Medicinal Chemistry
A section of Pharmaceuticals (ISSN 1424-8247).
Section Information
The section of Medicinal Chemistry welcomes manuscripts involving aspects within the definition of medicinal chemistry related to the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships. Novel strategies and methodologies with relevant application to chemical biology and medicinal chemistry are also welcome.
Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details covering all aspects of small molecules as drug candidates e.g. drug discovery and design, combinatorial chemistry, structure-property correlations, molecular modelling and bioinformatics. Short communications are also accepted; therefore, there is no restriction on the length of a paper. Download Section Flyer
Keywords
- New synthetic routes for drug candidates
- Lead discovery and optimization methods; structure–activity relationships and QSAR
- Structure-based drug design, molecular modelling, docking studies and crystal structure analysis
- Identification and validation of novel drug targets, and high-throughput screening
- Virtual screening, database mining, and machine learning in drug discovery
- Role of ADMET in drug discovery
- Chemical biology and chemical probes
Editorial Board
Topical Advisory Panel
Special Issues
Following special issues within this section are currently open for submissions:
- 20th Anniversary of Pharmaceuticals–Drug Design and Pharmacological Advances in Neurodegenerative Disease (Deadline: 20 October 2024)
- Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets (Deadline: 20 October 2024)
- Novel Therapies for the Treatment of Metastatic Prostate Cancer (Deadline: 20 October 2024)
- Alzheimer’s Disease: Small-Molecule Modulators of Novel Therapeutic Pathways (Deadline: 20 October 2024)
- Organochalcogen Molecules and Materials in Medicinal Chemistry (Deadline: 25 October 2024)
- Common Medications Used in Anesthesia (Deadline: 25 October 2024)
- Enzyme Inhibitors: Potential Therapeutic Approaches (Deadline: 25 October 2024)
- Selected Papers from the 9th International Electronic Conference on Medicinal Chemistry (ECMC2023) (Deadline: 25 October 2024)
- Pyrazole and Thiazole Derivatives in Medicinal Chemistry (Deadline: 25 October 2024)
- Development of Copper-Based Drugs: Synthesis, Characterisation and Biological Activity (Deadline: 30 October 2024)
- Design, Synthesis and Development of Novel Antiviral Agents (Deadline: 30 October 2024)
- Recent Advances and Future Approaches in Preventive and Therapeutic Effects of Vanadium Complexes (Deadline: 31 October 2024)
- Current Advances, Applications and Future Development of Transition Metal Complexes (Deadline: 31 October 2024)
- Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain (Deadline: 1 November 2024)
- In Silico and In Vitro Screening of Small Molecule Inhibitors (Deadline: 5 November 2024)
- Recent Advances in the Synthesis and Evaluation of Beta-Lactamase Inhibitors (Deadline: 10 November 2024)
- Therapeutic Potential of Vitamin D in Depressive Disorder and Anxiety Disorders (Deadline: 15 November 2024)
- Current Advances in Therapeutic Potential of Sigma Receptor Ligands (Deadline: 15 November 2024)
- Drug Candidates for the Treatment of Obesity, 2nd Edition (Deadline: 20 November 2024)
- Inhibitors of κB Kinase (IKK) and Nuclear Factor Kappa-B (NF-κB): Attractive Drug Targets (Deadline: 20 November 2024)
- A Commemorative Special Issue in Honor of Prof. Jolanta Saczko: Pharmaceutical Science in Electrochemotherapy (Deadline: 20 November 2024)
- Design, Synthesis, Evaluation and Biopharmaceutical Uses of Imatinib, Nilotinib and Their Analogues (Deadline: 22 November 2024)
- Design and Synthesis of Small Molecule Kinase Inhibitors (Deadline: 25 November 2024)
- Computer-Aided Drug Design and Drug Discovery (Deadline: 25 November 2024)
- Amyloid Composition and Structure-Based Development of Therapeutic and Diagnostic Agents (Deadline: 25 November 2024)
- Prodrugs: Design and Development (Deadline: 25 November 2024)
- Discovery of Natural Products as Potential Antidiabetic Agents (Deadline: 25 November 2024)
- Molecular Systems for the Delivery of Drugs and Contrast Agents (Deadline: 28 November 2024)
- Therapeutic Potential of Silver Nanoparticles (AgNPs) (Deadline: 30 November 2024)
- Advances in Peptide Chemistry and Medicinal Application (Deadline: 30 November 2024)
- Medicinal Metal Ions and Metal-Based Complex (Deadline: 30 November 2024)
- Antiviral Agents, 2024 (Deadline: 30 November 2024)
- Nitrogen Containing Scaffolds in Medicinal Chemistry 2023 (Deadline: 30 November 2024)
- Metal Chelating Agents in Medicinal Chemistry (Deadline: 30 November 2024)
- Innovative Applications and Therapeutic Potential of Cannabinoids (Deadline: 30 November 2024)
