Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated...
ATP-dependent SWI/SNF chromatin remodelling complexes are conserved multi-subunit assemblies that control genome activity. Functions of SWI/SNF complexes in plant development and growth have been well established, but the architecture of particular a...
Glioblastoma (GBM) is a deadly and incurable brain cancer with limited therapeutic options. PFI-3 is a small-molecule bromodomain (BRD) inhibitor of the BRM/BRG1 subunits of the SWI/SNF chromatin remodeling complex. The objective of this study is to...
30 July 2021
As one of the main industrial solid wastes, there are a large number of free alkaloids, chemically bound alkaloids, fluoride, and heavy metal ions in Bayer process red mud (BRM), which are difficult to remove and easily pollute groundwater as a resul...
The mining of layered soft bauxite under coal seams (BCS) will cause serious underground goaf disasters and surface Bayer process red mud (BRM) pollution. In order to realize the safe and efficient mining of BCS, the feasibility of recycling BRM as a...
The metastatic suppressor BRMS1 interacts with critical steps of the metastatic cascade in many cancer entities. As gliomas rarely metastasize, BRMS1 has mainly been neglected in glioma research. However, its interaction partners, such as NFκB,...
Divergent thinking tests are popular instruments to measure a person’s creativity. They often involve scoring fluency, which refers to the count of ideas generated in response to a prompt. The two-parameter Poisson counts model (2PPCM), a gener...
Background: Macromastia is a well-known issue in breast reconstruction. Skin-reducing mastectomy (SRM) was introduced as a skin-sparing mastectomy that utilizes a skin reduction pattern similar to breast reduction or breast lift surgery, specifically...
Human hepatitis B virus core protein (HBc) is a structural protein of the hepatitis B virus (HBV) and contributes to HBV regulation of host-cell transcription. However, the mechanisms of transcriptional regulation remain poorly characterized. To diss...
The tomato leaf miner (Tuta absoluta) is one of the top 20 plant pests worldwide. We cloned and identified the chromatin-remodelling ATPase genes ISWI and BRM by RACE and bioinformatic analysis, respectively; used RT-qPCR to examine their expression...
Renal cancer is among the deadliest human malignancies. MCM7, a cell cycle-regulating protein, is frequently overexpressed in cancers and is associated with hyperproliferation and cancer progression. miR-25-3p, miR-93-5p, and miR-106b-5p form the miR...
The novel coronavirus can cause a severe respiratory disease with impact on the central nervous system, as has been reported by several medical health services. In the COVID-19 pandemic caused by the SARS-CoV-2 neurotrophic virus, neurologists have f...
Background/Objectives: The BRG1 loss-of-function (LOF) mutation is found in ~10% of non-small cell lung cancer (NSCLC) cases, but its role in lung tumorigenesis is unclear and so it is investigated in this study. Methods: BRG1-knockout (KO) lines wer...
Through research, restoration of agro-ecological sites, and a renaissance of cultural awareness in Hawaiʻi, there has been a growing recognition of the ingenuity of the Hawaiian biocultural resource management system. The contemporary term for this s...
Raven’s Standard Progressive Matrices (SPM) test and related matrix-based tests are widely applied measures of cognitive ability. Using Bayesian Item Response Theory (IRT) models, I reanalyzed data of an SPM short form proposed by Myszkowski an...
National functions are categories of operations prioritised for restoration when disrupted by emergencies such as disasters. However, the simultaneous restoration of all national functions when some or all are paralysed is limited by time and resourc...
Ecdysone signaling in Drosophila remains a popular model for investigating the mechanisms of steroid action in eukaryotes. The ecdysone receptor EcR can effectively bind ecdysone-response elements with or without the presence of a hormone. For years,...
We aimed to evaluate the expression of the “targetable” androgen receptor (AR) in breast cancer brain metastases (BrM). An established, retrospective 57-patient cohort with metastatic breast cancer who underwent surgery for BrM at the Sun...
The Bell regression model (BRM) is a statistical model that is often used in the analysis of count data that exhibits overdispersion. In this study, we propose a Bayesian analysis of the BRM and offer a new perspective on its application. Specificall...
The ATP-dependent Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodeling complex (CRC) regulates the transcription of many genes by destabilizing interactions between DNA and histones. In plants, BRAHMA (BRM), one of the two catalytic ATPase su...
Sex differences are evident in adverse events (AEs) related to brain tumors, yet sex differences in AEs specific to brain metastases (BrMs) are underexplored. Lung cancer BrMs dominate among BrM, comprising over half of cases. This study examined sex...
The beta regression model (BRM) is used when the dependent variable may take continuous values and be bounded in the interval (0, 1), such as rates, proportions, percentages and fractions. Generally, the parameters of the BRM are estimated by the met...
Metabolic adaptation may happen in response to the pressure exerted by the microenvironment and is a key step in survival of metastatic cells. Brain metastasis occurs as a consequence of the systemic dissemination of tumor cells, a fact that correlat...
Utilizing supplementary cementitious materials is an effective way to fabricate low-carbon cement-based materials. In this paper, the composite mortars with good properties were prepared by mixing them with basic oxygen furnace slag (BOFS), Bayer red...
Bayer red mud (BRM) is a kind of solid waste with high hematite content, and its effective utilization is difficult due to the special physicochemical properties. In this work, Fe2O3 in BRM was reduced to Fe3O4 by biomass, and iron concentrate and hi...
