Journal Description
COVID
COVID
is an international, peer-reviewed, open access journal on the study of coronaviruses, coronavirus-related diseases and global impact, published monthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within ESCI (Web of Science), Scopus, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 17.7 days after submission; acceptance to publication is undertaken in 2.6 days (median values for papers published in this journal in the first half of 2024).
- Recognition of Reviewers: APC discount vouchers, optional signed peer review, and reviewer names published annually in the journal.
Latest Articles
The Role of COVID-19 Vaccination in Serological and Infectious Response in the Xokós Indigenous Community
COVID 2024, 4(9), 1476-1484; https://doi.org/10.3390/covid4090104 - 16 Sep 2024
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Objectives: This study aims to examine the serological and infectious characteristics of the Xokós indigenous community in Brazil, both prior to and following COVID-19 immunization; Methods: Immunofluorescence assays were employed to identify the SARS-CoV-2 viral antigen, while IgM and IgG antibody tests for
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Objectives: This study aims to examine the serological and infectious characteristics of the Xokós indigenous community in Brazil, both prior to and following COVID-19 immunization; Methods: Immunofluorescence assays were employed to identify the SARS-CoV-2 viral antigen, while IgM and IgG antibody tests for COVID-19 were utilized to assess the participants’ infectious and serological profiles in July 2020, before the commencement of the COVID-19 vaccination campaign, and in March 2022, during the booster dose vaccination campaign; Results: The majority of participants (n = 22) were female, with an average age of 42.20 years. The most prevalent comorbidity was hypertension (60%; n = 9), followed by hypertension associated with diabetes (20%; n = 3). No statistically significant correlation was found between the timing of vaccination and the levels of antigens or IgM. However, the prevalence of reactive antigens and IgM was 13.3% (n = 4) in the pre-vaccination group and 3.3% (n = 1) in the post-vaccination group. A statistically significant difference in IgG production was observed before and after vaccination (χ2(1) = 39.095, p < 0.01), as well as differences in IgG antibody detection before and after vaccination and in the vaccines used. Participants showed a higher probability of reactive IgG antibodies following vaccination; Conclusions: Our data demonstrate the beneficial effects of vaccination on the indigenous community, highlighting that continued immunization is a crucial step in protecting indigenous health and preventing severe outbreaks and deaths associated with the disease.
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Open AccessArticle
Geographical Mapping of COVID-19 Testing Rates in St. Louis: Influence of the Socioeconomic Index and Race on Testing in the Early Phase and Peak of the COVID-19 Pandemic
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Samuel B. Governor, William O. Effah, Joshua Ntajal, Cecilia Naa Ometse Nartey, Viktoriya Voytovych, Htu Sam, Mark B. Ulanja, Nhial T. Tutlam and Prince Otchere
COVID 2024, 4(9), 1463-1475; https://doi.org/10.3390/covid4090103 - 15 Sep 2024
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Purpose: This study aimed to explore how race and the socioeconomic index (SES) of residential zip codes influenced COVID-19 testing rates in St. Louis during the early and peak phases of the pandemic. Method: An ecological study was conducted using COVID-19 testing data
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Purpose: This study aimed to explore how race and the socioeconomic index (SES) of residential zip codes influenced COVID-19 testing rates in St. Louis during the early and peak phases of the pandemic. Method: An ecological study was conducted using COVID-19 testing data from March to November 2020 in St. Louis City, including 16,915 tests from 30 residential zip codes. Geographical mapping identified areas lacking testing, descriptive statistics characterized testing rates by race and SES, and robust linear regression modeled the association between testing rates and race, controlling for SES. Results: The overall testing rate was 303.97 per 10,000 population. Testing rates among Blacks, Whites, American Indians/Alaskan Natives, and Asians were 374.26, 247.77, 360.63, and 242.41 per 10,000, respectively. Higher rates were observed in low- and middle-SES zip codes compared with high-SES areas. Adjusted for SES, testing rates per 10,000 were higher by 125 (1.25%), 448 (4.48%), and 32 (0.32%) among Blacks, American Indians/Alaskan Natives, and Asians compared with Whites. Testing rates decreased by 56 (0.56%) per unit SES improvement. There was statistically significant SES finding and that of the difference between American Indians/Alaskan Natives and Whites. Geographical mapping showed higher rates in the inner core and lower rates in the periphery of St. Louis. Conclusions: Race and SES influence testing rates. Targeted interventions are needed in areas with low testing rates in St. Louis.
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Open AccessArticle
The Association between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan and Kuwait
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Malik Sallam, Kholoud Al-Mahzoum, Moudhi Ahmad Alenezi, Maryam Alsaeed, Fatmah Alsaeed, Noor Albayati, Sarah Alkhaldi, Rawan J. Obeidat and Muna Barakat
COVID 2024, 4(9), 1440-1462; https://doi.org/10.3390/covid4090102 - 12 Sep 2024
Abstract
Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long COVID and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries, where high endorsement of these theories has been reported. This
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Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long COVID and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries, where high endorsement of these theories has been reported. This study aimed to explore the association between endorsing COVID-19 conspiracy theories and the prevalence of self-reported long COVID symptoms among adults in Jordan and Kuwait in addition to other Arab countries. The study employed a cross-sectional design using Computer-Assisted Web Interviewing (CAWI), conducted in Arabic. Recruitment utilized convenience-based snowball sampling via social media and the survey was distributed in July 2024. Long COVID manifestations were assessed across ten recognized symptoms, and belief in conspiracy theories was measured using a five-point Likert scale across five items. The final study sample comprised 755 respondents, the majority of whom self-reported a history of confirmed COVID-19 diagnosis at least once (n = 493, 65.2%). The results indicated a neutral average attitude towards COVID-19 conspiracy theories (mean score = 15.18 ± 4.64 out of 30.00). Participants with high COVID-19 conspiracy theories scores were more likely to report high (aOR = 6.85, p < 0.001) or middle long COVID symptoms (aOR = 2.82, p = 0.008) compared to those with lower scores. Additional predictors of higher long COVID reporting included female sex, lower household income, frequent COVID-19 infections, and hospitalizations. The study results revealed a significant correlation between the endorsement of COVID-19 conspiracy theories and a higher frequency and magnitude of long COVID symptom reporting. The findings also highlighted the influence of sociodemographic factors and COVID-19 infection history on long COVID reporting, which suggests that public health strategies should address these factors to mitigate long COVID challenges effectively.
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(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities 2.0)
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Open AccessReview
Trust Us—We Are the (COVID-19 Misinformation) Experts: A Critical Scoping Review of Expert Meanings of “Misinformation” in the Covid Era
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Claudia Chaufan, Natalie Hemsing, Camila Heredia and Jennifer McDonald
COVID 2024, 4(9), 1413-1439; https://doi.org/10.3390/covid4090101 - 10 Sep 2024
Abstract
Since the WHO declared COVID-19 a pandemic, prominent social actors and institutions have warned about the threat of misinformation, calling for policy action to address it. However, neither the premises underlying expert claims nor the standards to separate truth from falsehood have been
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Since the WHO declared COVID-19 a pandemic, prominent social actors and institutions have warned about the threat of misinformation, calling for policy action to address it. However, neither the premises underlying expert claims nor the standards to separate truth from falsehood have been appraised. We conducted a scoping review of the medical and social scientific literature, informed by a critical policy analysis approach, examining what this literature means by misinformation. We searched academic databases and refereed publications, selecting a total of 68 articles for review. Two researchers independently charted the data. Our most salient finding was that verifiability relied largely on the claims of epistemic authorities, albeit only those vetted by the establishment, to the exclusion of independent evidentiary standards or heterodox perspectives. Further, “epistemic authority” did not depend necessarily on subject matter expertise, but largely on a new type of “expertise”: in misinformation itself. Finally, policy solutions to the alleged threat that misinformation poses to democracy and human rights called for suppressing unverified information and debate unmanaged by establishment approved experts, in the name of protecting democracy and rights, contrary to democratic practice and respect for human rights. Notably, we identified no pockets of resistance to these dominant meanings and uses. We assessed the implications of our findings for democratic public policy, and for fundamental rights and freedoms.
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(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities 2.0)
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Open AccessReview
Navigating the Dynamic Landscape of SARS-CoV-2: The Dual Role of Neutralizing Antibodies, Variability in Responses, and Strategies for Adaptive Pandemic Control
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Venkatesh Anand Iyer, Aditi Mohan, Dharmender Kumar and Praveen Dahiya
COVID 2024, 4(9), 1395-1412; https://doi.org/10.3390/covid4090100 - 9 Sep 2024
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The global pandemic sparked by the emergence of SARS-CoV-2 and its variants has imposed a substantial burden of morbidity and mortality. Central to the battle against these viral threats is the immune response, with a spotlight on the pivotal role played by neutralizing
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The global pandemic sparked by the emergence of SARS-CoV-2 and its variants has imposed a substantial burden of morbidity and mortality. Central to the battle against these viral threats is the immune response, with a spotlight on the pivotal role played by neutralizing antibodies. This comprehensive review delves into current research, unravelling the dual functionality of neutralizing antibodies acting as formidable barriers to viral replication and crucial facilitators of adaptive immune memory. Beyond this dual purpose, the review illuminates the nuanced variability characterizing neutralizing antibody responses to SARS-CoV-2. Emphasizing the dynamic nature of these responses, the review advocates for the plausible challenges in targeted therapeutic interventions. This review also attempts to compare various vaccination approaches and their impact on SARS-CoV-2, as well as offer insights into various Omicron variations. Recognizing the ever-evolving viral landscape, this exploration underscores the necessity of flexible approaches to address the diverse challenges posed by SARS-CoV-2 and its variants, contributing valuable insights to the ongoing global efforts in pandemic mitigation and public health safeguarding.
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Graphical abstract
Open AccessCommunication
The Subjective Well-Being of the Staff at a Teaching Dental Center in a COVID-19 Epidemiological Surveillance System between the Years 2020 and 2022
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Fabiola Antonella Corituma-Basaldua, Lucía Rafaela Negrón-Saldaña, Carola Rojas-Susanibar, Daniel Kevin Pérez-Alvarez, María Claudia Garcés-Elías and Roberto A. León-Manco
COVID 2024, 4(9), 1386-1394; https://doi.org/10.3390/covid4090099 - 3 Sep 2024
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Subjective well-being (SW) is understood as the personal judgment that an individual has about their value, perception, and level of satisfaction with respect to his or her life and existence. The present study had the purpose of understanding how pandemics have affected subjective
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Subjective well-being (SW) is understood as the personal judgment that an individual has about their value, perception, and level of satisfaction with respect to his or her life and existence. The present study had the purpose of understanding how pandemics have affected subjective well-being; therefore, the objective was to determine the subjective well-being of the staff at a teaching dental center in a COVID-19 epidemiological surveillance system between the years 2020 and 2022. A cross-sectional design was applied and was based on data from two records of the Centro Dental Docente of the Universidad Peruana Cayetano Heredia, Lima, Peru, between the years 2021 and 2022. The results show that the mean SW did not significantly vary (p = 0.114) between 2021 (69.32; SD = 19.92) and 2022 (63.16; SD = 29.87). At a bivariate level, significant associations were also observed between SW and multiple variables such as the diagnosis and type of COVID-19, vaccination, contact with COVID-19 patients, systemic conditions, body mass index, educational level, gender, and age. Meanwhile, according to the regression analysis, not having COVID-19 was positively associated with higher levels of subjective well-being. This study highlights the impact of the COVID-19 pandemic on the mental and emotional states of dental healthcare personnel, emphasizing the need for strategies to mitigate stress and anxiety in such critical work environments.
Full article
Open AccessArticle
Enhanced External Counterpulsation Improves Dyspnea, Fatigue, and Functional Capacity in Patients with Long COVID
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Jessie Fox, Farhan Ali, Marielisa Lopez, Sachin A. Shah, Christian W. Schmidt, Odayme Quesada, Timothy D. Henry and Monica Verduzco-Gutierrez
COVID 2024, 4(9), 1379-1385; https://doi.org/10.3390/covid4090098 - 2 Sep 2024
Abstract
Approximately 31% of patients previously infected with SARS-CoV-2 are living with symptoms of long COVID in the United States. Long COVID significantly reduces quality of life and increases morbidity and disability; however, treatment options are limited. Enhanced External Counterpulsation (EECP) is an FDA-approved,
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Approximately 31% of patients previously infected with SARS-CoV-2 are living with symptoms of long COVID in the United States. Long COVID significantly reduces quality of life and increases morbidity and disability; however, treatment options are limited. Enhanced External Counterpulsation (EECP) is an FDA-approved, non-invasive treatment for the management of cardiovascular symptoms with a mechanism of action which stimulates pathways that induce endothelial homeostasis, improving microvascular function, inflammation, and immune regulation, thereby potentially targeting the underlying etiology of long COVID. We recently reported that EECP improved symptoms in 231 patients with long COVID. Previous studies assessing the effects of EECP for long COVID have lacked a control group. As such, this analysis is the first comparing outcomes in patients with long COVID undergoing EECP (n = 33) to a non-treated group (control, n = 33). The patients were matched for baseline characteristics, and all patients completed patient-reported outcome assessments, including PROMIS Fatigue, the Duke Activity Status Index (DASI), and the Rose Dyspnea Scale (RDS), two times within a specified time interval. When comparing the average change from baseline in both groups, the EECP-treated patients’ improvement was significantly greater than the improvement in the control group across all measured endpoints, including PROMIS Fatigue (−15.0 ± 8.9 vs. −2.8 ± 5.9, p < 0.001) and DASI (+17.8 (11.8, 26.8) vs. +1.8 (−3.5, 5.5), p < 0.001), and there was an improvement of ≥1 in the RDS class (75.8% vs. 33.3%, p < 0.001). This study’s limitations include the small sample size and lack of information regarding concurrent treatments or interventions in the non-treated group; however, these preliminary data support EECP as a potential low-risk treatment option for patients with long COVID.
Full article
Open AccessHypothesis
Could the Spike Protein Derived from mRNA Vaccines Negatively Impact Beneficial Bacteria in the Gut?
