doi.org/10.3390/cells9020505
Available online: https://www.mdpi.com/2073-4409/9/2/505

“Mixing and Matching Chromosomes during Female Meiosis”
by Thomas Rubin et al.
Cells 2020, 9(3), 696; https://doi.org/10.3390/cells9030696
Available online: https://www.mdpi.com/2073-4409/9/3/696

“Managing the Oocyte Meiotic Arrest—Lessons from Frogs and Jellyfish”
by Catherine Jessus et al.
Cells 2020, 9(5), 1150; https://doi.org/10.3390/cells9051150
Available online: https://www.mdpi.com/2073-4409/9/5/1150

“A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I”
by Leonor Keating et al.
Cells 2020, 9(2), 390; https://doi.org/10.3390/cells9020390
Available online: https://www.mdpi.com/2073-4409/9/2/390

“Cell Cycle-Dependent Dynamics of the Golgi-Centrosome Association in Motile Cells”
by Keyada Frye et al.
Cells 2020, 9(5), 1069; https://doi.org/10.3390/cells9051069
Available online: https://www.mdpi.com/2073-4409/9/5/1069

“Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling”
by Zhixiang Wang.
Cells 2021, 10(12), 3327; https://doi.org/10.3390/cells10123327
Available online: https://www.mdpi.com/2073-4409/10/12/3327

“Cadmium (II)-Induced Oxidative Stress Results in Replication Stress and Epigenetic Modifications in Root Meristem Cell Nuclei of Vicia faba”
by Aneta Żabka et al.
Cells 2021, 10(3), 604; https://doi.org/10.3390/cells10030640
Available online: https://www.mdpi.com/2073-4409/10/3/640

“Glycosylation of Immune Receptors in Cancer”
by Ruoxuan Sun et al.
Cells 2021, 10(5), 1100; https://doi.org/10.3390/cells10051100
Available online: https://www.mdpi.com/2073-4409/10/5/1100

“DisA Limits RecG Activities at Stalled or Reversed Replication Forks”
by Rubén Torres et al.
Cells 2021, 10(6), 1357; https://doi.org/10.3390/cells10061357
Available online: https://www.mdpi.com/2073-4409/10/6/1357

“Mitochondrial Biogenesis, Mitochondrial Dynamics, and Mitophagy in the Maturation of Cardiomyocytes”
by Qianqian Ding et al.
Cells 2021, 10(9), 2463; https://doi.org/10.3390/cells10092463
Available online: https://www.mdpi.com/2073-4409/10/9/2463

“Comparing Biochemical and Raman Microscopy Analyses of Starch, Lipids, Polyphosphate, and Guanine Pools during the Cell Cycle of Desmodesmus quadricauda”
by Šárka Moudříková et al.
Cells 2021, 10(1), 62; https://doi.org/10.3390/cells10010062
Available online: https://www.mdpi.com/2073-4409/10/1/62

“Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter”
by Gerhard Wiche.
Cells 2021, 10(8), 2154; https://doi.org/10.3390/cells10082154
Available online: https://www.mdpi.com/2073-4409/10/8/2154

“A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer”
by Samantha M. Perez et al.
Cells 2021, 10(9), 2218; https://doi.org/10.3390/cells10092218
Available online: https://www.mdpi.com/2073-4409/10/9/2218

“p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties”
by Debora Bencivenga et al.
Cells 2021, 10(9), 2254; https://doi.org/10.3390/cells10092254
Available online: https://www.mdpi.com/2073-4409/10/9/2254

“The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks”
by Janne J. M. van Schie et al.
Cells 2021, 10(12), 3455; https://doi.org/10.3390/cells10123455
Available online: https://www.mdpi.com/2073-4409/10/12/3455