Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Evolution, Structure, and Functions of Apolipoproteins L
edited by Etienne Pays
submission deadline 10 Apr 2026 | 4 articles | Viewed by 11271 | Submission Open
Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation
Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases
edited by and Justyna Okarmus
submission deadline 10 Apr 2026 | 3 articles | Viewed by 9438 | Submission Open
Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Cellular Neuroscience)
Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances
edited by Tsung-Chieh Shih
submission deadline 10 Apr 2026 | 3 articles | Viewed by 7253 | Submission Open
Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins
(This special issue belongs to the Section Cellular Immunology)
New Tools to Address Old Challenges in Tolerogenic Cellular Therapies
edited by Konstantinos Mengrelis and
submission deadline 10 Apr 2026 | Viewed by 330 | Submission Open
Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation
Modeling Developmental Processes and Disorders in Zebrafish submission deadline 15 Apr 2026 | 13 articles | Viewed by 64671 | Submission Open
(This special issue belongs to the Section Cellular Biophysics)
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 15 Apr 2026 | 6 articles | Viewed by 35525 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 15 Apr 2026 | 5 articles | Viewed by 14440 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Zebrafish Disease Models submission deadline 15 Apr 2026 | 4 articles | Viewed by 9579 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Apr 2026 | 6 articles | Viewed by 6492 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies submission deadline 15 Apr 2026 | 3 articles | Viewed by 4182 | Submission Open
Keywords: hypoxia; oxidative stress; angiogenic markers; HIF-1/VEGF axis; retinal diseases; β -adrenoceptors; electroretinographic responses
(This special issue belongs to the Section Tissues and Organs)
Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression
edited by and Sudheer Kumar Gara
submission deadline 15 Apr 2026 | 1 articles | Viewed by 3159 | Submission Open
Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling
(This special issue belongs to the Section Cellular Pathology)
Decoding Cancer Metabolism: Recent Insights and Future Directions
edited by Parash Prasad and Snehasis R. Mishra
submission deadline 15 Apr 2026 | 2 articles | Viewed by 3149 | Submission Open
Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing
Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy
edited by , Stephanie L. Grillo and
submission deadline 15 Apr 2026 | 1 articles | Viewed by 2631 | Submission Open
Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies submission deadline 15 Apr 2026 | 1 articles | Viewed by 2222 | Submission Open
Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Cell Biology of the Eye: Development, Disorders, and Repair submission deadline 15 Apr 2026 | 1 articles | Viewed by 1185 | Submission Open
Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics  
Gut Dysbiosis in Inflammatory Diseases
edited by Weiwei Liu
submission deadline 15 Apr 2026 | 1 articles | Viewed by 1055 | Submission Open
Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation
(This special issue belongs to the Section Cellular Pathology)
Cellular Metabolism and Hormonal Signaling in Colorectal Cancer: Biomarkers and Therapeutic Opportunities
edited by Jibran Sualeh Muhammad
submission deadline 15 Apr 2026 | 1 articles | Viewed by 953 | Submission Open
Keywords: colorectal cancer; metabolic reprogramming; gut microbiome– metabolite interactions; therapy resistance; hormonal signaling
Advances in Annexin Biology
edited by , and Nunzia Novizio
submission deadline 15 Apr 2026 | 1 articles | Viewed by 851 | Submission Open
Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets
Yeast Stress Responses and Cell Death Regulation submission deadline 15 Apr 2026 | Viewed by 573 | Submission Open
Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death
Neurobiology of Sleep
edited by
submission deadline 15 Apr 2026 | Viewed by 236 | Submission Open
Keywords: sleep-wake regulation; neural circuits; glial biology; neurometabolism; sleep disorders; aging; neuropathology; astrocytes; GABAergic neurons
(This special issue belongs to the Section Cellular Neuroscience)
Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms submission deadline 20 Apr 2026 | 11 articles | Viewed by 39430 | Submission Open
Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular Mechanisms of Tumor Pathogenesis submission deadline 20 Apr 2026 | 11 articles | Viewed by 33346 | Submission Open
Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases
edited by Qingdong Guan
submission deadline 20 Apr 2026 | 3 articles | Viewed by 12399 | Submission Open
Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells
(This special issue belongs to the Section Cellular Immunology)
New Advances in Anticancer Therapy
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 9844 | Submission Open
Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology
(This special issue belongs to the Section Cellular Pathology)
Chromosomal Instability in Health and Disease
edited by Anna V. Roschke
submission deadline 20 Apr 2026 | 3 articles | Viewed by 8516 | Submission Open
Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Sperm Biology and Reproductive Health—Second Edition
edited by and
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7384 | Submission Open
Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation
