Ship emissions are a major cause of global air pollution, and in particular, emissions from the combustion of bunker fuels, such as heavy fuel oil (HFO), show strong impacts on the environment and human health. Therefore, sophisticated measurement te...
Characterization, identification, and detection of aerosol particles in their native atmospheric states remain a challenge. Recently, optical trapping-Raman spectroscopy (OT-RS) has been developed and demonstrated for characterization of single, airb...
Single-particle inductively coupled plasma mass spectrometry (spICP-MS) has been used for particle size measurement of diverse types of individual nanoparticles and micrometer-sized carbon-based particles such as microplastics. However, its applicabi...
Detection of microplastics in environmental samples requires fast, sensitive and selective analytical techniques, both in terms of the size of the microparticles and their concentration. Single particle inductively coupled plasma mass spectrometry (S...
10 December 2015
Regulatory efforts rely on nanometrology for the development and implementation of laws regarding the incorporation of engineered nanomaterials (ENMs) into industrial and consumer products. Copper is currently one of the most common metals used in th...
Biological agents used in biological warfare or bioterrorism are also present in bioaerosols. Prompt identification of a biological weapon and its characteristics is necessary. Herein, we optimized an environmentally adaptive detection algorithm that...
A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based me...
Adeno-associated viruses (AAVs) are a leading vector for gene therapy, yet their clinical utility is limited by the lack of robust quality control methods to distinguish between empty (AAVempty), partially loaded (AAVpartial), and fully DNA loaded (A...
Interactions between objects inside living cells are often investigated by looking for colocalization between fluorescence microscopy images that are recorded in separate colours corresponding to the fluorescent label of each object. The fundamental...
We present the first reported use of a CMOS-compatible single photon avalanche diode (SPAD) array for the detection of high-energy charged particles, specifically pions, using the Super Proton Synchrotron at CERN, the European Organization for Nuclea...
The execution step in apoptosis is the permeabilization of the outer mitochondrial membrane, controlled by Bcl-2 family proteins. The physical interactions between the different proteins in this family and their relative abundance literally determine...
Interferometric scattering microscopy (iSCAT) is a powerful tool for single-particle detection. However, the detection sensitivity is significantly limited by high-frequency noise. In this paper, we have proposed a novel method leveraging frequency c...
4 November 2021
A single-particle mass spectrometer (SPMS) with laser ionization was constructed to determine the chemical composition of single particles in real time. The technique was evaluated using various polystyrene latex particles with different sizes (125 n...
The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble...
The deposited particulate material within a fibrous filter affects the pressure drop which develops through three different stages. The implementation of a time-adjustable matrix is intended to cause detachment of particle structures from fibers with...
Titanium dioxide (TiO2) nano- and submicrometric particles’ widespread use in different sectors raised concerns about human and environmental exposure. The validation of analytical methods is essential to ensure reliability in risk assessment s...
Mercury, as one type of toxic heavy metal, represents a great threat to environmental and biological metabolic systems. Thus, reliable and sensitive quantitative detection of mercury levels is particularly meaningful for environmental protection and...
A single-molecule detection method was developed for nucleic acids based on mass spectrometry counting single liposome particles. Before the appearance of symptoms, a negligible amount of nucleic acids and biomarkers for the clinical diagnosis of the...
This study presents a channel-free, micro-well–template-assisted magnetic particle trapping method for efficient single-particle isolation without the need for microfluidic channels. Dual-surface silicon micro-well arrays were fabricated using...
The airborne 2D-S optical array probe has worked for more than ten years and has collected a large number of cloud particle images. However, existing detection methods cannot detect cloud particles with high precision due to the size differences of c...
The increased use of silica and silicon-containing nanoparticles (Si-NP) in agricultural applications has stimulated interest in determining their potential migration in the environment and their uptake by living organisms. Understanding the fate and...
Resistive Plate Chambers (RPCs) are a key active media of the muon systems of current and future collider experiments as well as the CALICE (semi-)digital hadron calorimeter. The outstanding issues with RPCs can be listed as the loss of efficiency fo...
The increasing use of nanomaterials in modern industries and consumer products has led to the release of various contaminants into wastewater streams and the surrounding environment. However, nanoparticle detection and characterisation in wastewater...
Microplastic particles have been found in drinking water sources worldwide and, thus, also in our food and beverages. Especially small microplastics, with sizes of 1 mm and less, cannot be identified reliably without spectroscopic means such as Fouri...
The use of tapered optical fibers, i.e., optical nanofibers, for spectroscopy and the detection of small numbers of particles, such as neutral atoms or molecules, has been gaining interest in recent years. In this review, we briefly introduce the opt...
We investigate the dynamics of a particle in a confined periodic system—a time-dependent oscillator confined by infinitely high and moving walls—and focus on the evolution of the phase of the wavefunction. It is shown that, for some speci...
