Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 17 articles | Viewed by 62361 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 5 articles | Viewed by 15104 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 3 articles | Viewed by 9883 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5360 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4607 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Transient Receptor Potential (TRP) Channels and Health and Disease
edited by Hiroki Kittaka and Makoto Tominaga
submission deadline 20 Feb 2026 | 8 articles | Viewed by 4475 | Submission Open
Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3309 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2927 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2878 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Current Advances in Plant Gene Regulatory Networks submission deadline 20 Feb 2026 | 1 articles | Viewed by 1463 | Submission Open
Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Advances in Molecular Research on Cancer Drug Targets and Drug Resistance
edited by , and Rakesh Kumar Srivastava
submission deadline 20 Feb 2026 | 1 articles | Viewed by 829 | Submission Open
Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers
Elucidating Roles of Cell Adhesion Molecules in Health and Disease
edited by Vladimir Sytnyk and
submission deadline 20 Feb 2026 | Viewed by 295 | Submission Open
Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs(IgSF-CAMs); integrins; cadherins; selectins; proteoglycans
Advances in T Cell Targeting for Cancer Immunotherapy
edited by Ryma Toumi
submission deadline 20 Feb 2026 | Viewed by 242 | Submission Open
Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy
Molecular Cell Biology of T Cells in Cancer and Infectious Diseases
edited by and João Viola
submission deadline 20 Feb 2026 | Viewed by 226 | Submission Open
Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism
(This special issue belongs to the Section Cellular Immunology)
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 151 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Autophagy)
Astrocytes: Roles and Functions in the Brain submission deadline 21 Feb 2026 | Viewed by 222 | Submission Open
Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting
Recent Advances in Regenerative Dentistry—Second Edition
edited by
submission deadline 25 Feb 2026 | 7 articles | Viewed by 29720 | Submission Open
Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking
(This special issue belongs to the Section Tissues and Organs)
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Feb 2026 | 6 articles | Viewed by 14863 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 4220 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease
Small Molecule Inhibitors: A New Era in Cancer Treatment
edited by , and Suman Asalla
submission deadline 25 Feb 2026 | 2 articles | Viewed by 1661 | Submission Open
Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance
Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs submission deadline 25 Feb 2026 | 1 articles | Viewed by 1237 | Submission Open
Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds
Remyelination: From Molecular Mechanism to Therapy submission deadline 25 Feb 2026 | 1 articles | Viewed by 986 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Feb 2026 | 1 articles | Viewed by 816 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 25 Feb 2026 | Viewed by 229 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease submission deadline 26 Feb 2026 | Viewed by 210 | Submission Open
Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling
(This special issue belongs to the Section Tissues and Organs)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 27 Feb 2026 | 3 articles | Viewed by 3760 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 2137 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets
edited by Saverio Gentile
submission deadline 27 Feb 2026 | Viewed by 199 | Submission Open
Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment
Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by Kyle Lauren Poulsen
submission deadline 27 Feb 2026 | Viewed by 194 | Submission Open
Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics
Role of Extracellular Matrix in Cancer and Disease submission deadline 28 Feb 2026 | 6 articles | Viewed by 19192 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 28 Feb 2026 | 3 articles | Viewed by 18095 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications submission deadline 28 Feb 2026 | 3 articles | Viewed by 16105 | Submission Open
Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors
(This special issue belongs to the Section Cellular Immunology)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 28 Feb 2026 | 2 articles | Viewed by 7559 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Adipose Tissue Functioning in Health and Diseases
edited by Richard C Chang
submission deadline 28 Feb 2026 | 3 articles | Viewed by 5891 | Submission Open
Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance
(This special issue belongs to the Section Tissues and Organs)
Skeletal Muscle: Structure, Physiology and Diseases submission deadline 28 Feb 2026 | 3 articles | Viewed by 5011 | Submission Open
Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging
(This special issue belongs to the Section Tissues and Organs)
Membrane Dynamics and the Role of Aquaporins in Plant Cells
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 4356 | Submission Open
Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Cell Therapeutics for Corneal Diseases submission deadline 28 Feb 2026 | 2 articles | Viewed by 3972 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
(This special issue belongs to the Section Tissues and Organs)
Unconventional T Cells in Health and Disease
edited by Lauren Howson
submission deadline 28 Feb 2026 | 2 articles | Viewed by 3972 | Submission Open
Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells
(This special issue belongs to the Section Cellular Immunology)
Cellular Mechanisms in Oral Cavity Homeostasis and Disease
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 3143 | Submission Open
Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment
Recent Advances in Microfluidics and Organoids for Biomedical Applications submission deadline 28 Feb 2026 | 3 articles | Viewed by 2685 | Submission Open
Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells
(This special issue belongs to the Section Tissues and Organs)
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 28 Feb 2026 | 4 articles | Viewed by 2578 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies
edited by and Sara Elfarrash
submission deadline 28 Feb 2026 | 1 articles | Viewed by 2104 | Submission Open
Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics
(This special issue belongs to the Section Cellular Aging)
Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics submission deadline 28 Feb 2026 | 1 articles | Viewed by 1807 | Submission Open
Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling
(This special issue belongs to the Section Tissues and Organs)
The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition
edited by and Silvano J. Santini
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1582 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms
edited by Tirthadipa Pradhan-Sundd
submission deadline 28 Feb 2026 | 1 articles | Viewed by 835 | Submission Open
Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells
Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies
edited by and
submission deadline 28 Feb 2026 | 1 articles | Viewed by 551 | Submission Open
Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics
(This special issue belongs to the Section Cellular Pathology)
Novel Insights into Neuroinflammation and Related Diseases
edited by Tahmineh Mokhtari
submission deadline 28 Feb 2026 | Viewed by 431 | Submission Open
Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies
(This special issue belongs to the Section Cellular Neuroscience)
Microautophagy: The Least Known of the Autophagy Strategies
edited by
submission deadline 28 Feb 2026 | Viewed by 257 | Submission Open
Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs
(This special issue belongs to the Section Autophagy)
Lung Development: Challenges and Opportunities
edited by David Warburton
submission deadline 28 Feb 2026 | Viewed by 215 | Submission Open
Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into Inherited Metabolic Disorders
edited by Paul Gissen
submission deadline 28 Feb 2026 | Viewed by 178 | Submission Open
Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks
(This special issue belongs to the Section Cellular Metabolism)
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