Twelve new and four known alkaloids including five different structural scaffolds were isolated from the sponge Stylissa massa collected in the South China Sea. Compound 1 is the first identified precursor metabolite of the classic 5/7/5 tricyclic sk...
Background/Objectives: Signaling imbalances involving epidermal growth factor receptor (EGFR) and aldose reductase (ALR2) are frequently associated with the biology of several solid tumors, including non-small-cell lung cancer (NSCLC) and breast canc...
Brucella suis, the causative agent of brucellosis, poses a significant public health and animal husbandry threat. However, the role of the alanine racemase (alr) gene, which encodes alanine racemase in Brucella, remains unclear. Here, we analyzed an...
Compared with traditional Al–Si die-cast alloys, which have good formability and low cost but poor brazeability and inadequate corrosion resistance, high-pressure die-cast (HPDC) Al–RE alloys exhibit superior comprehensive properties. To...
In general, FeCrAl alloys are faced with the separation of the high-chromium solid solution into α and α′ phases. For the Fe-25Cr-5Al-RE alloy, it is imperative to investigate the structure and morphology and their effect on the all...
Background/Objectives: Triple therapy combining targeted therapy (lenvatinib/bevacizumab), immune checkpoint inhibitors (ICIs), and interventional therapy (TACE/HAIC) has shown promising efficacy, but clinical outcomes differ among patients. We devel...
Adipose mesenchymal stem cell-derived exosomes (ADSC-Exo) have demonstrated therapeutic effects in liver diseases and injuries. The Augmenter of Liver Regeneration (ALR), a novel hepatic trophic growth factor, promotes hepatic structural and function...
Brucella, a zoonotic facultative intracellular pathogenic bacterium, poses a significant threat both to human health and to the development of the livestock industry. Alanine racemase (Alr), the enzyme responsible for alanine racemization, plays a pi...
The excretion behavior in daily life for the elderly and the disabled is a high frequency, high physical load, and risky behavior. Therefore, we proposed an auxiliary lavatory robot (ALR) with autonomous movement and self-cleaning capability. When th...
In cold-region industrial parks, prolonged heating seasons and intensive hot water demands trigger severe temporal mismatches between stochastic renewable generation and rigid thermal requirements. To address this, a multidimensional synergistic opti...
MIA40 and ALR of the MIA pathway mediate the import of protein precursors that form disulfides into the mitochondrial intermembrane space. This import pathway is suggested to be a linear pathway in which MIA40 first binds to the precursor via a disul...
Inflammasomes and innate immune cells have been shown to contribute to liver injury, thereby activating Kupffer cells, which release several cytokines, including IL-6, IL-1ß, and TNFα. Augmenter of liver regeneration (ALR) is a hepatotrop...
Large-scale pre-trained language representation and its promising performance in various downstream applications have become an area of interest in the field of natural language processing (NLP). There has been huge interest in further increasing the...
Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 (ALR-2) is an oxidoreductase enzyme that is most extensively studied therapeutic target for diabetes-related complications that can be inhibited by epalr...
In Mycoplasma hominis, two genes (alr and goiB) have been found to be associated with the invasion of the amniotic cavity, and a single gene (goiC) to be associated with intra-amniotic infections and a high risk of preterm birth. The syntopic presenc...
The relative energetic stability, mechanical properties, and thermodynamic behavior of B2-AlRE (RE = Sc, Y, La-Lu) second phases in Al alloys have been investigated through the integration of first-principles calculations with the quasi-harmonic appr...
The most recent scale to quantify psychological readiness before returning to sport is the ALR-RSI (Ankle Ligament Reconstruction—Return to Sport after Injury) scale. The aim of this study was the cross-cultural adaptation to Spanish and applic...
Magnesium (Mg2+) is the most abundant divalent ion in plants, participating in numerous metabolic processes in growth and development. CorA/MRS2/ALR type Mg2+ transporters are essential for maintaining Mg2+ homeostasis in plants. However, the candida...
Accurate forecasts of the U.S. renewable energy consumption mix are essential for planning transmission upgrades, sizing storage, and setting balancing market rules. We introduce a Bayesian Dirichlet ARMA model (BDARMA) tailored to monthly shares of...
In this paper, the possibility of applying different welding strategies to overlay an FeCrAl layer against corrosion from heavy liquid metal on a plain plate made of 316L austenitic stainless steel was investigated. This technology could be used in m...
Background/Objectives: Atractylodes lancea (Thunb.) DC. [Asteraceae] (ALR)-derived exosome-like nanoparticles (ALR-ELNs) exhibit anti-neuroinflammatory effects in microglial cells. However, the associated mechanisms and pathways are unknown. We...
The transient specificity pocket of aldose reductase only opens in response to specific ligands. This pocket may offer an advantage for the development of novel, more selective ligands for proteins with similar topology that lack such an adaptive poc...
This article focuses on the study of the mass transfer involved in the application of a bacterial antifouling technique for membrane bioreactors (MBR), via the addition of solid media. These alginate objects can contain a biological system capable of...
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue dam...
