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16 pages, 2562 KiB

Open AccessArticle

Morphological, Physiological, and Transcriptional Changes in Crocus sativus L. Under In Vitro Polyethylene Glycol-Induced Water Stress

by Suman Gusain and Rohit Joshi

Biology 2025, 14(1), 78; https://doi.org/10.3390/biology14010078 (registering DOI) - 15 Jan 2025

Abstract

Saffron (Crocus sativus L.), a perennial geophyte from the Iridaceae family, blooms in autumn and thrives in Mediterranean-like climates. It is highly valued for its therapeutic and commercial uses. While saffron cultivation generally requires minimal water, insufficient irrigation can negatively impact its [...] Read more.

Saffron (Crocus sativus L.), a perennial geophyte from the Iridaceae family, blooms in autumn and thrives in Mediterranean-like climates. It is highly valued for its therapeutic and commercial uses. While saffron cultivation generally requires minimal water, insufficient irrigation can negatively impact its yield. Although numerous studies have explored the detrimental impact of drought on saffron under field conditions, its impact in vitro remains largely unexplored. The present study aims to investigate the effects of polyethylene glycol (PEG) 6000 at concentrations of 0%, 5%, and 10% in inducing drought stress on saffron shoots under controlled conditions. The research focuses on evaluating morphological, physiological, and biochemical changes and analyzing the expression of drought-responsive genes. Shoot establishment was carried out on Murashige and Skoog (MS) medium supplemented with 6 mg/L 6-benzyladenine (BAP) and 1 mg/L naphthaleneacetic acid (NAA), while PEG 6000 was used to induce drought stress. Various morphological, biochemical, and molecular parameters were assessed 30 days after stress induction. Increasing PEG concentrations in the medium significantly reduced shoot regeneration, leading to increased apical tissue browning. Significant chlorophyll and carotenoid level changes were observed in shoots exposed to higher PEG concentrations. PEG-induced drought led to decreased plant growth and biomass and lowered relative water content of leaves. Lipid peroxidation, membrane damage, and H₂O₂ content increased, indicating heightened stress levels. Proline concentration significantly increased in plants subjected to 5% and 10% PEG compared to controls. Non-enzymatic antioxidant activity (phenolics, flavonoids, % inhibition, total reducing power, and total antioxidant activity) also increased with the severity of stress. In contrast, a decrease in the activity of superoxide dismutase (SOD) and peroxidase was observed in PEG-treated shoots. Significant changes in the expression of drought-related genes, such as DREB1, DREB2, AREB1, DHN1 (Dehydrin), and SnRK2, were observed in shoots exposed to 5% and 10% PEG. In conclusion, the study highlights that PEG, as an inducer of drought stress, negatively impacts saffron’s growth and physiological responses under in vitro conditions. It also triggers significant changes in biochemical and molecular mechanisms, indicating the plant’s susceptibility to water scarcity. Full article

(This article belongs to the Special Issue Molecular Genetics in Plant Responses to Abiotic Stress)

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20 pages, 1700 KiB

Open AccessArticle

Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia: Insights from High-Resolution Magnetic Resonance Imaging

by Evija Peiseniece, Nauris Zdanovskis, Kristīne Šneidere, Andrejs Kostiks, Guntis Karelis, Ardis Platkājis and Ainārs Stepens

Medicina 2025, 61(1), 130; https://doi.org/10.3390/medicina61010130 - 15 Jan 2025

Abstract

Background and Objectives: Cognitive impairment affects memory, reasoning, and problem-solving, with early detection being critical for effective management. The amygdala, a key structure in emotional processing and memory, may play a pivotal role in detecting cognitive decline. This study examines differences in amygdala [...] Read more.

Background and Objectives: Cognitive impairment affects memory, reasoning, and problem-solving, with early detection being critical for effective management. The amygdala, a key structure in emotional processing and memory, may play a pivotal role in detecting cognitive decline. This study examines differences in amygdala nuclei volumes in patients with varying levels of cognitive performance to evaluate its potential as a biomarker. Material and methods: This cross-sectional study of 35 participants was conducted and classified into three groups: the normal (≥26), moderate (15–25), and low (≤14) cognitive performance groups based on the Montreal Cognitive Assessment (MoCA) scores. High-resolution magnetic resonance imaging at 3.0 T scanner was used to assess amygdala nuclei volumes. Results: Significant amygdala atrophy was observed in multiple amygdala nuclei across cognitive performance groups, with more pronounced changes in the low-performance group. The right hemisphere nuclei, including the lateral and basal nuclei, showed more significant differences, indicating their sensitivity to cognitive decline. Conclusions: This study highlights the potential of amygdala nuclei atrophy as a biomarker for cognitive impairment. Additional research with larger sample sizes and longitudinal designs is needed to confirm these findings and determine their diagnostic value. Full article

(This article belongs to the Section Neurology)

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25 pages, 26496 KiB

Open AccessArticle

Antibacterial Properties of PMMA/ZnO(NanoAg) Coatings for Dental Implant Abutments

by Ana Maria Gianina Rehner (Costache), Dana-Ionela Tudorache, Alexandra Cătălina Bîrcă, Adrian Ionuț Nicoară, Adelina-Gabriela Niculescu, Alina Maria Holban, Ariana Hudiță, Florentina Cornelia Bîclesanu, Paul Cătălin Balaure, Anna Maria Pangică, Alexandru Mihai Grumezescu and George-Alexandru Croitoru

Materials 2025, 18(2), 382; https://doi.org/10.3390/ma18020382 (registering DOI) - 15 Jan 2025

Abstract

Infections continue to pose significant challenges in dentistry, necessitating the development of innovative solutions that can effectively address these issues. This study focuses on creating coatings made from polymethyl methacrylate (PMMA) enriched with zinc oxide–silver composite nanoparticles, layered to Ti6Al4V–titanium alloy substrates. The [...] Read more.

