To improve the reference potential stability of on-chip amperometric sensors, we propose a novel integrated Ag/AgCl reference electrode structure. This structure can refresh the saturated potassium chloride filling solution surrounding the Ag/AgCl el...
This study proposes a novel anti-resonant fiber sensing structure based on a composite “egg-shaped” configuration with surface plasmon resonance (SPR) effect. By designing a novel anti-resonant structure consisting of a semicircle and a s...
Photoacoustic (PA) spectroscopy techniques enable the detection of trace substances. However, lower threshold detection requirements are increasingly common in practical applications. Thus, we propose a systematic geometry topology optimization appro...
Cancer is one of the leading causes of mortality worldwide. In recent years, various kinds of biosensors based on optical fiber have been proposed for detection of cancer cells due to their advantages of accurate diagnosis, small size, low cost, and...
Procedures for the direct regeneration of entire plants from a shoot and root protoplasts of Arabidopsis thaliana have been optimized. The culture media for protoplast donor-plant cultivation and protoplast culture have been adjusted for optimal plan...
The controller area network (CAN) bus has become one of the most commonly used protocols in automotive networks. Some potential attackers inject malicious data packets into the CAN bus through external interfaces for implementing illegal operations (...
A carbon dioxide (CO2) gas sensor based on non-dispersive infrared (NDIR) technology has been developed and is suitable for use in portable devices for high-precision CO2 detection. The NDIR gas sensor comprises a MEMS infrared emitter, a MEMS thermo...
To realize the design of a medical sensor with excellent comprehensive performance indexes, herein, a plasma concentration sensing model satisfying the Parity-Time (PT) symmetric condition is proposed. In this paper, the transfer matrix method was us...
Diagnostic blood cell counting is of limited use in monitoring a minimal number of leukaemia cells, warranting further research to develop more sensitive and reliable techniques to identify leukaemia cells in circulation. In this work, a hemin–...
A label-free, sensitive, miniaturized sensing device was developed for detecting living cells in their flow stream. The outstanding performance of this biosensor in distinguishing living cells in cell suspension was achieved by integrating microstrip...
In this study, a tobramycin concentration-dependent whole-cell micro-biosensor (tob-HHAz) was constructed by fusing a tobramycin aptamer with a hammerhead ribozyme (HHR) from Schistosoma mansoni. The biosensor was obtained by integrating all the modu...
The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical, electrochemica...
Affinity biosensors of interdigitated electrodes have been widely used in cell detection. This research presents a mass-producible and disposable three-dimensional (3D) structure capacitive sensor based on the integrated circuit package lead frames f...
Light trapping micro-nano structures have been widely used to optimize the function of solar cell devices, especially microlens arrays (MLAs). In this article, we first prepared composite films by using sol-gel technology and the spin coating method,...
Synthetic nerve conduits have emerged as an alternative to guide axonal regeneration in peripheral nerve gap injuries. Migration of Schwann cells (SC) from nerve stumps has been demonstrated as one essential factor for nerve regeneration in nerve def...
Porcine diarrheagenic Escherichia coli strains exhibit heterogeneous virulence profiles involving multiple factors, complicating broad-spectrum serological diagnosis. Here, we designed a multiepitope fusion antigen, MEAET, containing predicted B-cell...
The precise isolation of circulating tumor cells (CTCs) from blood samples is a potent tool for cancer diagnosis and clinical prognosis. However, CTCs are present in extremely low quantities in the bloodstream, posing a significant challenge to their...
This article presents the distinctive butyrylcholinesterase (BChE) fluorescent probe P5, designed via a targeting-site method. This method was proposed to enhance the affinity of the probe for BChE by targeting the peripheral anionic site (PAS) of BC...
Cell detection in microscopy images can provide useful clinical information. Most methods based on deep learning for cell detection are fully supervised. Without enough labelled samples, the accuracy of these methods would drop rapidly. To handle lim...
Cancer cells often have dysregulated metabolism, which is largely characterized by the Warburg effect—an increase in glycolytic activity at the expense of oxidative phosphorylation—and increased glutamine utilization. Modern metabolomics tools offer...
Most publicly accessible single-cell Hi-C data are sparse and cannot reach a higher resolution. Therefore, learning latent representations (bin-specific embeddings) of sparse single-cell Hi-C matrices would provide us with a novel way of mining valua...
This study presents an innovative technique for the in situ analysis of aquatic biochemical elements detected through wet chemical processes. A new compact in situ phosphate analyzer based on sequential injection analysis, liquid waveguide capillary...
The L1 cell adhesion molecule (L1CAM) plays important roles in the development and plasticity of the nervous system as well as in tumor formation, progression, and metastasis. New ligands are necessary tools for biomedical research and the detection...
Hepatitis E virus (HEV) causes acute hepatitis in humans, which can progress to chronicity in immunosuppressed individuals. Almost all reported HEV infections are caused by Paslahepevirus balayani genotypes 1–4. The structural ORF2 protein...
Within the Shuo Huang Railway Company (Suning, China ) the long-term evolution for railways (LTE-R) network carries core wireless communication services for trains. The communication performance of LTE-R cells directly affects the operational safety...
