Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathophysiology of Central Nervous System Tumors
edited by Mariëtte E.G. Kranendonk
submission deadline 15 Mar 2025 | 2 articles | Viewed by 5129 | Submission Open
Keywords: CNS tumor; pediatric; adult; molecular profiling; multiomics; microenvironment
(This special issue belongs to the Section Cellular Pathology)
Crosstalk of Autophagy and Apoptosis: Recent Advances submission deadline 15 Mar 2025 | 1 articles | Viewed by 1873 | Submission Open
Keywords: autophagy  ; apoptosis  ; cell signaling  ; mitochondria  ; MAMs  ; lipid rafts  ; cancer therapy  ; autoimmunity
(This special issue belongs to the Section Autophagy)
Molecular Mechanisms of Signal Transduction in the Islet Cells
edited by
submission deadline 15 Mar 2025 | 1 articles | Viewed by 1384 | Submission Open
Keywords: islet cells; islets of Langerhans; insulin secretion; signaling mechanisms; molecular mechanisms
(This special issue belongs to the Section Tissues and Organs)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Mar 2025 | 1 articles | Viewed by 1362 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Human Inborn Errors of Immunity
edited by
submission deadline 15 Mar 2025 | Viewed by 388 | Submission Open
Keywords: inborn errors of immunity (IEI); primary immune deficiencies (PID); human; immune cells; susceptibility to infections; pathogens; autoimmunity; autoinflammation; allergy; malignancies; gene therapy; cellular therapy; hematopoietic stem cell transplantation (HSCT); pharmacotherapy
(This special issue belongs to the Section Cellular Immunology)
Exploring Tauopathy Through a Molecular Lens for Comprehensive Understanding
edited by Eleni Tsakiri and
submission deadline 15 Mar 2025 | Viewed by 362 | Submission Open
Keywords: synaptic dysfunction; Tau isoforms; Tau functions; Tau aggregation; neurodegeneration; post-translation modifications
CRISPR-Based Genome Editing in Translational Research—Third Edition
edited by , and Jifeng Zhang
submission deadline 15 Mar 2025 | Viewed by 199 | Submission Open
Keywords: genome; gene editing; CRISPR/Cas9
From Mechanisms to Therapeutics: Wnt Signaling in Cancer—Second Edition
edited by and
submission deadline 20 Mar 2025 | 6 articles | Viewed by 9685 | Submission Open
Keywords: Wnt; β -catenin; development; homeostasis; cancer; cancer stem cells (CSC); targeted cancer therapy; canonical Wnt signaling; non-canonical Wnt signaling
(This special issue belongs to the Section Cell Signaling)
Novel Insights into the Biofilms
edited by and Pierre Cornelis
submission deadline 20 Mar 2025 | 2 articles | Viewed by 2500 | Submission Open
Keywords: biofilms maturation; biofilm matrix; regulation; dispersion; eradication
Oral Cancer: Cellular and Molecular Mechanisms of Bone Invasion submission deadline 20 Mar 2025 | 1 articles | Viewed by 2251 | Submission Open
Keywords: oral squamous cell carcinoma; OSCC; bone invasion; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Updates of Stem Cell Applications in Bone Tissue Engineering
edited by Fahad Karim Kidwai
submission deadline 20 Mar 2025 | Viewed by 243 | Submission Open
Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells
(This special issue belongs to the Section Stem Cells)
Neuroblastoma: Molecular Mechanisms and Novel Treatment Strategies
edited by
submission deadline 20 Mar 2025 | Viewed by 190 | Submission Open
Keywords: neuroblastoma; tumorigenesis; biomarkers; drug discovery; experimental therapy
(This special issue belongs to the Section Cellular Pathology)
New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells submission deadline 25 Mar 2025 | 7 articles | Viewed by 14064 | Submission Open
Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment
(This special issue belongs to the Section Cell Methods)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 25 Mar 2025 | 8 articles | Viewed by 13164 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics
edited by
submission deadline 25 Mar 2025 | 2 articles | Viewed by 3092 | Submission Open
Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics
(This special issue belongs to the Section Cell Microenvironment)
Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome
edited by Eytan R. Barnea, and Guarano Alice
submission deadline 25 Mar 2025 | Viewed by 299 | Submission Open
Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control
(This special issue belongs to the Section Tissues and Organs)