The bi-reforming of methane (BRM) is a promising process which converts greenhouse gases to syngas with a flexible H2/CO ratio. As there are many factors that affect this process, the coupled effects of multi-parameters on the BRM product are investi...
The need for antibiotics in commercial laying hens is increasing owing to intensive farming systems. Amoxicillin trihydrate (AMX), an aminopenicillin β-lactam antibiotic, exerts broad bactericidal activity. However, its short half-life necessita...
We develop a novel approach improving existing target localization algorithms for distributed multiple-input multiple-output (MIMO) radars based on bistatic range measurements (BRMs). In the proposed algorithms, we estimate the target position with a...
Brain metastasis is one of the main causes of mortality among breast cancer patients, but the origins and the mechanisms that drive this process remain poorly understood. Here, we report that the upregulation of certain CXCR2-associated ligands in th...
JPEG AI, the first international standard for learned image compression, supports a continuous bit-rate range through four models whose operating points are adjusted by a Gain Unit. To reach a target bit rate, the Bit Rate Matching (BRM) process of t...
Brain metastasis (BrM) remains a significant cause of cancer-related mortality in epidermal growth factor receptor 2-positive (ERBB2+) breast cancer (BC) patients. We proposed here that a combination treatment of irreversible tyrosine kinase inhibito...
Numerous hospital laboratories in Indonesia need to implement improved bio-risk management (BRM) systems. There are many potential biohazards in laboratory activities that can impact health and the environment, leading to laboratory incidents. To min...
Plant biomass is an important parameter for crop management and yield estimation. However, since biomass cannot be determined non-destructively, other plant parameters are used for estimations. In this study, plant height and hyperspectral data were...
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly worldwide. So far, the etiology and the progression of AMD are not well known. Animal models have been developed to study the mechanisms involved in AMD; howeve...
Interocclusal records (IORs) created with bite registration materials (BRMs) accurately reflect the opposing teeth’s physiological and anatomical associations in digital and traditional dentistry. This study assessed the linear dimensional accu...
The massive stockpiles of Bayer-process red mud (BRM) severely compromise soil integrity, necessitating the urgent development of efficient large-scale utilization strategies. BRM contains large amounts of calcium, silicon, and aluminum. Theoreticall...
The evolution of mining-induced overburden fractures (MIOFs) and their dynamic monitoring are critical for preventing roof water hazards and gas disasters in coal mines. Conventional methods often fail to provide sufficient accuracy under the thin so...
Adaptive cellular immunity plays a major role in clearing microbial invasion of mucosal tissues in mammals. Following the clearance of primary pathogens, memory lymphocytes are established both systemically and locally at pathogen entry sites. Recent...
Background: Executive functions may underpin performance in live-fire tasks, whereas evidence for global physical fitness is mixed. We quantified the associations between cognitive flexibility (CF), inhibitory control (IC), overall physical fitness,...
The local regeneration of bone defects is regulated by general hormone, enzyme, ion, and vitamin levels. General diseases and dysregulation of the human mineral system can impact this process, even in alveolar crest. The aim of this study is to inves...
Piezoelectric actuated models are promising high-performance precision positioning devices used for broad applications in the field of precision machines and nano/micro manufacturing. Piezoelectric actuators involve a nonlinear complex hysteresis tha...
Rubber, as a kind of macromolecular material often used in large ships, aviation, aerospace, and other fields, has remarkable viscoelasticity at room temperature. Therefore, it is of great significance to evaluate the viscoelastic properties of polym...
Apples damaged by black root mold (BRM) lose moisture, vitamins, and minerals as well as carry dangerous toxins. Determination of the infection degree can allow for customized use of apples, reduce financial losses, and ensure food safety. In this st...
The complement system is crucial for immune surveillance, providing the body’s first line of defence against pathogens. However, an imbalance in its regulators can lead to inappropriate overactivation, resulting in diseases such as age-related...
Triple-negative breast cancer (TNBC) tends to metastasize to the brain, a step that worsens the patient’s prognosis. The specific hallmarks that determine successful metastasis are motility and invasion, microenvironment modulation, plasticity, and c...
The BC-brain questionnaire was developed by BC Cancer to detect health problems in patients with central nervous system (CNS) tumours in routine clinical care, treated with radiotherapy (RT), as part of the Prospective Outcomes and Support Initiative...
Objective: To determine if basal linear deposit (BLinD) is a specific lesion of age-related macular degeneration (AMD). Methods: The cohort was selected from a clinically and histopathologically validated archive (Sarks Archive) and consisted of 10 n...
Background/Objectives: Around 20% of cancer patients will develop brain metastases (BrMs), with 15–25% occurring in the posterior fossa (PF). Although the effectiveness of systemic therapies is increasing, surgery followed by stereotactic radio...
The Bruch’s membrane (BrM) is a five-layered extracellular matrix (ECM) that supports the retinal pigment epithelium (RPE). Normal age-related changes in the BrM may lead to RPE cell damage and ultimately to the onset and progression of age-related m...
The aim of this contribution is to identify and quantify the magnetic field parameter (MP) devices for charging electric vehicles (EVs). An EV is a mobile device. The EV remains a mobile device even when it is charging in a fixed charging stand. ICNI...
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