Thin-film detection technology plays a significant role in particle physics, X-ray imaging and radiation monitoring. In this paper, the detection capability of a Cs3Cu2I5 thin-film scintillator toward α particles is investigated. The flexible t...
This study describes the adaptation of non-linear microscopy for single-particle tracking (SPT), a method commonly used in biology with single-photon fluorescence. Imaging moving objects with non-linear microscopy raises difficulties due to the scann...
The timing of HIV-1 protease (PR) activation and the determinants of orderly Gag and Gag-Pol polyprotein cleavage, leading to structural maturation of virions, are not well-understood. Here, we employed total internal reflection microscopy to visuali...
Structure determination of proteins and macromolecular complexes by single-particle cryo-electron microscopy (cryo-EM) is poised to revolutionize structural biology. An early challenging step in the cryo-EM pipeline is the detection and selection of...
A variety of methods have been used to study atmospheric bioaerosols. A common technique employed for the detection and measurement of bioaerosols is the measurement of the autofluorescence of biological particles when excited by ultraviolet light. W...
In this study, typical haze pollution influenced by biomass burning (BB) activities in Changsha in the autumn of 2024 was investigated through the mixing state and evolution process of BB particles via the real-time measurement of single-particle aer...
Microplastic pollution is a growing public concern as these particles are ubiquitous in various environments and can fragment into smaller nanoplastics. Another environmental concern arises from widely used engineered nanoparticles. Despite the incre...
Over-expression of fluorescently-labeled markers for extracellular vesicles is frequently used to visualize vesicle up-take and transport. EVs that are labeled by over-expression show considerable heterogeneity regarding the number of fluorophores on...
The composition, sizes and shapes of particles in the clouds of Venus have previously been studied with a variety of in situ and remote sensor measurements. A number of major questions remain unresolved, however, motivating the development of an expl...
Extracellular vesicles (EVs) are promising biomarkers for liquid biopsy, but their clinical application is limited by intrinsic heterogeneity and the lack of methods capable of resolving functionally distinct EV subpopulations at the single-vesicle l...
The analysis of level statistics provides a primary method to detect signatures of chaos in the quantum domain. However, for experiments with ion traps and cold atoms, the energy levels are not as easily accessible as the dynamics. In this work, we d...
A new comprehensive analytical approach based on single-particle inductively coupled plasma-sector field mass spectrometry (spICP-SFMS) and electrical asymmetric-flow field-flow-fractionation combined with multi-angle light scattering detection (EAF4...
Single nucleotide polymorphisms (SNPs) present significant challenges in microbial detection and treatment, further raising the demands on sequencing technologies. In response to these challenges, we have developed a novel barcode-based approach for...
Microplastics are increasingly suspected of having serious negative effects on ecological systems and living organisms. These effects are different based on the materials of the microplastics, leading to the importance of the determination of the mat...
Harmful algal blooms pose significant risks to water resource management and aquatic ecosystem health, rendering early detection of algal bloom proliferation essential. In this study, we present an electrochemical strategy for the real-time detection...
A novel aerodynamic lens-based inlet system was developed for a wide particle size range, and it could extend the size range of transmitted particulate matter (PM) to 50 nm–10 μm. The lens system adopted a seven-stage aerodynamic focusing or...
A near-real-time automatic detection system, based on the synergy of continuous measurements taken by a ceilometer and a photometer, has been implemented in order to detect lofted atmospheric aerosol layers and estimate the aerosol load. When heavy-l...
Single-particle inductively coupled plasma mass spectrometry (spICP-MS) offers the unprecedented advantage of sensitive and selective detection of individual particles based on their constituent elements. It has been applied to the qualitative/quanti...
The fully depleted silicon on insulator (FDSOI) integrated circuit process has a buried oxygen layer in its structure, which provides many advantages to the FDSOI integrated circuit process, such as isolating the substrate from the conductive channel...
The short- and long-term impacts of nanoparticles (NPs) in consumer products are not fully understood. Current European Union (EU) regulations enforce transparency on products containing NPs in cosmetic formulations; however, those set by the U.S. Fo...
Potassium (K) is one of the main and most hazardous trace species released to the gas-phase during thermochemical conversion of biomass. Accurate experimental data and models of K release are needed to better understand the chemistry involved. Tunabl...
Aerosols play critical roles in atmospheric chemistry, climate regulation, industrial processes, and public health, necessitating accurate and real-time characterization of their physicochemical properties. This review presents a comprehensive overvi...
We introduce the two-point propagation field (TPPF)—a real-valued, phase-sensitive quantity defined as the functional derivative of the single-photon detection probability with respect to an infinitesimal opaque perturbation placed between the...
Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate the contribution of FUS wi...
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