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Review

RNA Modification in Inflammatory Bowel Diseases

1
Department of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
2
Department of Gastrointestinal Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
3
Kinshu-kai Medical Corporation, Osaka 558-0011, Japan
4
Food and Life-Science Laboratory, Prophoenix Division, IDEA Consultants, Inc., Osaka 559-8519, Japan
5
Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Frederikskaj 10B, 2. (Building C), 2450 Copenhagen SV, Denmark
6
Department of Clinical and Molecular Medicine, University of Rome “Sapienza,” Santo Andrea Hospital, Via di Grottarossa, 1035-00189 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Ferenc Sipos
Biomedicines 2022, 10(7), 1695; https://doi.org/10.3390/biomedicines10071695
Received: 14 June 2022 / Revised: 7 July 2022 / Accepted: 8 July 2022 / Published: 13 July 2022
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches. View Full-Text
Keywords: RNA modification; inflammatory bowel disease RNA modification; inflammatory bowel disease
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MDPI and ACS Style

Nakayama, M.; Ozato, Y.; Tsuji, Y.; Arao, Y.; Otsuka, C.; Hamano, Y.; Sumi, G.; Ofusa, K.; Uchida, S.; Vecchione, A.; Ishii, H. RNA Modification in Inflammatory Bowel Diseases. Biomedicines 2022, 10, 1695. https://doi.org/10.3390/biomedicines10071695

AMA Style

Nakayama M, Ozato Y, Tsuji Y, Arao Y, Otsuka C, Hamano Y, Sumi G, Ofusa K, Uchida S, Vecchione A, Ishii H. RNA Modification in Inflammatory Bowel Diseases. Biomedicines. 2022; 10(7):1695. https://doi.org/10.3390/biomedicines10071695

Chicago/Turabian Style

Nakayama, Mika, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, and Hideshi Ishii. 2022. "RNA Modification in Inflammatory Bowel Diseases" Biomedicines 10, no. 7: 1695. https://doi.org/10.3390/biomedicines10071695

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