Special Issue "Membrane Proteins: Structure, Function and Motion"
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 35270
Interests: biophysical chemistry of membrane proteins and membrane interacting peptides; peptide and protein ion transport; antimicrobial peptides
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Membrane proteins are present in all cells and are essential for their homeostasis and response to environmental changes. Membrane proteins are involved in a vast variety of dynamic cellular processes such as ionic and molecular transport, electron transport, signal transduction, enzymatic reactions, and intercellular communication. Despite their relative abundance and important roles in life processes, there is considerably less structural and functional information about membrane proteins in comparison to other types of proteins. The first high-resolution structure for a membrane protein was published in 1985, and, currently, more than1000 membrane protein structures (vs. more than 150,000 structures of other protein classes) have been determined. The main two challenges in determining membrane protein structures is in optimizing experimental conditions for their extraction/purification from cell membranes and their reconstitution in cell-like membranes. In their native environments, membrane proteins interact with both membrane lipids and other (membrane) proteins. This close interaction influences their biological function, which is not easily reproducible under in vitro conditions. In addition to technical problems in isolation and purification of membrane proteins in their native conformations, there are many questions about the molecular behavior of membrane proteins that are not yet answered or are only partially answered. Some of these problems include the specific and non-specific interactions of membrane proteins with lipids and other proteins, dynamic conformational changes and oligomerization of membrane proteins, membrane protein folding, modes of action of infectious structures (such as viruses) with membrane surface and membrane proteins, and the action of membrane proteins in their complex in vivo environment. As a result of these challenging problems, membrane protein studies have become a flourishing research field in molecular biophysics. Visualizing the dynamic nature of membrane proteins and their interconnections in the cell is a key element in understanding the complex, yet efficient, molecular machinery of life.
Dr. Masoud Jelokhani-Niaraki
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- membrane protein isolation and purification
- membrane protein structure
- dynamic conformation
- membrane protein folding
- protein–lipid and protein–protein interactions
- membrane protein oligomerization
- membrane transport
- signal transduction and cellular communication
- interaction with infectious agents
- membrane proteins in vivo