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From Lab to Launchpad: A Modular Transport Incubator for Controlled Thermal and Power Conditions of Spaceflight Payloads -
An Experimental Setup to Study Electron Transport and Thermalization in Cryogenic Para-Hydrogen Crystal Matrices -
Technique for Extracting Initial Parameters of Longitudinal Phase Space of Freshly Injected Bunches in Storage Rings, and Its Applications
Journal Description
Instruments
Instruments
is an international, peer-reviewed, open access journal on scientific instrumentation and its related methods and theory, published quarterly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within ESCI (Web of Science), Scopus, Inspec, CAPlus / SciFinder, INSPIRE, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 21.1 days after submission; acceptance to publication is undertaken in 3.8 days (median values for papers published in this journal in the first half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
- Journal Cluster of Instruments and Instrumentation: Actuators, AI Sensors, Instruments, Micromachines and Sensors.
Latest Articles
Deep-Learning-Based Bearing Fault Classification Using Vibration Signals Under Variable-Speed Conditions
Instruments 2025, 9(4), 33; https://doi.org/10.3390/instruments9040033 - 4 Dec 2025
Abstract
Predictive maintenance in industrial machinery relies on the timely detection of component faults to prevent costly downtime. Rolling bearings, being critical elements, are particularly prone to defects such as outer race faults and ball spin defects, which manifest as characteristic vibration patterns. In
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Predictive maintenance in industrial machinery relies on the timely detection of component faults to prevent costly downtime. Rolling bearings, being critical elements, are particularly prone to defects such as outer race faults and ball spin defects, which manifest as characteristic vibration patterns. In this study, we introduce a novel bearing vibration dataset collected on a testbench under both constant and variable rotational speeds (0–5000 rpm), encompassing healthy and faulty conditions. The dataset was used for failure classification and further enriched through feature engineering, resulting in input features that include raw acceleration, signal envelopes, and time- and frequency-domain statistical descriptors, which capture fault-specific signatures. To quantify prediction uncertainty, two different approaches are applied, providing confidence measures alongside model outputs. Our results demonstrate the progressive improvement of classification accuracy from 87.2% using only raw acceleration data to 99.3% with a CNN-BiLSTM (Convolutional Neural Network–Bidirectional Long Short-Term Memory) ensemble and advanced features. Shapley Additive Explanation (SHAP)-based explainability further validates the relevance of frequency-domain features for distinguishing fault types. The proposed methodology offers a robust and interpretable framework for industrial fault diagnosis, capable of handling both stationary and non-stationary operating conditions.
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(This article belongs to the Special Issue Instrumentation and Measurement Methods for Industry 4.0 and IoT)
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Open AccessFeature PaperArticle
RF Characterization and Beam Measurements with Additively Manufactured Fast Faraday Cups
by
Stephan Klaproth, Rahul Singh, Samira Gruber, Lukas Stepien, Herbert De Gersem and Andreas Penirschke
Instruments 2025, 9(4), 32; https://doi.org/10.3390/instruments9040032 - 28 Nov 2025
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The early stages of most particle accelerator chains produce sub-ns bunches with velocities in the range of 1% to 20% of the speed of light. Fast Faraday Cups (FFCs) are designed to measure the longitudinal charge distribution of these short bunches of free
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The early stages of most particle accelerator chains produce sub-ns bunches with velocities in the range of 1% to 20% of the speed of light. Fast Faraday Cups (FFCs) are designed to measure the longitudinal charge distribution of these short bunches of free charges. Coaxial designs have been utilized at the GSI Helmholtz Centre for Heavy Ion Research (GSI)’s linear accelerator UNILAC to characterize ion bunches with bunch lengths ranging from a few hundred ps to a few ns. The typical design goals are to avoid the pre-field of the charges and to suppress secondary electron emission (SEE) while preserving the capability of bunch-by-bunch measurements. This contribution presents a novel FFC design manufactured using additive manufacturing, e.g., laser powder bed fusion (LPBF), and compares it with a traditionally produced FFC. The article highlights the design process, RF characterization, and selected measurements with ion beam carried out at GSI.
