Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Basis in Chronic Kidney Disease submission deadline 25 Nov 2025 | 8 articles | Viewed by 22211 | Submission Open
Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria
(This special issue belongs to the Section Cellular Pathology)
Glial Cells in Aging Neuroscience
edited by
submission deadline 25 Nov 2025 | 2 articles | Viewed by 9557 | Submission Open
Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells
(This special issue belongs to the Section Cellular Aging)
Biomolecular Condensates in Oncology and Immunology submission deadline 25 Nov 2025 | 1 articles | Viewed by 1519 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
CAR T Cells in Human Cancers submission deadline 25 Nov 2025 | 1 articles | Viewed by 1514 | Submission Open
Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering
Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)
edited by Laxman Gangwani
submission deadline 28 Nov 2025 | 2 articles | Viewed by 4284 | Submission Open
Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments
(This special issue belongs to the Section Cellular Pathology)
Cellular Senescence and Senotherapies in the Aging Retina
edited by
submission deadline 28 Nov 2025 | Viewed by 355 | Submission Open
Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy
(This special issue belongs to the Section Cellular Aging)
Cell-to-Cell Crosstalk as a Target of Therapies submission deadline 30 Nov 2025 | 2 articles | Viewed by 13572 | Submission Open
Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis
(This special issue belongs to the Section Cell Microenvironment)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer
edited by Sumit Sen Santara, , Weshely Kujur and Sachin Mulik
submission deadline 30 Nov 2025 | 5 articles | Viewed by 11223 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
New Research on Immunity and Inflammation in Cardiovascular Disease
edited by Pavel Poredoš
submission deadline 30 Nov 2025 | 7 articles | Viewed by 10245 | Submission Open
Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease
(This special issue belongs to the Section Cells of the Cardiovascular System)
Recent Advances in Metabolism and Oxidative Stress in Human Diseases: 2nd Edition
edited by and Vanessa Cossu
submission deadline 30 Nov 2025 | 4 articles | Viewed by 8534 | Submission Open
Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism
(This special issue belongs to the Section Cellular Metabolism)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7668 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 30 Nov 2025 | 5 articles | Viewed by 6483 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
Genetic and Cellular Basis of Autoimmune Diseases
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6055 | Submission Open
Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes
(This special issue belongs to the Section Cellular Immunology)
Retinal Pigment Epithelium in Degenerative Retinal Diseases
edited by Jian Liu and Shintaro Horie
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5887 | Submission Open
Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms in Mitochondrial Function and Calcium Signaling
edited by Sergio De la Fuente and Jaime Santo-Domingo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4795 | Submission Open
Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling
(This special issue belongs to the Section Cellular Metabolism)
CRISPR-Based Genome Editing Approaches in Cancer Therapy
edited by Martin Pal
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4132 | Submission Open
Keywords: CRISPR; genome editing; cancer therapy; precision medicine
(This special issue belongs to the Section Cell and Gene Therapy)
Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
edited by Sauri Hernandez-Resendiz
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3854 | Submission Open
Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection
(This special issue belongs to the Section Tissues and Organs)
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 30 Nov 2025 | 2 articles | Viewed by 2847 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Neuroinflammation in Developmental Brain Diseases submission deadline 30 Nov 2025 | 1 articles | Viewed by 2776 | Submission Open
Keywords: neuroinflammation; endothelial injury; blood brain barrier; microglia; immune dysfunction; oxidative stress; autism spectrum disorders; epilepsy; cerebral palsy; schizophrenia; neurodevelopment; neurovascular brain signaling; inflammatory cytokines; immune cells
(This special issue belongs to the Section Cells of the Nervous System)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Nov 2025 | 1 articles | Viewed by 2670 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2095 | Submission Open
Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Wound Repair
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1694 | Submission Open
Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration
(This special issue belongs to the Section Cellular Pathology)
Updates of Stem Cell Applications in Bone Tissue Engineering
edited by Fahad Karim Kidwai
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1601 | Submission Open
Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells
(This special issue belongs to the Section Stem Cells)
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1458 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1236 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1143 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
Drug Resistance in Breast and Ovarian Cancers
edited by
submission deadline 30 Nov 2025 | Viewed by 430 | Submission Open
Keywords: breast cancer; endocrine resistance; ESR1 mutations; Trop-2; ovarian cancer; drug resistance; predictive biomarkers; personalized medicine
Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics
edited by Ben Wielockx
submission deadline 30 Nov 2025 | Viewed by 375 | Submission Open
Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology
(This special issue belongs to the Section Cellular Immunology)
Exploring Morphological Changes and Diversity in Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 342 | Submission Open
Keywords: morphology; heterogeneity; cancer; phenotype; shape
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
ROS in Atherosclerosis and Cardiometabolic Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open
Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia
(This special issue belongs to the Section Tissues and Organs)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Nov 2025 | Viewed by 136 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 30 Nov 2025 | Viewed by 114 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 1 Dec 2025 | 1 articles | Viewed by 1066 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 1 Dec 2025 | Viewed by 547 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 5 Dec 2025 | 6 articles | Viewed by 18191 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 10 Dec 2025 | 2 articles | Viewed by 4551 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Therapeutic Mechanism of Nervous System Inflammation—Second Edition submission deadline 10 Dec 2025 | 1 articles | Viewed by 2454 | Submission Open
Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system
(This special issue belongs to the Section Cells of the Nervous System)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 497 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 15 Dec 2025 | 21 articles | Viewed by 74971 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Neuroinflammation
edited by and Michael Breckwoldt
submission deadline 15 Dec 2025 | 14 articles | Viewed by 61322 | Submission Open
Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging
(This special issue belongs to the Section Cells of the Nervous System)
Focus on Machinery of Cell Death
edited by , Prashanta Kumar Panda and
submission deadline 15 Dec 2025 | 8 articles | Viewed by 19217 | Submission Open
Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy
(This special issue belongs to the Section Cellular Pathology)
Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities submission deadline 15 Dec 2025 | 5 articles | Viewed by 9468 | Submission Open
Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications submission deadline 15 Dec 2025 | 3 articles | Viewed by 5547 | Submission Open
Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis
(This special issue belongs to the Section Cellular Pathology)
Mitochondria and Metabolism in Cancer Stem Cells (CSCs)
edited by and Christopher Albanese
submission deadline 15 Dec 2025 | 2 articles | Viewed by 4243 | Submission Open
Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches
(This special issue belongs to the Section Stem Cells)
Cell Therapies in Cancer Treatment
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 2397 | Submission Open
Keywords: cellular therapies; cancer; immune
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 1894 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cells of the Nervous System)
Physics of Cancer: How Mechanobiology Drives Cancer Progression submission deadline 15 Dec 2025 | 1 articles | Viewed by 1678 | Submission Open
Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer
Mechanisms and Therapies in Chronic Pain
edited by Nikesh Kunder and June Bryan I. de la Peña
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1445 | Submission Open
Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management
(This special issue belongs to the Section Cellular Pathology)
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