To understand how pathology-induced changes in contractile protein isoforms modulate cardiac muscle function, it is necessary to quantify the temporal-mechanical properties of contractions that occur under various conditions. Pathological responses a...
Canine morbillivirus (CDV) is a viral agent that infects domestic dogs and a vast array of wildlife species. It belongs to the Paramyxoviridae family, genus Morbillivirus, which is shared with the Measles virus (MeV). Both viruses employ orthologous...
Nitrogen is an essential nutrient in many terrestrial ecosystems because it affects vegetation’s primary production. Due to the variety of nitrogen-containing substances and the differences in their composition across species, statistical approaches...
Shuanghuanglian oral liquid (SHL) is widely used in companion animals and poultry, but its molecular mechanism in pneumonia–myocarditis comorbidity and heart–lung inflammatory crosstalk remains largely unclear. This computational study in...
Superfluid and dissipative regimes in the dynamics of a two-component quasi-one-dimensional Bose–Einstein condensate (BEC) with unequal atom numbers in the two components have been explored. The system supports localized waves of the symbiotic...
In this study, we simulated biologically realistic agent-based models over neutral landscapes to examine how spatial structure affects the spread of a rabies-like virus in a two-species system. We built landscapes with varying autocorrelation levels...
Physiologically based pharmacokinetic (PBPK) modelling for biologics, such as monoclonal antibodies and therapeutic proteins, involves capturing complex processes, including target-mediated drug disposition (TMDD), FcRn-mediated recycling, and tissue...
Background: SYHA1805 is a potent farnesoid X receptor (FXR) agonist currently in development for Metabolic Dysfunction-Associated Steatohepatitis (MASH). Methods: To determine the first-in-human (FIH) dose and guide its clinical development, an integ...
Background/Objectives: Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lacrimal and salivary gland dysfunction, leading to dry eye and dry mouth. This study aimed to explore the potential associations between oxid...
Acute kidney injury (AKI) is a critical clinical syndrome characterized by a rapid decline in renal function, frequently resulting from ischemia, nephrotoxicity, or sepsis. It represents a major global health burden due to its high morbidity and mort...
Metagenomic next-generation sequencing (mNGS) is receiving increased attention for the detection of new viruses and infections occurring at the human–animal interface. The ability to actively transport and relocate this technology enables in si...
Anastomotic leaks after colorectal resection are serious surgical complications. We have compared the integrity of two common colorectal anastomosis techniques, end-to-side (ES) and end-to-end (EE), to control specimens using a novel experimental set...
The present study aimed to establish a physiologically based toxicokinetic (PBTK) model to investigate the absorption, retention, and transport of inhaled nano-sized titanium dioxide (TiO2-NPs) particles in rats, thereby providing a basis for underst...
Monkeypox (Mpox), caused by the monkeypox virus (MPXV), has re-emerged as a significant global public health concern, particularly following the 2022 outbreaks. Understanding its transmission dynamics is essential for designing effective control stra...
Brucellosis remains a significant public health and economic burden in many regions, primarily transmitted from livestock to humans through direct contact and environmental contamination. In this paper, we develop a novel cross-species epidemic model...
Canine coronavirus (CCoV), an alphacoronavirus belonging to the Coronaviridae family, is primarily associated with enteric infections in dogs. The ongoing evolution of coronaviruses through genetic recombination and mutation leads to the emergence of...
H5N1 Influenza A virus continues to pose a significant zoonotic threat, with increasing evidence of interspecies transmission and genetic adaptation. Previous studies primarily focused on avian or human isolates, with limited comprehensive analysis o...
The utilisation of synthetic torpor for interplanetary travel once seemed farfetched. However, mounting evidence points to torpor-induced protective benefits from the main hazards of space travel, namely, exposure to radiation and microgravity. To de...
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) efficiency constrains carbon fixation, making it a high-value target in biotechnology. The core task of this work is a supervised regression and ranking problem on Rubisco: given a numerical r...
Background/Objectives: The stimulator of interferon genes (STING) pathway plays a central role in innate immune signaling and represents an attractive therapeutic target for cancer immunotherapy. Amidobenzimidazole (ABZI) derivatives have emerged as...
Detailed knowledge of reproductive traits and success is essential for the effective conservation of rare and endangered species. It has been reported that Cephalanthera longifolia and C. rubra (Orchidaceae) were abundantly fruiting in some regions s...
Intramuscular fat (IMF) significantly impacts meat quality. Exosomes have attracted increasing attention for their regulatory roles in muscle-adipose tissue crosstalk; however, their precise mechanisms remain largely unclear. Based on this, this stud...
Rapid antigenic drift in the coronavirus spike protein motivates alternative antiviral strategies. We target the conserved nucleocapsid (N) protein—central to RNA binding, genome packaging, and replication—and perform a comparative, cross...
(1) Background and Purpose: Ebola virus (EBOV) is the causative agent of Ebola virus disease (EVD), which causes extremely high mortality and widespread epidemics. The only glycoprotein (GP) on the surface of EBOV particles is the key to mediating vi...
