Thrombosis and Metabolism

Dear Colleagues,

This Special Issue highlights the use of metabolomics in the field of thrombosis. Metabolomics data-analytical approaches are developing with accelerating speed, alongside technical improvements in instrumentation in the field. Thrombosis in the arterial bed leads to its obstruction and subsequent clinical manifestation as an acute atherothrombotic syndrome, where the most catastrophic are acute myocardial infarction and acute stroke. These two entities are the leading cause of mortality and morbidity in high-income countries. That is why research in this area is very important. Deep vein thrombosis (DVT) and pulmonary embolism have high morbidity, reduce quality of life, and can cause death. Only a few biomarkers or genetic risk factors have been identified so far in patients with DVT.

Specific areas for the Special Issue include but are not limited to changes in metabolic pathways, including carbohydrate metabolism, lipid metabolism, and thrombosis-induced amino acid metabolism; metabolomic changes in thrombus onset, growth and termination; analysis of thrombus composition, changes in fibrinogen to fibrin conversion, and fibrin degradation products; metabolomics of microbiome leading to thrombosis; analysis of thrombogenesis steps, markers of oxidative stress, inflammation; lipid analysis using state-of-the-art molecular methods, such as lipidomics and metabolomics, in association with clinical thrombotic syndromes; and thrombosis and metabolomics associated with cancer.

We invite review and viewpoint manuscripts devoted to various aspects within metabolite profiling. We also invite manuscripts with innovative and integrative solutions applicable in the near future. Reports of altered metabolomics pathways related to thrombosis and genetics providing the basis for undersanding the pathological mechanism and new pharmacological targets of thrombosis. The Special Issue is open for submission now, though a proper extension may be granted if you can kindly let us know in advance. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website.

Prof. Dr. Jan E. Dyr
Dr. Martin Maly
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.