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Alberto Rubio-Casillas, Mark Fabrowski, Carlo Brogna, David Cowley, Elrashdy M. Redwan and Vladimir N. Uversky
COVID 2024, 4(9), 1368-1378; https://doi.org/10.3390/covid4090097 - 25 Aug 2024
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The emergence of mRNA vaccines for SARS-CoV-2 has opened a new page in vaccine development. Nevertheless, concerns of experts have been expressed about unintentional side effects on the gut microbiota (GM). Previous studies showed that this virus acts as a bacteriophage, which infects
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The emergence of mRNA vaccines for SARS-CoV-2 has opened a new page in vaccine development. Nevertheless, concerns of experts have been expressed about unintentional side effects on the gut microbiota (GM). Previous studies showed that this virus acts as a bacteriophage, which infects and destroys specific bacterial strains in the GM. The present manuscript hypothesizes that the synthetic spike protein could create changes in the composition and the functioning of the GM by entering the intestinal cells after vaccination and impairing the symbiotic relationship between intestinal cells and the GM. An experimental protocol to test the hypothesis is suggested.
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Open AccessArticle
The Role of Intestinal Epithelial Permeability in Multisystem Inflammatory Syndrome in Children: A Case–Control Study
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Cathal Roarty, Clare Mills, Claire Tonry, Helen E. Groves, Chris Watson and Thomas Waterfield
COVID 2024, 4(9), 1355-1367; https://doi.org/10.3390/covid4090096 - 24 Aug 2024
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Background: Multisystem inflammatory syndrome in children (MIS-C) occurs after SARS-CoV-2 infection, with gastrointestinal symptoms a prominent feature. This syndrome has been proposed to be triggered by persistent SARS-CoV-2 antigenemia due to increased intestinal epithelial permeability. We obtained evidence for this in this study.
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Background: Multisystem inflammatory syndrome in children (MIS-C) occurs after SARS-CoV-2 infection, with gastrointestinal symptoms a prominent feature. This syndrome has been proposed to be triggered by persistent SARS-CoV-2 antigenemia due to increased intestinal epithelial permeability. We obtained evidence for this in this study. Methods: In a single-centre study, we recruited 83 children and analysed blood samples to quantify the circulating markers of increased intestinal permeability following SARS-CoV-2 infection. Publicly available proteomics MIS-C datasets were also accessed to assess the evidence for increased intestinal permeability. We further quantified SARS-CoV-2 antigenemia and the humoral response to SARS-CoV-2 spike protein. Results: Following SARS-CoV-2 infection, healthy children demonstrated no dysregulation of the intestinal epithelial barrier. In MIS-C, considerable increases in markers of epithelial dysfunction were observed, with similar increases noted in febrile controls. Furthermore, we found little evidence of persistent SARS-CoV-2 antigenemia in MIS-C. Conclusions: Our results suggest that although increased intestinal epithelial permeability is a feature of MIS-C, it is not unique to the condition, and persistent SARS-CoV-2 antigenemia does not occur.
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Open AccessArticle
ESCRT Protein VPS4A Is Required for the Formation of Replication Centers and Replication of Human Coronavirus 229E (HCoV-229E)
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Rinki Kumar, Rebecca Kaddis Maldonado, Neil D. Christensen, Maria C. Bewley, John M. Flanagan, Nicholas J. Buchkovich and Leslie J. Parent
COVID 2024, 4(9), 1338-1354; https://doi.org/10.3390/covid4090095 - 24 Aug 2024
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Human coronavirus 229E (HCoV-229E) is an alpha coronavirus that infects humans and bats. In common with all positive-strand RNA viruses, 229E infection causes rearrangements of the host’s intracellular membranes to form replication organelles, a highly conserved and vital step in the viral replication
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Human coronavirus 229E (HCoV-229E) is an alpha coronavirus that infects humans and bats. In common with all positive-strand RNA viruses, 229E infection causes rearrangements of the host’s intracellular membranes to form replication organelles, a highly conserved and vital step in the viral replication cycle. Here, we investigated the role of the ESCRT protein VPS4A in 229E infection. We found that functional VPS4A was required for the formation of replication organelles and localizing viral RNA to these structures in host cells to facilitate viral genome replication. We validated this effect using small molecule inhibitors to VPS4A, significantly reducing virus replication. We also showed that other ESCRTS, like CHMP4B, were required for the virus replication step, whereas VPS37A was involved in the post-replication stages. The absence of a functional VPS4A prevented the remodeling of membranes to form viral replication centers and, therefore, exposed the viral RNA, triggering an inflammatory immune response as indicated by elevated levels of IL-6. Interestingly, we observed the role of VPS4A to be similar for the OC43 coronavirus, indicating it could be conserved across all four coronavirus genera, including SARS-CoV-2. Understanding more about the replication of coronaviruses is imperative to finding more effective ways to control them.
