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32 pages, 3424 KiB  
Article
Application of Particle Swarm Optimization to a Hybrid H/Sliding Mode Controller Design for the Triple Inverted Pendulum System
by Yamama A. Shafeek and Hazem I. Ali
Algorithms 2024, 17(10), 427; https://doi.org/10.3390/a17100427 (registering DOI) - 24 Sep 2024
Abstract
The robotics field of engineering has been witnessing ra advancements and becoming widely engaged in our lives recently. Its application has pervaded various areas that range from household services to agriculture, industry, military, and health care. The humanoid robots are electro–mechanical devices that [...] Read more.
The robotics field of engineering has been witnessing ra advancements and becoming widely engaged in our lives recently. Its application has pervaded various areas that range from household services to agriculture, industry, military, and health care. The humanoid robots are electro–mechanical devices that are constructed in the semblance of humans and have the ability to sense their environment and take actions accordingly. The control of humanoids is broken down to the following: sensing and perception, path planning, decision making, joint driving, stability and balance. In order to establish and develop control strategies for joint driving, stability and balance, the triple inverted pendulum is used as a benchmark. As the presence of uncertainty is inevitable in this system, the need to develop a robust controller arises. The robustness is often achieved at the expense of performance. Hence, the controller design has to be optimized based on the resultant control system’s performance and the required torque. Particle Swarm Optimization (PSO) is an excellent algorithm in finding global optima, and it can be of great help in automatic tuning of the controller design. This paper presents a hybrid H/sliding mode controller optimized by the PSO algorithm to control the triple inverted pendulum system. The developed control system is tested by applying it to the nominal, perturbed by parameter variation, perturbed by external disturbance, and perturbed by measurement noise system. The average error in all cases is 0.053 deg and the steady controller effort range is from 0.13 to 0.621 N.m with respect to amplitude. The system’s robustness is provided by the hybrid H/sliding mode controller and the system’s performance and efficiency enhancement are provided by optimization. Full article
(This article belongs to the Special Issue Metaheuristic Algorithms in Optimal Design of Engineering Problems)
13 pages, 2295 KiB  
Article
The Seven-State RF MEMS Miniaturized Broadband Reconfigurable Step Attenuator
by Yuheng Si, Siming Chen, Peifang Fu, Jian Yu, Binyi Ma, Qiannan Wu and Mengwei Li
Micromachines 2024, 15(10), 1182; https://doi.org/10.3390/mi15101182 (registering DOI) - 24 Sep 2024
Abstract
This paper presents a three-channel reconfigurable step attenuator based on radio frequency (RF) microelectromechanical system (MEMS) switches, in response to the current issues of high insertion loss and low attenuation accuracy of attenuators. The coplanar waveguide (CPW), cross-shaped power dividers, RF MEMS switches, [...] Read more.
This paper presents a three-channel reconfigurable step attenuator based on radio frequency (RF) microelectromechanical system (MEMS) switches, in response to the current issues of high insertion loss and low attenuation accuracy of attenuators. The coplanar waveguide (CPW), cross-shaped power dividers, RF MEMS switches, and π-type attenuation resistor networks are designed as a basic unit of the attenuator. The attenuator implemented attenuation of 0~30 dB at 5 dB intervals in the frequency range of 1~25 GHz through two basic units. The results show that the insertion loss is less than 1.41 dB, the attenuation accuracy is better than 2.48 dB, and the geometric size is 2.4 mm × 4.0 mm × 0.7 mm. The attenuator can be applied to numerous fields such as radar, satellites, aerospace, electronic communication, and so on. Full article
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17 pages, 3214 KiB  
Article
Modelling and Validating the Nonthermal Plasma Parameters for Producing Liquid Hydrocarbon from Solid Polyolefin Wastes
by Mohammad Jakir Hossain Khan, Zilvinas Kryzevicius, Audrius Senulis, Audrone Zukauskaite and Jochen Uebe
Processes 2024, 12(10), 2067; https://doi.org/10.3390/pr12102067 (registering DOI) - 24 Sep 2024
Abstract
This study solved a set of equations to verify the dynamic optimal conditions of nonthermal plasma (NTP)-chemical conversion of solid polyolefin wastes into liquid petroleum hydrocarbons. Furthermore, a novel optimisation model was validated with non-linear experimental conditions to assess the quantitative relationship between [...] Read more.
This study solved a set of equations to verify the dynamic optimal conditions of nonthermal plasma (NTP)-chemical conversion of solid polyolefin wastes into liquid petroleum hydrocarbons. Furthermore, a novel optimisation model was validated with non-linear experimental conditions to assess the quantitative relationship between the process variables responsible for the degradation rate of wastes. The central composite design (CCD) experimental design was developed based on the Response Surface Model (RSM) technique. These techniques significantly improved the model predictions because of the more-detailed electrochemical description. Experiments were conducted in an in-house-designed and -developed NTP system with advanced data acquisition schemes. Both experimental and the numerical findings exhibited a good agreement, and the results indicated that the electrical factors of NTP could significantly affect the conversion yield (Yconv%) of solid polyolefin-derived wastes to liquid hydrocarbons. Additionally, the model investigation indicated that factors such as power discharge (), voltage intensity (), and reaction retention time (RTT) () significantly influenced the conversion yield. After optimisation, a maximum conversion percentage (Yconv%) of ≈93% was achieved. The findings indicated that this recommended framework could be effectively employed for scaling the plasma synergistic pyrolysis technique for generating the maximal Yconv% of plastic wastes to yield an oil. Thereafter, the analysis of variance (ANOVA) technique was applied to examine the accuracy of the developed structure in order to upgrade this laboratory-scale processes to an industrial-scale process with >95% effectiveness. The calorific value of the produced oil was seen to be from 43,570.5 J/g to 46,025.5 J/g due to changes of the arrangements of the process factors, which specified that the liquid hydrocarbons showed similar characteristics like commercial diesel in this respect. Full article
(This article belongs to the Special Issue Pollution Control and Recycling of Solid Wastes)
31 pages, 21167 KiB  
Article
Assessing Polarisation of Climate Phenomena Based on Long-Term Precipitation and Temperature Sequences
by Bernard Twaróg
Sustainability 2024, 16(19), 8311; https://doi.org/10.3390/su16198311 (registering DOI) - 24 Sep 2024
Abstract
This article presents an analysis of monthly precipitation totals based on data from the Global Precipitation Climatology Centre and monthly mean temperatures from the National Oceanic and Atmospheric Administration for 377 catchments located worldwide. The data sequences, spanning 110 years from 1901 to [...] Read more.