Infections continue to pose significant challenges in dentistry, necessitating the development of innovative solutions that can effectively address these issues. This study focuses on creating coatings made from polymethyl methacrylate (PMMA) enriched with zinc oxide–silver composite nanoparticles, layered to Ti6Al4V–titanium alloy substrates. The application of these materials aims to create a solution for the abutments utilized in complete dental implant systems, representing the area most susceptible to bacterial infections. The nanoparticles were synthesized using a hydrothermal method, optimized through specific temperature and pressure parameters to achieve effective morphologies and sizes that enhance antibacterial efficacy. The layers were applied to the titanium substrate using the spin coating technique, chosen for its advantages and compatibility with the materials involved. Comprehensive analyses were conducted on the antimicrobial powders, including X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Furthermore, the PMMA-based coatings incorporating antimicrobial nanoparticles were evaluated to ensure uniformity and homogeneity across the titanium alloy surface by IR mapping and SBF immersion–SEM analysis. The antimicrobial activity of the samples was demonstrated with impressive results against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, as assessed through biofilm modulation studies. The biocompatibility of the samples was validated through in vitro cell-based assays, which demonstrated excellent compatibility between PMMA-based coatings and human preosteoblasts, confirming their potential suitability for future use in dental implants. Full article

(This article belongs to the Special Issue Advances in New Alloys, Polymers and Composites for Biomedical Applications)

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22 pages, 12452 KiB

Open AccessArticle

Anticonvulsant Effects of Synthetic N-(3-Methoxybenzyl)oleamide and N-(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study

by Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor and Rita Nieto-Montesinos

Molecules 2025, 30(2), 333; https://doi.org/10.3390/molecules30020333 (registering DOI) - 15 Jan 2025

Abstract

Epilepsy is a chronic neurological disorder that affects nearly 50 million people worldwide. Experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the FAAH enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid [...] Read more.

Epilepsy is a chronic neurological disorder that affects nearly 50 million people worldwide. Experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the FAAH enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid anandamide. In this context, the use of macamides as therapeutic agents in neurological diseases has increased in recent years. With a similar structure to anandamide, several theories point to the FAAH–macamide interaction as a possible cause of FAAH enzymatic inhibition. In this work, we used in silico and in vivo techniques to analyze the potential therapeutic effect of three synthetic macamides in the treatment of epilepsy: N-3-methoxybenzyl-oleamide (3-MBO), N-3-methoxybenzyl-linoleamide (3-MBL), and N-3-methoxybenzyl-linolenamide (3-MBN). In the first stage, an in silico analysis was conducted to explore the energetic affinity of these macamides with rFAAH and their potential inhibitory effect. MD simulations, molecular docking, and MM/PBSA calculations were used for these purposes. Based on our results, we selected the two best macamides and performed an in vivo study to analyze their therapeutic effect in male Sprague Dawley rat models. Rats were subjected to an in vivo induction of epileptic status by the intraperitoneal injection of pilocarpine and analyzed according to the Racine scale. In silico results showed an energetic affinity of three macamides and a possible “plugging” effect of the membrane access channel to the active site as a potential cause of FAAH inhibition. On the other hand, the in vivo results showed an anticonvulsant effect of both macamides, with 3-MBL being the most active, resulting in a higher survival probability in the rats. This work represents one of the first studies on the use of macamides for the treatment of epilepsy. Full article

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6 pages, 5018 KiB

Open AccessInteresting Images

Reimagining Venom Harvesting: Practical Electrostimulation on Vespa velutina Nest in Nature

by Xesús Feás, Daniel J. Cabadas and Carmen Vidal

Diversity 2025, 17(1), 53; https://doi.org/10.3390/d17010053 (registering DOI) - 15 Jan 2025

Abstract

The growing interest in Vespa velutina venom stems primarily from its impact on human health due to stings and its potential pharmacological applications. Traditionally, venom extraction methods have relied on capturing individual hornets or removing and euthanizing entire nests, followed by dissection of [...] Read more.

The growing interest in Vespa velutina venom stems primarily from its impact on human health due to stings and its potential pharmacological applications. Traditionally, venom extraction methods have relied on capturing individual hornets or removing and euthanizing entire nests, followed by dissection of venom sacs—a labor-intensive and disruptive process. In this work, we present a novel, non-invasive approach to venom harvesting. Using a portable electrostimulation device, venom was extracted directly from active Vespa velutina nests in their natural habitat. This method eliminates the need for nest manipulation, significantly reducing disturbance and improving efficiency. These visuals highlight the practicality and potential of this groundbreaking technique, opening new avenues for sustainable and scalable venom collection. Full article

(This article belongs to the Section Animal Diversity)

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13 pages, 5664 KiB

Open AccessArticle

Numerical Study on the Effect of Tunnel Slope on Smoke Exhaust Performance in Metro Tunnels

by Yuxuan Yang and Qianbo Zhang

Fire 2025, 8(1), 28; https://doi.org/10.3390/fire8010028 (registering DOI) - 15 Jan 2025

Abstract

Utilizing the intermediate air shaft for smoke exhaust is one of the crucial emergency ventilation methods in metro tunnel fires. To study the impact of metro tunnel slope on smoke exhaust performance of intermediate air shaft, this paper employs numerical simulation to conduct [...] Read more.

Utilizing the intermediate air shaft for smoke exhaust is one of the crucial emergency ventilation methods in metro tunnel fires. To study the impact of metro tunnel slope on smoke exhaust performance of intermediate air shaft, this paper employs numerical simulation to conduct research from the following aspects: the longitudinal distribution of ceiling smoke temperature, visibility distribution, smoke layer height, and the smoke exhaust efficiency of intermediate air shaft. The results demonstrate that as the tunnel slope increases, the maximum ceiling temperature decreases, and the visibility at dangerous height increases. The smoke layer height on the downhill side of a sloped tunnel is higher than that of a horizontal tunnel, while the smoke layer height on the uphill side is lower. Under single-side smoke exhaust mode, the smoke exhaust efficiency of the 2# intermediate air shaft rises as the tunnel slope increases. However, under air supply plus smoke exhaust mode, the smoke exhaust efficiency of the 2# intermediate air shaft decreases with the growing tunnel slope. Full article

(This article belongs to the Special Issue Advances in Industrial Fire and Urban Fire Research: 2nd Edition)

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30 pages, 8556 KiB

Open AccessArticle

Optimization of Microgrid Dispatching by Integrating Photovoltaic Power Generation Forecast

by Tianrui Zhang, Weibo Zhao, Quanfeng He and Jianan Xu

Sustainability 2025, 17(2), 648; https://doi.org/10.3390/su17020648 (registering DOI) - 15 Jan 2025

Abstract

In order to address the impact of the uncertainty and intermittency of a photovoltaic power generation system on the smooth operation of the power system, a microgrid scheduling model incorporating photovoltaic power generation forecast is proposed in this paper. Firstly, the factors affecting [...] Read more.

