Medicinal Chemistry
A section of Pharmaceuticals (ISSN 1424-8247).
Section Information
The section of Medicinal Chemistry welcomes manuscripts involving aspects within the definition of medicinal chemistry related to the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships. Novel strategies and methodologies with relevant application to chemical biology and medicinal chemistry are also welcome.
Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details covering all aspects of small molecules as drug candidates e.g. drug discovery and design, combinatorial chemistry, structure-property correlations, molecular modelling and bioinformatics. Short communications are also accepted; therefore, there is no restriction on the length of a paper.
Keywords
- New synthetic routes for drug candidates
- Lead discovery and optimization methods; structure–activity relationships and QSAR
- Structure-based drug design, molecular modelling, docking studies and crystal structure analysis
- Identification and validation of novel drug targets, and high-throughput screening
- Virtual screening, database mining, and machine learning in drug discovery
- Role of ADMET in drug discovery
- Chemical biology and chemical probes
Editorial Board
Topical Advisory Panel
Special Issues
Following special issues within this section are currently open for submissions:
- Inflammation and Brain Diseases (Deadline: 15 June 2023)
- Selected Papers from the 8th International Electronic Conference on Medicinal Chemistry (ECMC2022) (Deadline: 15 June 2023)
- Advances in Acetylcholinesterase and Butyrylcholinesterase Inhibitors (Deadline: 15 June 2023)
- Design of Small Molecules to Target Metastatic Cancer Cells (Deadline: 30 June 2023)
- Novel Therapeutic Targets and Drug Candidates for the Treatment of Eye Diseases (Deadline: 30 June 2023)
- State of the Art of Medicinal Chemistry in Portugal (Deadline: 30 June 2023)
- Novel Imaging Probes: From Design to Applications (Deadline: 30 June 2023)
- Artificial Intelligence Applied to Medicinal Chemistry and Structural Biology (Deadline: 30 June 2023)
- Computational Methods in the Design of Anticancer Drugs (Deadline: 30 June 2023)
- Novel Therapies for the Treatment of Metastatic Prostate Cancer (Deadline: 5 July 2023)
- Hybrid Quantum–Classical (QM/MM) and Classical (MM) Molecular Dynamics (MD) Approaches in Pharmaceutical Research (Deadline: 15 July 2023)
- Drug Candidates for the Treatment of Multiple Myeloma (Deadline: 15 July 2023)
- Medicinal Chemistry and Pharmacological Activities of Heparin and Related Drugs (Deadline: 19 July 2023)
- Nucleic Acids in Medicinal Chemistry (Deadline: 26 July 2023)
- Novel Insights into Tuberculosis Research and Drug Discovery (Deadline: 31 July 2023)
- Drug Discovery of Antiprotozoal Agents (Deadline: 31 July 2023)
- Drug Candidates for the Prevention and Treatment of Cardiovascular Diseases in Patients with Diabetes Mellitus (Deadline: 31 July 2023)
- G‐quadruplex Ligands: Recent Advances (Deadline: 15 August 2023)
- Therapeutic Potential of Molecular Hydrogen (Deadline: 30 August 2023)
- Green Chemistry in Drug Synthesis (Deadline: 31 August 2023)
- Targeting p53 by Small Molecules: Application in Oncology (Deadline: 31 August 2023)
- Pyrimidine and Purine Derivatives in Medicinal Chemistry (Deadline: 31 August 2023)
- Current Advances, Applications and Future Development of Transition Metal Complexes (Deadline: 4 September 2023)
- Machine Learning Methods for Medicinal Chemistry (Deadline: 10 September 2023)
- Recent Developments of Chalcones and their Derivatives in Medicinal Chemistry (Deadline: 15 September 2023)
- Small Molecules Targeting Viral Polymerases (Deadline: 20 September 2023)
- Triazole and Derivatives in Medicinal Chemistry (Deadline: 28 September 2023)
- Antiparasitics 2023 (Deadline: 30 September 2023)
- Enzyme Inhibitors: Potential Therapeutic Approaches (Deadline: 30 September 2023)
- Methyl-Containing Pharmaceuticals (Deadline: 30 September 2023)
- Recent Advances in Nuclear Factor Kappa-B (NF-kB) Inhibitors for Cancer Therapy (Deadline: 30 September 2023)
- Hit to Lead Design of New Anti-Infective Drugs (Deadline: 30 September 2023)
- Design, Synthesis and Biological Evaluation with Potential Anti-inflammatory Activity (Deadline: 30 September 2023)
- Amyloidosis: Structure-Based Therapeutic Development and Prevention (Deadline: 30 September 2023)
- Novel Applications of Metabolomics in Drug Discovery (Deadline: 30 September 2023)
- Advances in HDAC Inhibitors (Deadline: 30 September 2023)
- Drug Candidates for the Treatment of Immune Disease 2023 (Deadline: 30 September 2023)
