Plant Natural Products: Mechanisms of Action for Promoting Health

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 758

Special Issue Editors

1. Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Zaragoza, Spain
2. Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50059 Zaragoza, Spain
Interests: pharmacology and pharmacy; pharmacognosy; ethnopharmacology; plant science; medicinal plants; food science; natural products; nutrition and dietetics; bioactive foods
Special Issues, Collections and Topics in MDPI journals

E-Mail Website1 Website2
Guest Editor
1. Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Zaragoza, Spain
2. Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50059 Zaragoza, Spain
Interests: natural products; western blot; neuroprotection; polyphenols; antioxidants; cell culture; oxidative stress; phytochemicals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Interest in plant-derived natural products has surged in recent decades, driven by the search for natural and sustainable health-promoting alternatives. Although these products have been used for millennia across various cultures, modern science is only beginning to unravel the molecular and biochemical mechanisms underlying their beneficial effects.

This Special Issue of Biology, titled "Plant Natural Products: Mechanisms of Action for Promoting Health," aims to compile cutting-edge research exploring how bioactive compounds from plants exert their biological effects. It covers a wide range of topics, from the identification and characterization of new therapeutic molecules to the study of their cellular and molecular mechanisms of action.

Understanding these mechanisms is crucial for discovering new drugs, developing effective dietary supplements, and providing a solid scientific basis for the use of natural products in traditional and complementary medicine. The studies in this Special Issue address how plant natural products interact with specific metabolic pathways, modulate the immune system, and influence critical cellular processes like apoptosis, inflammation, and oxidative stress.

By bridging basic research and clinical application, this Special Issue aims to enhance scientific knowledge and influence public health policies, treatment development, and sustainable agricultural practices. We invite readers to explore these innovative studies, which highlight the intrinsic value of plant natural products and their contemporary relevance to global health and medicine.

Prof. Dr. Francisco Les
Dr. Guillermo Cásedas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals
  • bioactivity
  • therapeutics
  • mechanisms
  • health promotion
  • metabolism
  • enzyme activity
  • bioactive compounds
  • pharmacognosy
  • plant extracts
  • polyphenols
  • ethnopharmacology
  • essential oils
  • aromatic plants
  • antioxidants
  • natural products

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 4878 KiB  
Article
Evaluation of the Therapeutic Potential of Traditionally-Used Natural Plant Extracts to Inhibit Proliferation of a HeLa Cell Cancer Line and Replication of Human Respiratory Syncytial Virus (hRSV)
by Ellie N. Brill, Natalie G. Link, Morgan R. Jackson, Alea F. Alvi, Jacob N. Moehlenkamp, Morgan B. Beard, Adam R. Simons, Linden C. Carson, Ray Li, Breckin T. Judd, Max N. Brasseale, Emily P. Berkman, Riley K. Park, Sedna Cordova-Hernandez, Rebecca Y. Hoff, Caroline E. Yager, Meredith C. Modelski, Milica Nenadovich, Dhruvi Sisodia, Clayton J. Reames, Andreas G. Geranios, Sean T. Berthrong, Anne M. Wilson, Ashlee H. Tietje and Christopher C. Stobartadd Show full author list remove Hide full author list
Biology 2024, 13(9), 696; https://doi.org/10.3390/biology13090696 - 5 Sep 2024
Viewed by 506
Abstract
Traditional approaches employing natural plant products to treat a wide array of ailments have been documented and described for thousands of years. However, there remains limited scientific study of the therapeutic potential or effectiveness of ethnobotanical applications. Increases in the incidence of cancer [...] Read more.
Traditional approaches employing natural plant products to treat a wide array of ailments have been documented and described for thousands of years. However, there remains limited scientific study of the therapeutic potential or effectiveness of ethnobotanical applications. Increases in the incidence of cancer and emerging infectious diseases demonstrate a growing need for advances in the development of therapeutic options. In this study, we evaluate the therapeutic potential of aqueous extracts prepared from four plants, purple aster (Symphyotrichum novae-angliae (L.) Nemsom), common sage (Salvia lyrata (L.)), northern spicebush (Lindera benzoin (L.) Blume), and lamb’s ear (Stachys byzantina (K.) Koch)) traditionally used in Native American medicine in Indiana, USA. Using a combination of cytotoxicity assays, immunofluorescence microscopy, and antiviral assays, we found that sage and spicebush extracts exhibit cytotoxic and antiproliferative effects on HeLa cell proliferation and that sage, spicebush, and aster extracts were capable of significantly inhibiting human respiratory syncytial virus (hRSV), a major respiratory pathogen of infants and the elderly. Chemical analysis of the four extracts identified four major compounds which were subsequently evaluated to identify the responsible constituents in the extracts. While none of the identified compounds were shown to induce significant impacts on HeLa cell proliferation, two of the compounds, (1S)-(-)-Borneol and 5-(hydroxymethyl)-furfural, identified in sage and spicebush, respectively, were shown to have antiviral activities. Our data suggest that several of the extracts tested exhibited either anti-proliferative or antiviral activity supporting future further analysis. Full article
(This article belongs to the Special Issue Plant Natural Products: Mechanisms of Action for Promoting Health)
Show Figures

Figure 1

Back to TopTop