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 28 Mar 2025 | 3 articles | Viewed by 2278 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 30 Mar 2025 | Viewed by 403 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
Male Reproductive Health and Infertility: A Look towards the Future II submission deadline 31 Mar 2025 | 6 articles | Viewed by 13619 | Submission Open
Keywords: sperm; male infertility; spermatogenesis; epigenetics; fertilization; exosomes; cell communication; oxidative stress; biomarkers
(This special issue belongs to the Section Reproductive Cells and Development)
Inflammatory Pathways in Psychiatric Disorders
edited by Teresa Femenía
submission deadline 31 Mar 2025 | 1 articles | Viewed by 8704 | Submission Open
Keywords: inflammation; immune system; psychiatry; emotion; cognition
(This special issue belongs to the Section Cells of the Nervous System)
Stroke Immunology: Mechanisms and Therapeutic Prospects
edited by Emmanuel Pinteaux and
submission deadline 31 Mar 2025 | 2 articles | Viewed by 6621 | Submission Open
Keywords: stroke; neuroimmunology; neuroinflammation; thromboinflammation; blood-brain barrier; glia; immunomodulation
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Basis of Alkaptonuria submission deadline 31 Mar 2025 | 2 articles | Viewed by 5548 | Submission Open
Keywords: Alkaptonuria; AKU; pathophysiology; post-genomics; histopathology; bioinformatics
(This special issue belongs to the Section Cellular Pathology)
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2025 | 2 articles | Viewed by 5139 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Adipose Tissue, Obesity, and Metabolic Diseases
edited by Takafumi Miyamoto
submission deadline 31 Mar 2025 | 4 articles | Viewed by 4870 | Submission Open
Keywords: adipose tissue; obesity; metabolic diseases; stress; inflammation; gut microbiota
(This special issue belongs to the Section Cellular Metabolism)
Signaling Regulation of Bone and Tooth Development
edited by Xiaofang Wang
submission deadline 31 Mar 2025 | 2 articles | Viewed by 3446 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis
(This special issue belongs to the Section Cell Signaling)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 31 Mar 2025 | 1 articles | Viewed by 3203 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Adenosine and Purinergic Receptors: Regulation and Essential Role in Human Disease
edited by Veronica Salmaso, and
submission deadline 31 Mar 2025 | 3 articles | Viewed by 3153 | Submission Open
Keywords: adenosine receptors; adenosine; purinergic signaling; P2 receptors; GPCRs; neurodegeneration; cancer; pain; inflammation; ischemia
(This special issue belongs to the Section Cellular Pathology)
Remyelination: From Basic Science to Therapies submission deadline 31 Mar 2025 | 1 articles | Viewed by 3062 | Submission Open
Keywords: myelin disease; neurodegeneration; CNS therapy; stem cells; regenerative therapies
(This special issue belongs to the Section Cells of the Nervous System)
Microbe–Heavy Metal Interactions
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 2816 | Submission Open
Keywords: horizontal gene transfer (HGT); gene duplication; natural selection; mutation; heavy metal resistance genes (MRGs); antibiotic resistance genes (ARGs); acid mine drainage (AMD); heavy metals; plasmids; mobile genetic elements (MGEs); transposons; extreme environments; bioremediation
Advances in Neurogenesis: 3rd Edition submission deadline 31 Mar 2025 | 2 articles | Viewed by 2749 | Submission Open
Keywords: neurogenesis; gliogenesis; cell plasticity; neurophysiology; behavior; neural circuits; cytogenic regulators; neuropsychiatric disorders; neurodegenerative disorders
Ca2+ Signaling and Calcium-Binding Proteins in Human Disease
edited by Nordine Helassa
submission deadline 31 Mar 2025 | 2 articles | Viewed by 2175 | Submission Open
Keywords: calcium signaling; calcium-binding protein; calmodulin; ion channels; cardiac arrhythmia; neurodegenerative disease
(This special issue belongs to the Section Cell Signaling)
New Insights of TGF-Beta Signaling in Cancer
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1798 | Submission Open
Keywords: cancer; TGF-beta; signaling crosstalk; smad signaling; non-Smad signaling; TGF-beta receptors; TGF-beta signaling inhibitors; TGF-beta paradox; epithelial-mesenchymal transition (EMT); mesenchymal-epithelial transition (MET)
(This special issue belongs to the Section Cellular Aging)
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 31 Mar 2025 | 2 articles | Viewed by 1480 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Membrane Damage and Repair in Organelles