In order to address the impact of the uncertainty and intermittency of a photovoltaic power generation system on the smooth operation of the power system, a microgrid scheduling model incorporating photovoltaic power generation forecast is proposed in this paper. Firstly, the factors affecting the accuracy of photovoltaic power generation prediction are analyzed by classifying the photovoltaic power generation data using cluster analysis, analyzing its important features using Pearson correlation coefficients, and downscaling the high-dimensional data using PCA. And based on the theories of the sparrow search algorithm, convolutional neural network, and bidirectional long- and short-term memory network, a combined SSA-CNN-BiLSTM prediction model is established, and the attention mechanism is used to improve the prediction accuracy. Secondly, a multi-temporal dispatch optimization model of the microgrid power system, which aims at the economic optimization of the system operation cost and the minimization of the environmental cost, is constructed based on the prediction results. Further, differential evolution is introduced into the QPSO algorithm and the model is solved using this improved quantum particle swarm optimization algorithm. Finally, the feasibility of the photovoltaic power generation forecasting model and the microgrid power system dispatch optimization model, as well as the validity of the solution algorithms, are verified through real case simulation experiments. The results show that the model in this paper has high prediction accuracy. In terms of scheduling strategy, the generation method with the lowest cost is selected to obtain an effective way to interact with the main grid and realize the stable and economically optimized scheduling of the microgrid system. Full article

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17 pages, 6108 KiB

Open AccessArticle

Ultimate Strength Analysis of Aluminium Honeycomb Sandwich Panels Subjected to Uniaxial Compressive Loads and Lateral Pressure

by Mohamed Elsaka and Yordan Garbatov

J. Mar. Sci. Eng. 2025, 13(1), 146; https://doi.org/10.3390/jmse13010146 (registering DOI) - 15 Jan 2025

Abstract

Ultimate strength is critical for hull structures because it determines the maximum load the structure can withstand before catastrophic failure. Aluminium honeycomb sandwich panels provide excellent energy absorption and a high strength-to-weight ratio. However, further investigation of honeycomb sandwich panel structural performance is [...] Read more.

Ultimate strength is critical for hull structures because it determines the maximum load the structure can withstand before catastrophic failure. Aluminium honeycomb sandwich panels provide excellent energy absorption and a high strength-to-weight ratio. However, further investigation of honeycomb sandwich panel structural performance is needed in typical marine conditions. This study focuses on the numerical analysis of honeycomb sandwich panels employing the nonlinear finite element method through the commercial software ANSYS. It investigates their performance under uniaxial compression and varying lateral pressure conditions while considering different cell edge lengths and core height configurations. Several structural configurations are compared to the experimental work published in the literature. Enhanced by experimental accuracy, the present study is a further step in expanding the application of honeycomb sandwich panels for ship hull applications that may lead to light and energy-efficient structures. Full article

(This article belongs to the Special Issue Advanced Studies in Marine Mechanical and Naval Engineering)

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15 pages, 17491 KiB

Open AccessArticle

Preparation and Optoelectrical Property of Silver Nanowire Transparent Conductive Film via Slot Die Coating

by Jiaqi Shan, Ye Hong, Haoyu Wang, Kaixuan Cui, Jianbao Ding and Xingzhong Guo

Coatings 2025, 15(1), 95; https://doi.org/10.3390/coatings15010095 (registering DOI) - 15 Jan 2025

Abstract

Silver nanowire transparent conductive films (AgNW TCFs), as the novel transparent electrode materials replacing ITO, are anticipated to be applied in numerous optoelectronic devices, and slot-die coating is currently acknowledged as the most suitable method for the mass production of large-sized AgNW TCFs. [...] Read more.

Silver nanowire transparent conductive films (AgNW TCFs), as the novel transparent electrode materials replacing ITO, are anticipated to be applied in numerous optoelectronic devices, and slot-die coating is currently acknowledged as the most suitable method for the mass production of large-sized AgNW TCFs. In this study, sodium carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA), as film-forming aids, and AgNWs, as conductive materials, were utilized to prepare a specialized AgNW ink, and a slot-die coating is employed to print and prepare AgNW TCFs. The optoelectrical properties of AgNW TCFs are optimized by adjusting the compositions of AgNW ink and the process parameters of slot-die coating. The suitable compositions of AgNW ink and the optimal parameters of slot-die coating are a CMC type of V, a PVA volume of 1 mL, a AgNW volume of 1.5 mL, a volume ratio of 30 and 45 nm AgNWs (2:1), and a coating height of 400 μm. The resultant AgNW TCFs achieve excellent comprehensive optoelectronic performance, with a sheet resistance of less than 50 Ω/sq, a visible light transmittance exceeding 92%, and a haze below 1.8%. This research provides a valuable approach to producing AgNW TCFs on a large scale via the slot-die coating. Full article

(This article belongs to the Special Issue Advanced Films and Coatings for Flexible Electronics)

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28 pages, 16016 KiB

Open AccessArticle

Comprehensive Characterization of the Odor-Active Compounds in Different Processed Varieties of Yunnan White Tea (Camellia sinensis) by GC×GC-O-MS and Chemometrics

by Junaid Raza, Baosong Wang, Yue Duan, Huanlu Song, Ali Raza and Dongfeng Wang

Foods 2025, 14(2), 271; https://doi.org/10.3390/foods14020271 (registering DOI) - 15 Jan 2025

Abstract

This study investigates the aroma characterization of unique white tea varieties from the Lüchun county of Yunnan province, Mainland China. These include shaken, unshaken, steam-cooked, and compressed varieties. The aroma profile of white tea varieties was analyzed using two-dimensional gas chromatography–olfactometry–mass spectrometry (GC×GC-O-MS), [...] Read more.

This study investigates the aroma characterization of unique white tea varieties from the Lüchun county of Yunnan province, Mainland China. These include shaken, unshaken, steam-cooked, and compressed varieties. The aroma profile of white tea varieties was analyzed using two-dimensional gas chromatography–olfactometry–mass spectrometry (GC×GC-O-MS), electronic nose (e-nose), and descriptive sensory evaluation. A chemometric approach was used to compare sensory scores to instrumental data. A total of 154 volatile compounds were detected in 16 white tea varieties through GC×GC-O-MS. Among these, 133 compounds were successfully identified through the National Institute of Standards and Technology (NIST) library, and 21 were listed as unknown. The identified volatile classes include aldehydes, such as hexanal and heptanal, which contribute to the green aroma of white tea, and alcohols like 2-heptanol and 3-hexen-1-ol, which exhibit fresh and floral odor notes. The content and relative odor active values (r-OAVs) of the volatile compounds were calculated. The chemometric data revealed significant variations in volatile contents between shaken and unshaken white tea varieties. The orthogonal partial least squares discriminant analysis (OPLS-DA) model showed strong validity and stability. This study describes the impact of processing conditions on the flavor profile of white tea and provides a solid foundation for monitoring the aroma quality of different processed white tea varieties. Full article

(This article belongs to the Special Issue Current Status and Future Perspectives in Flavor Chemistry and Technology in the Food Industry)

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42 pages, 7208 KiB

Open AccessReview

On-Demand Energy Provisioning Scheme in Large-Scale WRSNs: Survey, Opportunities, and Challenges

by Gerald K. Ijemaru, Kenneth Li-Minn Ang, Jasmine Kah Phooi Seng, Augustine O. Nwajana, Phee Lep Yeoh and Emmanuel U. Oleka

Energies 2025, 18(2), 358; https://doi.org/10.3390/en18020358 (registering DOI) - 15 Jan 2025

Abstract

Wireless rechargeable sensor networks (WRSNs) have emerged as a critical infrastructure for monitoring and collecting data in large-scale and dynamic environments. The energy autonomy of sensor nodes is crucial for the sustained operation of WRSNs. This paper presents a comprehensive survey on the [...] Read more.

Wireless rechargeable sensor networks (WRSNs) have emerged as a critical infrastructure for monitoring and collecting data in large-scale and dynamic environments. The energy autonomy of sensor nodes is crucial for the sustained operation of WRSNs. This paper presents a comprehensive survey on the state-of-the-art approaches and technologies in on-demand energy provisioning in large-scale WRSNs. We explore various energy harvesting techniques, storage solutions, and energy management strategies tailored to the unique challenges posed by the dynamic and resource-constrained nature of WRSNs. This survey categorizes existing literature based on energy harvesting sources, including solar, kinetic, and ambient energy, and discusses advancements in energy storage technologies such as supercapacitors and rechargeable batteries. Furthermore, we investigate energy management techniques that adaptively balance energy consumption and harvesting, optimizing the overall network performance. In addition to providing a thorough overview of existing solutions, this paper identifies opportunities and challenges in the field of on-demand energy provisioning for large-scale WRSNs. By synthesizing current research efforts, this survey aims to provide insight to researchers and policymakers in understanding the landscape of on-demand energy provisioning in large-scale WRSNs. The insights gained from this study pave the way for future innovations and contribute to the development of sustainable and self-sufficient wireless sensor networks, critical for the advancement of applications such as environmental monitoring, precision agriculture, and smart cities. Full article

(This article belongs to the Special Issue Wireless Charging Technology and Energy Management for Electronic and Electric Devices)

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18 pages, 239 KiB

Open AccessArticle

Cognitive Stimulation Therapy in Ireland: Exploring Perspectives of Trained Practitioners on the Barriers and Facilitators to the Implementation for People Living with Dementia

by Michelle E. Kelly, Saoirse Byrne, Roisin Lacey, Antoine Lemercier and Caoimhe Hannigan

Disabilities 2025, 5(1), 5; https://doi.org/10.3390/disabilities5010005 - 15 Jan 2025

Abstract

Dementia is recognised as a disability under the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD). People with disabilities like dementia have the right to access specialised health and social care services, including interventions that support independence and community participation. [...] Read more.

Dementia is recognised as a disability under the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD). People with disabilities like dementia have the right to access specialised health and social care services, including interventions that support independence and community participation. Cognitive Stimulation Therapy (CST) is an evidence-based psychosocial intervention that improves cognition, communication, confidence, and quality of life for people living with dementia (PLwD), but an implementation gap means that CST is often not available. This study examines whether trained CST practitioners implemented CST, their perceptions of the acceptability and efficacy of CST, whether the perceived acceptability and efficacy of CST predicted implementation, and practitioners’ opinions on the barriers and facilitators to CST implementation. A mixed-methods approach was used, with 62 participants (91.9% female). Although 95% of participants were trained to deliver CST, 45.2% did not facilitate CST groups. Statistical analysis showed that perceived efficacy significantly predicted both the likelihood of running CST groups (p = 0.006) and the number of groups delivered (p = 0.01). Thematic analysis of qualitative data identified the three key themes of ‘resources’, ‘awareness and education’, and ‘acceptability of CST’. Overall, the results show that while CST is acceptable and deemed highly effective, resources and staffing often impede implementation. The results are discussed in the context of prioritising the rights of people with disabilities and recommendations are made on improving access to evidence-based support. Full article

10 pages, 3582 KiB

Open AccessArticle

Clinical Efficacy of Three-Dimensional-Printed Pure Titanium Fracture Plates with Locking Screw Systems in Distal Tibia Fractures

by Ji Hye Choi, Jun Hyoung Lee, Seung Hyeop Lee and Woo Young Jang

Medicina 2025, 61(1), 137; https://doi.org/10.3390/medicina61010137 - 15 Jan 2025

Abstract

Background and Objectives: Distal tibia fractures are high-energy injuries characterized by a mismatch between standard plate designs and the patient’s specific anatomical bone structure, which can lead to severe soft tissue damage. Recent advancements have focused on the development of customized metal plates [...] Read more.

Background and Objectives: Distal tibia fractures are high-energy injuries characterized by a mismatch between standard plate designs and the patient’s specific anatomical bone structure, which can lead to severe soft tissue damage. Recent advancements have focused on the development of customized metal plates using three-dimensional (3D) printing technology. However, 3D-printed metal plates using titanium alloys have not incorporated a locking system due to the brittleness of these alloys. Therefore, this study aimed to determine whether a locking mechanism can be effectively implemented using 3D-printed pure titanium and further evaluate the clinical outcomes of such implants in patients with distal tibia fractures. Materials and Methods: Between March 2021 and June 2022, nine patients who underwent open reduction and internal fixation for distal tibia fractures using 3D-printed pure titanium plates were enrolled. Pure titanium powder (Ti Gr.2, Type A, 3D Systems, USA) was spread to a thickness of 30 μm and partially sintered using a 500 W laser to produce the 3D-printed metal plates. The locking screws were fabricated using a milling process. Open reduction and internal fixation were performed on the nine patients using 10 customized plates. The clinical efficacy was analyzed using the union rate, and complications, such as infection and skin irritation, were evaluated to ensure a comprehensive outcome assessment. Results: Surgical treatment was successfully performed on nine patients, with nine of ten plates remaining stable and undamaged. However, one patient with neurofibromatosis experienced a fractured metal plate, which necessitated revision surgery using a metal rod. No screw loosening or surgical wound complications occurred. Conclusions: This study showed that 3D-printed pure titanium plates with integrated locking screw systems provide a viable and effective solution for managing distal tibia fractures. Three-dimensional printing and pure titanium show promise for orthopedic advancements. Full article

(This article belongs to the Section Orthopedics)

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16 pages, 694 KiB

Open AccessArticle

Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy

by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț and Dragoş Vasile Nica

Medicina 2025, 61(1), 136; https://doi.org/10.3390/medicina61010136 - 15 Jan 2025

Abstract

Background and Objectives: Sodium butyrate (NaB) is a potent modulator of cancer-related gene networks. However, its precise mechanisms of action and effects at elevated doses remain insufficiently explored. This study investigated the impact of NaB at physiologically relevant doses on key cellular [...] Read more.

