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23 pages, 405 KB

Open AccessArticle

Do Carbon Exchanges Make a Difference to Carbon Disclosure and Performance? Evidence from Indonesia

by Ayu Oktaviani, Syahrial Shaddiq and Novika Rosari

J. Risk Financial Manag. 2026, 19(2), 120; https://doi.org/10.3390/jrfm19020120 (registering DOI) - 5 Feb 2026

The presence of the Indonesia Carbon Exchange (ICE) puts pressure on management to carry out its active role in reducing the potential of climate change through business strategies such as disclosure and improving carbon performance. This study seeks to prove the significant difference [...] Read more.

The presence of the Indonesia Carbon Exchange (ICE) puts pressure on management to carry out its active role in reducing the potential of climate change through business strategies such as disclosure and improving carbon performance. This study seeks to prove the significant difference in carbon disclosure and performance after the launch of the ICE, as well as to review the profound differences in the increase in carbon disclosure and performance in the high and low-polluting sectors in the population of companies listed on the Indonesia Stock Exchange for the 2022 and 2024 periods. The two research models used in formulating the results are the Wilcoxon test and the Difference-in-Differences model. The results of this study indicate a significant difference in carbon disclosure and performance after the launch of ICE, which illustrates the changing dynamics of environmental regulations encouraging companies to improve transparency and corporate carbon performance in an effort to maintain their legitimacy. This study shows that there was no significant difference in the comprehensiveness of carbon disclosure or the improvement in carbon performance between high- and low-polluting sectors after the launch of ICE. Full article

(This article belongs to the Special Issue Carbon Accounting, Climate Reporting, and Sustainable Finance)

21 pages, 3223 KB

Open AccessArticle

Capsaicin Improves Lipid Metabolism Disorders Caused by LPS-Induced Immune Stress in Weaned Piglets

by Jianlei Zhao, Wenyi Liu, Xin Zhang, Zechen Xie, Shuhan Liu, Wenjun Zhou and Lili Zhang

Vet. Sci. 2026, 13(2), 155; https://doi.org/10.3390/vetsci13020155 (registering DOI) - 5 Feb 2026

Abstract

The purpose of this study was to investigate the effect of capsaicin (CAP) on lipid metabolism in weaned piglets and its related mechanisms. Twenty-four weaned piglets with an initial body weight of 9.00 ± 0.30 kg were randomly divided into three groups, with [...] Read more.

The purpose of this study was to investigate the effect of capsaicin (CAP) on lipid metabolism in weaned piglets and its related mechanisms. Twenty-four weaned piglets with an initial body weight of 9.00 ± 0.30 kg were randomly divided into three groups, with eight replicates in each group. The control (CON) and lipopolysaccharide (LPS) groups were fed a basal diet, while the LPS and capsaicin group (LCA) received the basal diet supplemented with 4 mg/kg pure capsaicin (delivered via 800 mg/kg additive) for 35 days. About 4 h before sampling, piglets in the LPS and LCA groups were intraperitoneally injected with LPS at a dose of 100 μg/kg body weight, while those in the CON group were intraperitoneally injected with the same dose of normal saline. In this study, we found that the addition of 800 mg/kg CAP to the diet of piglets significantly reduced the accumulation of serum triglyceride (TG), non-esterified fatty acids (NEFA), and liver fat, and that CAP up-regulates expression of genes and proteins in the PPARα pathway, consistent with enhanced fatty acid oxidation. The intervention with 4 mg/kg CAP was also found to down-regulate cholesterol synthesis precursors (such as mevalonate, MVA), reduce pro-inflammatory phospholipids (such as phosphatidic acid–phosphatidylcholine, PA–PC), and modulate bile acid metabolism, thereby beneficially regulating blood lipid profiles (TC, TG, LDL-C) and disrupting the “lipid metabolism–inflammation” interaction cycle. Furthermore, CAP promoted fatty acid β-oxidation and bile acid metabolism by activating the TRPV1 channel, which alleviated hepatic lipid accumulation. These findings indicated that CAP has potential application value in improving lipid metabolism, intestinal health, and immune function in weaned piglets. However, its long-term safety and dose-dependent effects require further investigation. Full article

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20 pages, 3879 KB

Open AccessArticle

Management Evaluation of a Semi-Urban Beach in Northwestern Mexico

by Gisela García-Morales, María Sara Burrola-Sánchez, David Urías-Laborín and José Alfredo Arreola-Lizárraga

Geographies 2026, 6(1), 15; https://doi.org/10.3390/geographies6010015 (registering DOI) - 5 Feb 2026

Abstract

Evaluations of recreational beaches are necessary to guide their management. In this study, we conducted a socio-ecological evaluation to propose management guidelines for San Francisco beach in northwestern Mexico, using a beach quality index and recording user perceptions. The results showed that the [...] Read more.

Evaluations of recreational beaches are necessary to guide their management. In this study, we conducted a socio-ecological evaluation to propose management guidelines for San Francisco beach in northwestern Mexico, using a beach quality index and recording user perceptions. The results showed that the beach quality is high, based on the recreational, natural, and protection functions considered in the beach quality index. This finding was consistent with user perceptions of beach services, environmental conditions, and cleanliness. The findings of this study can be applied to strategies focused on the use and preservation of San Francisco Beach, aiming to maintain the natural landscape and sanitary quality, provide public services, ensure cleanliness, subdivide recreational areas, and implement year-round surveillance. Full article

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17 pages, 379 KB

Open AccessArticle

Macro-Financial Blind Spots in Emerging Markets: Non-Bank Intermediation, Funding Liquidity, and the Persistence of Global Shock Transmission

by Gustavo Henrique Rodrigues Pessoa and Ricardo Ratner Rochman

Int. J. Financial Stud. 2026, 14(2), 40; https://doi.org/10.3390/ijfs14020040 (registering DOI) - 5 Feb 2026

Abstract

Despite significant advances in bank regulation and the widespread adoption of macroprudential frameworks, emerging market economies remain persistently vulnerable to global financial shocks. Episodes such as the Global Financial Crisis, the COVID-19 market turmoil, and recent monetary tightening cycles reveal that financial stress [...] Read more.

Despite significant advances in bank regulation and the widespread adoption of macroprudential frameworks, emerging market economies remain persistently vulnerable to global financial shocks. Episodes such as the Global Financial Crisis, the COVID-19 market turmoil, and recent monetary tightening cycles reveal that financial stress originating in core markets continues to transmit rapidly and forcefully to emerging economies. This paper argues that such vulnerability reflects structural features of contemporary financial systems rather than deficiencies in domestic banking regulation alone. Adopting a conceptual and analytical approach, the article develops an integrated framework of macro-financial blind spots that links global financial cycles, non-bank financial intermediation, and regulatory fragmentation. The analysis highlights how funding liquidity, collateral valuation, margin dynamics, and market-based leverage amplify global shocks through channels that lie largely outside traditional, bank-centric macroprudential frameworks. As market-based finance expands, systemic risk increasingly originates in activities rather than institutions, limiting the effectiveness of entity-based regulation and reinforcing emerging markets’ role as price-takers in global portfolios. The paper contributes to the literature by synthesizing insights from macroprudential policy, market liquidity, and non-bank finance to explain the persistence of emerging market vulnerability in an era of globalized funding. It further derives policy implications for macro-financial governance, emphasizing the need for system-wide, activity-based approaches, improved data and transparency, and stronger domestic and international regulatory coordination. These findings are relevant for policymakers seeking to reconcile financial integration with systemic resilience in emerging markets. Full article

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34 pages, 480 KB

Open AccessReview

The Sovereign Wealth Fund Paradox: Evolution, Challenges, and Unresolved Issues

by David M. Kemme

J. Risk Financial Manag. 2026, 19(2), 119; https://doi.org/10.3390/jrfm19020119 (registering DOI) - 5 Feb 2026

Abstract

Sovereign wealth funds enhance the international movement of capital and often facilitate economic development in domestic and host countries. However, the lack of transparency and accountability of SWFs varies, and state ownership gives rise to suspicions and realizations of political motivations, unfair commercial [...] Read more.

Sovereign wealth funds enhance the international movement of capital and often facilitate economic development in domestic and host countries. However, the lack of transparency and accountability of SWFs varies, and state ownership gives rise to suspicions and realizations of political motivations, unfair commercial advantages, opportunities for corruption, and national security threats, thereby challenging the liberal economic order. This paper provides an overview and identifies major concerns and policy options associated with SWFs. Defining SWFs, measuring their size and transparency, domestic, cultural, and political origins, and policies for oversight and mitigation of geopolitical risk are discussed. The goals and behavior of SWFs are too diverse to draw broad, general conclusions. The growth in the number of funds and assets under management has increased their diversity, but the essential defining characteristic is that they are state-owned financial investment vehicles not subject to the hard budget constraints or regulations of comparable private sector, market-oriented entities. Transparency varies, with democratic country SWFs more transparent and less problematic than those of autocracies. SWFs have evolved into unbounded state-owned entities ushering in a new era of financial statecraft. Policies to guide their behavior and enforcement mechanisms are host-country specific and highly variable. An often-discussed international regulatory framework to mitigate geopolitical risk has not emerged and is not likely. Full article

(This article belongs to the Special Issue Globalization and Economic Integration)

17 pages, 4649 KB

Open AccessArticle

Radioanalytical Assessment and Mineral Chemistry Investigations in the Pegmatites of Eastern Desert, Egypt: Implications for Mining and Radiation Protection

by Mohamed M. Ghoneim, Mohamed Mitwalli, Hanaa A. El-Dokouny, Mai A. El-Lithy, Maher Dawoud, Yue-Yue Liu, Tariq Al-Abdullah and Abdelhalim S. Mahmoud

Geosciences 2026, 16(2), 69; https://doi.org/10.3390/geosciences16020069 (registering DOI) - 5 Feb 2026

Abstract

This study is carried out to investigate the radiological characteristics and mineralogical controls of natural radioisotopes (²³⁸U, ²²⁶Ra, ²³²Th, and ⁴⁰K) in granitic pegmatites from Abu Zawal Area (AZA) in the Eastern Desert of Egypt. The analyzed pegmatites, [...] Read more.

This study is carried out to investigate the radiological characteristics and mineralogical controls of natural radioisotopes (²³⁸U, ²²⁶Ra, ²³²Th, and ⁴⁰K) in granitic pegmatites from Abu Zawal Area (AZA) in the Eastern Desert of Egypt. The analyzed pegmatites, containing thorite, zircon, monazite, ferrocolumbite, and fergusonite, exhibit exceptionally high radioactivity concentrations of ²³⁸U ≤ 568; ²³²Th ≤ 674; ²²⁶Ra ≤ 170 (Bq kg⁻¹), significantly exceeding the world average permissible limits (35, 30, 30, and 400 Bq kg⁻¹ for ²³⁸U, ²²⁶Ra, ²³²Th, and ⁴⁰K, respectively). Comprehensive radiological assessment reveals severely elevated radiological impact associated with Ra_eq ≤ 1243 (Bq kg⁻¹) and hazard indices (H_ex≤ 3.36; ELCR ≤ 12.2 × 10⁻³) surpassing international safety thresholds (H_ex ≤ 1; ELCR ≤ 1 × 10⁻³). The observed disequilibrium between ²³⁸U and ²²⁶Ra (with ²²⁶Ra activities approximately half those of ²³⁸U) is attributed to the geochemical mobility of radium and potential selective leaching during late-stage hydrothermal alteration, while the overall enrichment of the uranium series over the thorium series is linked to the predominance of uranium-bearing minerals like zircon and fergusonite in these pegmatites. Mineralogical analysis demonstrates distinct radiation patterns: thorite and monazite dominate Th-derived gamma radiation and radon/thoron exhalation, while zircon and fergusonite control U enrichment and decay chain disequilibrium. Notably, nominally low-activity minerals like ferrocolumbite contribute to localized radiation hotspots through U/Th co-concentrations. The calculated absorbed dose rates ranged from 182 to 978 (nGy h⁻¹) and annual effective doses show extreme spatial variability correlated with Th-rich mineral assemblages. Full article

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35 pages, 2591 KB

Open AccessReview

Macaw Palm Propagation Strategies: Advances, Gaps, and Future Directions for a Promising Oleaginous Crop—A Review

by Vytória Piscitelli Cavalcanti, Laís da Silva Braga, Anna Carolina Abreu Francisco da Costa, José Victor Maurício de Jesus, Jorge Braga Ribeiro Junior, Heloisa Oliveira dos Santos, Rafael Peron Castro, Adão Felipe dos Santos and Joyce Dória

Plants 2026, 15(3), 488; https://doi.org/10.3390/plants15030488 (registering DOI) - 5 Feb 2026

Abstract

The Acrocomia aculeata is a promising palm tree for biofuel production, but it faces challenges related to propagation, especially due to seed dormancy. This article presents an integrative review, supported by bibliometrics, of the sexual and asexual propagation methods of the species, conducted [...] Read more.

The Acrocomia aculeata is a promising palm tree for biofuel production, but it faces challenges related to propagation, especially due to seed dormancy. This article presents an integrative review, supported by bibliometrics, of the sexual and asexual propagation methods of the species, conducted through searches in Scopus, SciELO, and Web of Science databases. The results indicate that sexual propagation is the predominant approach in the literature, although it faces significant challenges due to seed dormancy, such as the physical resistance to embryo protrusion imposed by the operculum. Asexual propagation demonstrates great potential through micropropagation techniques, which allow obtaining genetically uniform plants in relatively short periods. The non-deep physic dormancy exhibited by the seeds interferes with germination by constraining embryo growth potential and postponing the metabolic reactivation essential for successful germination. Despite the existence of promising methods for overcoming dormancy, additional studies are needed to understand the mechanisms involved in this process. This review maps the scientific literature to highlight areas of proven research success, identify critical gaps and underexplored topics, and indicate how future investigations can support the development of efficient propagation protocols and the establishment of commercial plantations. Full article

(This article belongs to the Section Plant Development and Morphogenesis)

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13 pages, 1666 KB

Open AccessArticle

Development and Validation of a Population Assay for the Seroprevalence of Lumpy Skin Disease

by Manjunatha Reddy Gundallahalli Bayyappa, Sudeep Nagaraj, Shraddha Bijalwan, Chethan Kumar Harlipura Basavarajappa, Sathish Bhadravati Shivachandra and Baldev Raj Gulati

Microorganisms 2026, 14(2), 373; https://doi.org/10.3390/microorganisms14020373 (registering DOI) - 5 Feb 2026

Abstract

Lumpy Skin Disease (LSD) is a transboundary bovine viral disease. It has a significant economic impact and is caused by the Lumpy Skin Disease Virus (LSDV). Effective surveillance tools are essential for the early detection of infection, outbreak control, and assessment of vaccination [...] Read more.

