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Review

Rho Family of Ras-Like GTPases in Early-Branching Animals

by 1,2,†, 3,† and 1,*,†
1
Division of Molecular Biology, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia
2
Division of Molecular Biology, Faculty of Science, University of Zagreb, HR-10000 Zagreb, Croatia
3
Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(10), 2279; https://doi.org/10.3390/cells9102279
Received: 9 September 2020 / Revised: 6 October 2020 / Accepted: 9 October 2020 / Published: 13 October 2020
(This article belongs to the Special Issue Rho family of GTPases in Model Organisms and Systems)
Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals. View Full-Text
Keywords: non-bilaterian animals; Rho GTPases; Cdc24; Rho; Rac; RhoBTB; Miro; Porifera; Ctenophora; Placozoa; Cnidaria non-bilaterian animals; Rho GTPases; Cdc24; Rho; Rac; RhoBTB; Miro; Porifera; Ctenophora; Placozoa; Cnidaria
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MDPI and ACS Style

Beljan, S.; Herak Bosnar, M.; Ćetković, H. Rho Family of Ras-Like GTPases in Early-Branching Animals. Cells 2020, 9, 2279. https://doi.org/10.3390/cells9102279

AMA Style

Beljan S, Herak Bosnar M, Ćetković H. Rho Family of Ras-Like GTPases in Early-Branching Animals. Cells. 2020; 9(10):2279. https://doi.org/10.3390/cells9102279

Chicago/Turabian Style

Beljan, Silvestar, Maja Herak Bosnar, and Helena Ćetković. 2020. "Rho Family of Ras-Like GTPases in Early-Branching Animals" Cells 9, no. 10: 2279. https://doi.org/10.3390/cells9102279

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