Exploring Innovative Approaches in Veterinary Health

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 438

Special Issue Editors


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Guest Editor
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China
Interests: PRRSV pathogenicity mechanism; virus-host interaction mechanism; PRRSV susceptible/resistant gene mining

E-Mail Website
Guest Editor
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China
Interests: PRRSV pathogenicity mechanism; virus-host interaction mechanism; PRRSV susceptible/resistant gene mining

Special Issue Information

Dear Colleagues,

Veterinary health is a rapidly evolving field that demands continuous innovation to address emerging challenges in animal disease prevention, diagnosis, and treatment. This Special Issue, “Exploring Innovative Approaches in Veterinary Health”, aims to highlight cutting-edge research and novel strategies that enhance veterinary practices, improve animal welfare, and contribute to public health. We welcome high-quality review articles and original research papers, as well as a limited number of case reports that provide valuable insights into innovative diagnostic, therapeutic, and management approaches. Topics of interest include advancements in diagnostic technologies, precision medicine in veterinary care, novel therapeutics, vaccine development, and integrative approaches to disease management. Additionally, we encourage research on the application of artificial intelligence, big data analytics, and digital tools in veterinary health. By fostering interdisciplinary collaboration and knowledge exchange, this Special Issue seeks to advance the veterinary profession and support sustainable animal health solutions.

Dr. Zhenbang Zhu
Dr. Zhendong Zhang
Guest Editors

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Keywords

  • veterinary innovation
  • animal disease diagnosis
  • precision veterinary medicine
  • novel therapeutics
  • vaccine development
  • digital veterinary health
  • artificial intelligence in veterinary science
  • big data in animal health
  • one health approach
  • sustainable veterinary solutions

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Published Papers (1 paper)

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Research

15 pages, 1040 KiB  
Article
Detection and Comparison of Sow Serum Samples from Herds Regularly Mass Vaccinated with Porcine Reproductive and Respiratory Syndrome Modified Live Virus Using Four Commercial Enzyme-Linked Immunosorbent Assays and Neutralizing Tests
by Chaosi Li, Gang Wang, Zhicheng Liu, Shuhe Fang, Aihua Fan, Kai Chen and Jianfeng Zhang
Vet. Sci. 2025, 12(5), 502; https://doi.org/10.3390/vetsci12050502 - 20 May 2025
Viewed by 192
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) modified live virus (MLV) vaccination is used to control PRRSV. In China, farms conduct random sampling from sow herds every 4 to 6 months. They use the enzyme-linked immunosorbent assay (ELISA) method to monitor the immune [...] Read more.
Porcine reproductive and respiratory syndrome virus (PRRSV) modified live virus (MLV) vaccination is used to control PRRSV. In China, farms conduct random sampling from sow herds every 4 to 6 months. They use the enzyme-linked immunosorbent assay (ELISA) method to monitor the immune status of the herd by tracking the positive rate or the sample-to-positive ratio. However, in farms that implement mass vaccination and have stable production, the positive rate of ELISA antibodies has decreased, especially in high-parity sows. This poses a considerable challenge to the current monitoring approach of PRRSV immunity. It remains unclear whether this reflects insufficient sensitivity of the kits for these special scenarios or the fact that the sows have truly lost immunity. In this study, 233 samples from four farms (A–D) across different regions of China were acquired. They were tested using four representative ELISA kits, two targeting the nucleocapsid protein (N) and two targeting the glycoprotein (GP) to evaluate PRRS immune status. The respective sample positive rates in A–D were 57.1–100%, 50.9–100%, 50–100%, and 75.7–100% using the kits. The positive rates using the four ELISA kits were 50.0–75.7%, 70.0–75.7%, 82.5–97.1%, and 100%, respectively, with poor agreement among them. The positive rates and humoral antibody levels for parity 1 and 2 sows were significantly lower than those with higher parities (>4). Eighty-eight ELISA-negative samples identified using ELISA kit A were verified using a viral neutralizing test (VNT), with only 15.9% of the samples testing negative. In conclusion, the ELISA antibody negativity issue existed, mostly occurring in specific farms tested using a specific kit. However, the low correlation with the VNT results and the poor agreements among the kits suggest that relying on one ELISA test is insufficient to monitor the immune status of PRRSV MLV-vaccinated herds. Full article
(This article belongs to the Special Issue Exploring Innovative Approaches in Veterinary Health)
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