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Open AccessArticle
State Contexts for a Public Health Emergency: The Divergence of Politics and Administration in COVID-19 Vaccination Rates
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Christian L. Janousek and Shihyun Noh
COVID 2024, 4(8), 1324-1337; https://doi.org/10.3390/covid4080094 - 21 Aug 2024
Abstract
Amid the array of challenges prompted by the COVID-19 pandemic, the policy response of governments proved vital. Different states in the U.S. pursued varied policy approaches that demonstrated distinct divergences in impact. Particularly, contrasting state contexts produced markedly assorted frameworks for the delivery
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Amid the array of challenges prompted by the COVID-19 pandemic, the policy response of governments proved vital. Different states in the U.S. pursued varied policy approaches that demonstrated distinct divergences in impact. Particularly, contrasting state contexts produced markedly assorted frameworks for the delivery of public health services, which indicate potential effects for COVID-19 policy implementation. Using the rates of COVID-19 vaccination as a measure of policy execution, the purpose of this study is to examine the political and administrative influences contributing to differences in COVID-19 public health policy outcomes among the states in the U.S. Ordinary least squares (OLS) regression models included data sources of nationally representative information pertaining to state public health attributes of politics and administration during the height of the pandemic and vaccine campaign. The findings suggest that state political leadership and fiscal capacity display significant associations with COVID-19 vaccination disparities, while other administrative indicators did not. The results signal important policy implications for the politics–administration dynamic within the COVID-19 pandemic and offer further understanding toward the roles of federalism and governance in future public health emergencies.
Full article
Open AccessArticle
Rapid Serological Test for COVID-19, One-Step-COVID-2019: Accuracy and Implications for Pandemic Control
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Luiz Antônio Alves de Menezes-Júnior, Aline Priscila Batista, Luciano Garcia Lourenção, Ana Maria Sampaio Rocha, Nara Nunes Lage, Keila Furbino Barbosa, George Luiz Lins Machado-Coelho and Adriana Lúcia Meireles
COVID 2024, 4(8), 1315-1323; https://doi.org/10.3390/covid4080093 - 20 Aug 2024
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Background: Accurate and rapid testing for COVID-19 is critical for effective disease management and control. The One-Step-COVID-2019-Test was developed as a rapid serological test to detect antibodies against SARS-CoV-2. Objective: To estimate the accuracy of the rapid serological test for COVID-19 using One-Step-COVID-2019.
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Background: Accurate and rapid testing for COVID-19 is critical for effective disease management and control. The One-Step-COVID-2019-Test was developed as a rapid serological test to detect antibodies against SARS-CoV-2. Objective: To estimate the accuracy of the rapid serological test for COVID-19 using One-Step-COVID-2019. Methods: We conducted a population-based serological survey with a stratified sampling of 593 adults between October and December 2020, prior to mass vaccination and during a period of limited availability of rapid tests. Participants provided 7.5 mL of serum, which was tested using the One-Step-COVID-2019-Test for IgM-IgG antibodies without distinction, as well as an in-house ELISA for IgG against the spike protein. Statistical analysis accounted for sampling weights, with accuracy assessed through sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index, and kappa coefficient, using ELISA as the reference standard. McNemar’s test identified significant differences between the test results. Results: The ELISA-based prevalence of infection was 11.1%. The One-Step-COVID-2019-Test showed low sensitivity (27.0–30.8%) but high specificity (89.9–96.6%), with poor agreement (kappa: 0.290–0.337), particularly among asymptomatic individuals. Conclusions: The One-Step-COVID-2019 rapid test for COVID-19 demonstrated inadequate performance, characterized by low sensitivity and poor reliability, making it unsuitable for effective serological surveillance.
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Open AccessArticle
Creation of a Spatiotemporal Algorithm and Application to COVID-19 Data
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Natalia Bou Sakr, Gihane Mansour and Yahia Salhi
COVID 2024, 4(8), 1291-1314; https://doi.org/10.3390/covid4080092 - 18 Aug 2024
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This study offers an in-depth analysis of the COVID-19 pandemic’s trajectory in several member countries of the European Union (EU) in order to assess similarities in their crisis experiences. We also examine data from the United States to facilitate a larger comparison across
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This study offers an in-depth analysis of the COVID-19 pandemic’s trajectory in several member countries of the European Union (EU) in order to assess similarities in their crisis experiences. We also examine data from the United States to facilitate a larger comparison across continents. We introduce our new approach, which uses a spatiotemporal algorithm to identify five distinct and recurring phases that each country underwent at different times during the COVID-19 pandemic. These stages include: Comfort Period, characterized by minimal COVID-19 activity and limited impacts; Preventive Situation, demonstrating the implementation of proactive measures, with relatively low numbers of cases, deaths, and Intensive Care Unit (ICU) admissions; Worrying Situation, is defined by high levels of concern and preparation as deaths and cases begin to rise and reach substantial levels; Panic Situation, marked by a high number of deaths relative to the number of cases and a rise in ICU admissions, denoting a critical and alarming period of the pandemic; and finally, Epidemic Control Situation, distinguished by limited numbers of COVID-19 deaths despite a high number of new cases. By examining these phases, we identify the various waves of the pandemic, indicating periods where the health crisis had a significant impact. This comparative analysis highlights the time lags between countries as they transitioned through these different critical stages and navigated the waves of the COVID-19 pandemic.
