1,866,513 Results Found

A thorough understanding of the functions of virulence regulators in Bacillus anthracis evolution and host adaptation, particularly the systematic host responses they trigger, requires an efficient infection model capable of resolving subtle mechanis...

Agriculture serves as a critical foundation for livelihoods, food security, and sustainable development across the Sahara–Sahelian region. However, this vital sector faces mounting pressures from recurrent armed conflicts that systematically un...

NUT carcinoma (NC) is a rare exceptionally aggressive malignancy, defined by NUTM1 gene translocations, most commonly generating a BRD4::NUTM1 fusion that results in a poor prognosis and limited therapeutic options. Oncolytic virotherapy has emerged...

In applying a hierarchical mixed model to genome-wide association analysis (GWAS) of longitudinal data, dimensionality reduction through modeling repeated measurements improves both computational efficiency and statistical power. Legendre polynomials...

Background/Objectives: Ureteric stents are commonly used in urological procedures. However, they can cause pain; haematuria; voiding symptoms; or stent migration. When stent migration occurs, this can cause a significant impact on the patients’...

Alzheimer’s disease (AD) is traditionally defined by Amyloid-β (Aβ) plaques and tau neurofibrillary tangles, yet these proteinopathies alone fail to explain disease heterogeneity, progression, and cognitive decline. Emerging evidence...

Point-of-care ultrasonography (POCUS) has become an integral part of intensive and emergency care. Despite the widespread use and availability of multipurpose ultrasound devices, the regular assessment of intracranial circulatory conditions has not b...

The construction of traditional underground utility tunnels faces prominent challenges, including high costs, long construction cycles, and limited workspace. Although 3D printing technology offers an effective solution to these issues, its practical...

Tendon healing is often hindered by unresolved inflammation and dysregulated immune responses, highlighting the need for innovative regenerative strategies. This study developed an immune-informed platform by functionalizing validated 3D tendon-mimet...

Pawnshop buildings are places where pawn transactions are conducted. They are usually composed of a front shop and a back building, and their shape resembles a fortress. As a typical gambling city, pawnshops in Macau appeared as early as the Qing Dyn...

Background/Objectives: The rising prevalence of extended-spectrum beta-lactamase (ESBL)-producing pathogens has emerged as a significant challenge in the treatment of pyelonephritis. This study aims to determine the frequency of ESBL-producing agents...

Background: The effects of fasting on serum kynurenines (KYNs) have been reported; however, no data are available on whether fasting also modifies their urinary excretion. Kidney organic anion transporters are involved in KYNs excretion, suggesting t...

Accurate determination of in situ stress is fundamental for the safe and efficient design of underground construction projects such as tunnels, caverns, and deep mining excavations. Conventional techniques—particularly overcoring and hydraulic...

The use of high-performance concrete is a common practice in the construction of large-span bridges, where creep deformation may exert a considerable influence. This article puts forth a practical calculation method for long-term creep deformation of...

Background: Euthyroid sick syndrome (ESS) is a common finding in critically ill patients, including children with diabetic ketoacidosis (DKA). However, its prevalence, specific hormonal patterns, and recovery in the pediatric population remain inadeq...

Silver nanoparticles were biosynthesized using the culture supernatant of Staphylococcus sp. YRA, a strain isolated from Colombian mining sediments. Synthesis was optimized at 1 mM AgNO₃, pH 7, 40 °C and 7 μg/mL extract, producing spherical, p...

Background/Objectives: This study aimed to evaluate the effect of breast cancer awareness training on screening beliefs and behaviour. Methods: This single-group pre-test/post-test quasi-experimental study included 286 women living in rural areas. Th...

Background: Comparative evidence for the effectiveness of High-Intensity Interval Training (HIIT) and Low-Intensity Steady-State (LISS) exercise derived from real-world settings using standardized anthropometric assessments and subjective perception...

The rapid proliferation of distributed energy resources (DERs), including photovoltaics, wind power, battery energy storage, and electric vehicles, has transformed traditional power systems into highly decentralized and data-rich environments. Virtua...

Natural and human-made hazards are increasing due to global warming and human activities. Occupant evacuation in complex buildings remains challenging due to unfamiliar building layouts, communication failures, and unpredictable occupant behavior. Th...

This study investigates the mechanical properties, moisture stability, and environmental safety of microbial-induced carbonate precipitation (MICP)-treated phosphogypsum (PG)-based mixtures (MPGT) for road base utilization. Optimal cementation soluti...

Solanum torvum is an important medicinal and culinary vegetable with poor seed propagation, characterized by low germination and limited seed longevity. This study examined the effects of fruit maturity stage, storage temperature, duration, and endog...

Astigmata is a diverse lineage of mites with significant ecological, medical, and economic importance, yet higher-level relationships within the group remain contentious due to incongruent morphological and molecular data. Here, we integrate multigen...

Background: Accurate diagnosis of periprosthetic joint infection (PJI) remains challenging, particularly in culture-negative and borderline cases where current practices lead to high diagnostic uncertainty. SynTuition™, a machine-learning-based...

The increasing size and complexity of wind turbines have intensified the need for reliable real-time condition monitoring and health assessment. However, conventional numerical models often involve high computational demand, limiting their applicabil...

