Biosynthesis and Applications of Natural Products
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 309
Special Issue Editors
Interests: natural products; natural product biosynthesis; protein engineering; enzymology
Special Issue Information
Dear Colleagues,
Natural products (NPs) have played a critical role in drug discovery and development for nearly a century. Many NPs possess complex structures that provide high specificity and potency to their drug targets. However, this structural complexity often makes them difficult to reproduce or modify using conventional organic synthesis techniques. Consequently, exploring the biosynthetic pathways for NP production and harnessing them for biosynthetic or semisynthetic approaches is an attractive avenue for the diversification of existing NPs or even the generation of new “unnatural” NP-like molecules. The biosynthesis of NPs involves the orchestrated action of a variety of proteins. While understanding the protein function, structure, and interaction with other proteins or small molecules is essential, we are still at the beginning of this long journey.
Therefore, we welcome manuscripts that advance our understanding of the biosynthesis and applications of natural products. We are open to research papers, review papers, and comparative studies. Topics of interest for this Special Issue include, but are not limited to, the following:
- Discovery and characterization of new natural products;
- Elucidation of biosynthetic gene clusters;
- Functional and structural characterization of individual enzymes;
- Total biosynthesis of natural products;
- Engineering study of individual enzymes;
- Combinatorial biosynthesis;
- Chemoenzymatic synthesis;
- Bioinformatics.
Dr. Shogo Mori
Dr. Sylvie Garneau-Tsodikova
Guest Editors
Manuscript Submission Information
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Keywords
- bioinformatics
- biosynthesis
- chemoenzyamtic synthesis
- combinatorial biosynthesis
- drug discovery
- drug development
- gene clusters
- natural products
- protein engineering
- secondary metabolites
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