edited by Yoko Shiba
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1234 | Submission Open
Keywords: membrane damage; organelle; pathogen; inorganic material; galectin
(This special issue belongs to the Section Intracellular and Plasma Membranes)
State of the Art in Computational Modeling of Cancer Immunotherapy submission deadline 31 Mar 2025 | Viewed by 484 | Submission Open
Keywords: oncoimmunology; modeling immune– tumor interactions; modeling combination immunotherapies; modeling adoptive cell therapies; mathematical modeling; data-driven models
(This special issue belongs to the Section Cellular Immunology)
Cell Death: Cell–Cell Interactions and Signaling Networks
edited by , Sun Chul Kang and
submission deadline 31 Mar 2025 | Viewed by 435 | Submission Open
Keywords: apoptosis; necrosis; pyroptosis; autophagic cell death; lysosome-dependent cell death; parthanatos; ferroptosis; anoikis; entosis; necroptosis; NETosis; mitotic catastrophe; healthy cell death tissue homeostasis
Organellar Ca2+ Transport in Plant versus Animal Cells: Can We Learn from Each Other?
edited by Shey-Shing Sheu and Marc Freichel
submission deadline 31 Mar 2025 | Viewed by 428 | Submission Open
Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging
(This special issue belongs to the Section Cell Microenvironment)
Molecular and Cellular Mechanisms of Liver Regeneration: From Biology to Therapy
edited by
submission deadline 31 Mar 2025 | Viewed by 290 | Submission Open
Keywords: liver regeneration; hepatocytes; chemokines; growth factors; liver diseases; signaling pathways; inflammation; liver immunobiology; fibrosis; cirrhosis
(This special issue belongs to the Section Tissues and Organs)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 31 Mar 2025 | Viewed by 263 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 31 Mar 2025 | Viewed by 223 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Cellular Senescence and Senotherapies in the Aging Retina
edited by
submission deadline 31 Mar 2025 | Viewed by 218 | Submission Open
Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy
(This special issue belongs to the Section Cellular Aging)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2025 | Viewed by 207 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
The Role of Secretory RNases and Extracellular RNAs in the Regulation of Inflammation and Organ Injury
edited by and
submission deadline 1 Apr 2025 | 1 articles | Viewed by 1361 | Submission Open
Keywords: RNase; extracellular RNAs; inflammation; sepsis; organ injury; innate immunity; neutrophils; monocyte/macrophages; endothelial cells
(This special issue belongs to the Section Tissues and Organs)
Development of PET Radiotracers for Imaging Alpha-Synuclein
edited by and Jamie Eberling
submission deadline 1 Apr 2025 | Viewed by 276 | Submission Open
Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography
(This special issue belongs to the Section Cellular Aging)
Cellular Models in Aging
edited by Michel Satya Naslavsky and Mateus Vidigal
submission deadline 1 Apr 2025 | Viewed by 127 | Submission Open
Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly
(This special issue belongs to the Section Cellular Aging)
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration submission deadline 10 Apr 2025 | 1 articles | Viewed by 1176 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases
(This special issue belongs to the Section Tissues and Organs)
Recent Advances in Astrocyte Neuron Communication submission deadline 10 Apr 2025 | Viewed by 700 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Sebaceous Gland in Skin Health and Disease
edited by and Monica Ottaviani
submission deadline 10 Apr 2025 | Viewed by 508 | Submission Open
Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Autism Spectrum Disorder
edited by Tanya Gandhi and
submission deadline 15 Apr 2025 | 4 articles | Viewed by 6478 | Submission Open
Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies
(This special issue belongs to the Section Cells of the Nervous System)
Cellular and Molecular Mechanisms of Lysosomal Storage Disorders
edited by
submission deadline 15 Apr 2025 | 2 articles | Viewed by 5295 | Submission Open
Keywords: lysosomes; lysosomal storage disorders; enzyme replacement; gene therapy; substrate reduction; pharmacological chaperones; autophagy; endosomal dysfunction
(This special issue belongs to the Section Cellular Pathology)
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