This article presents an analysis of monthly precipitation totals based on data from the Global Precipitation Climatology Centre and monthly mean temperatures from the National Oceanic and Atmospheric Administration for 377 catchments located worldwide. The data sequences, spanning 110 years from 1901 to 2010, are analysed. These long-term precipitation and temperature sequences are used to assess the variability in climate characteristics, referred to here as polarisation. This article discusses the measures of polarisation used in the natural sciences. This study adopts two measures to evaluate the phenomenon of polarisation. The first measure is defined based on a stationary time series, calculated as the ratio of the amplitude of values to the standard deviation. The second measure is proposed as the difference in trends of these values. Based on the analysis of monthly precipitation data in the studied catchments, polarisation components are confirmed in 25% of the cases, while in the remaining 75%, they are not. For temperature data, polarisation is confirmed in 12.2% of the cases and not in the remaining 88.8%. The trend analysis employs Mann–Kendall tests at a 5% significance level. The Pettitt test is used to determine the point of trend change for precipitation and temperature data. This article underscores the complex relationship between climate polarisation and sustainable development, reaffirming that sustainable development cannot be pursued in isolation from the challenges posed by climate change. It emphasises the importance of integrating environmental, social, and economic strategies to adapt to extreme climatic events and mitigate their effects. This research is supported by detailed graphical analyses, with the results presented in tabular form. Full article
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13 pages, 548 KiB  
Article
Evaluation of Different Lactic Acid Bacteria as Starter Cultures for Nono—A West African Fermented Dairy Product
by Onyeka M. Ikele, Chigoziri T. Ogu, Xiuping Jiang and George A. Cavender
Foods 2024, 13(19), 3030; https://doi.org/10.3390/foods13193030 (registering DOI) - 24 Sep 2024
Abstract
Nono is a traditional cultured dairy product consumed across West Africa. In this study, five cultures isolated from Nigerian-produced nono and three purified lactic acid bacteria from the USDA-NRRL were examined for use in preparing nono starter cultures. Isolated cultures were characterized using [...] Read more.
Nono is a traditional cultured dairy product consumed across West Africa. In this study, five cultures isolated from Nigerian-produced nono and three purified lactic acid bacteria from the USDA-NRRL were examined for use in preparing nono starter cultures. Isolated cultures were characterized using microbiological and biochemical tests, including 16s rDNA sequencing to identify the genotype. Each isolated strain was cultured and inoculated into UHT milk (1% v/v) and allowed to ferment for 24 h at 25 °C. Fermented products were evaluated for pH, moisture content, water activity, and viscosity, and their descriptive sensory properties were noted. The isolate that resulted in sensory properties most similar to traditional nono was then used as the primary strain for subsequent starter culture blends made with the NRRL cultures. These blends were used for the fermentation of nono and compared with commercial nono samples. Isolates obtained from nono were as follows: Lactobacillus fermentum, Lactobacillus paracasei, and, surprisingly, Lactobacillus rhamnosus, which has not been previously reported as a part of the nono microflora. There was no significant difference in the physical parameters of nono made from the individual indigenous isolates and a similar pattern was observed for the organisms from NRRL, except that their total titratable acidity and viscosities were significantly (p < 0.05) higher than those of the indigenous organisms. Compounded starter made with L. rhamnosus and NRRL cultures was then used to make nono that showed significantly (p < 0.05) different pH and viscosity values than commercially purchased nono, while sensory evaluation showed that nono made from the new starter culture had a high overall consumer acceptance score. Full article
(This article belongs to the Special Issue Dairy Products: Processing Technology and Sensory Properties)
27 pages, 3717 KiB  
Article
Antioxidant and Antibacterial Activities of Selected Medicinal Plants from Addis Ababa against MDR-Uropathogenic Bacteria
by Mebrahtu Eyasu, Juana Benedí, José Antonio Romero and Sagrario Martín-Aragón
Int. J. Mol. Sci. 2024, 25(19), 10281; https://doi.org/10.3390/ijms251910281 (registering DOI) - 24 Sep 2024
Abstract
This study determined the antioxidant and antibacterial activities of Thymus schimperi (Ts), Rhamnus prinoides (Rp), and Justicia schimperiana (Js) from Addis Ababa against MDR-Uropathogenic bacteria. Accordingly, Thymus schimperi had the highest total phenolic (TPC), flavonoid (TFC) and proanthocyanidin content. In Ts, [...] Read more.
This study determined the antioxidant and antibacterial activities of Thymus schimperi (Ts), Rhamnus prinoides (Rp), and Justicia schimperiana (Js) from Addis Ababa against MDR-Uropathogenic bacteria. Accordingly, Thymus schimperi had the highest total phenolic (TPC), flavonoid (TFC) and proanthocyanidin content. In Ts, the GC-MS analyses predicted 14 bioactive compounds. And among these, hexanedioic acid, bis(2-ethylhexyl) ester, thymol, and o-cymen-5-ol were the most predominant compounds, respectively. Six compounds were also predicted in Rp, where hexanedioic acid, bis(2-ethylhexyl) ester, β-D-glucopyranoside, methyl, and desulphosinigrin were the predominant, respectively. Whereas in the Js extract, five bioactive compounds were predicted, with hexanedioic acid, mono (2-ethylhexyl) ester, debrisoquine, and 8,11,14-heptadecatrienoate, methyl ester being predominant compounds, respectively. The extracts’ TPC showed a strong negative correlation with the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay (r = −0.999; p = 0.023). In addition, the TFC correlated significantly with the ABTS (2,2′-azino-di-(3-ethylbenzthiazoline sulfonic acid)) assay (r = 0.999; p = 0.032). Thymus schimperi showed the highest antibacterial activity against clinical isolates of Escherichia coli and Klebsiella pneumoniae ESBL at 1000 mg/mL, and Ts had the lowest MIC (4 mg/mL) among evaluated extracts against E. coli (ATCC25922). In conclusion, Ts and Rp possess higher predicted bioactive molecules, including antioxidant and antibacterial activities, which are potentially useful in treating urinary tract infections. Full article
(This article belongs to the Special Issue Bioactive Compounds of Natural Origin)
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20 pages, 1906 KiB  
Article
Antitumoral and Antiproliferative Potential of Synthetic Derivatives of Scorpion Peptide IsCT1 in an Oral Cavity Squamous Carcinoma Model
by Laertty Garcia de Sousa Cabral, Cyntia Silva de Oliveira, Vani Xavier Oliveira, Jr., Rosely Cabette Barbosa Alves, Jean-Luc Poyet and Durvanei Augusto Maria
Molecules 2024, 29(19), 4533; https://doi.org/10.3390/molecules29194533 (registering DOI) - 24 Sep 2024
Abstract
The oral cavity is a frequent site for head and neck cancers, which rank as the sixth most common cancer globally, with a 5-year survival rate slightly over 50%. Current treatments are limited, and resistance to therapy remains a significant clinical obstacle. IsCT1, [...] Read more.
The oral cavity is a frequent site for head and neck cancers, which rank as the sixth most common cancer globally, with a 5-year survival rate slightly over 50%. Current treatments are limited, and resistance to therapy remains a significant clinical obstacle. IsCT1, a membrane-active peptide derived from the venom of the scorpion Opisthacanthus madagascariensis, has shown antitumor effects in various cancer cell lines, including breast cancer and chronic myeloid leukemia. However, its hemolytic action limits its potential therapeutic use. This study aims to assess the antitumor and antiproliferative activities of synthetic peptides derived from IsCT1 (IsCT-P, AC-AFPK-IsCT1, AFPK-IsCT1, AC-KKK-IsCT1, and KKK-IsCT1) in the context of oral squamous cell carcinoma. We evaluated the cytotoxic effects of these peptides on tongue squamous cell carcinoma cells and normal cells, as well as their impact on cell cycle phases, the expression of proliferation markers, modulators of cell death pathways, and mitochondrial potential. Our results indicate that the IsCT1 derivatives IsCT-P and AC-AFPK-IsCT1 possess cytotoxic properties towards squamous cell carcinoma cells, reducing mitochondrial membrane potential and the proliferative index. The treatment of cancer cells with AC-AFPK-IsCT1 led to a positive modulation of pro-apoptotic markers p53 and caspases 3 and 8, a decrease in PCNA and Cyclin D1 expression, and cell cycle arrest in the S phase. Notably, contrary to the parental IsCT1 peptide, AC-AFPK-IsCT1 did not exhibit hemolytic activity or cytotoxicity towards normal cells. Therefore, AC-AFPK-IsCT1 might be a viable therapeutic option for head and neck cancer treatment. Full article
(This article belongs to the Special Issue Natural and Un-Natural Peptides)
15 pages, 1776 KiB  
Review
Ultrasound-Guided Botulinum Toxin-A Injections into the Masseter Muscle for both Medical and Aesthetic Purposes
by Marius Nicolae Popescu, Cristina Beiu, Carmen Andrada Iliescu, Andreea Racoviță, Mihai Berteanu, Mădălina Gabriela Iliescu, Ana Maria Alexandra Stănescu, Diana Sabina Radaschin and Liliana Gabriela Popa
Toxins 2024, 16(10), 413; https://doi.org/10.3390/toxins16100413 (registering DOI) - 24 Sep 2024
Abstract
With the increasing use of Botulinum toxin type A (BoNT-A) injections in the masseter muscles for both medical and aesthetic purposes, there is a constant need to continually enhance the efficacy of these treatments and reduce the risk of potential adverse events. This [...] Read more.
With the increasing use of Botulinum toxin type A (BoNT-A) injections in the masseter muscles for both medical and aesthetic purposes, there is a constant need to continually enhance the efficacy of these treatments and reduce the risk of potential adverse events. This review provides an in-depth analysis of the masseter muscle’s anatomical structure and essential landmarks and emphasizes the advantages of ultrasound (US) guidance in improving the precision of BoNT-A injections compared to conventional blind methods. The review is supplemented with comprehensive figures, including graphics, clinical images, and ultrasound visuals, to support the discussion. Potential complications such as paradoxical bulging, inadvertent injections into the risorius muscle or parotid gland, facial paralysis, and the risk of bone resorption are examined. Future research should aim at refining injection techniques and assessing the long-term effects of repeated treatments to ensure optimal patient care and safety. Full article
(This article belongs to the Special Issue Botulinum Toxins: New Uses in the Treatment of Diseases (Volume II))
33 pages, 503 KiB  
Review
Short Peptides as Powerful Arsenal for Smart Fighting Cancer
by Joanna Bojarska and Wojciech M. Wolf
Cancers 2024, 16(19), 3254; https://doi.org/10.3390/cancers16193254 (registering DOI) - 24 Sep 2024
Abstract
Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, and also in combinatorial approaches. Moreover, short peptides have relevance in cancer imaging or 3D culture. Thanks to the natural ‘smart’ [...] Read more.
Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, and also in combinatorial approaches. Moreover, short peptides have relevance in cancer imaging or 3D culture. Thanks to the natural ‘smart’ nature of short peptides, their unique structural features, as well as recent progress in biotechnological and bioinformatics development, short peptides are playing an enormous role in evolving cutting-edge strategies. Self-assembling short peptides may create excellent structures to stimulate cytotoxic immune responses, which is essential for cancer immunotherapy. Short peptides can help establish versatile strategies with high biosafety and effectiveness. Supramolecular short peptide-based cancer vaccines entered clinical trials. Peptide assemblies can be platforms for the delivery of antigens, adjuvants, immune cells, and/or drugs. Short peptides have been unappreciated, especially in the vaccine aspect. Meanwhile, they still hide the undiscovered unlimited potential. Here, we provide a timely update on this highly active and fast-evolving field. Full article
(This article belongs to the Collection Innovations in Cancer Drug Development Research)
14 pages, 884 KiB  
Article
Vulnerable Narcissism and Emotion Dysregulation as Mediators in the Link between Childhood Emotional Abuse and Binge Watching
by Valeria Verrastro, Danilo Calaresi, Fiorenza Giordano and Valeria Saladino
Eur. J. Investig. Health Psychol. Educ. 2024, 14(10), 2628-2641; https://doi.org/10.3390/ejihpe14100173 (registering DOI) - 24 Sep 2024
Abstract
Individuals who have faced childhood emotional abuse (CEA) may develop vulnerable narcissistic tendencies and experience difficulties in regulating their emotions. These psychological vulnerabilities can contribute to the adoption of binge watching as a maladaptive coping mechanism. The present study aimed to investigate the [...] Read more.
Individuals who have faced childhood emotional abuse (CEA) may develop vulnerable narcissistic tendencies and experience difficulties in regulating their emotions. These psychological vulnerabilities can contribute to the adoption of binge watching as a maladaptive coping mechanism. The present study aimed to investigate the potential mediating role of vulnerable narcissism and emotion dysregulation in the relationship between CEA and binge watching. Additionally, this study examined whether this model was gender-invariant. A sample of 1082 emerging adults, aged 18 to 25 (50% women), completed self-report questionnaires. The results revealed significant direct and indirect relationships among all the variables of interest, and the model was found to be invariant across genders. Notably, both men and women who experienced CEA and exhibited higher levels of vulnerable narcissism and emotion dysregulation reported engaging in higher levels of binge watching. These findings highlight the importance of the early identification of CEA, the implementation of targeted interventions, and the provision of trauma-informed care to address the negative consequences of CEA and mitigate the development of binge-watching behaviors. Moreover, the results emphasize the need for tailored prevention and intervention programs that address vulnerable narcissism and emotion dysregulation as potential pathways to inform effective therapeutic strategies. Full article
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23 pages, 1179 KiB  
Article
Towards a Closed-Loop Supply Chain: Assessing Current Practices in Empty Pesticide Container Management in Indonesia
by Lailafitri Handayani, Gatot Yudoko and Liane Okdinawati
Sustainability 2024, 16(19), 8310; https://doi.org/10.3390/su16198310 (registering DOI) - 24 Sep 2024
Abstract
Pesticides are essential to modern agriculture, significantly enhancing crop yields and quality to ensure global food security. Their critical role in preventing hunger is highlighted by the notable increase in global pesticide trade over the past decade. In Indonesia, pesticide usage has surged, [...] Read more.
Pesticides are essential to modern agriculture, significantly enhancing crop yields and quality to ensure global food security. Their critical role in preventing hunger is highlighted by the notable increase in global pesticide trade over the past decade. In Indonesia, pesticide usage has surged, with a 24% rise in registered pesticide formulations between 2017 and 2021. However, this increase presents challenges, particularly in the disposal of empty pesticide containers (EPC), which pose substantial environmental and health risks if improperly managed. To address this, a closed-loop supply chain (CLSC) is proposed as an effective, eco-friendly solution for the management of EPC waste. This study evaluates the implementation of a CLSC for EPC in Indonesia, employing rich picture analysis and stakeholder interviews to identify key challenges, opportunities, and strengths. Notable challenges include regulatory gaps, financial and operational feasibility, and limited farmer engagement. However, opportunities exist in enhancing environmental sustainability, generating economic benefits, and gaining support from industry groups. One key strength is the widespread practice of triple rinsing among farmers, with 62.63% of respondents already adopting this method. This study underscores the important of establishing clear and enforceable regulations, introducing financial incentives and supportive policies, promoting public–private partnerships, creating targeted behavior change interventions, and ensuring organizational commitments and training programs. These insights are crucial in developing a sustainable CLSC, ensuring both environmental and economic benefits. Full article
(This article belongs to the Special Issue Critical Issue on Waste Management for Environmental Sustainability)
11 pages, 1053 KiB  
Article
Hispidol Regulates Behavioral Responses to Ethanol through Modulation of BK Channels: A Novel Candidate for the Treatment of Alcohol Use Disorder
by Wooin Yang, Hee Jae Goh, Young Taek Han, Myon-Hee Lee and Dong Seok Cha
Molecules 2024, 29(19), 4531; https://doi.org/10.3390/molecules29194531 (registering DOI) - 24 Sep 2024
Abstract
Alcohol use disorder (AUD) is the most common substance use disorder and poses a significant global health challenge. Despite pharmacological advances, no single drug effectively treats all AUD patients. This study explores the protective potential of hispidol, a 6,4′-dihydroxyaurone, for AUD using the [...] Read more.
Alcohol use disorder (AUD) is the most common substance use disorder and poses a significant global health challenge. Despite pharmacological advances, no single drug effectively treats all AUD patients. This study explores the protective potential of hispidol, a 6,4′-dihydroxyaurone, for AUD using the Caenorhabditis elegans model system. Our findings demonstrate that hispidol-fed worms exhibited more pronounced impairments in thrashes, locomotory speed, and bending amplitude, indicating that hispidol exacerbated the detrimental effects of acute ethanol exposure. However, hispidol significantly improved ethanol withdrawal behaviors, such as locomotory speed and chemotaxis performance. These beneficial effects were absent in slo-1 worms (the ortholog of mammalian α-subunit of BK channel) but were restored with the slo-1(+) or hslo(+) transgene, suggesting the involvement of BK channel activity. Additionally, hispidol increased fluorescence intensity and puncta in the motor neurons of slo-1::mCherry-tagged worms, indicating enhanced BK channel expression and clustering. Notably, hispidol did not alter internal ethanol concentrations, suggesting that its action is independent of ethanol metabolism. In the mouse models, hispidol treatment also demonstrated anxiolytic activity against ethanol withdrawal. Overall, these findings suggest hispidol as a promising candidate for targeting the BK channel in AUD treatment. Full article
22 pages, 405 KiB  
Article
Exploring the Literacy Experiences of Preservice Early Childhood Teachers: Social and Contextual Influences, and Implications for Teacher Education
by Jennifer J. Chen, Yonggang Ren and Shirley O’Neill
Educ. Sci. 2024, 14(10), 1042; https://doi.org/10.3390/educsci14101042 (registering DOI) - 24 Sep 2024
Abstract
Considering that early literacy (reading and writing) is critical for later literacy and academic success, this study investigated the social and contextual influences on the early and current literacy experiences of 70 preservice early childhood teachers in the United States through a questionnaire. [...] Read more.
Considering that early literacy (reading and writing) is critical for later literacy and academic success, this study investigated the social and contextual influences on the early and current literacy experiences of 70 preservice early childhood teachers in the United States through a questionnaire. Analyses of both quantitative and qualitative data revealed eight key findings: First, the strongest influence on these individuals’ early literacy development was parents, followed by teachers. Second, their current literacy experiences were shaped primarily by professors/academic work followed by self-motivation. Third, nearly half of the preservice teachers regarded themselves as average readers and writers. While the majority of them enjoyed reading and more than half also enjoyed writing, those who lacked such enjoyment provided various reasons, especially citing insufficient intrinsic motivation, limited time for reading, and inadequate writing skills or ideas. Fourth, most of them prioritized their literacy time to fulfill academic requirements. Fifth, most devoted a limited amount of time to literacy activities. Sixth, there was a relatively strong positive correlation between reading fluency and writing fluency. Seventh, a positive correlation was found between years in college and writing fluency. Eighth, there was a negative correlation between grade point average and time spent writing per week. Full article
(This article belongs to the Section Teacher Education)
19 pages, 601 KiB  
Article
Blood Parameter Response in Growing Alpine Goat Kids Fed Diets Containing Extruded Flaxseed or Pumpkin Seed Cake
by Željka Klir Šalavardić, Josip Novoselec, Mislav Đidara and Zvonko Antunović
Agriculture 2024, 14(10), 1667; https://doi.org/10.3390/agriculture14101667 (registering DOI) - 24 Sep 2024
Abstract
Blood parameters can provide information on the nutritional status of goat kids, which is related to both health and performance. The present study aimed to research whether feeding extruded flaxseed (FS) and pumpkin seed cake (PC), as an alternative protein source in diets, [...] Read more.
Blood parameters can provide information on the nutritional status of goat kids, which is related to both health and performance. The present study aimed to research whether feeding extruded flaxseed (FS) and pumpkin seed cake (PC), as an alternative protein source in diets, has an effect on the hematological and serum biochemical parameters of goat kids during growth. In the small-scale goat farm, 31 French Alpine goat kids aged 32 days were used for the study. The goat kids were subjected to three different feeding treatments: a mixture containing soybean meal and extruded soybeans (CON), a mixture containing 16% PC (PC-16), and a mixture containing 9% FS (FS-9). They were monitored during the suckling, weaning, and post-weaning growth periods. PC-16 and FS-9 in goat kids’ diets did not result in any changes regarding average daily weight gain. The WBC count was higher in goat kids fed FS-9 and PC-16 compared to CON (9.84 and 9.54 vs. 6.61 × 109 L) diets during the weaning period. GGT activity was lowest in the serum of goat kids fed PC-16 compared to CON post-weaning (38.65 vs. 48.40 U/L). In addition, FS-19 increased GPx compared to kids fed PC-16 post-weaning (809.7 vs. 600.8 U/L). Regarding blood parameters, PC-16 and FS-9 can be used in goat kids’ nutrition as alternative sources of proteins on a small-scale goat farm without compromising goat kids’ growth. Full article
(This article belongs to the Special Issue Rational Use of Feed to Promote Animal Healthy Feeding)
15 pages, 2868 KiB  
Article
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer
by Rolando André Rios Villacis, Luiza Côrtes, Tatiane Ramos Basso, Luisa Matos do Canto, Jeferson Santos Souza, Mads Malik Aagaard, Maria Nirvana da Cruz Formiga, Samuel Aguiar, Jr., Maria Isabel Achatz and Silvia Regina Rogatto
Int. J. Mol. Sci. 2024, 25(19), 10275; https://doi.org/10.3390/ijms251910275 (registering DOI) - 24 Sep 2024
Abstract
A hereditary component of breast (BC) and colorectal cancer (CRC) has been described in approximately one-third of these tumor types. BC patients have an increased risk of developing CRC as a second primary tumor and vice versa. Germline genomic variants (NextSeq550, Illumina) were [...] Read more.
A hereditary component of breast (BC) and colorectal cancer (CRC) has been described in approximately one-third of these tumor types. BC patients have an increased risk of developing CRC as a second primary tumor and vice versa. Germline genomic variants (NextSeq550, Illumina) were investigated in 24 unrelated BC and/or CRC patients and 7 relatives from 3 index patients. Fifty-six pathogenic or likely pathogenic variants were identified in 19 of 24 patients. We detected single-nucleotide variants (SNVs) in CRC predisposition genes (MLH1 and MUTYH) and other promising candidates (CDK5RAP3, MAD1L1, NOS3, and POLM). Eighteen patients presented SNVs or copy number variants (CNVs) in DNA damage repair genes. We also identified SNVs recently associated with BC or CRC predisposition (PABPC1, TYRO3, MAP3K1, SLC15A4, and LAMA1). The PABPC1c.1255C>T variant was detected in nine unrelated patients. Each patient presented at least one SNV/CNV in a candidate gene, and most had alterations in more than one gene, reinforcing a polygenic model for BC/CRC predisposition. A significant fraction of BC/CRC patients with a family history of these tumors harbored deleterious germline variants in DNA repair genes. Our findings can lead to strategies to improve the diagnosis, genetic counseling, and treatment of patients and their relatives. Full article
(This article belongs to the Section Molecular Oncology)
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45 pages, 15577 KiB  
Article
Building Resilience through Territorial Planning: Water Management Infrastructure and Settlement Design in the Coastal Wetlands of Northern Apulia (Salpia vetus-Salapia) from the Hellenistic Period to Late Antiquity
by Roberto Goffredo and Darian Marie Totten
Land 2024, 13(10), 1550; https://doi.org/10.3390/land13101550 (registering DOI) - 24 Sep 2024
Abstract
This Gulf of Manfredonia has, for millennia, been the primary water feature of the coastal wetland of Northern Apulia, Italy, although modern reclamation works make writing its long-term history challenging. Our recent paleoenvironmental research has reconstructed the evolution of the southern half of [...] Read more.
This Gulf of Manfredonia has, for millennia, been the primary water feature of the coastal wetland of Northern Apulia, Italy, although modern reclamation works make writing its long-term history challenging. Our recent paleoenvironmental research has reconstructed the evolution of the southern half of this lagoon since the Neolithic period. Here, we write a history of water management and environmental change in this landscape from the perspective of two key urban sites: pre-Roman Salpia vetus and Roman Salapia. The Roman architectural historian Vitruvius recounts the abandonment of Salpia vetus and the refoundation of Salapia. We employ his narrative as a frame for a more complex environmental history, starting from a historiography of this landscape’s study and a summary of our interdisciplinary research agenda, which unifies environmental, topographical, remote sensing, and archaeological approaches. Resilience in this changeable wetland environment was only possible through an integrated and intentional management of water among rivers, the lagoon, and the Adriatic Sea. While Salpia vetus exploited this wetland and thrived for centuries, the settlement eventually collapsed due to human and environmentally impelled factors. Roman Salapia subsequently emerged with a different approach, new infrastructure, and a new location. This blueprint would sustain urban life in this wetland for six centuries and lay the groundwork for the Medieval town. Full article
(This article belongs to the Special Issue Resilience in Historical Landscapes)
14 pages, 2887 KiB  
Article
Renewable Diesel Production over Mo-Ni Catalysts Supported on Silica
by John Zafeiropoulos, George Petropoulos, Eleana Kordouli, Labrini Sygellou, Alexis Lycourghiotis and Kyriakos Bourikas
Catalysts 2024, 14(10), 662; https://doi.org/10.3390/catal14100662 (registering DOI) - 24 Sep 2024
Abstract
Nickel catalysts promoted with Mo and supported on silica were studied for renewable diesel production from triglyceride biomass, through the selective deoxygenation process. The catalysts were prepared by wet co-impregnation of the SiO2 with different Ni/(Ni + Mo) atomic ratios (0/0.84/0.91/0.95/0.98/1) and [...] Read more.
Nickel catalysts promoted with Mo and supported on silica were studied for renewable diesel production from triglyceride biomass, through the selective deoxygenation process. The catalysts were prepared by wet co-impregnation of the SiO2 with different Ni/(Ni + Mo) atomic ratios (0/0.84/0.91/0.95/0.98/1) and a total metal content equal to 50%. They were characterized by XRD, XPS, N2 physisorption, H2-TPR, and NH3-TPD. Evaluation of the catalysts for the transformation of sunflower oil to renewable (green) diesel took place in a high-pressure semi-batch reactor, under solvent-free conditions. A very small addition of Mo, namely the synergistic Ni/(Ni + Mo) atomic ratio equal to 0.95, proved to be the optimum one for a significant enhancement of the catalytic performance of the metallic Ni/SiO2 catalyst, achieving 98 wt.% renewable diesel production. This promoting action of Mo has been attributed to the significant increase of the metallic Ni active phase surface area, the suitable regulation of surface acidity, the acceleration of the hydro-deoxygenation pathway (HDO), the creation of surface oxygen vacancies, and the diminution of coke formation provoked by Mo addition. Full article
(This article belongs to the Special Issue Catalytic Conversion of Biomass to Chemicals)
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20 pages, 649 KiB  
Review
Microscopic Colitis: An Underestimated Disease of Growing Importance
by Kamil Rutkowski, Karina Udrycka, Barbara Włodarczyk and Ewa Małecka-Wojciesko
J. Clin. Med. 2024, 13(19), 5683; https://doi.org/10.3390/jcm13195683 (registering DOI) - 24 Sep 2024
Abstract
The aim of this paper is to raise awareness of MC as a clinically significant condition and to highlight its under-recognition, risk factors, diagnosis, management, and complications. This paper underlines the diagnostic and therapeutic challenges associated with the often nonspecific symptoms of MC. [...] Read more.
The aim of this paper is to raise awareness of MC as a clinically significant condition and to highlight its under-recognition, risk factors, diagnosis, management, and complications. This paper underlines the diagnostic and therapeutic challenges associated with the often nonspecific symptoms of MC. In order to create this article, we reviewed available articles found in the PubMed database and searched for articles using the Google Scholar platform. Microscopic colitis (MC) is a chronic inflammatory bowel disease, classified into three types: lymphocytic, collagenous, and unspecified. The average age of onset of MC is around 62–65 years and the disease is more common in women than men (nine times more common). The main symptom of MC is watery diarrhoea without blood, other symptoms include defecatory urgency, faecal incontinence, abdominal pain, nocturnal bowel movements, and weight loss. Once considered a rare disease, MC is now being diagnosed with increasing frequency, but diagnosis remains difficult. To date, a number of causative factors for MC have been identified, including smoking, alcohol consumption, medications (including NSAIDs, PPIs, SSRIs, and ICPIs), genetic factors, autoimmune diseases, bile acid malabsorption, obesity, appendicitis, and intestinal dysbiosis. It may be difficult to recognize and should be differentiated from inflammatory bowel diseases (Crohn’s disease and ulcerative colitis), irritable bowel syndrome (IBS), coeliac disease, infectious bowel disease, and others. Diagnosis involves biopsy at colonoscopy and histopathological evaluation of the samples. Treatment consists of budesonide oral (the gold standard) or enema. Alternatives include bile acid sequestrants (cholestyramine, colesevelam, and colestipol), biologics (infliximab, adalimumab, and vedolizumab), thiopurines, methotrexate, and rarely, surgery. Full article
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
23 pages, 5678 KiB  
Article
IV-YOLO: A Lightweight Dual-Branch Object Detection Network
by Dan Tian, Xin Yan, Dong Zhou, Chen Wang and Wenshuai Zhang
Sensors 2024, 24(19), 6181; https://doi.org/10.3390/s24196181 (registering DOI) - 24 Sep 2024
Abstract
With the rapid growth in demand for security surveillance, assisted driving, and remote sensing, object detection networks with robust environmental perception and high detection accuracy have become a research focus. However, single-modality image detection technologies face limitations in environmental adaptability, often affected by [...] Read more.
With the rapid growth in demand for security surveillance, assisted driving, and remote sensing, object detection networks with robust environmental perception and high detection accuracy have become a research focus. However, single-modality image detection technologies face limitations in environmental adaptability, often affected by factors such as lighting conditions, fog, rain, and obstacles like vegetation, leading to information loss and reduced detection accuracy. We propose an object detection network that integrates features from visible light and infrared images—IV-YOLO—to address these challenges. This network is based on YOLOv8 (You Only Look Once v8) and employs a dual-branch fusion structure that leverages the complementary features of infrared and visible light images for target detection. We designed a Bidirectional Pyramid Feature Fusion structure (Bi-Fusion) to effectively integrate multimodal features, reducing errors from feature redundancy and extracting fine-grained features for small object detection. Additionally, we developed a Shuffle-SPP structure that combines channel and spatial attention to enhance the focus on deep features and extract richer information through upsampling. Regarding model optimization, we designed a loss function tailored for multi-scale object detection, accelerating the convergence speed of the network during training. Compared with the current state-of-the-art Dual-YOLO model, IV-YOLO achieves mAP improvements of 2.8%, 1.1%, and 2.2% on the Drone Vehicle, FLIR, and KAIST datasets, respectively. On the Drone Vehicle and FLIR datasets, IV-YOLO has a parameter count of 4.31 M and achieves a frame rate of 203.2 fps, significantly outperforming YOLOv8n (5.92 M parameters, 188.6 fps on the Drone Vehicle dataset) and YOLO-FIR (7.1 M parameters, 83.3 fps on the FLIR dataset), which had previously achieved the best performance on these datasets. This demonstrates that IV-YOLO achieves higher real-time detection performance while maintaining lower parameter complexity, making it highly promising for applications in autonomous driving, public safety, and beyond. Full article
(This article belongs to the Section Sensor Networks)
22 pages, 1947 KiB  
Review
Terrestrial Animal Source Foods and Health Outcomes for Those with Special Nutrient Needs in the Life Course
by Lora Iannotti, Ana María Rueda García, Giulia Palma, Fanette Fontaine, Beate Scherf, Lynnette M. Neufeld, Rachel Zimmerman and Patrizia Fracassi
Nutrients 2024, 16(19), 3231; https://doi.org/10.3390/nu16193231 (registering DOI) - 24 Sep 2024
Abstract
Background. Animal source foods are under scrutiny for their role in human health, yet some nutritionally vulnerable populations are largely absent from consideration. Methods. Applying a Population Intervention/Exposure Comparator Outcome (PICO/PECO) framework and prioritizing systematic review and meta-analyses, we reviewed the literature on [...] Read more.
Background. Animal source foods are under scrutiny for their role in human health, yet some nutritionally vulnerable populations are largely absent from consideration. Methods. Applying a Population Intervention/Exposure Comparator Outcome (PICO/PECO) framework and prioritizing systematic review and meta-analyses, we reviewed the literature on terrestrial animal source foods (TASFs) and human health, by life course phase. Results. There were consistent findings for milk and dairy products on positive health outcomes during pregnancy and lactation, childhood, and among older adults. Eggs were found to promote early childhood growth, depending on context. Unprocessed meat consumption was associated with a reduced risk for anemia during pregnancy, improved cognition among school-age children, and muscle health in older adults. Milk and eggs represent a risk for food sensitivities/allergies, though prevalence is low, and individuals tend to outgrow the allergies. TASFs affect the human microbiome and associated metabolites with both positive and negative health repercussions, varying by type and quantity. Conclusions. There were substantial gaps in the evidence base for studies limiting our review, specifically for studies in populations outside high-income countries and for several TASF types (pig, poultry, less common livestock species, wild animals, and insects). Nonetheless, sufficient evidence supports an important role for TASFs in health during certain periods of the life course. Full article
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25 pages, 2637 KiB  
Article
Reflective Distributed Denial of Service Detection: A Novel Model Utilizing Binary Particle Swarm Optimization—Simulated Annealing for Feature Selection and Gray Wolf Optimization-Optimized LightGBM Algorithm
by Daoqi Han, Honghui Li and Xueliang Fu
Sensors 2024, 24(19), 6179; https://doi.org/10.3390/s24196179 (registering DOI) - 24 Sep 2024
Abstract
The fast growth of the Internet has made network security problems more noticeable, so intrusion detection systems (IDSs) have become a crucial tool for maintaining network security. IDSs guarantee the normal operation of the network by tracking network traffic and spotting possible assaults, [...] Read more.
The fast growth of the Internet has made network security problems more noticeable, so intrusion detection systems (IDSs) have become a crucial tool for maintaining network security. IDSs guarantee the normal operation of the network by tracking network traffic and spotting possible assaults, thereby safeguarding data security. However, traditional intrusion detection methods encounter several issues such as low detection efficiency and prolonged detection time when dealing with massive and high-dimensional data. Therefore, feature selection (FS) is particularly important in IDSs. By selecting the most representative features, it can not only improve the detection accuracy but also significantly reduce the computational complexity and attack detection time. This work proposes a new FS approach, BPSO-SA, that is based on the Binary Particle Swarm Optimization (BPSO) and Simulated Annealing (SA) algorithms. It combines these with the Gray Wolf Optimization (GWO) algorithm to optimize the LightGBM model, thereby building a new type of reflective Distributed Denial of Service (DDoS) attack detection model. The BPSO-SA algorithm enhances the global search capability of Particle Swarm Optimization (PSO) using the SA mechanism and effectively screens out the optimal feature subset; the GWO algorithm optimizes the hyperparameters of LightGBM by simulating the group hunting behavior of gray wolves to enhance the detection performance of the model. While showing great resilience and generalizing power, the experimental results show that the proposed reflective DDoS attack detection model surpasses conventional methods in terms of detection accuracy, precision, recall, F1-score, and prediction time. Full article
(This article belongs to the Section Sensor Networks)
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33 pages, 8989 KiB  
Article
‘Archetypal Load of Tension’: Idiosyncratic Idioms of Surrealism Created by Aleksander Krzywobłocki and Margit Reich-Sielska in the 1930s in Lviv
by Irena Kossowska
Arts 2024, 13(5), 145; https://doi.org/10.3390/arts13050145 (registering DOI) - 24 Sep 2024
Abstract
This article examines the artistic contributions of two members of the ‘artes’ group, active in Lviv (Lwów during the interwar period) from 1929 to 1935: Aleksander Krzywobłocki (1901–1979) and Margit Reich-Sielska (1900–1980). Situated within the ‘artes’ milieu, which emerged as the most cohesive [...] Read more.
This article examines the artistic contributions of two members of the ‘artes’ group, active in Lviv (Lwów during the interwar period) from 1929 to 1935: Aleksander Krzywobłocki (1901–1979) and Margit Reich-Sielska (1900–1980). Situated within the ‘artes’ milieu, which emerged as the most cohesive community among phenomena with a surrealist profile in the history of Polish art, their creative endeavors have faded from the collective memory of subsequent generations of art historians and critics, both within and beyond Poland. With the aim of elucidating the distinctive characteristics of Krzywobłocki and Sielska’s artistic attitudes, deeply rooted in the cultural landscape of interwar Galicia, this study explores their work as both manifestations of the avant-garde milieu in Lviv and contributions to the transnational surrealist movement. This examination takes a relational approach, considering their artistic output within a framework of trans-local and trans-regional connections. Drawing upon the works of various surrealists active in different European centers, I juxtapose the artistic approaches of Krzywobłocki and Sielska with other practitioners of the movement to highlight both convergences and differences in their expressions. By situating their artistic profiles within the broader modalities of surrealism as a polycentric movement and within the unique cultural context of Lviv—a city marked by its multiethnic, multicultural, and multiconfessional character—I argue that their imaginings should be classified as idiosyncratic idioms of surrealism. This hybrid expression, which developed on the peripheries of European artistic hubs, is primarily distinguished by an ‘archetypal load of tension’—a continual quest for archetypal content that has been lost in the modern world. Full article
(This article belongs to the Section Visual Arts)
13 pages, 988 KiB  
Review
Specific Sources Exert Influence on the Community Structures of Bioaerosols
by Changliang Nie, Yuqi Qiu, Tianxiao Pei and Yunhan Qin
Aerobiology 2024, 2(4), 72-84; https://doi.org/10.3390/aerobiology2040006 (registering DOI) - 24 Sep 2024
Abstract
Bioaerosols constitute a crucial component of atmospheric particulate matter, encompassing physical and chemical aerosol properties along with biological characteristics. They can influence global ecosystems, climate change dynamics, and air quality. Notably, bioaerosols serve as a significant pathway for transmitting respiratory infectious diseases, garnering [...] Read more.
Bioaerosols constitute a crucial component of atmospheric particulate matter, encompassing physical and chemical aerosol properties along with biological characteristics. They can influence global ecosystems, climate change dynamics, and air quality. Notably, bioaerosols serve as a significant pathway for transmitting respiratory infectious diseases, garnering widespread attention worldwide following major pandemics such as COVID-19. Thanks to the development of high-throughput sequencing technologies, studies on bioaerosols have flourished in recent years. Understanding the interconnectedness of sources, spatial and temporal distributions, influencing factors, and health risks associated with bioaerosols is imperative for devising pollution mitigation strategies and preventing the spread of related epidemics. This review provides an overview of bioaerosol sources while elucidating distribution patterns within their community structure across various source types. Lastly, this overview offers insights into future advancements in the field of bioaerosols along with corresponding recommendations. Full article
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19 pages, 4659 KiB  
Article
Evaluation of Bone Turnover around Short Finned Implants in Atrophic Posterior Maxilla: A Finite Element Study
by Andrii Kondratiev, Vladislav Demenko, Igor Linetskiy, Hans-Werner Weisskircher and Larysa Linetska
Prosthesis 2024, 6(5), 1170-1188; https://doi.org/10.3390/prosthesis6050084 (registering DOI) - 24 Sep 2024
Abstract
Background/Objectives: Dental implants have emerged as a modern solution for edentulous jaws, showing high success rates. However, the implant’s success often hinges on the patient’s bone quality and quantity, leading to higher failure rates in poor bone sites. To address this issue, [...] Read more.
Background/Objectives: Dental implants have emerged as a modern solution for edentulous jaws, showing high success rates. However, the implant’s success often hinges on the patient’s bone quality and quantity, leading to higher failure rates in poor bone sites. To address this issue, short implants have become a viable alternative to traditional approaches like bone sinus lifting. Among these, Bicon® short implants with a plateau design are popular for their increased surface area, offering potential advantages over threaded implants. Despite their promise, the variability in patient-specific bone quality remains a critical factor influencing implant success and bone turnover regulated by bone strains. Excessive strains can lead to bone loss and implant failure according to Frost’s “Mechanostat” theory. To better understand the implant biomechanical environment, numerical simulation (FEA) is invaluable for correlating implant and bone parameters with strain fields in adjacent bone. The goal was to establish key relationships between short implant geometry, bone quality and quantity, and strain levels in the adjacent bone of patient-dependent elasticity to mitigate the risk of implant failure by avoiding pathological strains. Methods: Nine Bicon Integra-CP™ implants were chosen. Using CT scans, three-dimensional models of the posterior maxilla were created in Solidworks 2022 software to represent the most challenging scenario with minimal available bone, and the implant models were positioned in the jaw with the implant apex supported by the sinus cortical bone. Outer dimensions of the maxilla segment models were determined based on a prior convergence test. Implants and abutments were considered as a single unit made of titanium alloy. The bone segments simulated types III/IV bone by different cancellous bone elasticities and by variable cortical bone elasticity moduli selected based on an experimental data range. Both implants and bone were treated as linearly elastic and isotropic materials. Boundary conditions were restraining the disto-mesial and cranial surfaces of the bone segments. The bone–implant assemblies were subjected to oblique loads, and the bone’s first principal strain fields were analyzed. Maximum strain values were compared with the “minimum effective strain pathological” threshold of 3000 microstrain to assess the implant prognosis. Results: Physiological strains ranging from 490 to 3000 microstrain were observed in the crestal cortical bone, with no excessive strains detected at the implant neck area across different implant dimensions and cortical bone elasticity. In cancellous bone, maximum strains were observed at the first fin tip and were influenced by the implant diameter and length, as well as bone quality and cortical bone elasticity. In the spectrum of modeled bone elasticity and implant dimensions, increasing implant diameter from 4.5 to 6.0 mm resulted in a reduction in maximum strains by 34% to 52%, depending on bone type and cortical bone elasticity. Similarly, increasing implant length from 5.0 to 8.0 mm led to a reduction in maximum strains by 15% to 37%. Additionally, a two-fold reduction in cancellous bone elasticity modulus (type IV vs. III) corresponded to an increase in maximum strains by 16% to 59%. Also, maximum strains increased by 86% to 129% due to a decrease in patient-dependent cortical bone elasticity from the softest to the most rigid bone. Conclusions: The findings have practical implications for dental practitioners planning short finned implants in the posterior maxilla. In cases where the quality of cortical bone is uncertain and bone height is insufficient, wider 6.0 mm diameter implants should be preferred to mitigate the risk of pathological strains. Further investigations of cortical bone architecture and elasticity in the posterior maxilla are recommended to develop comprehensive clinical recommendations considering bone volume and quality limitations. Such research can potentially enable the placement of narrower implants in cases of insufficient bone. Full article

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