Background and Objectives: Sodium butyrate (NaB) is a potent modulator of cancer-related gene networks. However, its precise mechanisms of action and effects at elevated doses remain insufficiently explored. This study investigated the impact of NaB at physiologically relevant doses on key cellular metrics (viability, confluence, cell number, morphology, nuclear integrity) and a comprehensive set of apoptosis and proliferation regulators (including underexplored genes) in colorectal cancer (CRC) cells. Materials and Methods: Human HCT-116 cells were treated with increasing NaB concentrations (0–20 mM). Cell viability, confluence, number, morphology, and nuclear integrity were assessed using MTT and imaging assays. RT-PCR was used to determine changes in the expression of critical pro-apoptotic players (BAX, CASP3, PUMA, TP53), anti-apoptotic facilitators (BCL-2, MCL-1), cell division regulators (PCNA, Ki-67, CDKN1), and inflammation genes (NF-κB). Results: This study provides the first exploration of MCL-1 and PCNA modulation by NaB in the context of CRC and HCT-116 cells, offering significant translational insights. All treatments reduced cell viability, confluence, and number in a dose-dependent manner (p < 0.0001). Gene expression revealed dose-related increases in most pro-apoptotic markers (BAX, CASP3, PUMA; p < 0.001), and decreases for the other genes (p < 0.001). BAX emerged as the most responsive gene to NaB, while TP53 showed minimal sensitivity, supporting NaB’s effectiveness in p53-compromised phenotypes. Nuclear condensation and fragmentation at higher NaB doses confirmed apoptotic induction. Conclusions: NaB can modulate critical apoptotic and cell cycle genes, disrupt tumor cell proliferation, and overcome resistance mechanisms associated with anti-apoptotic regulators such as MCL-1. By targeting both short-term and long-term anti-apoptotic defenses, NaB shows promise as a preventive and therapeutic agent in CRC, particularly in high-risk phenotypes with compromised p53 functionality. These findings support its potential for integration into combination therapies or dietary interventions aimed at enhancing colonic butyrate levels. Full article

(This article belongs to the Special Issue Intestinal Microbiome in Human Health and Disease—Recent Updates)

13 pages, 1347 KiB

Open AccessArticle

Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role?

by Alexandra Maria Boieriu, Cezar Dumitrel Luca, Carmen Daniela Neculoiu, Alina Bisoc and Diana Țînț

Medicina 2025, 61(1), 135; https://doi.org/10.3390/medicina61010135 - 15 Jan 2025

Abstract

Background and Objectives: Endothelial dysfunction (ED) and oxidative stress play major contributions in the initiation and progression of atherosclerosis. Diabetes is a pathological state associated with endothelial damage and enhanced oxidative stress. This study evaluated endothelial dysfunction and oxidative stress in patients [...] Read more.

Background and Objectives: Endothelial dysfunction (ED) and oxidative stress play major contributions in the initiation and progression of atherosclerosis. Diabetes is a pathological state associated with endothelial damage and enhanced oxidative stress. This study evaluated endothelial dysfunction and oxidative stress in patients with severe coronary artery disease (CAD) undergoing coronary artery bypass graft (CABG) surgery, comparing those with and without type 2 diabetes mellitus (T2DM). Materials and Methods: We included 84 patients with severe coronary artery disease (33 of whom had type 2 diabetes mellitus) who underwent clinical assessments, ultrasound, and coronaryangiography. The SYNTAXI score was calculated from the coronaryangiogram. Blood samples were collected to measure plasma serotonin (5-HT; SER) levels, as well as levels of superoxide dismutase 1(SOD-1) and lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) to assess oxidative stress. Brachial flow-mediated dilation (FMD) was used as a surrogate for endothelial dysfunction (ED),along with serum concentrations of 5-HT. Results: The coronary atherosclerotic burden, assessed using the SYNTAX I score, was more severe in patients with CAD and associated T2DM compared to those with CAD without T2DM (30.5 (17–54) vs. 29 (17–48); p = 0.05). The SYNTAX score was found to be positively correlated with T2DM (p = 0.029; r = 0.238).ED measured by FMD was associated with T2DM (p = 0.042; r = −0.223), with lower FMD measurements in T2DM patients when compared with individuals without this pathology (2.43% (0.95–5.67) vs. 3.46% (1.02–6.75); p = 0.079). Also, in the studied population, T2DM was correlated with serum 5-HT levels (764.78 ± 201 ng/mL vs. 561.06 ± 224 ng/mL; p < 0.001; r = 0.423), with higher plasma circulating levels of 5-HT in patients with T2DM. No statistically significant differences for oxidative stress markers (SOD-1 and LOX-1) were obtained when comparing T2DM and non-T2DM patients with severe CAD. Conclusions: ED (as assessed by brachial FMD and serum 5-HT) is more severe in in diabetic patients with severe CAD scheduled for CABG surgery, while oxidative stress (as evaluated through serum SOD-1 and LOX-1 concentrations) was not influenced by the presence of T2DM in this specific population. The most important finding of the present study is that circulating 5-HT levels are markedly influenced by T2DM. 5-HT receptor-targeted therapy might be of interest in patients undergoing CABG, but further studies are needed to confirm this hypothesis. Full article

(This article belongs to the Special Issue Cardiovascular Diseases and Type 2 Diabetes: 2nd Edition)

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20 pages, 3125 KiB

Open AccessArticle

A New Weighted Lindley Model with Applications to Extreme Historical Insurance Claims

by Morad Alizadeh, Mahmoud Afshari, Gauss M. Cordeiro, Ziaurrahman Ramaki, Javier E. Contreras-Reyes, Fatemeh Dirnik and Haitham M. Yousof

Stats 2025, 8(1), 8; https://doi.org/10.3390/stats8010008 - 15 Jan 2025

Abstract

In this paper, we propose a weighted Lindley (NWLi) model for the analysis of extreme historical insurance claims. It extends the classical Lindley distribution by incorporating a weight parameter, enabling more flexibility in modeling insurance claim severity. We provide a comprehensive theoretical overview [...] Read more.

