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Open AccessFeature PaperArticle

Differential Effects of Coating Materials on Viability and Migration of Schwann Cells

1
Center for Plastic-, Hand- and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany
2
Translational Molecular Pathology, University of Texas MD, Unit 951, 7435 Fannin Street, Houston, TX 77054, USA
3
Department of Traumatology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: C. Edi Tanase
Materials 2016, 9(3), 150; https://doi.org/10.3390/ma9030150
Received: 20 December 2015 / Revised: 19 February 2016 / Accepted: 24 February 2016 / Published: 3 March 2016
(This article belongs to the Special Issue Regenerative Materials)
Synthetic nerve conduits have emerged as an alternative to guide axonal regeneration in peripheral nerve gap injuries. Migration of Schwann cells (SC) from nerve stumps has been demonstrated as one essential factor for nerve regeneration in nerve defects. In this experiment, SC viability and migration were investigated for various materials to determine the optimal conditions for nerve regeneration. Cell viability and SC migration assays were conducted for collagen I, laminin, fibronectin, lysine and ornithine. The highest values for cell viability were detected for collagen I, whereas fibronectin was most stimulatory for SC migration. At this time, clinically approved conduits are based on single-material structures. In contrast, the results of this experiment suggest that material compounds such as collagen I in conjunction with fibronectin should be considered for optimal nerve healing. View Full-Text
Keywords: synthetic nerve conduits; nerve gaps; nerve defect injuries; extracellular matrix (ECM); Schwann cell migration; peripheral nerve regeneration synthetic nerve conduits; nerve gaps; nerve defect injuries; extracellular matrix (ECM); Schwann cell migration; peripheral nerve regeneration
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MDPI and ACS Style

Klein, S.; Prantl, L.; Vykoukal, J.; Loibl, M.; Felthaus, O. Differential Effects of Coating Materials on Viability and Migration of Schwann Cells. Materials 2016, 9, 150.

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