Lumpy Skin Disease (LSD) is a transboundary bovine viral disease. It has a significant economic impact and is caused by the Lumpy Skin Disease Virus (LSDV). Effective surveillance tools are essential for the early detection of infection, outbreak control, and assessment of vaccination coverage in endemic regions such as India. In this study, an in-house ELISA based on inactivated whole-virus antigen (WVA) was developed, optimized, and validated for the detection of LSDV antibodies in cattle. Its field applicability was assessed through a cross-sectional seroprevalence survey conducted across five Indian states. A local field isolate of LSDV (strain 5-Chitra) was cultured in MDBK cells, inactivated using binary ethylenimine (BEI), and used as the antigen source. The assay was optimized by checkerboard titration and evaluated against the Serum Neutralization Test (SNT). Diagnostic sensitivity and specificity were evaluated using the receiver operating characteristic (ROC) curve and area under the curve (AUC) analyses, while cross-reactivity was assessed using sera positive for HS, IBR, BQ, MCF, GTP, SPP, CE, FMD, and Brucellosis. Assay reproducibility was confirmed through inter- and intra-laboratory validation. For the seroprevalence study, 3230 cattle serum samples were collected using a stratified random sampling design across five Indian states, and logistic regression analysis of a subset of 1302 samples was performed to assess the influence of age and sex on LSDV seropositivity. Checkerboard titration identified optimal ELISA conditions at 50 ng of antigen per well, a 1:150 serum dilution, and a 1:10,000 dilution of anti-bovine HRP-conjugated secondary antibody. The WVA-ELISA demonstrated excellent diagnostic performance, with 100% sensitivity, 95% specificity, and no cross-reactivity with other ruminant bacterial or viral pathogens, and showed high laboratory reproducibility (κ > 0.96). Seroprevalence ranged from 50.6% to 71.1% across the five states, indicating widespread exposure to LSDV. Risk factor analysis revealed significantly higher odds of seropositivity among calves (≤1 year old) and female cattle, suggesting age- and sex-dependent susceptibility. Full article

(This article belongs to the Special Issue The Pathogenesis, Epidemiology and Diagnosis of Infectious Diseases in Livestock Animals, 2nd Edition)

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20 pages, 350 KB

Open AccessArticle

“There Is Shame and Pride, It’s Not Neutral”: Community Division and Commonalities in Mediatised Public Crisis

by Mona Chatskin

Journal. Media 2026, 7(1), 26; https://doi.org/10.3390/journalmedia7010026 (registering DOI) - 5 Feb 2026

Abstract

This paper examines how the Malka Leifer child sexual abuse crisis, mediatised across Australian mainstream, local and social media, impacted the Australian Jewish community. Guided by framing theory, this study uses mixed methods: a news framing analysis of ABC, The Age, the Herald [...] Read more.

This paper examines how the Malka Leifer child sexual abuse crisis, mediatised across Australian mainstream, local and social media, impacted the Australian Jewish community. Guided by framing theory, this study uses mixed methods: a news framing analysis of ABC, The Age, the Herald Sun and the Australian Jewish News across four critical discourse moments, and “peer conversation” focus groups across Jewish denominations. Findings reveal that, despite news media’s intentions, coverage consistently adopted an “otherness” frame when reporting Jewish community issues. Such simplified and limited approaches to news framing contrast with the multi-faceted nature of the ethnoreligious Jewish identity, exacerbating vulnerability in a community already navigating the legacies of the Australian Royal Commission into Institutional Responses to Child Sexual Abuse, and triggering responses ranging from engagement to unjustified notions of shame. The article argues that more reflexive reporting practices are needed to recognise the community’s multidimensional identities and mitigate harm in future public crises. Full article

(This article belongs to the Special Issue Global Media, Local Voices: The Dynamics of Diversity)

11 pages, 255 KB

Open AccessArticle

Efficacy of a Paradoxical Intervention in the Treatment of Sleep-Onset Insomnia in Women During and After the Climacteric Stage: A Pilot Study

by José Vicente Viguer, Martha Martín and Amelia Díaz

Psychiatry Int. 2026, 7(1), 36; https://doi.org/10.3390/psychiatryint7010036 (registering DOI) - 5 Feb 2026

Abstract

Paradoxical interventions involve asking patients to maintain or exaggerate the symptoms they wish to eliminate, with the aim of reducing them. These techniques received empirical support, particularly in the treatment of sleep-onset insomnia, during the 1980s. However, changes in sleep habits over recent [...] Read more.

Paradoxical interventions involve asking patients to maintain or exaggerate the symptoms they wish to eliminate, with the aim of reducing them. These techniques received empirical support, particularly in the treatment of sleep-onset insomnia, during the 1980s. However, changes in sleep habits over recent decades warrant further research on their current applicability. This article reports a pilot study involving 26 women (aged 40–70) with significant difficulty initiating sleep, who were randomly assigned to either a paradoxical or a non-paradoxical treatment; a prior waiting period was also used as a waitlist control. Both treatments produced statistically significant improvements in insomnia scores between pre- and post-treatment, with no significant differences between groups. These findings suggest that paradoxical interventions may be effective for the current treatment of sleep-onset insomnia and support the need for randomized clinical trials with larger samples. Full article

15 pages, 290 KB

Open AccessArticle

Body Composition, Emotional Dysregulation, and Suicide Risk in College Students

by Natalia Covili Arevalo, Camilo Aramburú-Navarro, Eduardo Sandoval-Obando, Felipe Caamaño-Navarrete, Carlos Arriagada-Hernández, Paulo Etchegaray-Pezo and Gerardo Fuentes-Vilugrón

Psychiatry Int. 2026, 7(1), 35; https://doi.org/10.3390/psychiatryint7010035 (registering DOI) - 5 Feb 2026

Abstract

Introduction: University students often describe their academic years as a period of continuous personal change, which may increase vulnerability to unhealthy lifestyle habits. These habits can influence body composition and are associated with both physical conditions (e.g., overweight, sedentary behavior) and psychological well-being, [...] Read more.

