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A Comparative Analysis of Oocyte Development in Mammals

INRAE, CNRS, Université de Tours, IFCE, PRC, F-37380 Nouzilly, France
CHU Bretonneau, Médecine et Biologie de la Reproduction-CECOS, 37044 Tours, France
Author to whom correspondence should be addressed.
Cells 2020, 9(4), 1002;
Received: 14 February 2020 / Revised: 6 April 2020 / Accepted: 9 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Manufacturing a Female Gamete: An Oocyte Story)
Sexual reproduction requires the fertilization of a female gamete after it has undergone optimal development. Various aspects of oocyte development and many molecular actors in this process are shared among mammals, but phylogeny and experimental data reveal species specificities. In this chapter, we will present these common and distinctive features with a focus on three points: the shaping of the oocyte transcriptome from evolutionarily conserved and rapidly evolving genes, the control of folliculogenesis and ovulation rate by oocyte-secreted Growth and Differentiation Factor 9 and Bone Morphogenetic Protein 15, and the importance of lipid metabolism. View Full-Text
Keywords: oocyte; mammals; evolution; gene expression; posttranscriptional control; Gdf9; Bmp15; lipids oocyte; mammals; evolution; gene expression; posttranscriptional control; Gdf9; Bmp15; lipids
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Dalbies-Tran, R.; Cadoret, V.; Desmarchais, A.; Elis, S.; Maillard, V.; Monget, P.; Monniaux, D.; Reynaud, K.; Saint-Dizier, M.; Uzbekova, S. A Comparative Analysis of Oocyte Development in Mammals. Cells 2020, 9, 1002.

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