1,862,523 Results Found

Background: Skin cancer progression is driven by the dysregulation of key oncogenic signaling pathways, including EGFR, BRAF V600E, and TGF-β, which collectively promote tumor proliferation, invasion, and metastatic progression. Targeting these...

The convergence of Lean manufacturing and Industry 4.0 requires digital infrastructures capable of transforming high-frequency telemetry into actionable insights. However, architectures that integrate near real-time data with closed-loop process cont...

Background: Axonal misdirection remains a major limitation in peripheral nerve repair. While nerve guidance conduits (NGCs) and nerve scaffolds (NSCs) have advanced structurally, it is unclear whether these designs effectively reduce misdirection com...

Despite the aesthetic potential of free-form envelopes in large-scale public buildings, geometric interlacing complexity, ambiguous façade boundaries, and constructability translation gaps persist as systemic barriers. This study addresses the...

Background: Glioblastoma (GBM) is a lethal, highly invasive, and recurrent brain tumor. Standard treatment combines maximal surgical resection, radiation, and chemotherapy; however, such approaches are often infeasible for tumors in eloquent brain re...

Botrytis cinerea poses a major threat to postharvest strawberries, causing significant losses due to gray mold. As a plant-derived antifungal agent, Rhodiola rosea L. essential oil (REO) possesses considerable healthcare benefits. However, its effect...

Background/Objectives: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) may modify the prognostic impact of established clinical and surgical factors in advanced ovarian cancer. A retrospective study was con...

Carpinus betulus is an important ornamental landscape tree species with colorful foliage. It is widely used in landscaping due to its upright tree shape, significant seasonal changes, and good tolerance to pruning. Propagation methods for C. betulus...

Persistent cloud cover and frequent rainfall in subtropical regions throughout the year significantly limit the applicability of optical remote sensing for tree species identification, thereby constraining dynamic forest monitoring and precise manage...

Antimicrobial resistance (AMR) in food-producing animals is a growing One Health concern. However, data on AMR in indicator microorganisms from clinically healthy dairy cattle in Latvia remain limited. This study aimed to characterize the AMR profile...

The optimal dietary balance between n-6 and n-3 polyunsaturated fatty acids (PUFAs), the safe upper intake of n-6 PUFAs—particularly linoleic acid—and the physiological consequences of their metabolic competition remain unresolved in the...

Background/Objectives: Botanical and nutraceutical approaches have increasingly been considered as alternatives or complements to conventional lipid-lowering therapies, particularly in individuals with mild-to-moderate dyslipidemia or statin intolera...

Cassava mosaic disease (CMD) is a major constraint to cassava production in sub-Saharan Africa, particularly in Burkina Faso, where it poses a serious threat to rural food security. This study examined the impact of adopting innovative cassava mosaic...

Accurate prediction of the zero-sequence impedance ($Z_0$) of three-legged zigzag grounding transformers is essential for ground-fault protection and power-quality performance, yet manufacturer analytical estimations often have limited accuracy. This pa...

Here, we describe a case of an asymptomatic 55-year-old male patient who underwent an abdominal ultrasound examination which showed a para-aortic anechoic lesion without color Doppler signals. A previously performed magnetic resonance imaging examina...

Coordinated mitigation of greenhouse gases (GHGs) and air pollutants (APs) offers an effective strategy to address climate and air quality challenges, yet systematic evaluations in medium-sized industrial cities remain limited, despite their coal-dep...

River regulation and embankment construction have fundamentally altered the hydrological relationships and sediment accumulation dynamics of floodplains worldwide. This study examines the accumulation conditions in the Upper Tisza (Hungary) floodplai...

Background/Objectives: This study focused on the sub-national regional heterogeneity in childhood obesity prevalence across five countries in south-east Europe and the correlation between this heterogeneity and socioeconomic differences. Previous stu...

The southern Central Asian Orogenic Belt (CAOB) underwent a major Early Paleozoic tectonic transition, yet its timing and mechanisms remain unclear. We present zircon U–Pb–Hf, whole-rock geochemical, and Sr–Nd isotopic data for newl...

This study proposes an integrated façade design framework that harmonizes the creative divergence of Generative AI with the economic efficiency of Design for Manufacturing and Assembly (DfMA). To address low productivity in the construction in...

In this report, we describe the synthesis and full spectroscopic characterization of a previously unreported podophyllotoxin (PTOX) analogue bearing a second 3,4,5-trimethoxyphenyl (TMP) unit at the C-4 position through an ester linkage. This dual-TM...

Background/Objectives: Museum fatigue decreases visitors’ interest due to environmental, social, and personal factors. However, it remains unclear whether physiological parameters can capture museum fatigue, and whether personal factors contrib...

Physical Education (PE) in primary education seems to be a privileged context for working on psychosocial factors, and the Sports Education Model (SEM) is of interest because of its potential in this regard. The purpose of this study was to conduct a...

To address the limitations of existing two-dimensional asperity shoulder-to-shoulder contact models and to investigate the normal and tangential contact mechanisms of rough surfaces, this study proposes a three-dimensional elastic contact model based...

Application of Artificial Intelligence-Generated Content (AIGC) in architectural design has increased rapidly. However, contemporary interpretations of traditional architectural heritage produced through such approaches often remain visually imitativ...