Introduction: University students often describe their academic years as a period of continuous personal change, which may increase vulnerability to unhealthy lifestyle habits. These habits can influence body composition and are associated with both physical conditions (e.g., overweight, sedentary behavior) and psychological well-being, including suicide risk. Method: A quantitative, non-experimental, cross-sectional, descriptive–comparative–correlational design was employed, using a non-probabilistic intentional sample of 174 university students. Data were collected using the OMRON 514C body composition monitor, the Difficulties in Emotional Regulation Scale (DERS-E), and Plutchik’s Suicide Risk Scale. Statistical analyses included descriptive statistics, independent samples t-tests for gender comparisons, Pearson’s correlation analyses, and multiple linear regression analyses to examine whether the observed bivariate associations remained significant after controlling for gender. Results: Descriptive analyses showed variability in body composition, emotional dysregulation, and suicide risk. Gender comparisons indicated that men presented higher weight, height, skeletal muscle mass, visceral fat level, and basal metabolic rate, whereas women reported higher body fat percentage, greater emotional dysregulation, and higher suicide risk. Correlation analyses revealed that suicide risk was negatively associated with skeletal muscle mass (r = −0.24, p = 0.002), basal metabolic rate (r = −0.21, p = 0.006), height (r = −0.27, p < 0.001), emotional rejection (r = −0.24, p = 0.001), and emotional confusion (r = −0.22, p = 0.004). Multiple regression analyses, controlling for gender, indicated that the associations between body composition indicators (skeletal muscle and basal metabolism) and suicide risk did not remain statistically significant (p > 0.05). In contrast, emotional dysregulation dimensions, particularly emotional rejection, maintained significant associations with suicide risk after adjustment for gender. Additionally, negative associations were found between BMI and emotional dysregulation, and between height and emotional clarity, even after controlling for gender. Discussion: The findings highlight emotional dysregulation as a central and robust factor associated with suicide risk in university students, whereas body composition indicators appear to play a more limited and gender-dependent role. The fact that associations between physical markers (skeletal muscle, basal metabolism) and suicide risk were mediated by gender underscores the importance of considering sociodemographic factors when interpreting body–mental health relationships. These results support the need for integrated biopsychosocial prevention strategies that address emotional regulation within the university context, while considering the differential impact of gender on both physical and psychological risk factors. Full article

21 pages, 2775 KB

Open AccessArticle

Comparative Genomics Reveals Host-Specific Adaptation of Pyricularia oryzae Strains Isolated from Rice and Barnyard Grass

by Wenda Sun, Xiaohan Zhang, Zhuan Zhang, Xiaofang Xie, Song Tang, Tian Song, Baoxu Lu, Jiafeng Wang, Zhibin Liang, Xiaofan Zhou and Yizhen Deng

J. Fungi 2026, 12(2), 109; https://doi.org/10.3390/jof12020109 (registering DOI) - 5 Feb 2026

Abstract

Barnyard grass, a widespread and persistent weed in rice paddies, belongs to the same family as rice and may act as a bridge host for the rice blast fungus. This study utilized comparative genomics to analyze six Pyricularia oryzae strains isolated from barnyard [...] Read more.

Barnyard grass, a widespread and persistent weed in rice paddies, belongs to the same family as rice and may act as a bridge host for the rice blast fungus. This study utilized comparative genomics to analyze six Pyricularia oryzae strains isolated from barnyard grass (Baicao series) and rice (GDYJ7 and ZJX18), integrating pathogenicity assays, whole-genome sequencing, and functional annotation. Pathogenicity tests demonstrated host specificity, as Baicao series strains caused typical lesion symptoms on barnyard grass but not on rice leaves, while GDYJ7 and ZJX18 caused lesions mainly on rice. Genomic analyses indicated that Baicao series strains possessed larger genomes (41.04 Mb to 41.16 Mb) with a higher content of repetitive sequences (6.68% to 7.09%) compared to rice strains GDYJ7 and ZJX18 (38.69 Mb and 39.05 Mb; 3.66% and 3.71% repeats). Phylogenetic analysis confirmed that Baicao series strains represent a grass-infecting pathotype of P. oryzae species, as they were grouped with the established grass-isolated P. oryzae strains, while GDYJ7 and ZJX18 were grouped with rice-isolated P. oryzae strains. However, Baicao series, GDYJ7 and ZJX18 are all relatively distant from P. grisea species. PCR amplification revealed that Baicao series strains harbored significantly fewer avirulence genes (Avr-Pib, Avr-Pizt, PWL3) than GDYJ7 and ZJX18 (Avr-Pib, Avr-Pizt, Avr-Pi9, Avr-Pik, PWL2), with Baicao9 retaining only Avr-Pib. In summary, our results suggested that the genomic sequences of the barnyard grass-isolated strains serve as a valuable resource for the study of P. oryzae strains with differential host preference and provide novel insights into the evolution of pathogen genomes during host adaptation. Full article

(This article belongs to the Section Fungal Genomics, Genetics and Molecular Biology)

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25 pages, 351 KB

Open AccessArticle

From Rhetoric to Implementation: Embedding the Rule of Law in EU Public Administration and Governance

by Dimitris Kirmikiroglou, Dimitra Tomprou and Paraskevi Boufounou

Adm. Sci. 2026, 16(2), 78; https://doi.org/10.3390/admsci16020078 (registering DOI) - 5 Feb 2026

Abstract

The rule of law, a foundational value of the European Union as enshrined in Article 2 of the Treaty on European Union, faces challenges in implementation due to historical and political factors that have evolved over the past decade, particularly within Member States [...] Read more.

The rule of law, a foundational value of the European Union as enshrined in Article 2 of the Treaty on European Union, faces challenges in implementation due to historical and political factors that have evolved over the past decade, particularly within Member States in the administrative domain. While institutional backsliding in countries like Hungary and Poland has drawn significant political attention, less emphasis has been placed on the role of public administrations in upholding or undermining the rule of law on a day-to-day basis. This paper argues that the sustainability of the rule of law in the EU requires more than legal compliance mechanisms. These alone do not address the underlying administrative and cultural factors necessary for effective implementation. Instead, it requires closer attention to how rule-of-law principles are embedded in the everyday functioning of public administrations. This argument is informed by the authors’ systematic examination of recent EU monitoring practices and administrative reform instruments. Adopting a mixed conceptual-empirical methodology, the paper draws on primary data from EU Rule of Law Reports (2020–2024), the EU Justice Scoreboard, the Recovery and Resilience Facility (RRF), and the Technical Support Instrument (TSI), complemented by relevant OECD/SIGMA indicators. Several structural obstacles emerge from the analysis. These include symbolic compliance, whereby organisations adopt formal structures without corresponding behavioural change; weak institutional leadership that fails to drive reform momentum; and the absence of integrated performance metrics, which hampers meaningful accountability. Fragmented ownership of reform agendas, in turn, breeds inconsistency in implementation. These challenges point to the limitations of a technocratic or legalistic approach to rule-of-law governance. Strategic leadership and organisational flexibility emerge from the evidence as preconditions—not merely facilitators—of genuine internalisation, though the relationship is context-dependent. Digitalisation can reinforce these dynamics, yet its contribution depends on whether it is embedded within broader integrity-oriented reforms. The paper advocates for a shift from externalized compliance mechanisms to a model that emphasizes administrative ownership through specific strategies such as developing integrity-based leadership programs and embedding governance practices that prioritize transparency and accountability. It proposes concrete institutional reforms, including performance-linked conditionalities that tie funding to measurable outcomes, ethical leadership academies to train future leaders, integrity audits to ensure accountability, and administrative benchmarking to set clear standards, as tools to foster autonomous, value-driven public institutions capable of adapting to evolving governance challenges while maintaining core democratic values. Full article

(This article belongs to the Special Issue New Developments in Public Administration and Governance)

14 pages, 246 KB

Open AccessArticle

Microbiological Efficacy and Cost-Effectiveness of Poultry Carcass Excision Sampling Methods in Brazil

by Pricila Borges, Luciana Mena, Sandra Heidtmann, José Queluz, Natalia Lopes, Jaqueline Cruvinel, Michele Nesi, Juliana Schmitz, Anabile Lisboa, Viviane Colla, Christiane Huller, Brunna Dutra and Eduardo Tondo

Microorganisms 2026, 14(2), 372; https://doi.org/10.3390/microorganisms14020372 (registering DOI) - 5 Feb 2026

Abstract

Brazil is among the world’s leading exporters of chicken meat, and microbiological evaluation of carcasses is essential to verify process hygiene and safety. This study assessed the microbiological effectiveness and economic impact of two sampling methods for poultry carcasses: the excision of pooled [...] Read more.

Brazil is among the world’s leading exporters of chicken meat, and microbiological evaluation of carcasses is essential to verify process hygiene and safety. This study assessed the microbiological effectiveness and economic impact of two sampling methods for poultry carcasses: the excision of pooled samples of skin and muscle from multiple carcass regions, as recommended by Brazilian authorities, and the excision of neck skin alone. In accordance with Brazilian authorities guidelines requiring carcass evaluation through Enterobacteriaceae counts, these microorganisms were employed to assess contamination across different regions of 90 carcasses. Subsequently, Enterobacteriaceae counts were performed on 144 carcasses using both sampling methods. Mesophilic microorganisms, total coliforms, Escherichia coli, and Staphylococcus were tested in ten carcasses sampled by both methods to confirm the results obtained from the enumeration of Enterobacteriaceae and results were evaluated using Shapiro–Wilk, Levene, F-test, Kruskal–Wallis, Dunn, and T-test. Additionally, costs related to labor time and protein waste were quantified in 18 slaughterhouses. Results showed that Enterobacteriaceae counts in neck, cloaca, and wing regions were similar but significantly lower than those in pooled dorsal samples (p < 0.05). Neck skin samples were statistically comparable to dorsal pooled samples and exhibited higher contamination than ventral samples, demonstrating equivalent or superior microbiological representativeness. The neck skin method required less time, produced less protein waste, and reduced costs by 99%, indicating a more efficient and cost-effective alternative for microbiological monitoring of poultry carcasses. Full article

(This article belongs to the Section Food Microbiology)

24 pages, 1191 KB

Open AccessArticle

Systemic–CFD Framework for Performance Optimization of R-Candy Propulsion Systems

by Alejandro Pisil-Carmona, Emilio-Noe Jimenez-Navarro, Diego-Alfredo Padilla-Pérez, Jhonatan-Fernando Eulopa-Hernandez, Pablo-Alejandro Arizpe-Carreon and Carlos Couder-Castañeda

Appl. Sci. 2026, 16(3), 1592; https://doi.org/10.3390/app16031592 (registering DOI) - 5 Feb 2026

Abstract

This study used a Systemic Modeling technique, based on the methodologies of Churchman and Ackoff, to integrate and assess the subsystems regulating the functionality of a Rocket Candy (R-Candy) motor. The nozzle and combustion chamber design was improved using a five-phase systemic architecture [...] Read more.

This study used a Systemic Modeling technique, based on the methodologies of Churchman and Ackoff, to integrate and assess the subsystems regulating the functionality of a Rocket Candy (R-Candy) motor. The nozzle and combustion chamber design was improved using a five-phase systemic architecture to assure the coherent interplay of essential factors, including pressure, temperature, and velocity fields. The principles of experimental rocketry are elucidated through the examination of impulse performance throughout class A to class C engines. A preliminary design was developed in SolidWorks 2024, incorporating the engine’s three main components: the igniter, the combustion chamber, and a convergent–divergent nozzle that enhances the acceleration of the exhaust gases. The system model was validated using simulations in FEATool and verified through experimentation. This allowed for the analysis of fluid behavior, as well as the geometry of the structures, initial parameters, and boundary conditions. The results demonstrate a strong correlation between the simulations and the experimental data, with discrepancies of less than 1.5%, confirming the reliability and feasibility of the nozzle design. The findings indicate that systemic modeling, in conjunction with CFD and experimentation, can provide a strategic framework for iterative refinement, optimization of key performance metrics, and the development of cost-effective, high-performance R-Candy engines for educational and experimental purposes. Full article

(This article belongs to the Special Issue Advanced Technologies in Intelligent Software Methodologies, Tools, and Techniques)

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17 pages, 912 KB

Open AccessReview

Fifth-Order Block Hybrid Approach for Solving First-Order Stiff Ordinary Differential Equations

by Ibrahim Mohammed Dibal and Yeak Su Hoe

AppliedMath 2026, 6(2), 21; https://doi.org/10.3390/appliedmath6020021 (registering DOI) - 5 Feb 2026

Abstract

This study introduces a novel single-step hybrid block method with three intra-step points that attains fifth-order accuracy, offering an accurate and computationally economical tool for solving first-order differential equations. The method is specifically designed to handle first-order differential equations with efficiency and precision [...] Read more.

This study introduces a novel single-step hybrid block method with three intra-step points that attains fifth-order accuracy, offering an accurate and computationally economical tool for solving first-order differential equations. The method is specifically designed to handle first-order differential equations with efficiency and precision while employing a constant step size throughout the computation. To further enhance accuracy, interpolation techniques are incorporated to approximate function values at specific positions, addressing the fundamental properties of the method and verifying its mathematical soundness. These analyses confirm that the scheme satisfies the essential requirements of stability, consistency, and convergence, ensuring reliability in practical applications. In addition, the method demonstrates strong adaptability, making it suitable for a broad spectrum of problem settings that involve both stiff and non-stiff systems. Numerical experiments are carried out, and the results consistently demonstrate that the proposed method is robust and effective under various test cases. The outcomes further reveal that it frequently outperforms several existing numerical approaches in terms of both accuracy and computational efficiency. Full article

(This article belongs to the Section Computational and Numerical Mathematics)

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22 pages, 2194 KB

Open AccessArticle

Enhancing the Production of Sour Beers by Adding Blueberries and Fermenting with Lachancea and Metschnikowia

by Elena Alonso, Carmen López, María Antonia Bañuelos, Carmen González and Antonio Morata

Fermentation 2026, 12(2), 91; https://doi.org/10.3390/fermentation12020091 (registering DOI) - 5 Feb 2026

Abstract

The increasing demand for alcohol-free craft beers with functional properties and distinctive sensory attributes has motivated the brewing industry to investigate alternative production strategies, such as the application of non-Saccharomyces yeasts, to obtain sour beers while reducing production time and associated costs. [...] Read more.

The increasing demand for alcohol-free craft beers with functional properties and distinctive sensory attributes has motivated the brewing industry to investigate alternative production strategies, such as the application of non-Saccharomyces yeasts, to obtain sour beers while reducing production time and associated costs. This study explores the combined use of Lachancea thermotolerans L31 and Metschnikowia pulcherrima M29 in the production of beers brewed with blueberries or enriched with grape anthocyanin concentrate. Physicochemical parameters such as pH, color, bitterness, total polyphenols, antioxidant capacity, and anthocyanin and volatile profiles were evaluated, and a sensory analysis was performed. The results showed that both the addition of blueberries and that of anthocyanin concentrate and fermentation with Lachancea and Metschnikowia significantly influenced the chemical and sensory properties of the beer. Mainly, pH values decreased from 4.35 to 3.50 and from 3.69 to 3.26, while antioxidant activity increased from 3 to 10 times, depending on the type of yeast and the addition of fruit. Alcohol content remained constant at approximately 5.0% v/v. This strategy allows for the production of beer with a distinctive profile and functional benefits, representing a step forward in craft beer development and opening new avenues for research and innovation in the sector. Full article

(This article belongs to the Special Issue Selected Papers from the 1st International Online Conference on Fermentation (IOCFE2025))

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23 pages, 77169 KB

Open AccessArticle

Structural Complexity of Quercus virgiliana Galls Induced by Andricus quercustozae (Hymenoptera: Cynipidae)

by Sanja Puljas, Juraj Kamenjarin and Ivica Šamanić

Int. J. Plant Biol. 2026, 17(2), 9; https://doi.org/10.3390/ijpb17020009 (registering DOI) - 5 Feb 2026

Abstract

Cynipid gall wasps are known for their ability to manipulate host plant development, redirecting undifferentiated tissues into complex, highly specialised structures. In this study, we investigated how Andricus quercustozae larvae manipulate axillary bud tissues of Quercus virgiliana across four key stages of gall [...] Read more.

Cynipid gall wasps are known for their ability to manipulate host plant development, redirecting undifferentiated tissues into complex, highly specialised structures. In this study, we investigated how Andricus quercustozae larvae manipulate axillary bud tissues of Quercus virgiliana across four key stages of gall development: initiation, differentiation and growth, maturation, and lignification. Using detailed histological analyses, we characterised progressive tissue differentiation within galls, focusing on the organisation of nutritive, protective, and vascular tissues. Gall development was marked by sustained hyperplasia and hypertrophy, extensive vascular proliferation, and progressive cell wall lignification, resulting in a complex organ optimised for larval nutrition and protection. To complement these anatomical observations, we conducted a preliminary transcriptomic comparison between gall tissue and unmodified leaf tissue. Gene expression analyses revealed suppression of photosynthesis-related functions and coordinated modulation of developmental, regulatory, and metabolic pathways, consistent with a transition from assimilatory leaf tissue to a specialised nutrient sink. Integration of anatomical and transcriptomic evidence supports a model in which cynipid gall wasps intervene at key regulatory nodes of bud development, progressively reprogramming host tissues to form a functionally autonomous gall. These findings provide new insight into the extended phenotype and highlight the plasticity of plant developmental programmes under insect control. Full article

(This article belongs to the Special Issue Plant Resistance to Insects)

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20 pages, 888 KB

Open AccessArticle

Writing Accuracy: How AI-Assisted Writing Instruction Can Support EFL Undergraduate Students

by Hana Almutairi, Abdullah A. Alfaifi and Mohammad Saleem

Information 2026, 17(2), 157; https://doi.org/10.3390/info17020157 (registering DOI) - 5 Feb 2026

Abstract

Recent research suggests that artificial intelligence (AI) tools allow EFL (English as a Foreign Language) learners to exert greater control over their language-learning process. Furthermore, these tools enhance their language skills by providing them with elements often absent in traditional classroom settings, such [...] Read more.

Recent research suggests that artificial intelligence (AI) tools allow EFL (English as a Foreign Language) learners to exert greater control over their language-learning process. Furthermore, these tools enhance their language skills by providing them with elements often absent in traditional classroom settings, such as autonomy and individual pace of learning. Specifically, AI-based tools, such AI chatbots, have the potential to facilitate learning and streamline tasks for both students and instructors in language-learning contexts. These digital companions (i.e., chatbots) can be methodically crafted and equipped with the required essential materials to support students in practising language skills independently, regardless of time or location. The current study presents an experiment conducted with undergraduate students at a university in Saudi Arabia to assess the effectiveness of a customised AI chatbot, WritePro (GPT-4), in improving their writing skills. Learners in the experimental group were instructed to use WritePro to navigate through their writing stages, focusing their queries on four key components: content and organisation, grammar mechanics, vocabulary usage, and sentence structure. The findings showed that WritePro serves as an effective tool for EFL learners to overcome several challenges in developing writing competencies. Therefore, the significance of these findings lies in the potential of AI tools to enable EFL instructors to effectively integrate chatbots into classroom instruction, supporting the development of students’ writing skills. Furthermore, these findings can be used as a basis for advocacy with university policymakers regarding the use of AI chatbots in language classrooms. Full article

(This article belongs to the Special Issue Advances in Digital Learning Processes: Innovation, Ethics and Governance)

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11 pages, 549 KB

Open AccessArticle

Screening of Rubella Virus, Cytomegalovirus, Hepatitis B Virus, Hepatitis C Virus, HIV, Syphilis, and Toxoplasma gondii Antibodies in Pregnant Women

by Fatih Mehmet Akıllı, Fatih Demir and Taylan Onat

Viruses 2026, 18(2), 206; https://doi.org/10.3390/v18020206 (registering DOI) - 5 Feb 2026

Abstract

TORCH pathogens are often asymptomatic in healthy adults but can cause foetal death when transmitted during pregnancy; therefore, accurate regional data are essential for screening. This study aimed to determine first-trimester TORCH seropositivity and to inform the development of hospital-based and national screening [...] Read more.

TORCH pathogens are often asymptomatic in healthy adults but can cause foetal death when transmitted during pregnancy; therefore, accurate regional data are essential for screening. This study aimed to determine first-trimester TORCH seropositivity and to inform the development of hospital-based and national screening algorithms. This study analysed test results from 7481 pregnant women aged 15–49 years who participated between January 2020 and December 2024. TORCH serological results obtained using the MAGLUMI X3/X6 system (Snibe, Shenzhen, China) were analysed with Statistical Package for the Social Sciences. Anti-HCV positivity was 0.12% (9/7166), anti-Toxoplasma gondii IgG positivity was 16.51% (1027/6207), anti-rubella IgG positivity was 95.5% (5809/6081), and anti-CMV IgG positivity was 98.67% (6130/6212). Syphilis seropositivity among pregnant women was 0.2% (13/4991). Significant differences by age groups (15–24, 25–34, and >35 years) were observed for rubella IgG (p < 0.001), T. gondii IgG (p < 0.001), and HBsAg positivity (p = 0.009). This study investigated TORCH seropositivity among pregnant women in our hospital region and underscores the need for targeted public health initiatives to reduce the risk of congenital infections. It recommends systematic first-trimester assessment of TORCH exposure, standardized data recordings, the establishment of national screening programmes, and careful consideration of testing costs. Full article

(This article belongs to the Section Human Virology and Viral Diseases)

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18 pages, 764 KB

Open AccessSystematic Review

Sperm Microbiota and Its Potential Impact on Male Fertility: A Systematic Review

by Raghda Youssef, Caroline Aimone-Vianna, Evelyne Schvoerer, Alain Lozniewski and Anne Julie Fattet

Reprod. Med. 2026, 7(1), 8; https://doi.org/10.3390/reprodmed7010008 (registering DOI) - 5 Feb 2026

Abstract

Background/Objectives: Infertility is a major public health concern, affecting one in six individuals worldwide and nearly one-quarter of couples in France. While a male, female, or combined factor can be identified in approximately 75% of cases, infertility remains unexplained in 10–25%. Genital [...] Read more.

Background/Objectives: Infertility is a major public health concern, affecting one in six individuals worldwide and nearly one-quarter of couples in France. While a male, female, or combined factor can be identified in approximately 75% of cases, infertility remains unexplained in 10–25%. Genital tract infections account for roughly 15% of male infertility cases and are often asymptomatic, being detected incidentally during routine evaluation prior to assisted reproductive technology (ART). Emerging evidence suggests that the seminal microbiota may contribute to sperm quality and male reproductive health. This systematic review aims to evaluate whether specific microbial profiles are associated with alterations in semen parameters. Methods: A comprehensive literature search was conducted in PubMed and ScienceDirect, yielding 165 and 1418 records, respectively. In the end, 20 articles were included in this systematic review. Results: Men with normal semen parameters commonly exhibited a higher abundance of Lactobacillus and Bifidobacterium, whereas Prevotella was more frequently observed in individuals with impaired semen quality. Several taxa—such as Gardnerella, Corynebacterium, and Staphylococcus spp.—were detected in both normal and altered semen profiles, suggesting that their impact on sperm quality may depend on reaching a pathogenic threshold. Conclusions: Current evidence supports an association between seminal microbiota composition and sperm quality. However, the heterogeneity of available studies and the lack of standardized methodologies limit the ability to draw firm conclusions. Further well-designed studies are required to clarify causal relationships and to determine the clinical relevance of seminal microbiota assessment in male infertility. Full article

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28 pages, 1235 KB

Open AccessReview

The Family in Transition: A Scoping Review of Retirement’s Relational Impacts

by Marilyn Cox and Heidi Cramm

Fam. Sci. 2026, 2(1), 4; https://doi.org/10.3390/famsci2010004 (registering DOI) - 5 Feb 2026

Abstract

Retirement marks a pivotal transition not only for individuals but also for their families. Existing research has examined relational aspects of retirement but primarily focuses on how family members influence the retiree’s well-being rather than on the impact of this transition on other [...] Read more.

Retirement marks a pivotal transition not only for individuals but also for their families. Existing research has examined relational aspects of retirement but primarily focuses on how family members influence the retiree’s well-being rather than on the impact of this transition on other family members and the broader family system. To address this imbalance, the present review synthesizes evidence drawing upon Family Life Course Theory and Family Systems Theory. Using a well-established five-stage framework, we conducted extensive database searches and refined our guiding research question. Of the 4034 studies identified, 61 were selected for detailed analysis. Data extraction and thematic coding, supported by MAXQDA 24 software, revealed eight interconnected themes: marital quality and conflict; dyadic adjustments between partners; financial impacts and concerns; time use and leisure; redistribution of domestic roles; health outcomes; emotional and psychological effects on the family unit; and intergenerational dynamics. Across these domains, gender consistently emerged as a central, asymmetrical determinant of adaptation. Ultimately, this review demonstrates that retirement constitutes a relational turning point within families and calls for future research to adopt inclusive, longitudinal designs, and for practitioners and policymakers to develop family-centred interventions that recognize the systemic impact of retirement. Full article

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18 pages, 17069 KB

Open AccessArticle

Rifaximin Protects Against Inflammation and Fibrosis in MASH: Any Role for Ethanol-Producing Bacteria?

by Mohamed Abouelkheir, Dalia A. Shabaan and Ahmed E. Taha

Pathogens 2026, 15(2), 170; https://doi.org/10.3390/pathogens15020170 (registering DOI) - 4 Feb 2026

Abstract

Metabolic Dysfunction-Associated Steato-Hepatitis (MASH) is a multiple-hit disease. Endotoxins, ethanol, and other metabolites of certain gut microbiota can reach the liver and accelerate inflammation and disease progression. Targeting ethanol-producing colonic bacteria with rifaximin could affect the progress of MASH. In the present study, [...] Read more.

Metabolic Dysfunction-Associated Steato-Hepatitis (MASH) is a multiple-hit disease. Endotoxins, ethanol, and other metabolites of certain gut microbiota can reach the liver and accelerate inflammation and disease progression. Targeting ethanol-producing colonic bacteria with rifaximin could affect the progress of MASH. In the present study, thirty mice were assigned to three groups (n = 10 mice per group). Mice received either a normal diet, a Western diet, or a Western diet with oral rifaximin. After 12 weeks, liver function, serum levels of TNF-α, interleukin (IL)-1β, IL-6, and lipopolysaccharides (LPS) were measured. Liver specimens were assessed for pathological changes, lipid deposition, and fibrosis. Expression of p53, GFAP, CD68, and TLR-4 in the liver was also assessed. Faecal samples were evaluated for ethanol contents. Lactobacillus acidophilus, in addition to ethanol-producing Klebsiella pneumoniae and Escherichia coli, were isolated, quantified, and tested for sensitivity to rifaximin. Rifaximin was able to ameliorate Western diet-induced biochemical changes and elevated TNF-α, IL-1β, IL-6, and LPS levels. Changes in liver histology, fibrosis, and lipid content were attenuated. Expressions of p53, GFAP, CD68, and TLR-4 in the liver were all reduced. The Western diet-induced increases in faecal ethanol or ethanol-producing bacteria were not corrected by rifaximin. After 12 weeks, isolated bacteria from the rifaximin group were rifaximin-resistant. Our findings imply that the protective impact of rifaximin in the MASH model is unlikely to be mediated by alteration of ethanol-producing colonic bacteria because of acquired rifaximin resistance. Rifaximin-induced reduction in endotoxemia and inflammation in the liver appears to be a more relevant explanation. Full article

15 pages, 308 KB

Open AccessReview

Brensocatib—Another Therapeutic “Window of Opportunity” for Patients with Bronchiectasis

by Florin-Dumitru Mihălțan, Ruxandra Ulmeanu and Ancuța-Alina Constantin

J. Clin. Med. 2026, 15(3), 1257; https://doi.org/10.3390/jcm15031257 - 4 Feb 2026

Abstract

Introduction: Bronchiectasis is a chronic, heterogeneous airway disease characterised by irreversible bronchial dilatation, recurrent infections, and persistent inflammation, leading to progressive lung damage, frequent exacerbations, and impaired quality of life. Neutrophil-driven inflammation, largely mediated by excessive activity of neutrophil serine proteases such as [...] Read more.

