The Role of Pharmacometrics in Drug Discovery and Development Process
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 62651
Special Issue Editors
Interests: pharmacokinetics; biopharmaceutics; oral absorption; dissolution methods
Special Issues, Collections and Topics in MDPI journals
Interests: population analysis; pharmacokinetics/pharmacodynamics/disease modeling; pharmacometrics; systems pharmacology; model-based-drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pharmacometrics is the science that integrates information on drug behavior, pharmacological response, and disease progression using mathematical models based on biology, pharmacology, and pathophysiology, along with statistical models that allow describing and explaining the sources of variability in the studied populations. Its quantitative, integrative, and translational capacity helps not only describe the observed behavior (prediction) but evaluate (simulation) with a greater degree of certainty unknown situations and scenarios. Model-informed approaches have revolutionized drug development and therapeutic use paradigm due to a more rational and efficient decision making, achieving significant support from the main regulatory agencies (FDA, EMA, PMDA).
This Special Issue is focused on new modeling strategies and methodologies, applications in the preclinical and clinical field that can highlight the relevance of pharmacometrics in the PK or PK/PD characterization, identification of relevant sources of variability, inter-species scaling, optimization of dosing schedules in special sub-groups of populations, optimal design, QTc prolongation, placebo and disease models, and exposure-response analysis using continuous or categorical data.
Dr. Victor Mangas Sanjuan
Prof. Dr. Inaki F. Troconiz
Guest Editors
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Keywords
- pharmacometrics
- population analysis
- pharmacokinetics
- pharmacodynamics
- modeling
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