Wood-based particleboards are a key component of sustainable building materials due to their renewable and low-carbon nature. However, their susceptibility to microbial contamination poses a significant challenge to indoor environmental quality and d...

The aim of the circular economy for plastics is to replace some of them with bio-based polymers in the future. In this work, second cheese whey (SCW) was used as a low-cost substrate for the production of the natural polyester poly(3-hydroxybutyrate)...

Mass M (kg) and peak intrusion L (mm) are jointly minimized for a CFRP-enabled battery pack enclosure under the GB 38031-2025 −40° side-pole extrusion condition. A 50-run explicit FE design of experiments is conducted and deterministically...

Multiple sclerosis (MS) is a chronic, immune-mediated neurological disorder characterized by inflammation, demyelination, and progressive neurodegeneration. While genetic susceptibility contributes to disease risk, a growing body of evidence highligh...

Remaining Useful Life (RUL) prediction is a key factor in fault diagnosis, prediction, and health management (PHM) during equipment operation and service. Its purpose is to predict the time interval from the current moment to the complete failure of...

In the context of power electronic interfaces in photovoltaic (PV), fuel cell, battery, and microgrid applications, the low output voltage of the DC source necessitates a voltage-boosting inverter. This paper proposes a single-source seven-level swit...

Urban community children’s play spaces play a crucial role in promoting both physical and mental health, significantly influencing children’s development and fostering a sense of belonging to the community. However, existing design practi...

Direct-current (DC) electrokinetics in microfluidic channels is inherently affected by Faradaic reactions at the electrode–electrolyte interfaces, which induce local changes in pH and conductivity and, consequently, alter particle behavior. In...

Enzymatic pretreatment is a promising method for modulating essential oil isolation. This study evaluated the effects of pectinase, cellulase, xylanase, and their mixture, applied in purified water or citrate buffer before Clevenger hydrodistillation...

This research investigates the uptake of potentially toxic elements (PTEs) by Brassica rapa L. grown in volcanic and clay soils with high natural background levels of these elements, and assesses related human health risks. The study was conducted in...

Common-mode voltage (CMV) is a critical concern in motor drive applications employing multilevel inverters, as it can lead to significant issues such as high-frequency noise, electromagnetic interference, and motor bearing degradation. These effects...

The continued growth of electric vehicle (EV) deployment has placed increasing emphasis on the development of charging infrastructure that is efficient, reliable, and compliant with safety requirements over a wide range of power levels. In EV chargin...

Generative AI (GenAI) is accelerating design space exploration and multimodal prototyping in industrial design (ID), bringing new efficiencies and possibilities to early-stage ideation and cross-media expression. Yet many studies do not clearly defin...

Peroxisome-proliferator–activated receptor delta (PPARδ) regulates metabolic, mitochondrial, and inflammatory pathways implicated in neurodegeneration, making it an attractive therapeutic target for amyotrophic lateral sclerosis (ALS). In...

Magnesium alloys’ poor corrosion resistance limits their applications as biodegradable bone repair materials. Alloying tailors Mg alloys’ microstructure and properties. The present study investigates the effect of 2 wt.% Ag addition on th...

Objectives: This randomized, controlled, parallel-group study was conducted to evaluate the effectiveness of daily almond consumption on acne lesion counts, skin hydration, sebum production, and skin microflora composition in 18–35-year-old you...

Image datasets characterized by high intra-image structural heterogeneity pose significant challenges for supervised classification, particularly when local patterns contribute unevenly to image-level decisions. In such scenarios, direct image-level...

Biological invasion is a major driver of biodiversity loss and ecosystem disruption, with non-native aquatic species threatening ecological integrity and economic stability. The Qinling Mountains, located in central China, serve as a crucial barrier...

The skin microbiome comprises a diverse community of bacteria, fungi, and archaea, all of which play a foundational role in maintaining skin health, immune tolerance, and barrier integrity. Recent advances in cosmetic science focus on the skin microb...

Nordic forest management is increasingly emphasizing multi-functional goals, expanding beyond timber production towards non-wood forest products such as wild berries. Wild berry yield maps are based on sample plot data combined with meteorological, r...

While facilitating tourists’ personal transformation, wellness healers simultaneously navigate their own quest for well-being in delivering wellness tourism services. However, existing research predominantly focuses on tourists’ psycholog...

With the increasing penetration of inverter-based photovoltaic (PV) generation, utility-scale grid-connected PV plants are frequently exposed to voltage regulation and voltage stability challenges driven by intermittent irradiance and limited reactiv...

Intrusion Detection Systems (IDSs) have evolved to safeguard networks and systems from cyber attacks. Anomaly-based Intrusion Detection Systems (A-IDS) have been commonly employed to detect known and unknown anomalies. However, conventional anomaly d...

The peanut, a globally important oil and economic crop, has thin, brittle pods that are prone to breakage under external forces during mechanical harvesting, transportation, and processing. To minimize this loss and reduce production costs, we conduc...

The study aims to develop a conceptual model for immersive chemical hazard response training that explicitly addresses four core operational constraints: time pressure, uncertainty, teamwork, and procedural/psychomotor precision. The model responds t...