Animal Models for Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 19
Special Issue Editor
Special Issue Information
Dear Colleagues,
Animal models remain central to unraveling human disease mechanisms, from gene-editing tools (e.g., CRISPR-Cas9) to humanized rodent models, and promoting advancements in disease biology and therapeutic development. Recent breakthroughs in organoid cultures and AI-driven drug screening have further enhanced our understanding of disease dynamics. Global resource-sharing initiatives (e.g., phenotypic databases, standardized protocols) have accelerated the translation of basic research into clinical applications. Key challenges include physiological disparities between species, the oversimplified modeling of complex diseases, and insufficient reproducibility. Future efforts should prioritize model refinement, standardized experimental workflows, and ethical alternatives. Establishing unified global reporting guidelines and quality evaluation frameworks will be critical to enhancing reliability.
This Special Issue welcomes the submission of original research, reviews, and perspectives that address the following topics: the innovative application of animal model technologies (e.g., gene editing, humanized models); the development of strategies able to bridge preclinical–clinical translation gaps; and the standardization of experimental design and reproducibility practices.
We aim to advance research concerning animal models, enhancing integration between basic science and clinical practice.
Dr. Yuning Song
Guest Editor
Manuscript Submission Information
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Keywords
- animal models
- translational research
- preclinical studies
- biomedical innovation
- reproducibility
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