1,813,133 Results Found

Nucleotide substitutions are common in cancer cells, and they occur in both protein coding regions and non-coding regions (5′ and 3′ UTRs and introns). Although substitutions in non-coding regions have the potential to alter gene expressi...

In this study, the insert length, location within the coat protein-encoding gene, and sequence orientation of the target fragment were optimized to construct an efficient virus-induced gene silencing (VIGS) system in melon using a Begomovirus solanum...

Recently, studies have increasingly focused on neuropathological and molecular alterations that occur in the early stages of neurodegenerative diseases to understand the primary pathogenesis. This review provides an updated overview of the early path...

Obesity is a multifaceted disease that significantly increases the risk of various chronic conditions. GLP-1R (co)-agonists first emerged as therapeutics for treatment of type 2 diabetes mellitus and have since become an established drug class for im...

Ecosystem services provided by coastal and marine environments are increasingly recognised as of paramount importance for human wellbeing. To inform marine spatial planning and its implementation, as well as to manage conflicts between marine resourc...

This study investigated the relationship between maternal barium (Ba) exposure and the risk of miscarriage using metabolomics and machine learning. Analyses were performed on samples from 183 pregnant women from Nanjing: the concentration of Ba in wh...

Background/Objectives: Functional continence and potency outcomes are paramount for the pentafecta of robotic-assisted laparoscopic radical prostatectomy (RARP). We describe a modified approach of the pubovesical complex (PVC)-sparing technique under...

This study conducted a quasi-natural experiment on Chinese mutual funds that signed the United Nations Principles for Responsible Investment (UNPRI) to examine whether institutional investors’ ESG commitments reduce ESG rating disagreements amo...

Background: Unsafe care remains a major global health challenge, contributing to millions of preventable deaths and ranking among the top ten causes of mortality and disability worldwide. The World Health Organization’s Global Patient Safety Ac...

The transition toward a circular economy is one of the most pressing challenges and opportunities of our time, requiring fundamental shifts in how we produce, consume, and manage materials [...]

Let G=(V,E) be a simple graph with the vertex set V and the edge set E|V|=n,|E|=m. An example of a vertex-decorated graph DG is a vertex-quadrangulated graph QG. The vertex quadrangulation QG of 4-regular graph G visually looks like a graph whose ver...

Temporary anchorage devices (TADs) have become integral in contemporary orthodontic biomechanics, providing reliable skeletal anchorage independent of dental support or patient compliance. This narrative review synthesizes the current evidence regard...

The problem of global climate change is becoming increasingly serious, drawing worldwide attention to the need for carbon emissions reduction. As a primary mode of transport, maritime shipping accounts for 2% of global carbon emissions. Therefore, re...

Rubber materials are widely used in industrial sectors such as petrochemicals and energy due to their excellent elasticity, flexibility, and sealing properties. However, in complex and demanding service environments, rubber is susceptible to swelling...

With the rapid development of new energy technologies, lithium-ion batteries (LIBs) have become one of the core technologies in modern energy storage and electric mobility [...]

In this article, we develop a novel kernel-based estimation framework for functional regression models in the presence of missing responses, with particular emphasis on the Missing At Random (MAR) mechanism. The analysis is carried out in the setting...

Background/Objectives: Oral squamous cell carcinoma (OSCC) often presents at an advanced stage; therefore, the early detection of precursor lesions is crucial. However, the risk assessment of precursor lesions such as oral epithelial dysplasia (OED)...

The building sector accounts for a significant portion of the global energy consumption and carbon dioxide (CO2) emissions, making it a critical area for improving energy efficiency. In Africa, the rapid energy demand and costs have further emphasize...

We report the first synthesis of 3,5-diamino-substituted dithieno[3,2-b:2′,3′-d]thiophene derivatives, bearing alkoxycarbonyl or acetyl groups at C-2 and C-6 positions. The target compounds were prepared via the reaction of 3,4-dibromothi...

Viral sepsis has gained increasing clinical and scientific attention as it represents a complex, life-threatening condition driven by a dysregulated host response to viral pathogens [...]

We show that epistemic uncertainty–our iterated ignorance about our own ignorance–inevitably thickens statistical tails, even under perceived thin-tailed environments from past realizations. Any claim of precise risk carries a margin of e...

Across the Baltic Sea region, areas situated in climate-sensitive water zones are increasingly exposed to environmental and socio-economic challenges. Gdańsk, Poland, is a prominent example where the rising threat of climate-related hazards, par...

South Africa’s persistent electricity shortages and recurrent load shedding remain among the most pressing challenges to national economic growth and social stability. This paper presents a techno-economic framework to assess how optimized depl...

As demand for high-performance energy storage grows across grid and mobility sectors, multivalent ion batteries (MVIBs) have emerged as promising alternatives to lithium-based systems due to their potential for higher volumetric energy density and ma...

Artificial intelligence (AI) is rapidly transforming cardiovascular medicine, with profound implications for congenital heart disease (CHD). Tetralogy of Fallot (ToF), the most common cyanotic disease, requires lifelong surveillance and complex manag...

