Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses
Abstract
1. Introduction
2. Rho GTPases
3. Regulation of Rho GTPase Activities
4. Rho GTPases in Cell Transformation, Cancer Stemness and Tumor Formation
4.1. Rho
4.2. Rac
5. Rho GTPases in Primary Tumor Growth and Angiogenesis
5.1. Rho GTPases in Primary Tumor Growth
5.1.1. Rho in Cell Cycle Progression, Proliferation and Tumor Growth
5.1.2. Rac and Cdc42 in Cell Cycle Progression, Proliferation and Tumor Growth
5.2. Rho GTPases in Angiogenesis
5.2.1. Rho
5.2.2. Rac and Cdc42
6. Rho GTPases in Breast Cancer Metastasis
6.1. Rho GTPases in Migration and Invasion
6.1.1. Rho
6.1.2. Rac and Cdc42
6.2. Rho GTPases in Intravasation and Survival in Circulation
6.3. Rho GTPases in Extravasation and Metastatic Colonization
6.3.1. RhoA
6.3.2. Rac1 and Cdc42
7. Rho GTPases in Breast Cancer Therapy Resistance
8. Use of Rho GTPases as a Prognostic Tool for Breast Cancer
9. Conclusions and Future Perspectives
Funding
Conflicts of Interest
References
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Rho GTPase | Percentage (%) Mutated in Invasive Breast Cancer | Most Prominent Mutation Type (Percentage (%) of Total Cases) |
---|---|---|
RhoA | 1.38 | Deletion (0.46) |
RhoB | 0.37 | Amplification (0.18) |
RhoC | 0.83 | Amplification (0.28) |
Rac1 | 0.46 | Amplification (0.37) |
Rac2 | 0.37 | Amplification (0.37) |
Rac3 | 4.15 | Amplification (3.69) |
Cdc42 | 0.83 | Deletion (0.37) |
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Humphries, B.; Wang, Z.; Yang, C. Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses. Cells 2020, 9, 2167. https://doi.org/10.3390/cells9102167
Humphries B, Wang Z, Yang C. Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses. Cells. 2020; 9(10):2167. https://doi.org/10.3390/cells9102167
Chicago/Turabian StyleHumphries, Brock, Zhishan Wang, and Chengfeng Yang. 2020. "Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses" Cells 9, no. 10: 2167. https://doi.org/10.3390/cells9102167
APA StyleHumphries, B., Wang, Z., & Yang, C. (2020). Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses. Cells, 9(10), 2167. https://doi.org/10.3390/cells9102167