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Design, Preparation and Performance Study of On-Chip Flow-Through Amperometric Sensors with an Integrated Ag/AgCl Reference Electrode

School of Information Engineering and Science, Shenyang University of Technology, Shenyang 110870, China
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Author to whom correspondence should be addressed.
Micromachines 2018, 9(3), 114; https://doi.org/10.3390/mi9030114
Received: 23 January 2018 / Revised: 27 February 2018 / Accepted: 28 February 2018 / Published: 7 March 2018
(This article belongs to the Special Issue Microfluidic Sensors)
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Abstract

To improve the reference potential stability of on-chip amperometric sensors, we propose a novel integrated Ag/AgCl reference electrode structure. This structure can refresh the saturated potassium chloride filling solution surrounding the Ag/AgCl electrode. We then designed a flow-through amperometric sensor and a multilayer microfluidic chip based on the integrated reference electrode. In order to improve the detection signal strength of the flow-through sensor, a numerical simulation model was established. The simulation results showed that a combination of (1) using a step-type detection cell structure that maintains micro-channel width while reducing micro-channel height, and (2) controlling the sample flow rate to limit the mass transfer of the sensor surface effectively, improves the detection signal strength. The step-type detection cell structure had dimensions of 200 μm × 200 μm × 100 μm (length × width × height), and the electroosmotic flow driving voltage was 120 V/cm. Finally, successful trace detection of Mg2+ and Pb2+ in the water was achieved using the amperometric sensor and microfluidic chip: detection limits were 5 μmol/L and 84 μmol/L. The preparation of an on-chip flow-through amperometric sensor with an integrated Ag/AgCl reference electrode will facilitate improved portability of microfluidic detection technology. View Full-Text
Keywords: microfluidic chip; amperometric detection; integrated Ag/AgCl reference electrode; detection cell structure optimization; mass transfer microfluidic chip; amperometric detection; integrated Ag/AgCl reference electrode; detection cell structure optimization; mass transfer
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Zhang, H.; Chuai, R.; Li, X.; Zhang, B. Design, Preparation and Performance Study of On-Chip Flow-Through Amperometric Sensors with an Integrated Ag/AgCl Reference Electrode. Micromachines 2018, 9, 114.

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