In vivo dynamics of protein levels in bacterial cells depend on both intracellular regulation and relevant population dynamics. Such population dynamics effects, e.g., interplay between cell and plasmid division rates, are, however, often neglected i...
Background/Aims: Diabetes mellitus is a major cause of atherosclerotic cardiovascular disease (ASCVD). We examined a large population and tested the efficacy of a voluntary lifestyle program in prediabetic and diabetic subjects. Methods: Of 133,764 s...
Population genomics can improve the design, deployment, and monitoring of genetic mosquito control strategies by revealing how genetic variation, population structure, and movement influence intervention outcomes. Here, we present a decision-oriented...
29 January 2019
(1) Background: Although the health effects of future climate change have been examined in previous studies, few have considered additive impacts of population expansion, ageing, and adaptation. We aimed to quantify the future heat-related years of l...
Background: Cardiovascular diseases (CVD) are still the leading cause of death in developed countries. The aim of this study was to calculate the potential for CV risk reduction when using three different prevention strategies to evaluate the effect...
(1) This research paper aims to conduct a comprehensive review of the existing scientific literature on intentional dental modifications within the African population. By synthesizing and analysing studies, this paper aims to shed light on the preval...
Mitochondrial DNA (mtDNA) exhibits distinct characteristics distinguishing it from the nuclear genome, necessitating specific analytical methods in genetic studies. This comprehensive review explores the complex role of mtDNA in a variety of genetic...
13 November 2021
The SARS-CoV-2 pandemic led to lockdowns, which affected the elderly, a high-risk group. Lockdown may lead to weight gain due to increased food intake and reduced physical activity (PA). Our study aimed to analyze the impact of a 12-month lifestyle i...
Home fall injuries amongst the general population are common and costly. In the Home Injury Prevention Intervention (HIPI) trial, we showed that 26% of medically treated home fall injuries could be prevented by a package of home modifications underta...
The coastal city of Guasave, Sinaloa, located on the Mexican Pacific coast, is subject to extreme precipitation events, which have caused flooding with damage to the city’s infrastructure. The factors that influence flooding are vegetation, geo...
Immunocompromised pediatric populations (children with inborn errors of immunity, HIV infection, and cancer, as well as those undergoing hematopoietic stem-cell transplantation) have severe nutritional challenges, with malnutrition depending on the u...
Cardiometabolic risk factors are frequent in children and adolescents with excess weight. The aim of this study was to evaluate the effects of lifestyle modifications on alterations in lipid and glycemic profiles and uric acid values in a pediatric p...
9 December 2021
Early in the SARS-CoV-2 pandemic, many national public health authorities implemented non-pharmaceutical interventions to mitigate disease outbreaks. Panamá established mandatory mask use two months after its first documented case. Initial com...
Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N...
9 May 2017
American Indians experience high rates of cardiovascular diseases (CVD). Environmental tobacco smoke (ETS) has been linked to CVD, possibly due to pro-inflammatory and oxidative stress pathways. We examined the relationship between self-reported expo...
We predicted small-scale hydrodynamics, including the effect of the aquaculture farming infrastructure, for a region within the group of salmon farm concessions identified in the Chilean regulation as ACS-7. The geographical region corresponds to the...
We study how small harmful mutations spread in populations that reproduce asexually. This process is known as Muller’s ratchet—it means that even though these mutations are damaging, they can still build up over generations. To explore th...
The population pyramids in Europe have changed in the last decades, particularly in Spain, where population aging is observed and implies an increase in the dependency ratio. The present study aims to modify a mathematical model of population defined...
Pulmonary fibrosis is a progressive interstitial lung disease characterized by persistent alveolar epithelial injury, aberrant repair, and excessive extracellular matrix deposition. Increasing evidence indicates that disease progression is closely as...
In the inland waters of the Balkans, many brown trout populations have been severely depleted. Therefore, identifying potential threats to their continued survival and ranking populations based on their biological and evolutionary importance enables...
Plants have a lot of diversity in epigenetic modifications such as DNA methylation in their natural populations or cultivars. Although many studies observing the epigenetic diversity within and among species have been reported, the mechanisms how the...
In this article, we present a modified auxiliary equation method. We harness this modification in three fundamental models in the biological branch of science. These models are the biological population model, equal width model and modified equal wid...
The biological progression of aging encompasses complex physiological processes. As individuals grow older, their physiological functions gradually decline, including compromised immune responses, leading to immunosenescence. Immunosenescence signifi...