In this paper, we propose a weighted Lindley (NWLi) model for the analysis of extreme historical insurance claims. It extends the classical Lindley distribution by incorporating a weight parameter, enabling more flexibility in modeling insurance claim severity. We provide a comprehensive theoretical overview of the new model and explore two practical applications. First, we investigate the mean-of-order P (MOOP

_{(P)}

) approach for quantifying the expected claim severity based on the NWLi model. Second, we implement a peaks over a random threshold (PORT) analysis using the value-at-risk metric to assess extreme claim occurrences under the new model. Further, we provide a simulation study to evaluate the accuracy of the estimators under various methods. The proposed model and its applications provide a versatile tool for actuaries and risk analysts to analyze and predict extreme insurance claim severity, offering insights into risk management and decision-making within the insurance industry. Full article

(This article belongs to the Section Reliability Engineering)

33 pages, 5547 KiB

Open AccessArticle

Preserving the Past: A Dynamic Analysis of Heritage Tourism and Land Conservation in Mamluk Cairo

by Amany E. Salem, Ahmed Tawhid Eissa, Thowayeb H. Hassan and Mahmoud I. Saleh

Heritage 2025, 8(1), 30; https://doi.org/10.3390/heritage8010030 - 15 Jan 2025

Abstract

Historic urban cities face increasing pressure from tourism, necessitating sophisticated approaches to visitor management that protect both heritage values and local communities. The current study develops new sustainable metrics—sustainable visitor capacity (SVC) and Sustainable Visitation Index (SVI)—to provide a multifaceted assessment of heritage [...] Read more.

Historic urban cities face increasing pressure from tourism, necessitating sophisticated approaches to visitor management that protect both heritage values and local communities. The current study develops new sustainable metrics—sustainable visitor capacity (SVC) and Sustainable Visitation Index (SVI)—to provide a multifaceted assessment of heritage destination management beyond simple visitor volume calculations. The SVC considers operating hours, site capacity, and walking time, while the SVI holistically evaluates time efficiency, spatial distribution, and physical comfort. Applying these metrics to seven routes through the historic Mamluk monuments revealed significant variations in sustainability performance, with SVI scores ranging from 48.9 at Al-Ṣalῑba/Al-Sayyida Zaynab Streets to 92.8 at Northern Al-Mu’izz Street. The findings demonstrate that while the recommended daily visitor capacity ranges from 1286 to 2182 visitors across different routes, actual visitation frequently exceeds these thresholds, particularly in commercial zones. Geographic analyses and on-site studies identified the integration of tourist activities with commercial, residential, and religious uses as a critical factor contributing to overcrowding, especially evident in areas like Al-Ṣalῑba Street, where low SVI scores reflect challenges with unorganized markets and local congestion. The study offers site-specific recommendations for heritage managers, focusing on dynamic visitor management systems and zoning strategies that consider the dual function of these historic corridors as both tourist attractions and vital local thoroughfares. This research provides heritage managers with practical tools to quantify and enhance the sustainability of visitor experiences while preserving site integrity within complex urban heritage contexts. Full article

30 pages, 2447 KiB

Open AccessReview

Unmanned Aircraft Systems (UASs): Current State, Emerging Technologies, and Future Trends

by Gennaro Ariante and Giuseppe Del Core

Drones 2025, 9(1), 59; https://doi.org/10.3390/drones9010059 - 15 Jan 2025

Abstract

Unmanned aircraft, commonly referred to as drones, represent a valuable alternative for various operational tasks due to their versatility, flexibility, cost-effectiveness, and reusability. These features make them particularly advantageous in environments that are hazardous or inaccessible to humans. Recent developments have highlighted a [...] Read more.

Unmanned aircraft, commonly referred to as drones, represent a valuable alternative for various operational tasks due to their versatility, flexibility, cost-effectiveness, and reusability. These features make them particularly advantageous in environments that are hazardous or inaccessible to humans. Recent developments have highlighted a significant increase in the use of unmanned aircraft within metropolitan areas. This growth has necessitated the implementation of new regulations and guidelines to ensure the safe integration of UAS into urban environments. Consequently, the concept of UAM has emerged. UAM refers to an innovative air transportation paradigm designed for both passengers and cargo within urban settings, leveraging the capabilities of drones. This review manuscript explores the latest advancements for UAS, focusing on updated regulations, definitions, enabling technologies, and airspace classifications relevant to UAM operations. Additionally, it provides a comprehensive overview of unmanned aircraft systems, including their classifications, key features, and primary applications. Full article

30 pages, 570 KiB

Open AccessReview

Recent Research Progress on Ground-to-Air Vision-Based Anti-UAV Detection and Tracking Methodologies: A Review

by Arowa Yasmeen and Ovidiu Daescu

Drones 2025, 9(1), 58; https://doi.org/10.3390/drones9010058 - 15 Jan 2025

Abstract

Unmanned Aerial Vehicles (UAVs) are increasingly gaining popularity, and their consistent prevalence in various applications such as surveillance, search and rescue, and environmental monitoring requires the development of specialized policies for UAV traffic management. Integrating this novel aerial traffic into existing airspace frameworks [...] Read more.

Unmanned Aerial Vehicles (UAVs) are increasingly gaining popularity, and their consistent prevalence in various applications such as surveillance, search and rescue, and environmental monitoring requires the development of specialized policies for UAV traffic management. Integrating this novel aerial traffic into existing airspace frameworks presents unique challenges, particularly regarding safety and security. Consequently, there is an urgent need for robust contingency management systems, such as Anti-UAV technologies, to ensure safe air traffic. This survey paper critically examines the recent advancements in ground-to-air vision-based Anti-UAV detection and tracking methodologies, addressing the many challenges inherent in UAV detection and tracking. Our study examines recent UAV detection and tracking algorithms, outlining their operational principles, advantages, and disadvantages. Publicly available datasets specifically designed for Anti-UAV research are also thoroughly reviewed, providing insights into their characteristics and suitability. Furthermore, this survey explores the various Anti-UAV systems being developed and deployed globally, evaluating their effectiveness in facilitating the integration of small UAVs into low-altitude airspace. The study aims to provide researchers with a well-rounded understanding of the field by synthesizing current research trends, identifying key technological gaps, and highlighting promising directions for future research and development in Anti-UAV technologies. Full article

(This article belongs to the Special Issue Unmanned Traffic Management Systems)

22 pages, 40787 KiB

Open AccessArticle

Autonomous Landing Guidance for Quad-UAVs Based on Visual Image and Altitude Estimation

by Lingxia Mu, Shaowei Cao, Youmin Zhang, Xielong Zhang, Nan Feng and Yuan Zhang

Drones 2025, 9(1), 57; https://doi.org/10.3390/drones9010057 - 15 Jan 2025

Abstract

In this paper, an autonomous landing guidance strategy is proposed for quad-UAVs, including landing marker detection, altitude estimation, and adaptive landing commands generation. A double-layered nested marker is designed to ensure that the marker can be captured both in high and low altitudes. [...] Read more.