Advancements in Research on hiPSC-Derived Cells
edited by Akhilesh Kumar
submission deadline 20 Apr 2026 | 2 articles | Viewed by 5695 | Submission Open
Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering
(This special issue belongs to the Section Stem Cells)
Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer
edited by Giusi Alberti and
submission deadline 20 Apr 2026 | 3 articles | Viewed by 4816 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research
pH Sensing, Signalling, and Regulation in Cellular Processes 
edited by Maike Glitsch
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2320 | Submission Open
Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets
(This special issue belongs to the Section Cell Signaling)
Advances in Molecular Genomics and Pathology of Cancers
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2106 | Submission Open
Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Signalling Mechanisms Regulating Cardiac Fibroblast Function
edited by Haofei Wang and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1336 | Submission Open
Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting
Mesenchymal Stem/Stromal Cell Therapies: Innovations in Regenerative Medicine and Translational Applications
edited by Giandomenico Amico and Paolo Elia Cappella
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1172 | Submission Open
Keywords: mesenchymal stem cells (MSCs); stromal cells; microvesicles; exosomes; extracellular vesicles (EVs); immunomodulatory properties; bone marrow; adipose tissue; Wharton’ s jelly; cord blood; placenta; amnion
(This special issue belongs to the Section Stem Cells)
Cell Death and Its Clearance in Health and Disease
edited by
submission deadline 20 Apr 2026 | Viewed by 603 | Submission Open
Keywords: cell death; phagocytosis; immune homeostasis; inflammation
(This special issue belongs to the Section Cellular Pathology)
Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance submission deadline 20 Apr 2026 | Viewed by 305 | Submission Open
Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System
edited by Emanuela Paldino
submission deadline 20 Apr 2026 | Viewed by 276 | Submission Open
Keywords: microglia; macrophages; neurological disorders
Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders submission deadline 20 Apr 2026 | Viewed by 273 | Submission Open
Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy
(This special issue belongs to the Section Cellular Neuroscience)
Stress-Induced Acute Immune Activation and Its Biological Consequences
edited by Ana Cicvaric
submission deadline 20 Apr 2026 | Viewed by 269 | Submission Open
Keywords: stress-induced immune signaling; acute immune activation; innate immune cell activation; cytokine response; cellular stress responses; inflammation and homeostasis
Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis
edited by and
submission deadline 20 Apr 2026 | Viewed by 215 | Submission Open
Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial– mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence
Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
edited by
submission deadline 20 Apr 2026 | Viewed by 197 | Submission Open
Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell
(This special issue belongs to the Section Cellular Immunology)
New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)
edited by
submission deadline 20 Apr 2026 | Viewed by 159 | Submission Open
Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 25 Apr 2026 | 5 articles | Viewed by 24586 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cellular Neuroscience)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 25 Apr 2026 | 3 articles | Viewed by 5930 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Insights into Platelet Function, 2nd Edition submission deadline 25 Apr 2026 | 5 articles | Viewed by 4144 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis
edited by Alessandra Loda and
submission deadline 25 Apr 2026 | 1 articles | Viewed by 3648 | Submission Open
Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors
Stem Cells in Action: Unlocking the Potential of Next-Generation Therapies
edited by George G. Koliakos
submission deadline 25 Apr 2026 | 2 articles | Viewed by 2231 | Submission Open
Keywords: stem cell biology; differentiation and niche interaction; secretome/extracellular vesicles; organoids and disease modeling; regenerative medicine and tissue repair; immunomodulation and antimicrobial function; cell-based therapies and  cGMP translation; scaffold and biomaterial integration
(This special issue belongs to the Section Stem Cells)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 25 Apr 2026 | 1 articles | Viewed by 1198 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Gene Editing Using Synthetic Nucleic Acids
edited by
submission deadline 25 Apr 2026 | Viewed by 178 | Submission Open
Keywords: gene editing; synthetic nucleic acids; genetic diseases; targeted gene therapy; antisense binding
(This special issue belongs to the Section Cell and Gene Therapy)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 30 Apr 2026 | 25 articles | Viewed by 88856 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cellular Neuroscience)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 30 Apr 2026 | 5 articles | Viewed by 26833 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities submission deadline 30 Apr 2026 | 11 articles | Viewed by 23399 | Submission Open
Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
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