Medicinal Chemistry
A section of Pharmaceuticals (ISSN 1424-8247).
Section Information
The section of Medicinal Chemistry welcomes manuscripts involving aspects within the definition of medicinal chemistry related to the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships. Novel strategies and methodologies with relevant application to chemical biology and medicinal chemistry are also welcome.
Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details covering all aspects of small molecules as drug candidates e.g. drug discovery and design, combinatorial chemistry, structure-property correlations, molecular modelling and bioinformatics. Short communications are also accepted; therefore, there is no restriction on the length of a paper. Download Section Flyer
Keywords
- New synthetic routes for drug candidates
- Lead discovery and optimization methods; structure–activity relationships and QSAR
- Structure-based drug design, molecular modelling, docking studies and crystal structure analysis
- Identification and validation of novel drug targets, and high-throughput screening
- Virtual screening, database mining, and machine learning in drug discovery
- Role of ADMET in drug discovery
- Chemical biology and chemical probes
Editorial Board
Topical Advisory Panel
Special Issues
Following special issues within this section are currently open for submissions:
- Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells (Deadline: 13 December 2024)
- Last Trends of Antileishmanial Drug Discovery and Development (Deadline: 14 December 2024)
- Small Molecules as Antimicrobials 2024 (Deadline: 15 December 2024)
- Application of 2D and 3D-QSAR Models in Drug Design (Deadline: 24 December 2024)
- 20th Anniversary of Pharmaceuticals—Recent Advances in Metallodrug Design and Application (Deadline: 25 December 2024)
- Recent Advancements in the Development of Antiprotozoal Agents (Deadline: 25 December 2024)
- Mitochondrial Protease ClpP in Antitumor-Drug Development: Recent Advances and Challenges (Deadline: 25 December 2024)
- Histamine Receptor Ligands in Medicinal Chemistry (Deadline: 25 December 2024)
- Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications (Deadline: 25 December 2024)
- Chirality: The Important Factor for Drug Discovery and Development (Deadline: 25 December 2024)
- Computational Predictions of Molecules with Potential Therapeutic Effects (Deadline: 30 December 2024)
- Discovery and Development of Novel Analgesics (Deadline: 31 December 2024)
- Drug Discovery of Antiprotozoal Agents 2024 (Deadline: 31 December 2024)
- Recent Advances in Psychiatric Medications (Deadline: 31 December 2024)
- Structural and Computationally Driven Molecule Design in Drug Discovery: 2nd Edition (Deadline: 31 December 2024)
- Computational Methods in Drug Development (Deadline: 31 December 2024)
- Sex Differences in Pharmaceutical Practice (Deadline: 31 December 2024)
- Therapeutic Potential of Aldehyde Dehydrogenases (Deadline: 31 December 2024)
- Chemoinformatics and Drug Design, 2nd Edition (Deadline: 20 January 2025)
- Classical and Quantum Molecular Simulations in Drug Design (Deadline: 20 January 2025)
- Emerging Trends in Liquid Chromatography and Mass Spectrometry-Based Analyses of Pharmaceuticals (Deadline: 20 January 2025)
- 20th Anniversary of Pharmaceuticals—Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry (Deadline: 24 January 2025)
- Antioxidants in the Processes of Retarding Ageing (Deadline: 24 January 2025)
- Advanced Strategies in Drug Design and Development of Small Molecules as Therapeutic Agents (Deadline: 25 January 2025)
- Modern Approach to Neuroendocrine Neoplasms Diagnosis and Treatment (Deadline: 25 January 2025)
- Recent Advances in the Discovery and Development of Drugs for Civilization Diseases (Deadline: 25 January 2025)
- Natural Products-Assisted Organic Synthesis in Medicinal Chemistry (Deadline: 31 January 2025)
- Novel Anti-proliferative Agents, 2nd Edition (Deadline: 31 January 2025)
- Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development (Deadline: 31 January 2025)
- Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets (Deadline: 15 February 2025)
- Design, Synthesis and Development of Novel Antiviral Agents (Deadline: 20 February 2025)
- Advances in Peptide Chemistry and Medicinal Application (Deadline: 20 February 2025)
- Neurodegenerative Disorders: Computer – Aided Drug Design, Еxperimental Аpproaches and Mechanisms (Deadline: 20 February 2025)
- New Pharmaceuticals in Diagnosis, Prognosis and Treatment of Myelofibrosis and Myeloproliferative Neoplasms (Deadline: 20 February 2025)
- Nano-Strategies in Fighting Cancer (Deadline: 20 February 2025)
- New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments (Deadline: 20 February 2025)
- Indole Derivatives as Targeted Melatonin and Serotonin Receptor Ligands (Deadline: 23 February 2025)
- Drug Discovery and Development Targeting NMDA Receptors (Deadline: 24 February 2025)
- Click Reactions in Medicinal Chemistry II (Deadline: 25 February 2025)
- Boron in Medicinal Chemistry: From Synthesis to Therapeutic Applications (Deadline: 25 February 2025)
- Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition (Deadline: 25 February 2025)
- Small Molecule Drug Discovery: Driven by In-Silico Techniques (Deadline: 25 February 2025)
- The 20th Anniversary of Pharmaceuticals—New Insights in Medicinal Chemistry of Nitrogen-Containing Compounds (Deadline: 25 February 2025)
- Flavonoids in Medicinal Chemistry: Trends and Future Directions (Deadline: 25 February 2025)
- Advances and Future Trends in Development of Novel Antifungals and Antifungal Therapy (Deadline: 26 February 2025)
- Antibiotic Resistance in Gram-Negative Bacteria: The Threat From the Pink Corner, 2nd Edition (Deadline: 28 February 2025)
- Design, Synthesis and Biological Evaluation with Potential Anti-inflammatory Activity (Deadline: 28 February 2025)
- Recent Advances in the Synthesis and Evaluation of Beta-Lactamase Inhibitors (Deadline: 10 March 2025)
- Hybrid Drugs: Design and Applications 2024 (Deadline: 20 March 2025)
- Triazole and Derivatives in Medicinal Chemistry, 2nd Edition (Deadline: 20 March 2025)
- Immunogenomics for Drug Discovery in Leukemia (Deadline: 20 March 2025)
- Drug Candidates for the Prevention and Treatment of Cardiovascular Diseases in Patients with Diabetes Mellitus, 2nd Edition (Deadline: 25 March 2025)
- Prodrugs: Design and Development (Deadline: 25 March 2025)
- Current Advances in Therapeutic Potential of Sigma Receptor Ligands (Deadline: 25 March 2025)
- Design, Synthesis, Evaluation and Biopharmaceutical Uses of Imatinib, Nilotinib and Their Analogues (Deadline: 25 March 2025)
- Antiviral Agents, 2024 (Deadline: 25 March 2025)
- The Role of Molecular Docking in the Design of Targeted Therapeutic Entities and Nanomaterials (Deadline: 25 March 2025)
- Antimalarial Drug Candidates (Deadline: 25 March 2025)
- The 20th Anniversary of Pharmaceuticals—Advances in Medicinal Chemistry (Deadline: 28 March 2025)
- Molecular Systems for the Delivery of Drugs and Contrast Agents (Deadline: 28 March 2025)
- Drug Discovery and Development for Parasitic Diseases (Deadline: 31 March 2025)
- Synthesis and Biological Activity of Metal Complexes (Deadline: 31 March 2025)
- Integrating Machine Learning (ML) into Medicinal Chemistry and Cheminformatics (Deadline: 31 March 2025)
- Sulfur-Containing Scaffolds in Medicinal Chemistry (Deadline: 31 March 2025)
- Green Synthesis and Biological Evaluation of Quinazolinone-Based Compounds (Deadline: 31 March 2025)
- Development of Copper-Based Drugs: Synthesis, Characterisation and Biological Activity (Deadline: 31 March 2025)
- Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress (Deadline: 20 April 2025)
- Medicinal Potential of Cannabidiol and New Structural Analogs (Deadline: 23 April 2025)
- Pyrazole and Thiazole Derivatives in Medicinal Chemistry (Deadline: 25 April 2025)
- Pharmacotherapy of Dyslipidemias, 2nd Edition (Deadline: 25 April 2025)
- Targeting The Nuclear Factor Kappa-B (NF-κB) Pathway for Drug Discovery (Deadline: 25 April 2025)
- Synthetic Inhibitors of Nucleoside Monophosphate-Kinases (Deadline: 25 April 2025)
- Design and Synthesis of Small Molecule Kinase Inhibitors (Deadline: 25 April 2025)
- The 20th Anniversary of Pharmaceuticals—Heterocyclic Compounds and Their Application in Therapy (Deadline: 30 April 2025)
- Chalcones: Structure, Function, and Applications (Deadline: 30 April 2025)
- β-Lactams and β-Lactamase Inhibitors: Recent Advances (Deadline: 30 April 2025)
- Biosimilars Development Strategies (Deadline: 20 May 2025)
- Design, Synthesis and Biological Assessment of Amphiphiles (Deadline: 20 May 2025)
- Common Medications Used in Anesthesia (Deadline: 25 May 2025)
- Current Trends to Discover New Drugs Targeting Protease Inhibition (Deadline: 25 May 2025)
- Multitargeted Compounds: A Promising Approach in Medicinal Chemistry (Deadline: 25 May 2025)
- Amyloid Composition and Structure-Based Development of Therapeutic and Diagnostic Agents (Deadline: 25 May 2025)
- Targeting Opioid Receptors for Innovative Therapies: Present and Emerging Concepts in Opioid Cure (Deadline: 25 May 2025)
- Novel Drug Targets and Drug Candidates for Neglected Tropical Diseases (Deadline: 30 May 2025)
- Current Advances, Applications and Future Development of Transition Metal Complexes (Deadline: 30 May 2025)
- Pharmaceuticals 2024—Recent Advances in Pharmaceutical Sciences Towards a Healthy Life (Deadline: 31 May 2025)
- Targeting Molecular Pathways in Hematological Malignancies and Beyond: Small Molecule Inhibitors and PROTACs (Deadline: 31 May 2025)
- In Silico and In Vitro Screening of Small Molecule Inhibitors (Deadline: 10 June 2025)
- Topoisomerases as Targets for Novel Drug Discovery (Deadline: 20 June 2025)
- Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation (Deadline: 25 June 2025)
- Dysregulation of cAMP and cPIP Synthesis: Implications for Disease and Advances in Therapeutic Development (Deadline: 25 June 2025)
- Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology (Deadline: 30 June 2025)
- A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases (Deadline: 30 June 2025)
- Integrating Medicinal Chemistry and Mass Spectrometry: New Opportunities and Challenges (Deadline: 30 June 2025)
- Novel Imidazole Derivatives in Medicinal Chemistry (Deadline: 25 July 2025)
- Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition (Deadline: 25 September 2025)
- Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology (Deadline: 22 October 2025)
Topical Collections
Following topical collections within this section are currently open for submissions:
