NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Polythiophene Nanoparticles
2.3. Physico-Chemical Characterization
2.4. Photothermal Properties of Polythiophene Nanocomposites
2.5. Cell Culture
2.6. Cytotoxicity
2.7. Cellular Uptake Assay
2.8. Hyperthermia Effects of PTh–NPs
2.9. In Vitro Cell Apoptosis Analysis
2.10. Statistical Analysis
3. Results and Discussion
3.1. Physicochemical Characterization
3.2. Thermogravimetric (TGA) and Differential Scanning Calorimetry (DSC) Study
3.3. Photothermal Analysis and Photothermal Stability of PTh–NPs
3.4. In Vitro Cell Ablation Test
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Concentration of PTh–NPs (µg/mL) | Maximum Temperature (°C) Recorded under Different Power Supply of NIR 808 nm for Different Concentration of Substrate | |||
---|---|---|---|---|
1.0 W/cm2 | 1.5 W/cm2 | 2.0 W/cm2 | 2.5 W/cm2 | |
100 | 35.0 | 39.2 | 45.1 | 53.5 |
200 | 36.0 | 42.5 | 49.4 | 57.7 |
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Bhattarai, D.P.; Kim, B.S. NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells. Cells 2020, 9, 2122. https://doi.org/10.3390/cells9092122
Bhattarai DP, Kim BS. NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells. Cells. 2020; 9(9):2122. https://doi.org/10.3390/cells9092122
Chicago/Turabian StyleBhattarai, Deval Prasad, and Beom Su Kim. 2020. "NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells" Cells 9, no. 9: 2122. https://doi.org/10.3390/cells9092122