1,846,498 Results Found

The aim of the study was to characterize the prevalence of comorbidities and molecular genetic status in patients with familial hypercholesterolemia (FH) and non-familial hypercholesterolemia (non-FH). This cross-sectional observational study include...

Current research on glial cells has primarily focused on central nervous system glial cells (CNS glia), with relatively fewer studies on EGCs. Given the critical role of EGCs in maintaining intestinal homeostasis and neural function, this study aimed...

Functional ankle instability (FAI) is a common consequence of lateral ankle sprains, characterized by impaired sensorimotor control. While orthoses and localized vibration have shown individual benefits for FAI, their combined application in a wearab...

Soil salinization leads to soil nutrient loss and decreased crop yield. This research aims to determine the optimal reduction rate of diammonium phosphate (DAP) and suitable microbial inoculant for alfalfa cultivation and nitrogen-level improvement i...

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide. CVDs are associated with multiple factors, including oxidative stress, mediated endothelial dysfunction, vascular inflammation, and atherothrombosis. Although traditional...

Industrial-grade printed circuit boards (PCBs) exhibit high structural order and inherent geometric symmetry, where minute surface defects essentially constitute symmetry-breaking anomalies that disrupt topological integrity. Detecting these anomalie...

Out-of-distribution (OOD) detection is essential for ensuring the reliability of machine learning models deployed in safety-critical applications. Existing methods often rely solely on statistical properties of feature distributions while ignoring th...

Tuberculosis (TB) remains a global public health emergency, with multidrug-resistant TB (MDR-TB) and rifampicin-resistant TB (RR-TB) posing critical challenges. Conventional longer regimens are characterized by suboptimal effectiveness, high toxicity...

The size of offshore wind turbine towers is increasing, and they are subjected to larger and more complex loads, which imposes more stringent requirements on the fatigue performance of welded plates in new offshore wind turbine towers. This study inv...

Background/Objectives: Wound infections caused by multidrug-resistant Gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, pose a major clinical challenge. This study evaluated the interactions betwee...

To address the low efficiency of corn straw collection, this study aims to optimize the design of the straw shredding mechanism of corn straw harvesters. A multi-blade arrangement shredding mechanism was designed, with ANSYS 2022 employed for gas-pha...

To address the high-temperature and high-cost challenges of the conventional dry oxidation process in boron diffusion for n-type tunnel oxide passivated contact solar cells, this study proposes a dry–wet–dry mixed oxidation drive-in proce...

Seasonal dynamics in wetland landscapes are closely associated with habitat availability and are likely to influence the spatial organization and diversity of waterbird communities. However, most existing studies rely on static land-cover representat...

An infinite-horizon H∞ linear-quadratic control problem is considered. This problem has the following features: (i) the control cost in the cost functional has a positive small coefficient (small parameter), meaning that the control cost is muc...

Background: Comprehensive conservative management (CCM) is a possible option in end-stage clinical disease, requiring multidisciplinary support and offering survival comparable to dialysis while improving quality of life in frail patients. Despite it...

Tea is produced from the fresh leaves of the tea plant (Camellia sinensis), and the quality of tea is directly dictated by its raw material. Although factors such as tea cultivar, fertilization, and cultivation practices are known to affect fresh lea...

Autoimmune thyroid diseases (AITDs), including Hashimoto thyroiditis and Graves’ disease, are the most common autoimmune endocrinopathies, affecting up to 5% of the population. Pathogenetic pathways have not yet been fully elucidated, even thou...

Background: The development of greener synthetic routes to active pharmaceutical ingredients (APIs) is a key challenge in sustainable chemistry. Methods: In this work, we explored the use of deep eutectic solvents (DESs) in the multi-step synthesis o...

Cyclodextrins and chitosan are biomaterials largely used as pharmaceutical excipients due to their biocompatibility, biodegradability, and low/absent toxicity, associated with a number of favorable properties. In particular, cyclodextrins complexatio...

The Sichuan–Yunnan–Guizhou Pb-Zn metallogenic belt (SYG metallogenic belt), a crucial metallogenic unit on the southwestern margin of the Yangtze Block, is a key part of the South China low-temperature metallogenic domain. The incorporati...

Leading agribusiness firms are pivotal to modernizing agricultural supply chains, yet evidence on how digital transformation translates into high-quality development remains fragmented. Using a 2024 sample of 30 Chinese national agribusiness leaders...

Diabetic foot complications represent a major global health burden and arise from a multifactorial interaction between neuropathy, ischemia, infection, and impaired wound repair. Increasing evidence suggests that, beyond traditional vascular and meta...

Heavy metal contamination poses critical challenges for the cultivation of medicinal plants. This study explores cadmium (Cd)-induced morpho-physiological and metabolic responses in Salvia officinalis (So) and the rare endemic Salvia ceratophylloides...

High sample complexity presents a major challenge in applying multi-agent reinforcement learning (MARL) to dynamic, high-dimensional sports such as basketball. To address this problem, we proposed the knowledge-embedded modular framework (KEMF), whic...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease and is characterized by excessive lipid accumulation in hepatocytes. Endoplasmic reticulum (ER) stress and inflammation play important roles in hepatic...

The use of explosives in both open-pit and underground mining is associated with a sudden increase in pressure during the detonation of explosive charges [...]

Water resource monitoring can provide beneficial information supporting water management; however, present operational systems are small and provide only a subset of the information needed. Primary advancements consist of the clear explanation of wat...

The non-destructive and chemical-free determination of anthocyanin content in single maize kernels is of great importance for plant-breeding programs. Previous studies have mainly relied on Near-Infrared Reflectance (NIR) spectroscopy and color-based...

Background/Objectives: Coupled with the already-problematic background rates of traditional cigarette consumption during pregnancy, the surging epidemic of electronic cigarette usage among pregnant women redoubles the importance of understanding the...

Identifying critical infrastructure in transportation networks requires metrics that can capture both the topological structure and how demand is redistributed during disruptions. Conventional graph-theoretic approaches fail to jointly quantify these...

Background/Objectives: The rhizome of Gastrodia elata Blume (Tianma) is a functional food with medicinal value in China, used to improve the health of the central nervous system and reported to exhibit anti-cellular senescent activity. P-hydroxybenza...

Sustainable agriculture increasingly relies on biostimulants like protein hydrolysates (PHs) to enhance crop resilience. This study characterized and compared three plant-derived PHs (PH1, PH2, and PH3) from the Malvaceae, Brassicaceae, and Fabaceae...

This study was conducted to investigate the effects of dietary polyunsaturated fatty acid (PUFA) levels and FME (flavor and multiple enzymes) on the reproductive performance, nutrient digestion, and metabolism, immunity, and antioxidant capacity of s...

Habitat fragmentation and human disturbance pose major challenges to bird movement and ecological connectivity, highlighting the need for effective ecological network construction in conservation planning. Although coastal ecological networks have re...

This study proposes a circular economy strategy to recover phenolic compounds by valorizing shrimp shell waste into a chitosan biosorbent (CH-B). Its adsorption efficiency was evaluated compared to commercial activated carbon (AC) and synthetic XAD-4...

Potyvirus genomes are expressed as a single large open reading frame, which is translated into a polyprotein that is post-translationally cleaved by three virus-encoded proteases into 10 functional proteins. Several of these potyviral proteins, inclu...

This study presents an Italian adaptation of the Teachers’ Reporting Attitude Scale for Child Sexual Abuse (TRAS-CSA), aiming to assess teachers’ attitudes towards reporting suspected cases of child sexual abuse (CSA) and to explore the s...

Background: Osteoarthritis (OA) is a degenerative joint disease characterized by extracellular matrix (ECM) breakdown, inflammation, and pain-associated functional impairment. Current pharmacological treatments primarily provide symptomatic relief wi...

Integrated water and nitrogen management plays a crucial role in the sustainable intensification of rapeseed production, particularly in water-limited regions. This two-year field study (2022–2024) evaluated the interactive effects of three irr...

Understanding how abiotic influences affect organisms and their interactions within ecological communities has long been of interest to ecologists. The significance of this comprehension has increased given rapid human-induced climate change. Wind sp...

This study provides a detailed comparative analysis of a three-hybrid intrusion detection method aimed at strengthening network security through precise and adaptive threat identification. The proposed framework integrates an Autoencoder-Gaussian Mix...

The ground impedance (insulation resistance Risol) of photovoltaic (PV) modules is usually measured only in the dry state, even though arrays frequently operate under dew-wet or rain-wet conditions, when leakage paths can change. We measured dry insu...

Field cancerization is a fundamental paradigm in tumorigenesis, emphasizing that carcinogenesis begins long before the appearance of clinically detectable lesions and often precedes recognizable premalignant changes. A direct manifestation of this pr...

The tip-of-the-tongue (TOT) phenomenon is a transient state in which speakers momentarily fail to retrieve a known word despite preserved semantic knowledge and a strong sense of imminent recall. This review integrates cognitive and neural evidence w...

Incorporating waste engine oil bottoms (WEOBs) as rejuvenators into reclaimed asphalt pavement offers a sustainable solution to reduce the consumption of non-renewable resources. To explore the effect of WEOBs on aged asphalt, WEOB-rejuvenated asphal...

Objectives: The overall objective of this study is to examine prenatal patients ascertained without an abnormal ultrasound (US) or an abnormal cell-free DNA (cfDNA) finding to provide a unique understanding of pathogenic copy number variants, identit...

This review synthesizes the state of the art in flapping foil technology and bridges the distinct engineering domains of bio-inspired propulsion and power generation via flow energy harvesting. This review is motivated by the observation that propuls...

Serotonin is most often mentioned in association with the brain, neuronal circuits, and behavior [...]

Background: Dengue virus (DENV) is becoming a global public health problem, but the immunogenicity of DENV structural proteins is not fully understood. Methods: We predicted the epitope-based immunogenicity of DENV proteins from four serotypes in sil...

Traditional macrolide antimicrobials are inhibitors of cytochrome P4503A (CYP3A) in cattle liver. Monensin (MON), an ionophore with a narrow safety margin, undergoes CYP3A-dependent O-demethylation, and its incompatibility with macrolides is well rec...