To address the existing problems of frequent manual tray handling, poor continuity, and insufficient coordination in fully automatic transplanters, this study designed an integrated multi-layer tray-handling and dual-claw coordinated seedling pick-an...

Antimony (Sb) contamination in agricultural soils threatens the safety of rapeseed production, yet the mechanisms driving cultivar differences in seed Sb accumulation remain unclear. A pot experiment was conducted with two Sb-tolerant cultivars showi...

Learning environments are increasingly expected to enable students to develop competencies necessary for addressing complex social, environmental, and technological challenges in sustainable societies. Within this context, instructional approaches th...

The development of innovative wound dressings capable of accelerating diabetic wound healing while simultaneously reducing scar formation is a significant clinical challenge. In this study, we designed and fabricated a multifunctional nanofibrous sca...

Background: Oxidative stress plays a critical role in cancer initiation and progression. Although vitamin D exhibits multiple anti-tumorigenic properties, its antioxidant effects across different cancer types remain incompletely characterized. This s...

Background: Ovarian cancer (OC) remains the most common cause of gynecological cancer-related death, and about 70% of these deaths are from advanced high-grade serous ovarian cancer (HGSOC). Cysteine-rich secretory protein 3 (CRISP3) is related to va...

While it is a global imperative that firms should achieve superior environmental, social, and governance (ESG) performance, the specific impact of ESG on export product quality remains under-explored. Based on stakeholder theory and principal–a...

Background: The ninth edition of the TNM classification introduced refinements in nodal staging, subdividing mediastinal N2 disease into N2a (single-station) and N2b (multi-station) involvement, alongside several stage group adjustments. The aim of t...

The genus Blunervirus comprises plant viruses that infect a diverse range of plants, but no blunervirus has been reported infecting elm trees (Ulmus parvifolia) in China to date. Using high-throughput sequencing and reverse-transcription PCR assays,...

Diffuse large B-cell lymphoma (DLBCL) is a common, aggressive non-Hodgkin lymphoma with significant molecular heterogeneity. This variability arises in part from its distinct molecular subtypes, including germinal center B-cell-like (GCB) DLBCL, acti...

Background: To evaluate the effects of preoperative topical ripasudil, a Rho-associated protein kinase (ROCK) inhibitor, on Schlemm’s canal (SC) morphology in patients with primary open-angle glaucoma (POAG). Methods: This study included 95 SC...

Patients with prior acute myocardial infarction (AMI) generally show low rates of achieving secondary prevention targets. Here we evaluated adherence to guideline-recommended secondary prevention strategies after AMI in Saudi Arabia. This ambispectiv...

Passive transplacental immunity is crucial for neonatal protection from infections. Following Clostridioides difficile (C. difficile) infection, infants do not develop disease, although C. difficile colonization is highly prevalent in infants. This w...

Cherubism is a rare fibro-osseous disorder of the jaws that typically presents in early childhood and is recognised as genetically heterogeneous. While the condition is well described in non-African populations, African data and molecular confirmatio...

DLBCLs constitute an aggressive type of lymphoma with varied clinical, molecular and genetic features. The cells are characterized by NFkB pathway disturbances and BCL-2 and mTOR protein deregulation, which significantly inhibit apoptosis. Hence, man...

Carbon sinks have been widely recognized as critical components of climate change mitigation and achieving carbon neutrality. With rapid urbanization, protecting and optimizing urban carbon sinks remain major challenges. This study uses Zhengzhou as...

To address the challenge of complex quality control in shared manufacturing arising from loose “partner” relationships, a quality disclosure mechanism is incorporated into a shared manufacturing supply chain. By developing a platform-led...

Background: The oxidative balance score (OBS) is an indicator for assessing total oxidant status. This cross-sectional study aimed to investigate the relationships between OBS and factors associated with well-being among middle-aged and elderly women...

Adaptability and flexibility in teaching with digital technologies are essential for instructors to navigate dynamic and ever-evolving educational contexts. However, little has been done to investigate the underlying competencies required of instruct...

Background: Awkward postures are among the most prevalent ergonomic risk factors in occupational environments, including industrial settings. Conventional ergonomic risk assessments rarely address the relationship between sustained awkward postures a...

Guan Yu (d. AD 220), better known by his posthumous title as Guan Gong or Lord Guan, was a prominent military general in the late Han dynasty (AD 206–220). For centuries, Lord Guan has been widely worshipped as both a god of war and a god of we...

With the rapid development of genomic big data and genome-wide association study technologies, massive genomic data are available for the genetic dissection, development and utilization of important economic traits. Various GWAS algorithms have becom...

Introduction: Given the growing prevalence of eating-related health problems among children, it is essential to promote well-being and investigate the factors that may underlie these issues. Emotional intelligence has been identified in several studi...

To overcome the limitations of conventional control strategies in simultaneously suppressing external sway disturbances and internal parameter variations—induced by strong eddy current effects in marine canned magnetic bearings (MBs)—this...

Post-disaster reconstruction in resource-constrained contexts is often delayed by limited material supply, skilled labor, and planning capacity. Following the Mw 7.7 earthquake that struck near Mandalay, Myanmar, in March 2025, extensive housing dama...