- Targeting Opioid Receptors for Innovative Therapies: Present and Emerging Concepts in Opioid Cure (Deadline: 30 November 2024)
- Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells (Deadline: 13 December 2024)
- Last Trends of Antileishmanial Drug Discovery and Development (Deadline: 14 December 2024)
- Small Molecules as Antimicrobials 2024 (Deadline: 15 December 2024)
- Design, Synthesis and Biological Evaluation with Potential Anti-inflammatory Activity (Deadline: 22 December 2024)
- Application of 2D and 3D-QSAR Models in Drug Design (Deadline: 24 December 2024)
- Topoisomerases as Targets for Novel Drug Discovery (Deadline: 25 December 2024)
- Mitochondrial Protease ClpP in Antitumor-Drug Development: Recent Advances and Challenges (Deadline: 25 December 2024)
- Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications (Deadline: 25 December 2024)
- Recent Advancements in the Development of Antiprotozoal Agents (Deadline: 25 December 2024)
- Chirality: The Important Factor for Drug Discovery and Development (Deadline: 25 December 2024)
- 20th Anniversary of Pharmaceuticals—Recent Advances in Metallodrug Design and Application (Deadline: 25 December 2024)
- Histamine Receptor Ligands in Medicinal Chemistry (Deadline: 25 December 2024)
- Computational Predictions of Molecules with Potential Therapeutic Effects (Deadline: 30 December 2024)
- Drug Discovery of Antiprotozoal Agents 2024 (Deadline: 31 December 2024)
- Discovery and Development of Novel Analgesics (Deadline: 31 December 2024)
- Therapeutic Potential of Aldehyde Dehydrogenases (Deadline: 31 December 2024)
- Recent Advances in Psychiatric Medications (Deadline: 31 December 2024)
- Computational Methods in Drug Development (Deadline: 31 December 2024)
- Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition (Deadline: 31 December 2024)
- Sex Differences in Pharmaceutical Practice (Deadline: 31 December 2024)
- Emerging Trends in Liquid Chromatography and Mass Spectrometry-Based Analyses of Pharmaceuticals (Deadline: 20 January 2025)
- Chemoinformatics and Drug Design, 2nd Edition (Deadline: 20 January 2025)
- Classical and Quantum Molecular Simulations in Drug Design (Deadline: 20 January 2025)
- 20th Anniversary of Pharmaceuticals—Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry (Deadline: 24 January 2025)
- Antioxidants in the Processes of Retarding Ageing (Deadline: 24 January 2025)
- Recent Advances in the Discovery and Development of Drugs for Civilization Diseases (Deadline: 25 January 2025)
- Advanced Strategies in Drug Design and Development of Small Molecules as Therapeutic Agents (Deadline: 25 January 2025)
- Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development (Deadline: 31 January 2025)
- Natural Products-Assisted Organic Synthesis in Medicinal Chemistry (Deadline: 31 January 2025)
- Novel Anti-proliferative Agents, 2nd Edition (Deadline: 31 January 2025)
- New Pharmaceuticals in Diagnosis, Prognosis and Treatment of Myelofibrosis and Myeloproliferative Neoplasms (Deadline: 20 February 2025)
- Indole Derivatives as Targeted Melatonin and Serotonin Receptor Ligands (Deadline: 23 February 2025)
- Drug Discovery and Development Targeting NMDA Receptors (Deadline: 24 February 2025)
- Small Molecule Drug Discovery: Driven by In-Silico Techniques (Deadline: 25 February 2025)
- Flavonoids in Medicinal Chemistry: Trends and Future Directions (Deadline: 25 February 2025)
- Antibiotic Resistance in Gram-Negative Bacteria: The Threat From the Pink Corner, 2nd Edition (Deadline: 28 February 2025)
- Immunogenomics for Drug Discovery in Leukemia (Deadline: 20 March 2025)
- Hybrid Drugs: Design and Applications 2024 (Deadline: 20 March 2025)
- The Role of Molecular Docking in the Design of Targeted Therapeutic Entities and Nanomaterials (Deadline: 25 March 2025)
- Antimalarial Drug Candidates (Deadline: 25 March 2025)
- Green Synthesis and Biological Evaluation of Quinazolinone-Based Compounds (Deadline: 31 March 2025)
- Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics (Deadline: 31 March 2025)
- Synthesis and Biological Activity of Metal Complexes (Deadline: 31 March 2025)
- Drug Discovery and Development for Parasitic Diseases (Deadline: 31 March 2025)
- Design, Synthesis and Biological Assessment of Amphiphiles (Deadline: 20 May 2025)
- Pharmaceuticals 2024—Recent Advances in Pharmaceutical Sciences Towards a Healthy Life (Deadline: 31 May 2025)
- Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation (Deadline: 25 June 2025)
- Integrating Medicinal Chemistry and Mass Spectrometry: New Opportunities and Challenges (Deadline: 30 June 2025)
Topical Collections
Following topical collections within this section are currently open for submissions:
