Autonomous driving requires robust and highly accurate perception technologies. Various deep learning algorithms based on only image processing satisfy this requirement, but few such algorithms are based on LiDAR. However, images are only one part of...
Information is the currency of life, but the origin of prebiotic information remains a mystery. We propose transitional pathways from the cosmic building blocks of life to the complex prebiotic organic chemistry that led to the origin of information...
Despite the recent advances in this field, there are limited methods for translating organoid-based study results to clinical response. The goal of this study was to develop a pharmacokinetic/pharmacodynamic (PK/PD) model to facilitate the translatio...
Fibrinogen is an abundant blood plasma protein that, inter alia, participates in blood coagulation. It polymerizes to form a fibrin clot that is among the major components of the thrombus. Fibrinogen reactions with various reactive metabolites may in...
The treatment of respiratory tract infections is threatened by the emergence of bacterial resistance. Immunomodulatory drugs, which enhance airway innate immune defenses, may improve therapeutic outcome. In this concept paper, we aim to highlight the...
The effects of accelerated crucible rotation technique (ACRT) and dynamic translation on liquid phase diffusion (LPD) growth of SixGe1−x single crystals have been separately investigated numerically in earlier works and were found to have a very posi...
This systematic review synthesises computational models of language deficits in bilingual aphasia, focusing on code-switching and translation. Per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this study...
Traumatic brain injury (TBI) is increasingly recognized as a relevant initiating factor in tau-related neurodegenerative processes, yet the quantitative link between a controlled mechanical insult and the long-term spatiotemporal evolution of tau pat...
Understanding the aetiology of the diverse recovery patterns in bilingual aphasia is a theoretical challenge with implications for treatment. Loss of control over intact language networks provides a parsimonious starting point that can be tested usin...
Neuropsychiatric diseases are characterized by complex molecular underpinnings that remain challenging to fully elucidate. Molecular dynamics (MD) simulations have emerged as a powerful computational tool, providing a crucial bridge between static ge...
Animal models are essential for elucidating human disease mechanisms and advancing translational research. Here, we used a well-established rat tail-suspension model to investigate the pathophysiological changes associated with simulated microgravity...
Background/Objectives: Patient safety depends on healthcare systems’ ability to learn from clinical experience and translate insights into system-level improvement. Significant Event Audit (SEA) is well established but may only partly capture t...
Interaction of proteins with charged macromolecules is involved in many processes in cells. Firstly, there are many naturally occurred charged polymers such as DNA and RNA, polyphosphates, sulfated glycosaminoglycans, etc., as well as pronouncedly ch...
Deamidation of asparagine (Asn) residues is a nonenzymatic post-translational modification of proteins. Asn deamidation is associated with pathogenesis of age-related diseases and hypofunction of monoclonal antibodies. Deamidation rate is known to be...
S-glutathionylation is an oxidative post-translational modification, which is involved in the regulation of many cell signaling pathways. Increasing amounts of studies show that it is crucial in cell homeostasis and deregulated in several pathologies...
The eukaryotic translation initiation factor 4E (eIF4E) family plays a dual role in plants, regulating cap-dependent protein synthesis and mediating susceptibility to viruses in the family Potyviridae. In cowpea (Vigna unguiculata (L.) Walp.), an eco...
DNA polymerase
Background/Objectives: Digital twin technology has attracted growing attention in orthopedics for its potential to support patient-specific modeling, simulation, and data-driven clinical decision-making. However, despite the rapid growth in the liter...
Cancer cells can evade immune surveillance through binding of its transmembrane receptor CD47 to CD172a on myeloid cells. CD47 is recognized as a promising immune checkpoint for cancer immunotherapy inhibiting macrophage phagocytosis. N-terminal post...
Therapeutic monoclonal antibodies (mAbs) have been a promising therapeutic approach for several diseases and a wide variety of mAbs are being evaluated in clinical trials. To accelerate clinical development and improve the probability of success, pha...
Background/Objectives: The diagnosis of syndesmotic instability remains challenging, particularly in quantifying posterior fibular translation. This study aimed to assess the Lateral Tibiofibular Index (LTI), a novel lateral projection–based pa...
This study examines the deformation and failure mechanisms of two reservoir bank landslides: the traction-type Baijiabao landslide and the translational Baishuihe landslide. Based on long-term monitoring data and a hydro-mechanical coupled numerical...
A large and growing body of research implicates aberrant immune response and compositional shifts of the intestinal microbiota in the pathogenesis of many intestinal disorders. The molecular and physical interaction between the host and the microbiot...
Non-stationarity is increasingly recognized as a defining feature of contemporary hydroclimatic regimes, challenging the statistical assumptions that underpin inter-annual discharge deficits analysis and water-resources design. This study investigate...
The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer’s Disease. It has been reported tha...
Infrared image simulation is challenging because it is complex to model. To estimate the corresponding infrared image directly from the visible light image, we propose a three-level refined light-weight generative adversarial network with cascaded gu...
The effect of gene expression burden on engineered cells has motivated the use of “whole-cell models” (WCMs) that use shared cellular resources to predict how unnatural gene expression affects cell growth. A common problem with many WCMs is their ina...
Brain disease has become one of this century’s biggest health challenges, urging the development of novel, more effective treatments. To this end, neuromodulation represents an excellent method to modulate the activity of distinct neuronal regi...
This article presents the velocity and singularity analysis for a five-degree-of-freedom (5-DOF) parallel-serial manipulator. The hybrid structure of the manipulator combines a tripod-like parallel part and a serial part, represented as two carriages...
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in v...
The rate of nucleation of crystals is the subject of extensive research, since it—together with the nucleation time—determines the number of crystals growing; in turn, their number is related to their size. Experimental studies show that,...
Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action that resul...
In the forefront of ophthalmic innovation, biomimetic 3D printing and bioprinting technologies are redefining patient-specific therapeutic strategies. This critical review systematically evaluates their application spectrum, spanning oculoplastic rec...
The paper discusses the relation between the “non-statement view” of the structuralist program in philosophy of science and agent-based simulation and the use of this relation for a deeper understanding of the verification and the validat...
A family of nonparametric tests is developed for testing exponentiality against decreasing mean residual life (DMRL) alternatives using generalized cumulative residual Tsallis entropy (GCRTE). For entropy-order pairs in a theoretically certified regi...
This review provides a comprehensive synthesis of the field’s evolution along two complementary axes, organized as a dual-axis chrono-spatial framework that reimagines how computational methods in medicine can be understood. The longitudinal ax...
We report the application of a recently proposed approach for modeling biological systems using a maximum entropy production rate principle in lieu of having in vivo rate constants. The method is applied in four steps: (1) a new ordinary differential...
The development of separate building performance simulation tools has brought about a significant need for the integration of multi-domain simulations that would enable multiple building performance analyses to be conducted from a single building mod...
A real downburst event that occurred in the city of Genoa, Italy, on 14 August 2018, is simulated using the full-cloud model CM1. The initiation of the thunderstorm cell is triggered through the warm bubble technique, which allows simulating the whol...
Background: Sudden contamination of the pediatric oropharynx by regurgitated material, emesis, or blood is a time-critical airway emergency. Rapid clearance may be required to restore laryngeal visualization and permit ventilation and tracheal intuba...
This paper presents an algorithm to translate building topology in an object-oriented architectural building model (Building Information Modeling, BIM) into an object-oriented physical-based energy performance simulation by using an object-oriented p...
Due to the fact that earthquakes cannot be predicted, earthquake simulation is of great importance. An earthquake simulator is a device that reproduces the seismic waves generated by an earthquake. The aim of this work is to present the design and pr...
In this paper an interoperability solution is proposed, aiming to go from (building) construction models to energy simulation. Moreover, the energy simulation results will feed the KPI’s analysis of a designed building. The proposed solution will be...
The 2019 pandemic had a direct impact on all educational stakeholders. While many teachers and trainers regarded the changes with some scepticism, others embraced the opportunity to integrate technology into their teaching-and-learning methods and re...
For the purpose of improving uniformity and efficiency of microwave heating, moving components are widely used. In this paper, a kind of stretching microwave oven with a conveyor belt is designed. The conveyor belt and the stretching motion of the up...
(1) Background: The kinematic characteristics of disc prosthesis undergoing complex motion are not well understood. Therefore, examining complex motion may provide an improved understanding of the post-operative behavior of spinal implants. (2) Metho...
Binary translation, as an important bridge for application compatibility between different instruction set architectures (ISAs), has attracted much attention in the industry. However, due to hardware resource limitations of the target ISA, the transl...
The efficiency and accuracy of target recognition in synthetic aperture radar (SAR) imagery have seen significant progress lately, stemming from the encouraging advancements of automatic target recognition (ATR) technology based on deep learning. How...
One important issue that affects the performance of neural machine translation is the scale of available parallel data. For low-resource languages, the amount of parallel data is not sufficient, which results in poor translation quality. In this pape...
Virtual simulators of embedded systems and analyses of student surveys regarding their use at the early stage of the process of learning embedded systems, are presented in this article. The questionnaires were prepared in the Polish language, and the...
of 41