- GPCRs: Ligands and Beyond 2023 (Deadline: 30 September 2023)
- Multidrug Resistance in Bacteria and New Therapeutic Options (Deadline: 30 September 2023)
- Antioxidants in the Processes of Retarding Ageing (Deadline: 1 October 2023)
- Drug Insights: Vitamin D and Its Analogs 2023 (Deadline: 10 October 2023)
- Drug Candidate for the Treatment of Glioblastoma (Deadline: 13 October 2023)
- Molecular Systems for the Delivery of Drugs and Contrast Agents (Deadline: 15 October 2023)
- Novel Heterocyclic Compounds for Drug Discovery (Deadline: 26 October 2023)
- Topoisomerases as Targets for Novel Drug Discovery (Deadline: 30 October 2023)
- The Role of Molecular Docking in the Design of Targeted Therapeutic Entities and Nanomaterials (Deadline: 30 October 2023)
- Targeting the Adenosinergic Axis in Cancer Therapy (Deadline: 30 October 2023)
- Structural and Computational-Driven Molecule Design in Drug Discovery (Deadline: 30 October 2023)
- Boron in Medicinal Chemistry: From Synthesis to Therapeutic Applications (Deadline: 31 October 2023)
- Immune-Related Adverse Effects of Checkpoint Inhibitors in Cancer Patients (Deadline: 31 October 2023)
- Zebrafish as a Powerful Tool for Drug Discovery 2023 (Deadline: 31 October 2023)
- Feature Reviews in Medicinal Chemistry (Deadline: 31 October 2023)
- Antibiotic Resistance in Gram-Negative Bacteria: The Threat from the Pink Corner (Deadline: 31 October 2023)
- Pyrazole and Thiazole Derivatives in Medicinal Chemistry (Deadline: 31 October 2023)
- Discovery and Development of New Antimycobacterial Agents (Deadline: 31 October 2023)
- Emerging Therapeutic Candidates for Stroke Treatment (Deadline: 10 November 2023)
- The Current Drug Discovery Landscape for Chagas Disease, HAT and Leishmaniasis: Target Validation and Chemotherapy (Deadline: 15 November 2023)
- Chirality: The Important Factor for Drug Discovery and Development (Deadline: 15 November 2023)
- Medicinal Chemistry of Indole and Quinoline Derivatives: Trends, and Future Directions as Therapeutic Drugs (Deadline: 22 November 2023)
- 20th Anniversary of Pharmaceuticals—Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry (Deadline: 30 November 2023)
- Pharmacotherapy of Dyslipidemias (Deadline: 30 November 2023)
- Prodrugs: Design and Development (Deadline: 30 November 2023)
- Kinase Inhibitors in Targeted Cancer Therapy (Deadline: 30 November 2023)
- New Perspectives on Chemoinformatics and Drug Design (Deadline: 30 November 2023)
- Discovery of Glucosidase Inhibitors and Other Targets as Potential Antidiabetic Agents (Deadline: 30 November 2023)
- Novel Candidates for the Drug Treatment of Alzheimer’s Disease (Deadline: 30 November 2023)
- Enzyme Inhibitors: Recent Advances in the Anticancer Research (Deadline: 30 November 2023)
- Amyloid Beta: New Rational Structure-Based Therapeutic Development (Deadline: 15 December 2023)
- Histamine Receptor Ligands in Medicinal Chemistry (Deadline: 15 December 2023)
- The 20th Anniversary of Pharmaceuticals—Advances in Medicinal Chemistry (Deadline: 20 December 2023)
- Recent Advances and Future Approaches in Preventive and Therapeutic Effects of Vanadium Complexes (Deadline: 29 December 2023)
- Click Reactions in Medicinal Chemistry II (Deadline: 29 December 2023)
- Mass Spectrometry-Based Lipidomics in Drugs Discovery (Deadline: 31 December 2023)
- Synthesis of Mimetics of Natural Compounds in Drug Development (Deadline: 31 December 2023)
- Heterocyclic Compounds in Medicinal Chemistry (Deadline: 31 December 2023)
- Computer-Aided Molecular Modeling and Simulation in Drug Design (Deadline: 31 December 2023)
- Alzheimer’s Disease: Small-Molecule Modulators of Novel Therapeutic Pathways (Deadline: 31 December 2023)
- Structure and Ligand Based Drug Design (Deadline: 31 December 2023)
- Application of 2D and 3D-QSAR Models in Drug Design (Deadline: 31 December 2023)
- Recent Efforts in Drug Discovery and Development for the Treatment of Parasitic Infections (Deadline: 31 December 2023)
- Sex Differences in Pharmaceutical Practice (Deadline: 31 December 2023)
- Nitrogen Containing Scaffolds in Medicinal Chemistry 2023 (Deadline: 29 February 2024)
- The 20th Anniversary of Pharmaceuticals—Metal-Based Drugs for Cancer Treatment, Antibacterial and Antiviral Applications (Deadline: 29 February 2024)
- Drug Development Targeting the Metabolic Nuclear Receptors: Recent Advances (Deadline: 1 June 2024)
- The 20th Anniversary of Pharmaceuticals—Heterocyclic Compounds and Their Application in Therapy (Deadline: 31 August 2024)
Topical Collection
Following topical collection within this section is currently open for submissions:
