Effects of Diet and Nutrition on Gut Microbiota

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 641

Special Issue Editors


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Guest Editor
Department of Physiology and Pathophysiology, Xi'an Jiaotong University, Xi'an, China
Interests: gut microbiota; nutrition; MASLD; lipid metabolism

Special Issue Information

Dear Colleagues,

The gut microbiota, often termed the "second genome", critically influences the pathogenesis of metabolic diseases through metabolite exchange, immune modulation, and neuroendocrine signaling. Emerging evidence highlights that dietary patterns (e.g., the Mediterranean diet and intermittent fasting) and specific nutrients (e.g., dietary fiber and polyphenols) can reshape microbial communities to improve host health. Interventions such as probiotics, prebiotics, and functional foods also demonstrate clinical promise in addressing microbiota-related dysbiosis.

However, key challenges remain, including incomplete mechanistic insights, inadequate consideration of population heterogeneity, and unclear translational pathways. This Special Issue prioritizes the molecular mechanisms and clinical translation of diet–microbiota–host interactions, with a focus on the following:

  1. Dynamic microbiota–metabolite mapping during disease progression and therapeutic target validation.
  2. Building machine learning models that leverage gut microbiota signatures to predict risks of hypertension, hyperlipidemia, and hyperglycemia.
  3. Multi-omics integration in precision nutrition strategies.
  4. Clinical translation of functional foods for metabolic disorders.

We welcome original research, reviews, and methodological papers from microbiology, nutrition, and clinical medicine to advance microbiota-guided precision nutrition. Submissions addressing mechanistic insights, clinical validation, or scalable interventions are particularly encouraged.

Dr. Heng Yuan
Prof. Dr. Sunmin Park
Guest Editors

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Keywords

  • gut microbiota
  • nutrition
  • MASLD
  • functional food
  • hypertension
  • metabolism

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Published Papers (1 paper)

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Research

15 pages, 2714 KiB  
Article
Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024
by Jianhui Mo, Wanghong Su, Jiale Qin, Jiayu Feng, Rong Yu, Shaoru Li, Jia Lv, Rui Dong, Yue Cheng and Bei Han
Microorganisms 2025, 13(7), 1696; https://doi.org/10.3390/microorganisms13071696 - 18 Jul 2025
Viewed by 424
Abstract
A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core [...] Read more.
A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core Collection (WoSCC) and SCOPUS databases (January 2001–December 2024) to analyze the annual publication trends with GraphPad Prism 9.5.1, to evaluate co-authorship, keywords clusters, and co-citation patterns with VOSviewer 1.6.20, and conducted keyword burst detection and keyword co-occurrence utilizing CiteSpace v6.4.1. We have retrieved 2485 relevant publications published over the past 24 years. A 481-fold increase in global annual publications in this field was observed. China was identified as the most productive country, while the United States demonstrated the highest research impact. For the contributor, Yang Tao (University of Toledo, USA) and the University of Florida (USA) have emerged as the most influential contributors. Among journals, the highest number of articles was published in Nutrients (n = 135), which also achieved the highest citation count (n = 5397). The emergence of novel research hotspots was indicated by high-frequency keywords, mainly “hypertensive disorders of pregnancy”, “mendelian randomization”, “gut-heart axis”, and “hepatitis B virus”. “Trimethylamine N-oxide (TMAO)” and “receptor” may represent promising new research frontiers in the gut microbiota–hypertension nexus. The current research trends are shifting from exploring the factors influencing gut microbiota and hypertension to understanding the underlying mechanisms of these factors and the potential therapeutic applications of microbial modulation for hypertension management. Full article
(This article belongs to the Special Issue Effects of Diet and Nutrition on Gut Microbiota)
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