In this paper, an autonomous landing guidance strategy is proposed for quad-UAVs, including landing marker detection, altitude estimation, and adaptive landing commands generation. A double-layered nested marker is designed to ensure that the marker can be captured both in high and low altitudes. A deep learning-based marker detection method is designed where the intersection of union is replaced by the normalized Wasserstein distance in the computation of non-maximum suppression to improve the detection accuracy. The UAV altitude measured by inertial measurement unit is fused with vision-based altitude estimation data to improve the accuracy during the landing process. An image-based visual servoing method is designed to guide the UAV approach to the landing marker. Both simulation and flight experiments are conducted to verify the proposed strategy. Full article

(This article belongs to the Collection Feature Papers Collection of the World’s Top 2% Scientists in Drones)

10 pages, 1066 KiB

Open AccessCommunication

Occurrence of Pestalotiopsis sp. on Ornamental Plants Camellia japonica L. in Romanian Public Gardens

by Andreea-Mihaela Florea, Andrei-Mihai Gafencu, Florin-Daniel Lipșa, Iulian Gabur and Eugen Ulea

Horticulturae 2025, 11(1), 93; https://doi.org/10.3390/horticulturae11010093 - 15 Jan 2025

Abstract

Camellias are evergreen shrubs native to the eastern and southern regions of Asia. In Romania, camellias are popular ornamental plants grown in pots. Pestalotiopsis species have a worldwide distribution and are pathogenic to a wide range of hosts. They also represent an [...] Read more.

Camellias are evergreen shrubs native to the eastern and southern regions of Asia. In Romania, camellias are popular ornamental plants grown in pots. Pestalotiopsis species have a worldwide distribution and are pathogenic to a wide range of hosts. They also represent an important group of endophytes capable of producing a variety of bioactive secondary metabolites. This paper reports the occurrence of grey blight and twig or branch dieback caused by Pestalotiopsis sp. on Camellia japonica L. grown in pots and used in the landscaping of a public garden located in Iasi city, Romania (GPS coordinates: 47°09′24.0″ N 27°35′15.6″ E). Pestalotiopsis species were identified based on morphological characteristics and Sanger sequencing. Genomic analysis of the fungal isolate coded P_CJ_24, obtained from living plants, was based on ribosomal internal transcribed spacer region amplification using the LSU primers. This first report of Pestalotiopsis species infection of ornamental plants in Romania suggests that new plant pathogens can be introduced in new environmental conditions through plant pods and their incidence increases with the widespread of plant material among gardens. Full article

(This article belongs to the Special Issue Sustainable Management of Pathogens in Horticultural Crops)

18 pages, 733 KiB

Open AccessArticle

The Production of an Economical Culture Medium from Apple Pomace for the Propagation of Non-Conventional Cidermaking Yeast Starters

by Josefina M. Fontanini, Andrea C. Origone, Marcela P. Sangorrín, Carmen R. Maturano, Christian A. Lopes and M. Eugenia Rodríguez

Fermentation 2025, 11(1), 33; https://doi.org/10.3390/fermentation11010033 - 15 Jan 2025

Abstract

The aim of the present study was to evaluate the use of different chemical treatments of apple pomace in order to produce an economical culture medium for the propagation of two non-conventional yeast strains. An experimental design approach was used for the optimization [...] Read more.

The aim of the present study was to evaluate the use of different chemical treatments of apple pomace in order to produce an economical culture medium for the propagation of two non-conventional yeast strains. An experimental design approach was used for the optimization of the hydrolysis conditions of apple pomace. Both acid and alkaline treatment conditions were tested. The optimal hydrolysis conditions to disrupt the pomace lignocellulosic structure were 1% w/v of H₃PO₄, 121 °C, and 40 min for acid treatment, while 6% w/v of NH₄OH, 20 °C, and 2 h were optimal for the alkaline condition. Saccharomyces uvarum NPCC 1420 and Saccharomyces eubayanus NPCC 1292 yeasts were able to grow in the liquid fraction obtained from both acid and alkaline treatments. However, the medium with the acid treatment was found to be more suitable for yeast growth, showing, for both strains, higher µmax and biomass production and lower td and λ than that observed for the medium with the alkaline treatment. According to the growth parameter analysis for both strains, the acid treatment was selected for further studies. By taking advantage of this agroindustrial by-product, a circular economy approach is promoted, reducing environmental impact and fostering sustainable development. Full article

(This article belongs to the Special Issue Waste as Feedstock for Fermentation)

14 pages, 1000 KiB

Open AccessArticle

Correlation Between Cryptococcus Infection and the Nasal Mycobiota in a Population of Free-Ranging Koalas (Phascolarctos cinereus) in New South Wales, Australia

by Andrew S. McPherson, Sophie L. Haworth, Alex Kan, Luisa Monteiro de Miranda and Mark B. Krockenberger

J. Fungi 2025, 11(1), 64; https://doi.org/10.3390/jof11010064 - 15 Jan 2025

Abstract

Cryptococcosis is a fungal disease in humans and animals, caused by the Cryptococcus neoformans and Cryptococcus gattii species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. Nasal colonisation and subclinical cryptococcosis [...] Read more.