Gathering data on electron collisions in plasmas is a vital part of conducting plasma simulations. However, data on neutral radicals and neutrals formed in the plasma by reactions between different radicals are usually not readily available. While th...
The study of minor chemical species in terrestrial planets’ atmospheres can teach us about the chemistry, dynamics and evolution of the atmospheres through time. Phosphine or methane on terrestrial planets are potential biosignatures, such that...
The collision cross sections (CCS), momentum transfer cross sections (MTCS), or scattering cross sections (SCS) of an electron–neutral pair are important components for computing the electric conductivity of a plasma gas. Larger collision cross...
This paper focuses on a strongly coupled specific ecological system consisting of two prey species and one predator. We explore a unique positive equilibrium solution of the system that is globally asymptotically stable. Additionally, we show that th...
Individual tree species classification is essential for detailed forest inventories, ecosystem monitoring, and biodiversity assessment. While UAV-acquired RGB and multispectral (MS) imagery have advanced tree species mapping, most studies focus on a...
Accurate measurement of stem diameter is essential to forest inventory. As a millimeter-level measuring tool, terrestrial laser scanning (TLS) has not yet reached millimeter-level accuracy in stem diameter measurements. The objective of this study is...
The red palm weevil Rhynchophorus ferrugineus is an invasive pest from southeastern Asia and Melanesia that has spread widely across the Middle East and the Mediterranean Basin over the last 30 years. Its endophagous larvae cause huge amounts of dama...
There is difficulty in accurately modelling adhesive influence in structural performance of cross laminated timber (CLT), due to a lack of available knowledge on the heat performance of adhesives. Therefore, the main aim of this research was to evalu...
Models that incorporate known species-mixing effects on tree growth are essential tools to properly design silvicultural guidelines for mixed-species stands. Here, we developed generalized height–diameter (h-d) and basal area growth models for...
Vertical slot fishways (VSFs) are crossing devices that are built on rivers or streams. They were initially designed to help salmons to complete their migratory cycle by crossing permanent obstructions. In order to favor the passage of smaller or ben...
The study of radiation effects in DNA is a multidisciplinary endeavour, connecting the physical, chemical and biological sciences. Despite being mostly filtered by the ozone layer, sunlight radiation is still expected to (photo)ionise DNA in sizeable...
Riverine environmental information includes important data to collect, and the data collection still requires personnel’s field surveys. These on-site tasks still face significant limitations (i.e., hard or danger to entry). In recent years, as...
Softwood is widely employed in construction and faces high demand. Australia is grappling with substantial timber scarcity, specifically related to radiata pine, which is the dominant structural timber in the construction sector. However, Australia h...
In the Mediterranean basin, wildfires burn an average of 600,000 ha per year, causing severe ecological, economic, and social impacts. Fire behavior modeling is essential for wildfire prevention and control. Three-dimensional physics-based fire behav...
Radiation metrology is crucial in space, for instance in monitoring the conditions on-board space vehicles. The energy released in matter by ionizing radiation is due to the atomic and molecular ionization processes, which have been investigated for...
A monolayer consisting of two types of particles, with energetically favored alternating stripes of the two components, is studied by Monte Carlo simulations and within a mesoscopic theory. We consider a triangular lattice model and assume short-rang...
Leaf-level hyperspectral-based species identification has a long research history. However, unlike hyperspectral image-based species classification models, convolutional neural network (CNN) models are rarely used for the one-dimensional (1D) structu...
We explore the emergence of the collisional broadening of hadrons under the influence of different media using the hadronic transport approach SMASH (Simulating Many Accelerated Strongly interacting Hadrons), which employs vacuum properties and conta...
In the research for sustainable construction, cross-laminated timber (CLT) has gained popularity and become a widely used engineered timber product. However, there are few numerical studies of the structural behaviour of CLT. Among other issues, the...
Infrared hyperspectral remote sensing is effective for chemical gas detection because gas molecules exhibit characteristic absorption features in the mid- and long-wave infrared region. This study considers coexisting gas components along a common li...
Hundreds of millions of people around the world have been affected by Type 2 diabetes (T2D) which is a metabolic disorder. Clinical research has revealed T2D as a possible risk factor for Alzheimer’s disease (AD) development (and vice versa). A...
Brown trout (Salmo trutta), like many other freshwater species, is threated by the release in its natural environment of alien species and the restocking with allochthonous conspecific stocks. Many conservation projects are ongoing and several morpho...
We developed a model for estimating the carbon storage and volume of entire forest stands at the provincial level, aiming to improve the accuracy of regional productivity assessments. Based on data from the branches, roots, leaves, and trunks of eigh...
Nonlinearity and spatial autocorrelation are common features observed in marine fish datasets but are often ignored or not considered simultaneously in modeling. Both features are often present within ecological data obtained across extensive spatial...
Efficient recombination is critical to both plant breeding and gene cloning. However, almost all traditional recombination studies and genetic improvements require the slow and labor-intensive population construction process, and little is known abou...
Stainless-steel bipolar plates (BPPs) are attractive for proton exchange membrane water electrolysis (PEMWE) due to their low cost and manufacturability, yet their use is limited by severe corrosion. Despite the advantages of plasma-enhanced atomic l...
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