In recent years, efforts in the development of lab-on-a-chip (LoC) devices for point-of-care (PoC) applications have increased to bring affordable, portable, and sensitive diagnostics to the patients’ bedside. To reach this goal, research has shifted...
Because of their intrinsic characteristics, telomeres are genomic loci that pose significant problems during the replication of the genome. In particular, it has been observed that telomeres that are maintained in cancer cells by the alternative mech...
Extracellular vesicles (EVs), which are small membrane vesicles secreted from cells into bodily fluids, are promising candidates as biomarkers for various diseases. We propose a simple, highly sensitive method for detecting EVs using a microchip. The...
Bone diseases such as osteoporosis, delayed or impaired bone healing, and osteoarthritis still represent a social, financial, and personal burden for affected patients and society. Fully humanized in vitro 3D models of cancellous bone tissue are need...
The number of infectious spots or pathological structures recorded on dermatological images is a tool to aid in the diagnosis and monitoring of disease progression. Dermatological images for the detection and monitoring of the evolution of acne infec...
Partial discharge (PD) detection effectively identifies insulation defects in power equipment. Radio frequency (RF) methods for PD detection offer promising advantages due to their non-invasive measurement capability and ability to locate discharge s...
The sealing technology of proton exchange membrane fuel cells (PEMFCs) is a critical factor in ensuring their performance, impacting driving safety and range efficiency. To guarantee the safe operation of PEMFCs in complex environments, it is essenti...
The echoes collected by wideband radar systems provide abundant information on target scatterers, which is beneficial to target detection, classification, and recognition. However, as the radar range resolution increases, range cell migration (RCM) d...
This study presents the design, development, and implementation of a novel modular three-axis cutting force measurement system for turning lathes. The system employs miniature load cells in an innovative two-channel slotted dynamometer structure, off...
In this work, a quasi-D-shaped photonic crystal fiber (PCF)-based surface plasmon resonance (SPR) biosensor is proposed and numerically investigated using the finite element method (FEM) implemented in COMSOL Multiphysics version 6.2 for the detectio...
Traditional medical techniques are constrained by macro-scale detection methods, making it difficult to capture dynamic changes at the cellular level. The miniaturization and high-throughput capabilities of integrated circuit technology enable precis...
Wastewater contains a significant quantity of organic matter, continuously causing environmental pollution. Timely and accurate detection of organic content in water can facilitate improved wastewater treatment and better protect the environment. Mic...
Cancer metastasis is one of the primary reasons for cancer-related fatalities. Despite the achievements of cancer research with microfluidic platforms, understanding the interplay of multiple factors when it comes to cancer cells is still a great cha...
In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving si...
Polydimethylsiloxane (PDMS) is a polymer widely used for fabrication and prototyping of microfluidic chips. The porous matrix structure of PDMS allows small hydrophobic molecules including some fluorescent dyes to be readily absorbed to PDMS and resu...
Microbial community composition, function, and viability are important for biofilm-based sewage treatment technologies. Most studies of microbial communities mainly rely on the total deoxyribonucleic acid (DNA) extracted from the biofilm. However, nu...
Circulating tumor cells (CTCs) that enter the bloodstream play an important role in the formation of metastases. The prognostic significance of CTCs as biomarkers obtained from liquid biopsies is intensively investigated and requires accurate methods...
Background: Primary cells derived from connective tissues contain mesenchymal stem/stromal cell (MSC)–like progenitors with chondrogenic potential relevant for cartilage repair. However, donor- and tissue-specific variability and the lack of ro...
Single planar fuel cell elements consisting of metallic interconnectors that are bonded and sealed by a thin glass solder layer form the core of a solid oxide fuel cell. For reliable operation, the bonding layer has to adhere well and must be without...
Silicon photomultipliers (SiPMs) are single-photon sensitive solid-state detectors that are becoming popular for several applications, thanks to massive performance improvements over the last years. Starting as a replacement for the photomultiplier t...
Cell observation is crucial in life science research, and advancements in microscopy are essential for deciphering biological phenomena. These technological developments have significantly enhanced our understanding of cellular mechanisms and process...
In this article, a terahertz metamaterial biaxial strain pressure sensor structure is proposed, which can address the problems of the low sensitivity, the narrow pressure measurement range, and the uniaxial-only detection of existing terahertz pressu...
MicroRNA-155-3p (miR-155-3p) is an important biomarker in various pathological conditions, including cancer, making the development of sensitive and specific detection methods crucial. Here, we present a molecular beacon (MB-G4) that underwent a conf...
To meet the demand for online monitoring of acetylene (C2H2) in transformer oil, a high-sensitivity detection system based on photoacoustic spectroscopy (PAS) is presented. The system integrates custom-designed modules for signal acquisition, phase-s...
Cell adhesion molecules (CAMs) are key regulators of tissue structural integrity and functional coordination, yet their specific role in the adaptation of yak lung tissue to high-altitude hypoxia remains unelucidated. Thus, we employed transcriptomic...
of 6