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Open AccessArticle
Synchronous Biaxial Straining of Foils and Thin Films with In Situ Capabilities
by
Michael Pegritz, Philipp Payer, Alice Lassnig, Stefan Wurster, Megan J. Cordill and Anton Hohenwarter
Instruments 2025, 9(4), 31; https://doi.org/10.3390/instruments9040031 - 26 Nov 2025
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A common method to examine the reliability of thin films and small volumes of irradiated materials being used in aerospace, energy, and protective coating applications is biaxial straining. With such tests, the fracture and deformation mechanisms occurring under multi-axial stress states can be
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A common method to examine the reliability of thin films and small volumes of irradiated materials being used in aerospace, energy, and protective coating applications is biaxial straining. With such tests, the fracture and deformation mechanisms occurring under multi-axial stress states can be investigated, which can strongly differ from the simpler uniaxial one. However, devices that can apply a precise and synchronously applied biaxial strain tend to be too large for foils or thin films and do not allow for additional observation methods to be applied to examine film fracture or deformation during the test. A prototype device that can apply synchronous equi-biaxial and semi-biaxial strains and can be combined with multiple in situ methods is introduced. The device is light and compact in design, which allows it to be mounted on optical light microscopes, atomic force microscopes, inside scanning electron microscopes, and even on X-ray beamlines for reflection or transmission measurements. Additionally, digital image correlation was utilized in two geometries to measure strains on a local or global level. The possible errors associated with the device and experiments on polyimide foils and a 100 nm tungsten film on polyimide are presented.
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Open AccessCommunication
Conceptual Study on the Implementation of NRTA for Industrial Applications
by
Melissa Azzoune, Ludovic Mathieu, Ngoc Duy Trinh, Mourad Aïche, Laurence Villatte, Fabrice Piquemal, Lionel Tondut and Sylvain Pelletier
Instruments 2025, 9(4), 30; https://doi.org/10.3390/instruments9040030 - 26 Nov 2025
Abstract
Neutron Resonance Transmission Analysis (NRTA) is a non-destructive technique allowing the elemental and isotopic characterization of materials and objects. This study represents a first step toward understanding the NRTA technique and developing a novel compact system adapted for industrial applications. The industrial feasibility
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Neutron Resonance Transmission Analysis (NRTA) is a non-destructive technique allowing the elemental and isotopic characterization of materials and objects. This study represents a first step toward understanding the NRTA technique and developing a novel compact system adapted for industrial applications. The industrial feasibility of the NRTA was assessed by simulating a compact system using the Monte Carlo code MCNP 6.1. Neutron transmission spectra were generated for various metallic samples, ranging from 0.1 mm to 1 cm in thickness, and analyzed using a home-developed quantification method that incorporates nuclear cross sections from the ENDF/B-VIII.0 library and accounts for instrumental resolution. For this first study, an idealized configuration was considered, with a 0 µs pulsed neutron source and a Gaussian resolution function, to validate the methodology under a simple controlled condition. The results demonstrate that the areal densities of isotopes of Uranium and Plutonium can be determined with relative deviations below 10%, even under compact measurement conditions. This study validates the characterization method and represents a first step toward the continued development of an industrial NRTA prototype for rapid, non-destructive isotopic control of nuclear materials.
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(This article belongs to the Special Issue Instrumentation and Measurement Methods for Industry 4.0 and IoT)
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Open AccessArticle
Designing a Femtosecond-Resolution Bunch Length Monitor Using Coherent Transition Radiation Images
by
Ana Guisao-Betancur, Joseph Wolfenden, Erik Mansten, Sara Thorin, Johan Lundquist, Oliver Grimm and Carsten P. Welsch
Instruments 2025, 9(4), 29; https://doi.org/10.3390/instruments9040029 - 25 Nov 2025
Abstract
Ultrashort bunch length measurements are crucial for characterizing electron beams in short-pulse accelerators, including novel accelerators like EuPRAXIA and those used for free-electron lasers (FELs). This work provides an overview of the design process and the current status of a single-shot bunch length
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Ultrashort bunch length measurements are crucial for characterizing electron beams in short-pulse accelerators, including novel accelerators like EuPRAXIA and those used for free-electron lasers (FELs). This work provides an overview of the design process and the current status of a single-shot bunch length monitor prototype based on a broadband spatial imaging system for coherent transition radiation (CTR), which was recently installed at the MAX IV short-pulse facility (SPF). The THz-based imaging system was designed using optical system simulation software for full bunch simulation. CTR images were captured experimentally, followed by image analysis for comparison with reference bunch length data from the transverse deflecting cavity (TDC). This paper presents the conceptualization and design choices for the optical system of the bunch length monitor, the current experimental set-up, the installation details, and preliminary positive observations confirming the potential of this method as a novel approach to bunch length monitoring using spatial CTR images and a scalar technique, with potential for future bunch profile measurements.
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(This article belongs to the Special Issue Plasma Accelerator Technologies)
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Open AccessArticle
Geant4-Based Characterization of Muon, Electron, Photon, and Hadron Signals from Atmospheric Showers in a Water Cherenkov Detector
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Luiz Augusto Stuani Pereira and Raiff Hugo Santos
Instruments 2025, 9(4), 28; https://doi.org/10.3390/instruments9040028 - 24 Nov 2025
Abstract
Cherenkov radiation is a widely used detection mechanism in high-energy and astroparticle physics experiments, particularly in water-based detectors operated by leading cosmic-ray observatories. Its popularity stems from its robustness, cost-effectiveness, and high detection efficiency across a broad range of environmental conditions. In this
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Cherenkov radiation is a widely used detection mechanism in high-energy and astroparticle physics experiments, particularly in water-based detectors operated by leading cosmic-ray observatories. Its popularity stems from its robustness, cost-effectiveness, and high detection efficiency across a broad range of environmental conditions. In this study, we present a detailed Monte Carlo characterization of a Water Cherenkov Detector (WCD) using the Geant4 simulation toolkit as a general, experiment-independent reference for understanding detector responses to secondary cosmic-ray particles. The detector is modeled to register secondary particles produced by the interaction of high-energy cosmic-ray primaries with the Earth’s atmosphere, which give rise to extensive air showers composed of hadronic, electromagnetic, and muonic components capable of reaching ground level. By simulating the differential energy spectra and angular distributions of these particles at the surface, we evaluate the WCD response in terms of energy deposition, Cherenkov photon production, photoelectron generation at the photomultiplier tube, and the resulting charge spectra. The results establish a systematic and transferable baseline for detector performance characterization and particle identification, providing a physically grounded reference that can support calibration, trigger optimization, and analysis efforts across different WCD-based experiments.
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(This article belongs to the Special Issue Instruments for Astroparticle Physics)
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Open AccessArticle
Evaluation of a Low-Power Computer Vision-Based Positioning System for a Handheld Landmine Detector Using AprilTag Markers
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Adam D. Fletcher, Edward Cheadle, John Davidson, Daniel Conniffe, Frank Podd and Anthony J. Peyton
Instruments 2025, 9(4), 27; https://doi.org/10.3390/instruments9040027 - 7 Nov 2025
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A positioning system employing visual fiducial markers (AprilTags) has been implemented for use with handheld mine detection equipment. To be suitable for a battery-powered real-time application, the system has been designed to operate at low power (<100 mW) and frame rates between 30
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A positioning system employing visual fiducial markers (AprilTags) has been implemented for use with handheld mine detection equipment. To be suitable for a battery-powered real-time application, the system has been designed to operate at low power (<100 mW) and frame rates between 30 and 50 fps. The system has been integrated into an experimental dual-mode detector system. Position-indexed metal detector and ground-penetrating radar data from laboratory and field trials are presented. The accuracy and precision of the vision-based system are found to be 1.2 cm and 0.5 cm, respectively.
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Open AccessArticle
A Broad Photon Energy Range Multi-Strip Imaging Array Based upon Single Crystal Diamond Schottky Photodiode
by
Claudio Verona, Maurizio Angelone, Marco Marinelli and Gianluca Verona-Rinati
Instruments 2025, 9(4), 26; https://doi.org/10.3390/instruments9040026 - 28 Oct 2025
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A multi-strip detector made of synthetic single crystal diamond (SCD), based on a p-type/intrinsic diamond/Schottky metal transverse configuration and operating at zero bias voltage, was developed for imaging from extreme UV (EUV) to soft X-rays. The photodetector was patterned with 32 strips made
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A multi-strip detector made of synthetic single crystal diamond (SCD), based on a p-type/intrinsic diamond/Schottky metal transverse configuration and operating at zero bias voltage, was developed for imaging from extreme UV (EUV) to soft X-rays. The photodetector was patterned with 32 strips made of boron-doped diamond directly deposited, by means of the CVD technique and the standard lithographic technique, on top of the HPHT diamond growth substrate. The width of each strip and the gap between two adjacent strips were 100 μm and 20 μm, respectively. The strips were embedded in intrinsic SCD of an active area of 3.2 × 2.5 mm2, also deposited using the CVD technique in a separate growing machine. In the present structure, the prototype photodetector is suitable for 1D imaging. However, all the dimensions above can be varied depending on the applications. The use of p-type diamond strips represents an attempt to mitigate the photoelectron emission from metal contacts, a non-negligible problem under EUV irradiation. The detector was tested with UV radiation and soft X-rays. To test the photodetector as an imaging device, a headboard (XDAS-DH) and a signal processing board (XDAS-SP) were used as front-end electronics. A standard XDAS software was used to acquire the experimental data. The results of the tests and the detector’s construction process are presented and discussed in the paper.
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Open AccessArticle
Real-Time Dose Monitoring via Non-Destructive Charge Measurement of Laser-Driven Electrons for Medical Applications
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David Gregocki, Petra Köster, Luca Umberto Labate, Simona Piccinini, Federico Avella, Federica Baffigi, Gabriele Bandini, Fernando Brandi, Lorenzo Fulgentini, Daniele Palla, Martina Salvadori, Simon Gerasimos Vlachos and Leonida Antonio Gizzi
Instruments 2025, 9(4), 25; https://doi.org/10.3390/instruments9040025 - 23 Oct 2025
Abstract
Laser-accelerated electron beams, in the so-called Very High-Energy Electron (VHEE) energy range, are of great interest for biomedical applications. For instance, laser-driven VHEE beams are envisaged to offer suitable compact accelerators for the promising field of FLASH radiotherapy. Radiobiology experiments carried out using
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Laser-accelerated electron beams, in the so-called Very High-Energy Electron (VHEE) energy range, are of great interest for biomedical applications. For instance, laser-driven VHEE beams are envisaged to offer suitable compact accelerators for the promising field of FLASH radiotherapy. Radiobiology experiments carried out using laser-driven beams require the real-time knowledge of the dose delivered to the sample. We have developed an online dose monitoring procedure, using an Integrating Current Transformer (ICT) coupled to a suitable collimator, that allows the estimation of the delivered dose on a shot-to-shot basis under suitable assumptions. The cross-calibration of the measured charge with standard offline dosimetry measurements carried out with RadioChromic Films (RCFs) is discussed, demonstrating excellent correlation between the two measurements.
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(This article belongs to the Special Issue Plasma Accelerator Technologies)
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Open AccessArticle
LBT Italia: Current Achievements and Future Directions
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Silvia Tosi, Ester Marini, Felice Cusano, Andrea Rossi, Roberto Speziali and Roberta Carini
Instruments 2025, 9(4), 24; https://doi.org/10.3390/instruments9040024 - 21 Oct 2025
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The Large Binocular Telescope (LBT) is a world-leading astronomical observatory, where the Italian partnership has played an important role in increasing the telescope’s productivity, both through an optimized observing strategy and through peer-reviewed publications that are well recognized by the international astronomical community.
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The Large Binocular Telescope (LBT) is a world-leading astronomical observatory, where the Italian partnership has played an important role in increasing the telescope’s productivity, both through an optimized observing strategy and through peer-reviewed publications that are well recognized by the international astronomical community. This manuscript provides an updated overview of the active and past instruments at LBT, together with key usage statistics. In particular, we analyze the operational performance recorded in the LBT Italia night logs during INAF’s observing time and assess the scientific impact of each instrument. Between 2014 and 2025, LBT Italia produced an average of 14 refereed publications per year, based on an annual average of 311 h of on-sky time. This corresponds to approximately 2.2 nights of telescope time per publication. The results of this analysis are placed in an international context to evaluate the competitiveness of LBT, and we outline future perspectives for scientific exploitation.
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Open AccessFeature PaperArticle
A Two-Plane Proton Radiography System Using ATLAS IBL Pixel-Detector Modules
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Hendrik Speiser, Claus Maximillian Bäcker, Johannes Esser, Alina Hild, Marco Iampieri, Ann-Kristin Lüvelsmeyer, Annsofie Tappe, Helen Thews, Kevin Kröninger and Jens Weingarten
Instruments 2025, 9(4), 23; https://doi.org/10.3390/instruments9040023 - 14 Oct 2025
Abstract
Accurate knowledge of a patient’s anatomy during every treatment fraction in proton therapy is an important prerequisite to ensure a correct dose deposition in the target volume. Adaptive proton therapy aims to detect those changes and adjust the treatment plan accordingly. One way
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Accurate knowledge of a patient’s anatomy during every treatment fraction in proton therapy is an important prerequisite to ensure a correct dose deposition in the target volume. Adaptive proton therapy aims to detect those changes and adjust the treatment plan accordingly. One way to trigger a daily re-planning of the treatment is to take a proton radiograph from the beam’s-eye view before the treatment to check for possible changes in the water equivalent thickness (WET) along the path due to daily changes in the patient’s anatomy. In this paper, the Two-Plane Imaging System (TPIS) is presented, comprising two ATLAS IBL silicon pixel-detector modules developed for the tracking detector of the ATLAS experiment at CERN. The prototype of the TPIS is described in detail, and proof-of-principle WET images are presented, of two-step phantoms and more complex phantoms with bone-like inlays (WET 10 to 40 mm). This study shows the capability of the TPIS to measure WET images with high precision. In addition, the potential of the TPIS to accurately determine WET changes over time down to 1 mm between subsequently taken WET images of a changing phantom is shown. This demonstrates the possible application of the TPIS and ATLAS IBL pixel-detector module in adaptive proton therapy.
Full article
(This article belongs to the Special Issue Medical Applications of Particle Physics, 2nd Edition)
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Open AccessArticle
Assessment of Radiological Dispersal Devices in Densely Populated Areas: Simulation and Emergency Response Planning
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Yassine El Khadiri, Ouadie Kabach, El Mahjoub Chakir and Mohamed Gouighri
Instruments 2025, 9(4), 22; https://doi.org/10.3390/instruments9040022 - 3 Oct 2025
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The increasing threat of terrorism involving Radiological Dispersal Devices (RDDs) necessitates comprehensive evaluation and preparedness strategies, especially in densely populated public areas. This study aims to assess the potential consequences of RDD detonation, focusing on the effective doses received by individuals and the
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The increasing threat of terrorism involving Radiological Dispersal Devices (RDDs) necessitates comprehensive evaluation and preparedness strategies, especially in densely populated public areas. This study aims to assess the potential consequences of RDD detonation, focusing on the effective doses received by individuals and the ground deposition of radioactive materials in a hypothetical urban environment. Utilizing the HotSpot code, simulations were performed to model the dispersion patterns of 137Cs and 241Am under varying meteorological conditions, mirroring the complexities of real-world scenarios as outlined in recent literature. The results demonstrate that 137Cs dispersal produces a wider contamination footprint, with effective doses exceeding the public exposure limit of 1 mSv at distances up to 1 km, necessitating broad protective actions. In contrast, 241Am generates higher localized contamination, with deposition levels surpassing cleanup thresholds near the release point, creating long-term remediation challenges. Dose estimates for first responders highlight the importance of adhering to operational dose limits, with scenarios approaching 100 mSv under urgent rescue conditions. Overall, the findings underscore the need for rapid dose assessment, early shelter-in-place orders, and targeted decontamination to reduce population exposure. These insights provide actionable guidance for emergency planners and first responders, enhancing preparedness protocols for RDD incidents in major urban centers.
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Open AccessArticle
From Lab to Launchpad: A Modular Transport Incubator for Controlled Thermal and Power Conditions of Spaceflight Payloads
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Sebastian Feles, Ilse Marie Holbeck and Jens Hauslage
Instruments 2025, 9(3), 21; https://doi.org/10.3390/instruments9030021 - 18 Sep 2025
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Maintaining physiologically controlled conditions during the transport of biological experiments remains a long-standing but under-addressed challenge in spaceflight operations. Pre-launch thermal or mechanical stress induce artefacts that compromise the interpretation of biological responses to space conditions. Existing transport systems are limited to basic
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Maintaining physiologically controlled conditions during the transport of biological experiments remains a long-standing but under-addressed challenge in spaceflight operations. Pre-launch thermal or mechanical stress induce artefacts that compromise the interpretation of biological responses to space conditions. Existing transport systems are limited to basic heating of small sample containers and lack the capability to power and protect full experimental hardware during mission-critical phases. A modular transport incubator was developed and validated that combines active thermal regulation, battery-buffered power management, and mechanical protection in a compact, field-deployable platform. It enables autonomous environmental conditioning of complex biological payloads and continuous operation of integrated scientific instruments during ground-based transport and recovery. Validation included controlled experiments under sub-zero ambient temperatures, demonstrating rapid warm-up, stable thermal regulation, and uninterrupted autonomous performance. A steady-state finite difference thermal model was experimentally validated across 21 boundary conditions, enabling predictive power requirement estimation for mission planning. Field deployments during multiple MAPHEUS® sounding rocket campaigns confirmed functional robustness under wind, snow, and airborne recovery scenarios. The system closes a critical infrastructure gap in spaceflight logistics. Its validated performance, modular architecture, and proven operational readiness establish it as an enabling platform for standardized, reproducible ground handling of biological payloads and experiment hardware.
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Open AccessFeature PaperReview
Faraday Cups: Principles, Designs, and Applications Across Scientific Disciplines—A Review
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Bharat Singh Rawat, Narender Kumar, Debdeep Ghosal, Daliya Aflyatunova, Benjamin Rienäcker and Carsten. P. Welsch
Instruments 2025, 9(3), 20; https://doi.org/10.3390/instruments9030020 - 28 Aug 2025
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Beam diagnostics are essential tools for monitoring the performance of charged particle beams and the safe operation of particle accelerators. The performance of an accelerator is determined by evaluating the properties of beam particles, such as energy, charge, spatial, and temporal density distributions,
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Beam diagnostics are essential tools for monitoring the performance of charged particle beams and the safe operation of particle accelerators. The performance of an accelerator is determined by evaluating the properties of beam particles, such as energy, charge, spatial, and temporal density distributions, which require very specific instruments. Faraday Cups (FCs) have emerged as important beam diagnostic devices because of their ability to accurately measure the beam charge and, in some cases, the charge distribution, which can be subsequently used to reconstruct transverse beam profiles. This paper aims to provide a detailed review of FCs, their principles, and their design challenges. FCs have applications in various scientific disciplines that include the measurement of beam current/intensity in particle accelerators, in addition to those for mass spectrometry, beam profiles/total beam currents for broad ion beams, thermonuclear fusion, and antimatter experiments. This review also covers and discusses the versatility of FCs in various scientific disciplines, along with showcasing the technological advancements that include improved collector materials, novel designs, enhanced measurement techniques, and developments in electronics and data acquisition (D.A.Q). A summary of the challenges faced while working with the FCs, such as sensitivity, calibration, and potential errors, is included in this review.
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Open AccessArticle
Effects of Polymerization Initiators on Plastic Scintillator Light Output
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Mustafa Kandemir and Bora Akgün
Instruments 2025, 9(3), 19; https://doi.org/10.3390/instruments9030019 - 22 Aug 2025
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Polymerization initiators are commonly used to lower the processing temperatures and accelerate the synthesis of plastic scintillators. However, these additives can reduce light output. Since plastic scintillator tiles, fibers, and bars are used in countless radiation detection instruments, from PET scanners to LHC
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Polymerization initiators are commonly used to lower the processing temperatures and accelerate the synthesis of plastic scintillators. However, these additives can reduce light output. Since plastic scintillator tiles, fibers, and bars are used in countless radiation detection instruments, from PET scanners to LHC calorimeters, any loss in light output immediately degrades the timing and energy resolution of the whole system. Understanding how the initiators alter scintillation performance is therefore important. In this study, five different plastic scintillator samples were produced with varying concentrations of two initiators, 2,2-Azobis(2-methylpropionitrile) (AIBN) and benzoyl peroxide (BPO), along with a reference sample containing no initiators. The relative light yield (RLY) was measured using four different gamma sources. Analyzing the Compton edges revealed that higher initiator concentrations consistently decrease the light output. This study shows that keeping the initiator concentration at 0.2% limits the reduction to 8%, whereas 0.5–1% loadings can lower the yield by 20–35%, providing realistic bounds on initiator levels for future plastic scintillator productions.
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Open AccessArticle
Apparatus and Experiments Towards Fully Automated Medical Isotope Production Using an Ion Beam Accelerator
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Abdulaziz Yahya M. Hussain, Aliaksandr Baidak, Ananya Choudhury, Andy Smith, Carl Andrews, Eliza Wojcik, Liam Brown, Matthew Nancekievill, Samir De Moraes Shubeita, Tim A. D. Smith, Volkan Yasakci and Frederick Currell
Instruments 2025, 9(3), 18; https://doi.org/10.3390/instruments9030018 - 18 Jul 2025
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Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated
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Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated system for the agile and reliable production of radiopharmaceuticals. The system performs transmutations, dissolution, and separation for a range of radioisotopes. Steps in the production of 89Zr-oxalate are used as an exemplar to illustrate its use. Three-dimensional (3D) printing was exploited to design and manufacture a target holder able to include solid targets, in this case an 89Y foil. Spot welding was used to attach 89Y to a refractory tantalum (Ta) substrate. A commercially available CPU chiller was repurposed to efficiently cool the metal target. Furthermore, a commercial resin (ZR Resin) and compact peristaltic pumps were employed in a compact (10 × 10 × 10 cm3) chemical separation unit that operates automatically via computer-controlled software. Additionally, a standalone 3D-printed unit was designed with three automated functionalities: photolabelling, vortex mixing, and controlled heating. All components of the assembly, except for the target holder, are housed inside a commercially available hot cell, ensuring safe and efficient operation in a controlled environment. This paper details the design, construction, and modelling of the entire assembly, emphasising its innovative integration and operational efficiency for widespread radiopharmaceutical automation.
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Open AccessArticle
Technique for Extracting Initial Parameters of Longitudinal Phase Space of Freshly Injected Bunches in Storage Rings, and Its Applications
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Hongshuang Wang, Yongbin Leng and Yimei Zhou
Instruments 2025, 9(3), 17; https://doi.org/10.3390/instruments9030017 - 17 Jul 2025
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This paper presents a technique for extracting the initial parameters of the longitudinal phase space of freshly injected bunches in an electron storage ring. This technique combines simulation of single-bunch longitudinal phase space evolution with a bunch-by-bunch data acquisition and processing system, enabling
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This paper presents a technique for extracting the initial parameters of the longitudinal phase space of freshly injected bunches in an electron storage ring. This technique combines simulation of single-bunch longitudinal phase space evolution with a bunch-by-bunch data acquisition and processing system, enabling high-precision determination of initial phase space parameters during electron storage ring injection—including the initial phase, initial bunch length, initial energy offset, initial energy spread, and initial energy chirp. In our experiments, a high-speed oscilloscope captured beam injection signals, which were then processed by the bunch-by-bunch data acquisition system to extract the evolution of the injected bunch’s phase and length. Additionally, a single-bunch simulation software package was developed, based on mbtrack2 and PyQt5, that is capable of simulating the phase space evolution of bunches under different initial parameters after injection. By employing a genetic algorithm to iteratively align simulation results with experimental data, the remaining initial phase space parameters of the injected bunch can be accurately determined.
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Open AccessArticle
An Experimental Setup to Study Electron Transport and Thermalization in Cryogenic Para-Hydrogen Crystal Matrices
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Piergiorgio Antonini, Massimo Benettoni, Armando F. Borghesani, Caterina Braggio, Roberto Calabrese, Giovanni Carugno, Federico Chiossi, Ugo Gasparini, Franco Gonella, Marco Guarise, Alen Khanbekyan, Alessandro Lippi, Augusto Lombardi, Emilio Mariotti, Madiha M. Makhdoom, Giuseppe Messineo, Jacopo Pazzini, Giuseppe Ruoso, Luca Tomassetti and Marco Zanetti
Instruments 2025, 9(3), 16; https://doi.org/10.3390/instruments9030016 - 29 Jun 2025
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We present an experimental apparatus to investigate electron transport and thermalization in cryogenic para-hydrogen crystal matrices. This paper describes the techniques used to grow and characterize the cryogenic para-hydrogen crystals, the optical system employed to photoextract electrons, and the charge collection system used
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We present an experimental apparatus to investigate electron transport and thermalization in cryogenic para-hydrogen crystal matrices. This paper describes the techniques used to grow and characterize the cryogenic para-hydrogen crystals, the optical system employed to photoextract electrons, and the charge collection system used to study the behavior of electrons within the solid matrix. By probing the fundamental charge transport and energy loss processes in a quantum solid, such as para-hydrogen, this study paves the way for future precision experiments that leverage the unique properties of cryogenic crystal matrices.