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Open AccessReview
The Evolution of Serological Assays during Two Years of the COVID-19 Pandemic: From an Easy-to-Use Screening Tool for Identifying Current Infections to Laboratory Algorithms for Discovering Immune Protection and Optimizing Vaccine Administration
by
Eleonora Nicolai, Flaminia Tomassetti, Stefano Pignalosa, Serena Redi, Mariapaola Marino, Umberto Basile and Marco Ciotti
COVID 2024, 4(8), 1272-1290; https://doi.org/10.3390/covid4080091 - 16 Aug 2024
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The emergence of COVID-19 has evolved into a global pandemic, causing an unprecedented public health crisis marked by unprecedented levels of morbidity never seen in the recent past. Considerable research efforts have been made in the scientific community to establish an optimal method
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The emergence of COVID-19 has evolved into a global pandemic, causing an unprecedented public health crisis marked by unprecedented levels of morbidity never seen in the recent past. Considerable research efforts have been made in the scientific community to establish an optimal method to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and to understand the induced immune response. This review examined the development of serological tests during the COVID-19 pandemic, considering the factors affecting sensitivity and specificity, which are key to promote an efficient vaccination strategy for public health. The market has witnessed the introduction of various serological tests for the detection of SARS-CoV-2, such as the chemiluminescence immunoassay (CLIA), which emerged as a powerful and rapid tool to monitor the antibody response before and after vaccination or infection. Therefore, developing serological tests by studying antibody trends and persistence is essential for creating long-term strategies. Our analysis underscores the multifaceted applications of serological tests in pandemic management with a focus on the critical insights they provide into antibody dynamics that help in managing the ongoing pandemic and shaping future public health initiatives, providing a basis for optimizing the future response to viral threats.
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Open AccessArticle
The Impact of COVID-19 on Construction Project Performance: A Case Study in Pakistan
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Syed Rafay Ali Bukhari, Abdur Rehman Nasir, Roberto Greco and Luigi Mollo
COVID 2024, 4(8), 1253-1271; https://doi.org/10.3390/covid4080090 - 16 Aug 2024
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COVID-19 has had unprecedented effects on construction markets globally due to supply chain disruptions and workforce restrictions, etc. However, construction industries in developing countries are more vulnerable to the obstacles associated with the pandemic. As such, the goal of this paper is to
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COVID-19 has had unprecedented effects on construction markets globally due to supply chain disruptions and workforce restrictions, etc. However, construction industries in developing countries are more vulnerable to the obstacles associated with the pandemic. As such, the goal of this paper is to capture the impact of COVID-19 on construction projects’ performance in developing countries by taking the Pakistani construction sector into perspective. A multistep project-based research methodology was adopted, including a literature analysis and questionnaire survey with 20 construction professionals to assess factors affected by COVID-19; formulation of open-ended questions against each factor; collecting data using semi structured interviews; and presenting challenges and adopted mitigation strategies to examine the perceived impact. Results showed that the pandemic has caused a total of 13 factors to impact the project performance, which are grouped under four construction groups, including material and equipment, human resource, occupational health and safety, and financial and contracts. The factors impacted the most by the pandemic are cash flow management, supply chain disruptions, increased overheads, construction safety measures, material shortage, contractual issues, and construction workforce. This research contributes to the body of knowledge by providing a foundation for researchers to enhance investigating the impact of the COVID-19 in developing countries.
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Open AccessArticle
MMS19 and IFIH1 Host Genetic Variants Associate with SARS-CoV-2 Infection in Elderly Residents of Long-Term Care Facilities
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Sandra Franco, Macedonia Trigueros, Dolors Palacín, Josep Maria Bonet-Simó, Maria del Mar Isnard, Nemesio Moreno, Lourdes Mateu, Nuria Prat, Marta Massanella and Miguel Angel Martinez
COVID 2024, 4(8), 1245-1252; https://doi.org/10.3390/covid4080089 - 7 Aug 2024
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has significantly affected older adults. Identifying host COVID-19 susceptibility genes in elderly populations remains a challenge. Here, we aimed to identify host genetic factors influencing the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We
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The coronavirus disease 2019 (COVID-19) pandemic has significantly affected older adults. Identifying host COVID-19 susceptibility genes in elderly populations remains a challenge. Here, we aimed to identify host genetic factors influencing the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We genotyped 12 single-nucleotide polymorphisms (SNPs) previously associated with the innate immune response in a total of 97 elderly (age > 65 years) residents of three long-term care facilities located in Barcelona, Spain. Individuals were PCR-tested during the SARS-CoV-2 outbreaks between September and November 2020. SARS-CoV-2 PCR tests revealed infections in 81 residents. Importantly, the 16 uninfected residents remained SARS-CoV-2 seronegative until vaccination (January and February 2021). After adjusting for sex and age, we found that two SNPs were significantly associated with SARS-CoV-2 infection susceptibility—MMS19 nucleotide excision repair protein homolog (MMS19)/rs2236575 (p = 0.029) and interferon-induced helicase C domain-containing 1 (IFIH1)/rs1990760 (p = 0.034). No association with SARS-CoV-2 infection was found for 10 additional genotyped SNPs, which included 4 SNPs on chromosome 12 in the gene encoding oligoadenylate synthetase (OAS). Our results indicate that MMS19/rs2236575_A and IFIH1/rs1990760_TC genetic variants were associated with a resistance to SARS-CoV-2 infection in a cohort of institutionalized seniors.
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(This article belongs to the Topic Multifaceted Efforts from Basic Research to Clinical Practice in Controlling COVID-19 Disease)
Open AccessArticle
Classification of High-Resolution Chest CT Scan Images Using Adaptive Fourier Neural Operators for COVID-19 Diagnosis
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Anusha Gurrala, Krishan Arora, Himanshu Sharma, Shamimul Qamar, Ajay Roy and Somenath Chakraborty
COVID 2024, 4(8), 1236-1244; https://doi.org/10.3390/covid4080088 - 7 Aug 2024
Abstract
In the pursuit of advancing COVID-19 diagnosis through imaging, this paper introduces a novel approach utilizing adaptive Fourier neural operators (AFNO) for the analysis of high-resolution computed tomography (HRCT) chest images. The study population comprised 395 patients with 181,106 labeled high-resolution COVID-19 CT
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In the pursuit of advancing COVID-19 diagnosis through imaging, this paper introduces a novel approach utilizing adaptive Fourier neural operators (AFNO) for the analysis of high-resolution computed tomography (HRCT) chest images. The study population comprised 395 patients with 181,106 labeled high-resolution COVID-19 CT images from the HRCTCov19 dataset, categorized into four classes: ground glass opacity (GGO), crazy paving, air space consolidation, and negative for COVID-19. The methods included image preprocessing, involving resizing and normalization, followed by the application of the AFNO model, which enables efficient token mixing in the Fourier domain independent of input resolution. The model was trained using the Adam optimizer with a learning rate of 1 × 10−⁴ and evaluated using metrics such as accuracy, precision, recall, and F1 score. The results demonstrate AFNO’s superior performance in few-shot segmentation tasks over traditional self-attention mechanisms, achieving an overall accuracy of 94%. Specifically, the model showed high precision and recall for the GGO and negative classes, indicating its robustness and effectiveness. This research has significant implications for the development of AI-powered diagnostic tools, particularly in environments with limited access to high-quality imaging data and those where computational efficiency is critical. Our findings suggest that AFNO could serve as a powerful model for analyzing HRCT images, potentially leading to improved diagnosis and understanding of COVID-19, representing a critical step in combating the pandemic.
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(This article belongs to the Special Issue Artificial Intelligence and Machine Learning Applications for Developing the Diagnosis of COVID-19)
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Open AccessCommunication
Does COVID-19 Revamp Nurses’ Compassion? Post-Pandemic Approach in Qatar
by
George Vellaramcheril Joy, Kamaruddeen Mannethodi, Albara Mohammad Ali Alomari, Kalpana Singh, Nesiya Hassan, Jibin Kunjavara and Badriya Al Lenjawi
COVID 2024, 4(8), 1227-1235; https://doi.org/10.3390/covid4080087 - 6 Aug 2024
Abstract
Aim: This study aimed to identify self-compassion among staff nurses after the COVID-19 pandemic in Qatar. Design: Descriptive cross-sectional survey design. Methods: Anonymous data were collected through an online survey using Microsoft Forms from 300 nurses in 14 health facilities in Qatar. The
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Aim: This study aimed to identify self-compassion among staff nurses after the COVID-19 pandemic in Qatar. Design: Descriptive cross-sectional survey design. Methods: Anonymous data were collected through an online survey using Microsoft Forms from 300 nurses in 14 health facilities in Qatar. The organization had almost 10,000 nursing staff working in different facilities. Data were gathered using a structured online questionnaire and included socio-demographic information, and the Self-Compassion Scale—Short Form was used to collect the remaining data. Correlation, t-test, and ANOVA analyses were conducted. Results: Nurses in the study showed high self-compassion. Among the sub-domain ‘mindfulness’, they showed comparatively high scores (7.96 ± 1.55), and the lowest score was for ‘isolation’ (6.15 ± 1.99). The score for ‘self-kindness’ was 7.29 ± 1.55, that for ‘self-judgement’ was 6.79 ± 2.01, that for ‘common humility’ was 6.62 ± 1.47, and that for the sub-domain ‘over-identified’ was 6.47 ± 1.91. Mindfulness scores were high among the nurse leaders. Moreover, over-identified scores were high among the nurses who were currently working under COVID-19 at the time of data collection. Conclusions: Nurses faced many difficulties while working during the COVID-19 pandemic, including a heavy workload and tension. The current study’s findings add to our understanding of how COVID-19 affected the development of self-compassion. A rise in mindfulness, which aids nurses in managing stress at work and building resilience, further underscores an increase in nurses’ acceptance of the COVID-19 pandemic. The findings also highlight how crucial it is to encourage self-compassion in individuals and offer them emotional support at such times, especially when there is a significant risk factor for mental health, such as COVID-19.