Introduction: Bronchiectasis is a chronic, heterogeneous airway disease characterised by irreversible bronchial dilatation, recurrent infections, and persistent inflammation, leading to progressive lung damage, frequent exacerbations, and impaired quality of life. Neutrophil-driven inflammation, largely mediated by excessive activity of neutrophil serine proteases such as neutrophil elastase, represents a central pathogenic mechanism and an important therapeutic target. Methods: Brensocatib, a first-in-class, selective, and reversible inhibitor of dipeptidyl peptidase-1 (DPP-1), prevents the activation of neutrophil serine proteases during neutrophil maturation in the bone marrow. By reducing downstream protease activity, brensocatib modulates aberrant neutrophilic inflammation without broadly suppressing immune function. Results: Clinical studies, including the Phase-2 WILLOW trial and the Phase-3 ASPEN trial, have demonstrated that brensocatib significantly reduces exacerbation frequency, prolongs time to first exacerbation, and lowers sputum neutrophil protease activity, with a favourable safety profile. Importantly, these benefits were observed across multiple patient subgroups and in addition to standard-of-care therapies. Conclusions: As the first FDA-approved (12 August 2025) mechanism-based therapy for non–cystic fibrosis bronchiectasis, brensocatib represents a paradigm shift toward targeted, precision treatment of neutrophil-mediated airway disease. Its clinical efficacy, biomarker-driven rationale, and potential to reduce antibiotic dependence highlight brensocatib as a cornerstone therapy in bronchiectasis management and a promising strategy for other neutrophil-driven inflammatory conditions. Full article

(This article belongs to the Special Issue Advances in Pulmonary Disease Management and Innovation in Treatment)

24 pages, 13217 KB

Open AccessArticle

Evolution of the Hydrocarbon Migration System in the Western Region of the Kuqa Foreland Basin

by Hao Zhang, Xiaoxue Wang, Xiaofei Zhao, Mingyu Pu and Xiuxiang Lü

Appl. Sci. 2026, 16(3), 1591; https://doi.org/10.3390/app16031591 - 4 Feb 2026

Abstract

The western Kuqa Foreland Basin exhibits complex hydrocarbon distribution with unclear accumulation processes. This study integrated seismic data, microscopic observations, crude oil properties, and basin modelling to establish a dynamic hydrocarbon migration model for the study area. The results indicated two distinct accumulation [...] Read more.

The western Kuqa Foreland Basin exhibits complex hydrocarbon distribution with unclear accumulation processes. This study integrated seismic data, microscopic observations, crude oil properties, and basin modelling to establish a dynamic hydrocarbon migration model for the study area. The results indicated two distinct accumulation phases. During the early phase (16–5 Ma), hydrocarbons migrated eastward along a single unconformity and accumulated in the buried-hill reservoir of well E937 in the southern part of the Baicheng hydrocarbon-generating depression. In contrast, the southwestern region failed to accumulate hydrocarbons because of its distance from the Triassic source rock hydrocarbon generation centre and complex migration pathways. During the late phase (5–0 Ma), the Jurassic hydrocarbon generation centre shifted westward, and hydrocarbons migrated through a composite conduit system comprising faults, weathered crust, and sandstone structural ridges. This process promoted the expansion of the eastern E937 well trap, whereas well WEN54 and other southwestern wells exhibited hydrocarbon accumulation potential. The simulation results predicted that hydrocarbon reservoirs in the eastern region were mainly concentrated in the Qiulitage structural belt east of well E938. This study provides a theoretical basis and predictive guidance for hydrocarbon exploration in this area. Full article

(This article belongs to the Topic Advanced Technology for Oil and Nature Gas Exploration)

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24 pages, 662 KB

Open AccessArticle

Quality-by-Design Compounding of Semisolids Using an Electronic Mortar and Pestle Device for Compounding Pharmacies: Uniformity, Stability, and Cleaning

by Hudson Polonini, Carolina Schettino Kegele, Savvas Koulouridas and Marcone Augusto Leal de Oliveira

Pharmaceutics 2026, 18(2), 205; https://doi.org/10.3390/pharmaceutics18020205 - 4 Feb 2026

Abstract

Background/Objectives: Manual preparation of semisolid formulations (creams, ointments, gels) is prone to variability in mixing energy and time, which may compromise uniform API distribution. This study aimed to evaluate an Electronic Mortar and Pestle (EMP; Unguator™) as a standardized compounding tool, with [...] Read more.

Background/Objectives: Manual preparation of semisolid formulations (creams, ointments, gels) is prone to variability in mixing energy and time, which may compromise uniform API distribution. This study aimed to evaluate an Electronic Mortar and Pestle (EMP; Unguator™) as a standardized compounding tool, with objectives to: (i) validate stability-indicating UHPLC methods; (ii) assess content uniformity across jar strata; (iii) quantify the impact of mixing time and rotation speed via design of experiments (DOE); and (iv) verify cleaning effectiveness and cross-contamination risk. Methods: Five representative formulations were compounded: urea 40%, clobetasol 0.05%, diclofenac 2.5% in hyaluronic acid 3% gel, urea 10% + salicylic acid 1%, and hydroquinone 5%. UHPLC methods were validated per ICH Q2(R2) and stress-tested under acid, base, oxidative, thermal, and UV conditions. Homogeneity was assessed by stratified sampling (top/middle/bottom). A 3² factorial DOE (time: 2/6/10 min; speed: 600/1500/2400 rpm) modeled effects on % label claim and RSD. Cleaning validation employed hydroquinone as a tracer, with swab sampling pre-/post-use and post-sanitization analyzed by HPLC. Results: All UHPLC methods met specificity, linearity, precision, accuracy, and sensitivity criteria and were stability-indicating (Rs ≥ 1.5). Formulations achieved 90–110% label claim with strata CV ≤ 5%. DOE revealed speed as the dominant factor for clobetasol, urea, and diclofenac, while time was more influential for salicylic acid; gels exhibited curvature, indicating diminishing returns at high rpm. Model-predicted optima were implementable on the Unguator™ with minor rounding of rpm/time. Cleaning validation confirmed post-sanitization residues below LOQ and <10 ppm acceptance. Conclusions: The Unguator™ provides a practical, parameter-controlled route for compounding pharmacies to standardize semisolid preparations, achieving reproducible layer-to-layer content uniformity within predefined criteria under the evaluated conditions through programmable set-points and validated cycles. DOE-derived rpm–time relationships define an operational design space within the studied ranges and support selection of implementable device settings and set-points. Importantly, the DOE-derived “optima” in this study are optimized for assay-based content uniformity (mean % label claim and strata variability). Cleaning validation supports a closed, low-cross-contamination workflow, facilitating consistent routines for both routine and complex formulations. Overall, the work implements selected QbD elements (QTPP—Quality Target Product Profile; CQA—Critical Quality Attribute definition; CPP—Critical Process Parameter identification; operational design space; and a proposed control strategy) and should be viewed as a step toward broader lifecycle QbD implementation in compounding. Full article

(This article belongs to the Special Issue Extemporaneous Formulations: Filling the Gap in the Pharmaceutical Industry with Personalized Medicines, 2nd Edition)

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