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Open AccessArticle
Proton Irradiation and Thermal Restoration of SiPMs for LEO Missions
by
Alexis Luszczak, Lucas Finazzi, Leandro Gagliardi, Milagros Moreno, Maria L. Ibarra, Federico Golmar and Gabriel A. Sanca
Instruments 2025, 9(3), 15; https://doi.org/10.3390/instruments9030015 - 26 Jun 2025
Cited by 1
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Silicon Photomultipliers (SiPMs) are optical sensors widely used in space applications due to their high photon detection efficiency, low power consumption, and robustness. However, in Low Earth Orbit (LEO), their performance degrades over time due to prolonged exposure to ionizing radiation, primarily from
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Silicon Photomultipliers (SiPMs) are optical sensors widely used in space applications due to their high photon detection efficiency, low power consumption, and robustness. However, in Low Earth Orbit (LEO), their performance degrades over time due to prolonged exposure to ionizing radiation, primarily from trapped protons and electrons. The dominant radiation-induced effect in SiPMs is an increase in dark current, which can compromise detector sensitivity. This study investigates the potential of thermal annealing as a mitigation strategy for radiation damage in SiPMs. We designed and tested PCB-integrated heaters to selectively heat irradiated SiPMs and induce recovery processes. A PID-controlled system was developed to stabilize the temperature at 100 °C, and a remotely controlled experimental setup was implemented to operate under irradiation conditions. Two SiPMs were simultaneously irradiated with 9 MeV protons at the EDRA facility, reaching a 1 MeV neutron equivalent cumulative fluence of (9.5 ± 0.2) × 108 cm−2. One sensor underwent thermal annealing between irradiation cycles, while the other served as a control. Throughout the experiment, dark current was continuously monitored using a source measure unit, and I–V curves were recorded before and after irradiation. A recovery of more than 39% was achieved after only 5 min of thermal cycling at 100 °C, supporting this recovery approach as a low-complexity strategy to mitigate radiation-induced damage in space-based SiPM applications and increase device lifetime in harsh environments.
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Open AccessArticle
Compact and Handheld SiPM-Based Gamma Camera for Radio-Guided Surgery and Medical Imaging
by
Fabio Acerbi, Aramis Raiola, Cyril Alispach, Hossein Arabi, Habib Zaidi, Alberto Gola and Domenico Della Volpe
Instruments 2025, 9(2), 14; https://doi.org/10.3390/instruments9020014 - 15 Jun 2025
Cited by 1
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In the continuous pursuit of minimally invasive interventions while ensuring a radical excision of lesions, Radio-Guided Surgery (RGS) has been for years the standard for image-guided surgery procedures, such as the Sentinel Lymph Node biopsy (SLN), Radio-guided Seed Localization (RSL), etc. In RGS,
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In the continuous pursuit of minimally invasive interventions while ensuring a radical excision of lesions, Radio-Guided Surgery (RGS) has been for years the standard for image-guided surgery procedures, such as the Sentinel Lymph Node biopsy (SLN), Radio-guided Seed Localization (RSL), etc. In RGS, the lesion has to be identified precisely, in terms of position and extension. In such a context, going beyond the current one-point probes, introducing portable but high-resolution cameras, handholdable by the surgeon, would be highly beneficial. We developed and tested a novel compact, low-power, handheld gamma camera for radio-guided surgery. This is based on a particular position-sensitive Silicon Photomultiplier (SiPM) technology—the FBK linearly graded SiPM (LG-SiPM). Within the camera, the photodetector is made up of a 3 × 3 array of 10 × 10 mm2 SiPM chips having a total area of more than 30 × 30 mm2. This is coupled with a pixelated scintillator and a parallel-hole collimator. With the LG-SiPM technology, it is possible to significantly reduce the number of readout channels to just eight, simplifying the complexity and lowering the power consumption of the readout electronics while still preserving a good position resolution. The novel gamma camera is light (weight), and it is made to be a fully stand-alone system, therefore featuring wireless communication, battery power, and wireless recharge capabilities. We designed, simulated (electrically), and tested (functionally) the first prototypes of the novel gamma camera. We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively.
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