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(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
Open AccessArticle
Assessing the Intention to Use a First-Generation Vaccine against COVID-19 Using Quantile Regression: A Cross-Sectional Study in Spain
by
Jorge de Andrés-Sánchez, Mario Arias-Oliva and Jorge Pelegrín-Borondo
COVID 2024, 4(8), 1211-1226; https://doi.org/10.3390/covid4080086 - 5 Aug 2024
Abstract
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Understanding the factors that influence the intention to use vaccines is crucial for implementing effective public health policies. This study examined the impact of various cognitive, affective, normative, and sociodemographic variables on the intention to be vaccinated against COVID-19 with the first-generation AstraZeneca
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Understanding the factors that influence the intention to use vaccines is crucial for implementing effective public health policies. This study examined the impact of various cognitive, affective, normative, and sociodemographic variables on the intention to be vaccinated against COVID-19 with the first-generation AstraZeneca vaccine. A survey of 600 residents of Spain was used to assess the influence and hierarchy of the drivers of the intention to vaccinate via least-squares and quantile regressions. The most significant factors were the perceptions of efficacy and social influence, both of which had positive impacts (p < 0.0001). The positive influence of fear of COVID-19 and the negative influence of fear of the vaccine were also significant in shaping the central tendency toward vaccination. However, these fear-related variables, particularly the fear of COVID-19, lost importance in quantile adjustments outside the central tendency. Among the sociodemographic variables, only the negative impact of income was statistically significant. These results are valuable for the development of vaccination policies because they measure the sensitivity of attitudes toward vaccination to exogenous variables not only in the central values, as is common in similar studies, but also across the entire range of responses regarding the intention to vaccinate. This additional analysis, which is not commonly performed in studies on vaccine acceptance, allows us to distinguish between variables which are consistently related to the intention to vaccinate and those that influence only expected responses.
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Open AccessArticle
Vascular Care Delivery during the COVID-19 Pandemic: Impact of Office-Based Laboratory and Ambulatory Surgery Center
by
Scott S. Berman, Daniel Nguyen, Megon L. Berman, Joshua A. Balderman, Jennifer Clark, Luis R. Leon, Bernardo Mendoza, Joseph E. Sabat and John P. Pacanowski
COVID 2024, 4(8), 1204-1210; https://doi.org/10.3390/covid4080085 - 5 Aug 2024
Abstract
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Objective: To evaluate how access to an office-based laboratory (OBL) and ambulatory surgery center (ASC) impacted vascular care during the Coronavirus Disease 2019 (COVID-19) pandemic. Methods: Vascular procedures performed by our group during the 6-week period before COVID-19 restrictions (group 1) and in
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Objective: To evaluate how access to an office-based laboratory (OBL) and ambulatory surgery center (ASC) impacted vascular care during the Coronavirus Disease 2019 (COVID-19) pandemic. Methods: Vascular procedures performed by our group during the 6-week period before COVID-19 restrictions (group 1) and in the first 6-week period during the COVID-19 restrictions (group 2) were reviewed. The number of procedures performed was categorized as hospital inpatient (HIP), hospital outpatient (HOP), OBL, ASC, and vein center (VC). The procedures were also grouped by type: aneurysm (AAA), carotid (CAR), peripheral arterial disease (PAD), amputation/wound care (AMP), vascular access (VA), deep vein thrombosis (DVT), and venous reflux (CVI). The number of healthcare provider contact points for each patient undergoing care at the HOP, OBL, and ASC were also collected and compared between groups 1 and 2. Differences between groups were determined using the two-way ANOVA. Results: There were no statistically significant differences between groups 1 and 2 for procedure location or type of procedure (p > 0.05). Patient contact with healthcare providers decreased between groups 1 and 2 for ambulatory care. However, projecting the number of contacts for patients in group 2 if they had to have ambulatory care in the HOP setting (913) compared to contacts in the OBL and ASC setting (588) was statistically significant (p < 0.05). No patient or staff member at the OBL or ASC developed COVID-19 infection because of the care received at these venues. Conclusions: The ability to provide essential care for patients in an ambulatory environment was enhanced using our OBL and ASC without compromising safety, efficacy, or transmission of the virus to patients or staff during the height of the COVID-19 pandemic and limited their contact with healthcare workers and therefore reduced the consumption of personal protective equipment by healthcare personnel.
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