Dietary guidelines recommended by key health agencies are generally designed for a global population. However, ethnicity affects human disease and environment-gene interactions, including nutrient intake. Historically, isolated human populations with...
Intestinal organoids are 3D cell structures that replicate some aspects of organ function and are organized with a polarized epithelium facing a central lumen. To enable more applications, new technologies are needed to access the luminal cavity and...
The Particle Swarm Optimization (PSO) method is a global optimization technique based on the gradual evolution of a population of solutions called particles. The method evolves the particles based on both the best position of each of them in the past...
The paper presents a memetic modification of the classical genetic algorithm by introducing a cyclic symmetrization of the population, symmetrizing the parental points around the current population leader. Such an operator provides a more spherical d...
30 March 2023
Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asy...
26 May 2022
The COVID-19 pandemic caused a lot of social and health chaos. Our main aim in this study was to examine the impact of the COVID-19 pandemic on occupational balance in the Spanish population, one year post the beginning of the pandemic compared with...
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganis...
Ribosomal RNA is a major component of the ribosome. This RNA plays a crucial role in ribosome functioning by ensuring the formation of the peptide bond between amino acids and the accurate decoding of the genetic code. The rRNA carries many chemical...
Differential Evolution (DE) is a method of optimization used in symmetrical optimization problems and also in problems that are not even continuous, and are noisy and change over time. DE optimizes a problem with a population of candidate solutions a...
Background: Carotid artery stenting (CAS) could lead to a modification of the carotid bifurcation geometry with possible clinical implications. This study aimed to clarify the geometrical impact of three carotid stents with different designs on the c...
Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible f...
Infestations have persisted following a sudden and intense outbreak of the bark beetle Orthotomicus erosus along the Croatian coast, necessitating a continuous battle against this pest. A recommended protective action is the utilization of pheromone...
11 January 2023
In this study, six aircraft noise reduction strategies including the optimization of aircraft type, regulation of night flight number, optimization of flight procedure, modification of operating runway, land use planning and installation of sound ins...
Herpesviruses are double-stranded DNA viruses occurring at a high prevalence in the human population and are responsible for a wide array of clinical manifestations and diseases, from mild to severe. These viruses are classified in three subfamilies...
Parkinson’s disease (PD) is a neurodegenerative disease with a high prevalence among the middle-aged and elderly population. The pathogenesis of PD is closely linked to the misfolding and aggregation of α-synuclein, which contributes to t...
Despite being highly preventable, stroke is the second-most common cause of death and disability in the world. Secondary prevention is critical as the stroke recurrence risk is 6- to 15-fold higher than the risk of stroke in the general population. S...
The environment affects population dynamics through multiple drivers. Here we explore a simplified version of such influence in a three-species food chain, making use of the Hastings–Powell model. This represents an idealized resource–consumer–predat...
Background/Objectives: Socioeconomic hardship during the COVID-19 pandemic was associated with lower vaccine uptake. Since the pandemic has exacerbated socioeconomic challenges faced by sexual and gender minority populations, including employment inc...
Distinct breeding populations of Coffea canephora often exhibit genetic divergence, yet the biological pathways underlying yield and leaf rust resistance in contrasting populations remain poorly understood. Here, we performed a comparative genomic an...
Adaptive changes encompass physiological, morphological, or behavioral modifications occurring in organisms in response to specific environmental conditions. These modifications may become established within a population through natural selection. Wh...
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensuring the dynamic control of gene regulation in every cell type. These modifications are associated with gene activation or repression, depending on the...
Methylmercury (MeHg) has conventionally been investigated for effects on nervous system development. As such, epigenetic modifications have become an attractive mechanistic target, and research on MeHg and epigenetics has rapidly expanded in the past...
Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence exponentially increases with age and could reach up to 8% in the elderly population. The management of AF...
Habitat modification is a major factor in the decline of reptile populations. The degree of the decline has been shown to be directly related to the intensity of habitat modification. Farming practices and urbanization are just two of the factors inv...
Oil tea camellia (Camellia spp.) is an important woody oil crop with a high nutritional and economic value. Whole-genome resequencing (WGR) technology can provide an in-depth understanding of the genetic background of this plant as well as a referenc...
The problem of finding the optimal open-loop control for discrete-time stochastic dynamical systems is considered. It is assumed that the initial conditions and external influences are random. The average value of the Bolza functional defined on indi...
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