Effects of Diet and Nutrition on Gut Microbiota

Dear Colleagues,

The gut microbiota, often termed the "second genome", critically influences the pathogenesis of metabolic diseases through metabolite exchange, immune modulation, and neuroendocrine signaling. Emerging evidence highlights that dietary patterns (e.g., the Mediterranean diet and intermittent fasting) and specific nutrients (e.g., dietary fiber and polyphenols) can reshape microbial communities to improve host health. Interventions such as probiotics, prebiotics, and functional foods also demonstrate clinical promise in addressing microbiota-related dysbiosis.

However, key challenges remain, including incomplete mechanistic insights, inadequate consideration of population heterogeneity, and unclear translational pathways. This Special Issue prioritizes the molecular mechanisms and clinical translation of diet–microbiota–host interactions, with a focus on the following:

1. Dynamic microbiota–metabolite mapping during disease progression and therapeutic target validation.
2. Building machine learning models that leverage gut microbiota signatures to predict risks of hypertension, hyperlipidemia, and hyperglycemia.
3. Multi-omics integration in precision nutrition strategies.
4. Clinical translation of functional foods for metabolic disorders.

We welcome original research, reviews, and methodological papers from microbiology, nutrition, and clinical medicine to advance microbiota-guided precision nutrition. Submissions addressing mechanistic insights, clinical validation, or scalable interventions are particularly encouraged.

Dr. Heng Yuan
Prof. Dr. Sunmin Park
Guest Editors

Manuscript Submission Information

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