A new series of angular tricyclic pyrrolo[3,2-c]quinoline derivatives (PQs) was designed and synthesized to further explore the previously promising antiproliferative activity exhibited by the 4-benzodioxole-substituted hit 7d. Accordingly, several s...

The large-scale integration of wind power into the grid has led to a reduction in system inertia, threatening frequency stability. There is an urgent need to accurately assess the inertia support capability of wind turbines, providing a theoretical b...

Indocyanine green (ICG) is widely used in minimally invasive surgery for real-time fluorescence imaging of vascular, biliary, and urological structures. Although its intravenous use has been extensively validated, data on intraureteral administration...

The ongoing decarbonisation of power systems is displacing synchronous generators (SGs) with converter-based plants, requiring a consistent assessment of grid-following inverters (GFLIs) and grid-forming inverters (GFMIs). Using an openly available f...

Genomic organization and its comparative analysis throughout all major kingdoms of life are extensively studied across multiple scales, ranging from individual gene-level analyses to system-wide investigations. This work introduces a novel framework...

Multimodal nanocomposites that combine optical and magnetic functionalities are of great interest for applications such as imaging and temperature sensing. Ternary CuInS2 (CIS)-based quantum dots (QDs) offer low toxicity, strong near-infrared (NIR) e...

The papermaking and recycling industries face increasing demands to improve efficiency, product quality, and environmental performance under conditions of water closure and high furnish variability. This study presents a comprehensive assessment of p...

Chronic low-grade inflammation and oxidative stress induced by the exposome represent key drivers of skin aging and related imperfections. The development of experimental models suitable for studying these metabolic processes is therefore of primary...

The application of advanced Artificial Intelligence (AI) techniques in astroparticle experiments represents a major advancement in both data analysis and experimental design. As space missions become increasingly complex, integrating AI tools is esse...

This work presents a comprehensive study of quantum correlations and their degradation under environmental dephasing within the atomic hydrogen system. By analyzing the magnetic coupling between the electron and proton spins in the 1s hyperfine state...

Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, often diagnosed at advanced stages. The 5-methylcytosine (m5C) RNA modification plays a crucial role in tumorigenesis, influencing cell proliferation, differentiation, met...

In commercial aviation, accurate estimation of the remaining track miles (RTM) during descent is essential for energy-efficient trajectory management. Currently, pilots often rely on heuristics and experience due to the lack of consistent RTM informa...

Objectives: Bone defects, resulting from many causes, represent a challenge in maxillofacial and orthopedic surgery. Regenerative medicine offers promising strategies by introducing exogenous materials to modify the tissue environment and modulate th...

Humidity control in residential buildings is fundamental to ensuring indoor comfort, health, and energy efficiency. This study evaluates the relationship between indoor relative humidity and its impacts on thermal comfort, HVAC energy performance, bi...

The root economics spectrum predicts coordinated trait shifts to a heterogeneous soil environment, yet how roots strategically respond to litter-driven nutrient patches is not fully understood. We conducted a litter addition experiment (CK: 0, Low: 3...

Quillaja saponaria Molina, a tree species endemic to central Chile, is critical to the pharmaceutical and biotechnology industries due to its triterpenic saponins, which exhibit potent immunostimulant, antiviral, and surfactant activities. However, t...

During fetal life, the hepatic artery (HA) is responsible for a small contribution to the total hepatic blood inflow; however, it plays a key role in maintaining liver perfusion and reflects fetal hemodynamic adaptation. With advances in ultrasonogra...

The electrification of agricultural tractors is a key step toward improving energy efficiency and reducing environmental emissions. However, quantitative evaluation of drivetrain performance remains limited because workload data for electric tractors...

Two new species of Glenurus Hagen, 1866 are herein described. Glenurus maya sp. n. is described from Southern Mexico and Guatemala, and G. oswaldi sp. n. from the Antilles. A lectotype for G. heteropteryx Gerstaecker, 1885 is determined, and G. disco...

Accurate wind power prediction is of great significance for grid stability and renewable energy integration. Addressing the challenge of effectively integrating physical mechanisms with data-driven methods in wind power prediction, this paper innovat...

Background/Objectives: Exercise supports physical and cognitive health through neurotrophin-mediated pathways, with irisin playing a key role in neuroprotection and synaptic plasticity. As adolescence represents a period of heightened neuroplasticity...

This study assesses how Data-Driven Decision-Making (DDDM) impacts marketing practices and research. Using the PRISMA 2020 protocol, this research conducted systematic reviews of 94 peer-reviewed articles and utilized bibliometric and thematic analys...

Laser additive manufacturing shows great promise for repairing high-value carburized gears, but the underlying relationships among thermal history, microstructure, and properties remain insufficiently quantified. This study uniquely integrates finite...

Background: Vaspin (also known as serpinA12) is a recent discovery among adipokines. It plays a significant role in obesity-related conditions, many of which are classified as chronic, inflammatory or lifestyle diseases. Due to its anti-inflammatory...

Klebsiella pneumoniae is one of the most significant nosocomial pathogens and an important cause of human infections worldwide. The microorganism is capable of producing different capsular polysaccharides (CPSs), which are the primary receptors for c...