Cryptococcosis is a fungal disease in humans and animals, caused by the Cryptococcus neoformans and Cryptococcus gattii species complexes. Clinical cryptococcosis primarily manifests as upper respiratory tract disease; however, dissemination to other organs, particularly the brain, can occur. Nasal colonisation and subclinical cryptococcosis are common in koalas (Phascolarctos cinereus) due to their shared environmental niche with Cryptococcus: Eucalyptus trees. However, for reasons that remain unclear, the prevalence of clinical disease is low in koalas. Interactions between respiratory pathogens and the nasal mycobiome are thought to play a role in the development and progression of numerous respiratory diseases. As such, this study aimed to characterise the mycobiome of the nasal vestibule in koalas with and without evidence of cryptococcal colonisation and subclinical disease via the next-generation sequencing (NGS) of the ITS1 region of the fungal internal transcribed spacer (ITS) gene. Samples were collected from 47 koalas from a population of free-ranging koalas in the Liverpool Plains, NSW, Australia, with a known history of Cryptococcus exposure and nasal colonisation. Of the 47 animals tested, 6.4% were culture-positive only, 4.3% were seropositive only, and 2.1% were culture- and seropositive. C. gattii was detected in four samples via NGS. C. neoformans was not detected via NGS. There were no significant differences in the nasal mycobiomes of Cryptococcus-positive and -negative animals; thus, we could not establish a definitive association between the mycobiome and infection outcomes. We identified a number of fungal genera that were significantly more abundant in samples from Cryptococcus-positive animals, but there was no apparent relationship between these genera and the development of cryptococcosis. This study represents the first investigation of the nasal mycobiota of wild koalas. Further studies involving koalas with clinical disease are necessary to determine the role of the nasal mycobiota in the development of cryptococcosis. Full article

(This article belongs to the Special Issue Fungal Diseases in Animals, 3rd Edition)

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23 pages, 25140 KiB

Open AccessArticle

Flood Risk Assessment and Zoning for Niamey and Lokoja Metropolises in Niger and Nigeria

by Youssoufa Doulla Nouhou, Martins Yusuf Otache, Salamatou Abdourahamane Illiassou, Olasunkanmi Habeeb Okunola, Appollonia Aimiosino Okhimamhe and Thanh Thi Nguyen

Hydrology 2025, 12(1), 17; https://doi.org/10.3390/hydrology12010017 - 15 Jan 2025

Abstract

With the increasing frequency of floods in recent decades, particularly in West Africa, many regions have faced unusual and recurrent flooding events. Communities in flood-prone areas experience heightened insecurity, loss of property, and, in some cases, serious injuries or fatalities. Consequently, flood risk [...] Read more.

With the increasing frequency of floods in recent decades, particularly in West Africa, many regions have faced unusual and recurrent flooding events. Communities in flood-prone areas experience heightened insecurity, loss of property, and, in some cases, serious injuries or fatalities. Consequently, flood risk assessment and mitigation have become essential. This comparative study between Niamey and Lokoja employs Geographic Information Systems (GIS) and the Analytical Hierarchy Process (AHP) to delineate flood susceptibility, vulnerability, and risk zones. The study utilized a comprehensive range of thematic layers, with weight percentages assigned to each parameter as follows: 29% for elevation, 24% for slope, 15% for the Topographic Wetness Index (TWI), 9% for drainage density, 9% for distance from rivers, 4% for both precipitation and the Normalized Difference Water Index (NDWI), and 2% each for the Normalized Difference Vegetation Index (NDVI) and soil type. To validate these weightings, a consistency ratio was calculated, ensuring it remained below 10%. The findings reveal that 32% of the Niamey study area is at risk of flooding, compared to approximately 15% in Lokoja. The results highlight a very high flood potential, particularly in areas near the Niger River, with this potential decreasing as elevation increases. Given the current prevalence of extreme weather events in West Africa, it is crucial to employ effective tools to mitigate their adverse impacts. This research will assist decision-makers in quantifying the spatial vulnerability of flood-prone areas and developing effective flood risk assessment and mitigation strategies in the region. Full article

(This article belongs to the Section Water Resources and Risk Management)

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18 pages, 1542 KiB

Open AccessReview

Image-Based Monitoring of Thermal Ablation

by Xinyi Wang, Shiqing Zhao and Aili Zhang

Bioengineering 2025, 12(1), 78; https://doi.org/10.3390/bioengineering12010078 - 15 Jan 2025

Abstract

Thermal therapy is a commonly used local treatment technique in clinical practice. Monitoring the treatment process is essential for ensuring its success. In this review, we analyze recent image-based methods for thermal therapy monitoring, focusing particularly on their feasibility for synchronous or immediate [...] Read more.

Thermal therapy is a commonly used local treatment technique in clinical practice. Monitoring the treatment process is essential for ensuring its success. In this review, we analyze recent image-based methods for thermal therapy monitoring, focusing particularly on their feasibility for synchronous or immediate postoperative monitoring. This includes thermography and other techniques that track the physical changes in tissue during thermal ablation. Potential directions and challenges for further clinical applications are also summarized. Full article

(This article belongs to the Special Issue Advances in Thermal Therapy)

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18 pages, 1176 KiB

Open AccessArticle

Long-Term Trends and Ecological Risks of Heavy Metal Accumulation in Cultivated Land of Songnen Plain, China

by Zonglai Liu, Jinying Li, Yanan Chen, Fengjun Zhang and Wei Feng

Toxics 2025, 13(1), 59; https://doi.org/10.3390/toxics13010059 - 15 Jan 2025

Abstract

Heavy metal pollution in agricultural soils poses a serious threat to food security. Therefore, it is crucial to conduct risk assessments and issue early warnings about high levels of metal contamination for the sustained prosperity of agriculture. To assess the risks, identify the [...] Read more.

Heavy metal pollution in agricultural soils poses a serious threat to food security. Therefore, it is crucial to conduct risk assessments and issue early warnings about high levels of metal contamination for the sustained prosperity of agriculture. To assess the risks, identify the sources, quantify the amounts, and determine the extent of pollution from seven heavy metals, as well as to provide early warnings, 78 soil samples were collected from farmed lands in the Songnen Plain of Jilin Province. The average concentrations of Zn, Cu, Mn, Pb, Cd, Ni, and As were found to be 2.05, 1.5, 0.2, 1.09, 2.68, 1.53, and 1.17 times higher than the background values of Chinese soils, respectively. Source analysis indicated that toxic Pb originates from vehicle exhaust emission, while Cd, Cu, and Ni are attributed to industrial activities. Zn and As are likely associated with agricultural practices, and Mn predominantly stems from natural environmental sources. The geo-accumulation index suggests relatively high, accumulation levels for Zn, Cu, Mn, and Pb. Meanwhile, the single-factor pollution index indicates elevated pollution levels of Zn, Cu, and Cd. Potential ecological risk assessment reveals that certain areas within Changchun and Baicheng cities exhibit higher ecological risks. Notably, Cd has the highest potential ecological risk index (RI) of the seven heavy metals and warrants special attention. By analyzing annual pollutant accumulations, predictions can be made about the heavy metal content in four cities within the Songnen Plain, enabling the issuance of early warnings regarding soil heavy metal risks. The findings suggest that without proactive measures to mitigate heavy metal accumulation in soils, Changchun and Songyuan will reach severe pollution levels by 2031 and 2029, respectively. Full article

(This article belongs to the Special Issue Assessment and Remediation of Heavy Metal Contamination in Soil)

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