Recent Advances in Physiologically Based Pharmacokinetics
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 1268
Special Issue Editor
Special Issue Information
Dear Colleagues,
The physiologically based pharmacokinetic (PBPK) model employs differential equations to analyze drug dynamics across various body tissues. This modeling approach, extensively applied within the pharmaceutical industry, is instrumental in predicting and evaluating drug efficacy and safety profiles. Focusing on accurately forecasting alterations in enzyme and transporter protein functions within organs, PBPK modeling offers significant advantages for studying special populations, including the elderly, pregnant women, neonates, and patients with hepatic or renal dysfunction, as well as for assessing drug–drug interactions. Recently, pharmacometrics has become a standard regulatory tool, facilitating analyses of surrogate endpoints to support accelerated drug approvals. Furthermore, it plays a pivotal role in critical trial phases for dose selection, dosing strategies for special populations (e.g., pediatric patients), dose regimen optimization, efficacy predictions, and dosing in unstudied patient populations. Furthermore, the PBPK model integrates in vitro mechanistic data to predict exposure profiles of new drug formulations. It can also incorporate individual patient characteristics to optimize personalized treatment regimens, thereby reducing the risk of adverse reactions, even toxic side effects.
Prof. Dr. Li Liu
Guest Editor
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Keywords
- physiologically based pharmacokinetic (PBPK) model
- pharmacometrics
- drug–drug interaction
- pharmacokinetics and pharmacodynamics
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