Inflammasomes are protein scaffolds required for the activation of caspase-1 and the subsequent release of interleukin (IL)-1β, IL-18, and danger signals, as well as the induction of pyroptotic cell death to restore homeostasis following infecti...
Retroviruses are major causes of disease in animals and human. Better understanding of the initial host immune response to these viruses could provide insight into how to limit infection. Mouse retroviruses that are endemic in their hosts provide an...
As rate-limited enzyme of polyol pathway, aldose reductase (ALR2) is one of the key inhibitory targets for alleviating diabetic complications. To reduce the toxic side effects of the inhibitors and to decrease the level of oxidative stress, the inhib...
Hepatic ischemia reperfusion injury (IRI) is a major complication in liver resection and transplantation. Here, we analyzed the impact of recombinant human augmenter of liver regeneration (rALR), an anti-oxidative and anti-apoptotic protein, on the d...
This paper introduces an ambient light rejection (ALR) circuit for the autonomous adaptation of a subretinal implant system. The sub-retinal implants, located beneath a bipolar cell layer, are known to have a significant advantage in spatial resoluti...
The present study investigates the influence of atomizing air-to-liquid mass ratio (ALR) on the near-field spray characteristics and stability of a novel twin-fluid injector that integrates bubble-bursting for primary atomization and shear-induced se...
In this paper, we propose a general method to detect outliers from contaminated estimates of various image estimation applications. The method does not require any prior knowledge about the purpose, theory or hardware of the application but simply re...
Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking...
Arctium lappa L. (A. lappa) is a popular medicinal plant with promising hepatoprotective activity. This study investigated the protective effect of A. lappa root extract (ALRE) on lead (Pb) hepatotoxicity, pointing to its ability to modulate oxidativ...
In this study, a three-dimensional CFD transient model is established for predicting species concentration distribution in the biodegradation of phenol in an airlift reactor (ALR). The gas–liquid flow in the ALR is determined by the Euler&ndash...
Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing...
Advanced control systems have been recently implemented in wastewater treatment plants (WWTPs) to optimize activated sludge processes, reduce operational costs, and decrease energy consumption, with the aim of moving toward sustainable operation. Rea...
The pattern of bounding box representation and regression has long been dominant in CNN-based pedestrian detectors. Despite the method’s success, it cannot accurately represent location, and introduces unnecessary background information, while pedest...
Porcine epidemic diarrhea (PED), which is caused by the porcine epidemic diarrhea virus (PEDV), has occurred worldwide and poses a serious threat to the pig industry. Intestine is the main function site of PEDV; therefore, it is important to develop...
Background/Objectives: An increase in body fat is linked to abnormalities in energy metabolism. We aimed at determining cardiometabolic risk in Algerian participants with obesity alone and with or without type 2 diabetes. The study measured the conce...
The stereospecificity in binding to aldose reductase (ALR2) of two fidarestat {6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide} stereoisomers [(2S,4S)and (2R,4S)] has been investigated by means of molecular dynamics simulations us...
Forest soils play a key role in the global carbon (C) pool and in mitigating climate change. The mechanisms by which understory and litter management affect soil organic C (SOC) concentrations are unclear in subtropical forests. We collected soils al...
Even bubble column reactors (BCR) and airlift reactors (ALR) have been developed in terms of various related aspects towards mass transfer enhancement, the effective analysis of gas diffuser types on mass transfer and gas–liquid hydrodynamic characte...
The pandemic causes social distancing and lockdown, which impedes consumer confidence and contracts the economy. Hence, this study analyzes the corona (COVID-19) impact on the airline industry revenues (ALR) and forecast by the vector autoregression...
Shear walls are commonly adopted as main structural members to resist vertical and lateral forces, thanks to their high load capacity and high lateral stiffness. However, their lateral capacity can be impaired in the presence of openings, which can r...
Logistic regression methods have been widely used for landslide research. However, previous studies have seldom paid attention to the frequent occurrence of spatial autocorrelated residuals in regression models, which indicate a model misspecificatio...
Many researchers have focused on multi-phase reactor development for improving mass transfer performance. However, solid particle addition in gas–liquid contactor for better oxygen mass transfer performance is still limited. Hence, this study a...
The ability of bacterial pathogens to form biofilms is an important virulence mechanism in relation to their pathogenesis and transmission. Biofilms play a crucial role in survival in unfavorable environmental conditions, acting as reservoirs of micr...
Air-core-liquid-ring (ACLR) atomizers present a specific type of internal mixing pneumatic atomizers, which can be used for efficient atomization of high viscous liquids. Generally, atomization efficiency is considered as a correlation between energy...
This study explores the optimisation of nozzle design for external twin fluid, single-stage atomisation in handling high-viscosity, shear-thinning polydimethylsiloxane (PDMS). A single PDMS grade was employed and atomised using unheated sonic air and...
Cinnabarinic acid (CA) is a phenoxazinone metabolite produced by Pycnoporus fungi and reported to have antibacterial activity. This study compared CA production by Pycnoporus cinnabarinus HEMIM-53 in three culture systems, Shake flasks (FSK), a Stirr...
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