Special Issue "Innate Immune Sensing of Viruses and Viral Evasion"
Deadline for manuscript submissions: 15 June 2020.
Interests: virus–host interaction; innate immune responses
Interests: restriction factors; cytidine deaminases; gene evolution; animal models; non-primate lentiviruses; foamy retroviruses; uncoating
Innate immunity represents the first line of defense against viruses. The success of the immediate response relies on the recognition of invariant features encoded by viruses termed pathogen-associated molecular patterns (PAMPs) by specialized sensors called pattern recognition receptors (PRRs). The consequence of this surveillance network and the downstream pathway activation is the secretion of cytokines, type I interferons (IFNs), and the expression of interferon-stimulated genes. Viruses have evolved multiple ways to dampen the host IFN response by interfering, disrupting, or evading specific host regulators, both up- and downstream of IFN induction. Recent discoveries have shown that the sensing pathways are highly regulated by post-translational modifications and co-regulating proteins. Moreover, emerging evidence indicates that there exists crosstalk between the sensing pathways. Furthermore, unexpected pathways seem to play important roles in detecting and responding to viral infections. This Special Issue will cover recent discoveries in the regulation of innate immune pathways during viral infections, novel mechanisms of exploitation, or the manipulation of regulators of the pathways by viruses and novel cellular network complexes that play a role in sensing viruses.
Dr. Renate König
Dr. Carsten Münk
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- innate sensing
- viral counteraction
- pattern-recognition receptor complex
- regulation of innate pathways
- innate immune response
- virus–host interaction